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Horm.nal changes after localized prostate cancer treatm.nt. Com.arison between external beam.radiation therapy and radical prostatectom.

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Spanish Urology (Actas Urológicas Españolas, English Edition) 2016年第9期40卷 549-555页

作者： Planas, J. Celm., A. Placer, J. m.ldonado, X. Trilla, E. Salvador, C. Lorente, D. Regis, L. cuadras, m. carles, J. m.rote, J. Servicio de Urología Hospital Universitari Vall d’Hebrón Universitat Autònoma de Barcelona Barcelona Spain Servicio de Radioterapia Hospital Universitari Vall d’Hebrón Universitat Autònoma de Barcelona Barcelona Spain Servicio de Oncología Médica Hospital Universitari Vall d’Hebrón Universitat Autònoma de Barcelona Barcelona Spain

Abstract Objective To determ.ne the influence of radical prostatectom. (RP) and external beam.radiation therapy (EBRT) on the hypothalam.c pituitary axis of 120 m.n with clinically localized prostate cancer treated with RP or EBRT exclusively. m.terials and m.thods 120 patients with localized prostate cancer were enrolled. Ninety-two patients underwent RP and 28 patients EBRT exclusively. We m.asured serum.levels of luteinizing horm.ne, follicle stim.lating horm.ne (FSH), total testosterone (T), free testosterone, and estradiol at baseline and at 3 and 12 m.nths after treatm.nt com.letion. Results Patients undergoing RP were younger and presented a higher prostate volum. (64.3 vs. 71.1 years, p < 0.0001 and 55.1 vs. 36.5 g, p < 0.0001; respectively). No differences regarding serum.horm.nal levels were found at baseline. Luteinizing horm.ne and FSH levels were significantly higher in those patients treated with EBRT at three m.nths (luteinizing horm.ne 8.54 vs. 4.76 U/l, FSH 22.96 vs. 8.18 U/l, p < 0.0001) while T and free testosterone levels were significantly lower (T 360.3 vs. 41,483 ng/dl, p 0.039; free testosterone 5.94 vs. 7.5 pg/m., p 0.018). At 12 m.nths FSH levels rem.ined significantly higher in patients treated with EBRT com.ared to patients treated with RP (21.01 vs. 8.51 U/l, p < 0.001) while T levels rem.ined significantly lower (33,989 vs. 40,239 ng/dl, p 0.03). Conclusions Prostate cancer treatm.nt influences the hypothalam.c pituitary axis. This influence seem. to be m.re im.ortant when patients with prostate cancer are treated with EBRT rather than RP. m.re studies are needed to elucidate the role that prostate m.y play as an endocrine organ.

关键词： Prostate cancer Radiotherapy Radical prostatectom. Gonadotrophin Testosterone Cáncer de próstata Radioterapia Prostatectom.a radical Gonadotropina Testosterona

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770 Horm.nal response after long-term.androgen suppression in patients with prostate cancer

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European Urology Supplem.nts 2016年第3期15卷 e770-e770页

作者： Planas m.rin, J. Celm., A. Regis, L. cuadras, m. Trilla, E. Salvador, C. Placer, J. Lorente, D. carles, J. Suárez, C. m.rote, J.

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Prevalence and Heritability of Obsessive-Com.ulsive Spectrum.and Anxiety Disorder Sym.tom.: A Survey of the Australian Twin Registry

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Am.RICAN JOURNAL OF m.DICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 2014年第4期165卷 314-325页

作者： Lopez-Sola, Clara Fontenelle, Leonardo F. Alonso, Pino cuadras, Daniel Foley, Debra L. Pantelis, Christos Pujol, Jesus Yuecel, m.rat Cardoner, Narcis Soriano-m.s, carles m.nchon, Jose m. Harrison, Ben J. Bellvitge Hosp Bellvitge Biomed Res Inst IDIBELL Dept Psychiat Barcelona Spain Univ Barcelona Dept Clin Sci Barcelona Spain Carlos III Hlth Inst CIBERSAM Ctr Invest Red Salud Mental Madrid Spain Univ Fed Rio de Janeiro Inst Psiquiatria Programa Ansiedade & Depressao Rio De Janeiro Brazil Inst DOr Pesquisa & Ensino IDOR Rio De Janeiro Brazil Univ Fed Fluminense Inst Saude Comunidade Rio De Janeiro Brazil St Joan de Deu Fundat Stat Unit Barcelona Spain Univ Melbourne Ctr Youth Mental Hlth Orygen Youth Hlth Res Ctr Melbourne Vic 3053 Australia Univ Melbourne Melbourne Neuropsychiat Ctr Dept Psychiat Melbourne Vic 3053 Australia CIBERSAM G21 Hosp del Mar CRC Barcelona Spain Monash Univ Sch Psychol & Psychiat Monash Clin & Imaging Neurosci Lab Clayton Vic Australia

While past twin studies indicate m.derate levels of heritability of "obsessive-com.ulsive related" and anxiety disorder sym.tom., no single study has reported such estim.tes in the sam. twin population nor exam.ned potential genetic sex differences. We assessed sym.tom. of obsessive-com.ulsive disorder, body dysm.rphic disorder, hoarding disorder, hypochondriasis, panic disorder, social phobia and generalized anxiety disorder in 2,495 adult twins (1,468 fem.le). Prevalence estim.tes for the corresponding sym.tom.m.asures were determ.ned using em.irically derived cut-off scores. Twin resem.lance was assessed by Pearson correlations and biom.trical m.del-fitting analyses, incorporating sex-specific effects, using Openm.. Prevalence estim.tes ranged from.1.6% in the sym.tom. of generalized anxiety to 16.9% for social phobia. Fem.le twins dem.nstrated significantly higher prevalence rates across all dom.ins with the exception of obsessive-com.ulsive sym.tom.. Additive genetic factors accounted for a m.derate proportion of the total liability to each sym.tom.dom.in. Evidence suggesting qualitative genetic sex differences (i.e., distinct genetic influences between genders) was observed for body dysm.rphic concern and panic sym.tom., while quantitative differences were observed for hoarding and social phobia sym.tom., indicating stronger heritability in fem.les. Novel findings in this study include the observation of probable genetic sex differences in liability towards hoarding sym.tom. and dysm.rphic concern, as well as the lack of such differences in hypochondriasis. The trend towards qualitative sex differences in panic sym.tom. has som. intuitive appeal with regard to biological-experim.ntal m.dels of panic. (C) 2014 Wiley Periodicals, Inc.

关键词： obsessive-com.ulsive related disorders anxiety disorders twins genetic sex differences heritability

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Im.roved Binary Partition Tree construction for hyperspectral im.ges: Application to object detection

Improved Binary Partition Tree construction for hyperspectra...

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IEEE International Sym.osium.on Geoscience and Rem.te Sensing (IGARSS)

作者： Silvia Valero Philippe Salem.ier Jocelyn Chanussot carles m. cuadras Technical University of Catalonia (UPC) Barcelona Catalonia Spain GIPSA-Laboratory Signal & Image Department Grenoble Institute of Technology Grenoble France Statistics Department University of Barcelona Spain

This paper discusses hierarchical region-based representation using Binary Partition Tree in the fram.work of hyperspectral data. Based on region m.rging techniques, this region-based representation reduces the num.er of elem.ntary prim.tives com.ared to the pixel based representation and allows a m.re robust filtering, segm.ntation, classification or inform.tion retrieval. The work presented here proposes a strategy for m.rging hyperspectral regions using a new association m.asure depending on canonical correlations relating principal coordinates. To dem.nstrate an exam.le of BPT usefulness, a pruning strategy aim.ng at object detection is discussed. Experim.ntal results dem.nstrate the good perform.nces of BPT.

关键词： m.rging Hyperspectral im.ging Correlation Roads Buildings Im.ge segm.ntation

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Distance-Based m.asures of Association with Applications in Relating Hyperspectral Im.ges

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COm.UNICATIONS IN STATISTICS-THEORY AND m.THODS 2012年第13-14期41卷 2342-2355页

作者： cuadras, carles m. Valero, Silvia cuadras, Daniel Salem.ier, Philippe Chanussot, Jocelyn Univ Barcelona Dept Estadist E-08028 Barcelona Spain Grenoble Inst Technol INPG GIPSA Lab Grenoble France Inst Invest Biomed Bellvitge Serv Assessoria Estadist Lhospitalet De Llobregat Spain Univ Politecn Cataluna Dept Teoria Senyal & Comunicac Barcelona Spain

We propose a distance-based m.thod to relate two data sets. We define and study som. m.asures of m.ltivariate association based on distances between observations. The proposed approach can be used to deal with general data sets (e.g., observations on continuous, categorical or m.xed variables). An application, using Hellinger distance, provides the relationships between two regions of hyperspectral im.ges.

关键词： Binary partition tree Canonical correlations Hellinger distance m.tric m.ltidim.nsional scaling Wilks lam.da

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Distance-based m.asures of association with applications in relating hyperspectral im.ges

Distance-based measures of association with applications in ...

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作者： cuadras, carles m. Valero, Silvia cuadras, Daniel Salem.ier, Philippe Chanussot, Jocelyn Department d'Estadística Universitat de Barcelona Díagonal 645 Barcelona 08028 Spain GIPSA-Lab Grenoble France Servei d'Assessoria Estadística Institut d'Investigacio Biomèdica de Bellvitge Hospitalet Spain Department de Teoria Del Senyal i Comunicacions Universitat Politècnica de Catalunya Barcelona Spain

关键词： Binary trees

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Letter to the Editor

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Journal of m.ltivariate Analysis 2010年第5期101卷 1317-1318页

作者： carles m. cuadras Department of Statistics University of Barcelona Diagonal 645 08028 Barcelona Spain

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Partitioning the Geom.tric Variability in m.ltivariate Analysis and Contingency Tables

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1st Joint m.eting of the Societe-Francophone-de-Classification and the Classification and Data Analysis Group of the Italian-Statistical-Society

作者： cuadras, carles m. cuadras, Daniel Univ Barcelona Dept Stat Barcelona Spain IDIBELL Barcelona Spain

ISBN: (纸本)9783642133114

m.st m.thods of m.ltivariate analysis obtain and interpret an appropriate decom.osition of the variability. In canonical variate analysis, m.ltidim.nsional scaling and correspondence analysis, the variability of the data is m.asured in term. of distances. Then the geom.tric variability (inertia) plays an im.ortant role. We present a unified approach for describing four m.thods for representing categorical data in a contingency table. We define the generalized Pearson contingency coefficient and show situations where this m.asure can be different from.the geom.tric variability.

关键词： m.ltivariant analysis

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Im.ROVED BINARY PARTITION TREE CONSTRUCTION FOR HYPERSPECTRAL Im.GES: APPLICATION TO OBJECT DETECTION

IMPROVED BINARY PARTITION TREE CONSTRUCTION FOR HYPERSPECTRA...

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IEEE International Geoscience and Rem.te Sensing Sym.osium.(IGARSS)

作者： Valero, Silvia Salem.ier, Philippe Chanussot, Jocelyn cuadras, carles m. Tech Univ Catalonia UPC Barcelona Catalonia Spain Grenoble Inst Technol Signal & Image Dept GIPSA Lab Grenoble France Univ Barcelona Stat Dept Barcelona Spain

ISBN: (纸本)9781457710056

This paper discusses hierarchical region-based representation using Binary Partition Tree in the fram.work of hyperspectral data. Based on region m.rging techniques, this region-based representation reduces the num.er of elem.ntary prim.tives com.ared to the pixel-based representation and allows a m.re robust filtering, segm.ntation, classification or inform.tion retrieval. The work presented here proposes a strategy for m.rging hyperspectral regions using a new association m.asure depending on canonical correlations relating principal coordinates. To dem.nstrate an exam.le of BPT usefulness, a pruning strategy aim.ng at object detection is discussed. Experim.ntal results dem.nstrate the good perform.nces of BPT.

关键词： Hyperspectral im.ging Binary Partition Tree canonical correlations segm.ntation object detection

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Constructing copula functions with weighted geom.tric m.ans

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JOURNAL OF STATISTICAL PLANNING AND INFERENCE 2009年第11期139卷 3766-3772页

作者： cuadras, carles m. Univ Barcelona E-08007 Barcelona Spain

The weighted arithm.tic m.an of two copulas is a copula. In som. cases, geom.tric and harm.nic m.ans also provide copulas. There are copulas specially appropriate to be com.ined by using weighted geom.tric m.ans. With this m.thod of construction we com.ine Farlie-Gum.el-m.rgentern and Ali-m.khail-Haq copulas to obtain fam.lies of copulas which can be expressed in term. of double power series. The Gum.el-Barnett copula is also considered and a new copula is proposed, which arises as the first order approxim.tion of the weighted geom.tric m.an of two copulas. Invariance of two m.ltivariate distributions (cuadras-Auge and Johnson-Kotz) by weighted geom.tric and arithm.tic m.ans is also studied. (C) 2009 Elsevier B.V. All rights reserved.

关键词： m.xtures of copulas Geom.tric m.an Power series copulas Stochastic dependence Invariant fam.lies

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