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国际中医中药杂志 2024年第1期46卷 119-123页

作者：邵玉莹鲁菁屈媛媛冯楚文郭述豪李彬彬陈涛杨添淞黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院教务科哈尔滨150040 黑龙江省针灸临床(脑病)神经生物学重点实验室哈尔滨150040

中医传统功法是中医防治疾病的重要手段,可通过外调骨骼肌肉、内调身心脏腑,促进血液循环、改善睡眠障碍、提升代谢和免疫能力,达到防病治病、延长寿命、强身健体的目的,在治疗慢性疲劳综合征、运动性疲劳、卒中后疲劳、癌因性疲劳等各... 详细信息

中医传统功法是中医防治疾病的重要手段,可通过外调骨骼肌肉、内调身心脏腑,促进血液循环、改善睡眠障碍、提升代谢和免疫能力,达到防病治病、延长寿命、强身健体的目的,在治疗慢性疲劳综合征、运动性疲劳、卒中后疲劳、癌因性疲劳等各类疲劳方面疗效显著。

关键词：疲劳中医传统功法研究进展综述

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Packet-size aware scheduling algorithms in guard band for time sensitive networking

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CCF Transactions on Networking 2020年第1期3卷 4-20页

作者： Zhang, chuwen Wang, Yi Yao, Ruyi Zhou, Boyang Cheng, liang Xu, Yang li, Xiaoguang Cheng, Jian liu, Bin Department of Computer Science and Technology Tsinghua University Beijing China Institute of Future Networks Southern University of Science and Technology Shenzhen China PCL Research Center of Networks and Communications Peng Cheng Laboratory Shenzhen China Fudan University Shanghai China Lehigh University Bethlehem USA Peng Cheng Laboratory Shenzhen China

As an emerging and promising technology, Time Sensitive Networking (TSN) can be widely used in many real-time systems such as Industrial Internet of Things (IIoT) and Cyber Physical System (CPS). TSN, while ensuring the bounded latency and jitter, exhibits the disadvantage of not being able to efficiently use the bandwidth resources in the guard band. In this paper, we propose an algorithm family named Packet-size Aware Shaping (PAS), which is inspired by abstracting the problem of utilizing the guard band to a classic Precedence-Constrained Knapsack Problem (PCKP). PAS works with the existing TSN standards, having achieved the goal of guaranteeing the end-to-end latency for scheduled time-sensitive applications while fully utilizing the available bandwidth in the guard band for others. Furthermore, we have proposed and implemented several hardware designs for both the current standard TSN scheduler and the programmable one. The simulation results show that the PAS family can achieve satisfying performance in maximizing the resource utilization in the guard band. The synthesis results on Xilinx Vivado show that our proposed Multi-group Push-In-First-Out (MPIFO) scheduler can achieve 100 Mpps scheduling rate for 1024 scheduling items, which is fast enough to support the high-speed TSN.

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Flexible and tunable terahertz all-dielectric metasurface composed of ceramic spheres embedded in a ferroelectric / elastomer composite

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OPTICS EXPRESS 2018年第9期26卷 11633-11638页

作者： Lan, chuwen Zhu, Di Gao, Jiannan li, Bo Gao, Zehua Beijing Univ Posts & Telecommun Sch Informat & Commun Engn Beijing Lab Adv Informat Networks Beijing 100876 Peoples R China Beijing Univ Posts & Telecommun Sch Informat & Commun Engn Beijing Key Lab Network Syst Architecture & Conve Beijing 100876 Peoples R China Tsinghua Univ Shenzhen Grad Sch Adv Mat Inst Shenzhen Peoples R China

Terahertz (THz) all-dielectric metasurfaces made of high-index and low-loss resonators have attracted more and more attention due to their versatile properties. However, the all-dielectric metasurfaces in THz suffer from limited bandwidth and low tunability. Meanwhile, they are usually fabricated on flat and rigid substrates, and consequently their applications are restricted. Here, a simple approach is proposed and experimentally demonstrated to obtain a flexible and tunable THz all-dielectric metasurface. In this metasurface, micro ceramic spheres (ZrO2) are embedded in a ferroelectric (strontium titanate) / elastomer (polydimethylsiloxane) composite. It is shown that the Mie resonances in micro ceramic spheres can be thermally and reversibly tuned resulting from the temperature dependent permittivity of the ferroelectric / PDMS composite. This metasurface characterized by flexibility and tunability is expected to have a more extensive application in active THz devices. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

关键词： Mie resonances Mie theory Negative refractive index Refractive index Scanning electron microscopy Terahertz spectroscopy

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青少年慢性疲劳综合征的诊断现状分析

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神经损伤与功能重建 2023年第12期18卷 782-785页

作者：陈涛孙忠人李彬彬冯楚文屈媛媛王庆勇李超然杨添淞黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院康复二科哈尔滨150040 黑龙江省中医药信息学重点实验室哈尔滨150040 浙江中医药大学杭州310000

慢性疲劳综合征(chronic fatigue syndrome,CFS)是一种以持续不缓解的病态性疲劳为特征的疾病,严重影响患者的身心健康。既往关于CFS的研究大多聚焦于成年人,较少开展对青少年群体的针对性研究。研究显示,青少年CFS患者患病率逐年增高,... 详细信息

慢性疲劳综合征(chronic fatigue syndrome,CFS)是一种以持续不缓解的病态性疲劳为特征的疾病,严重影响患者的身心健康。既往关于CFS的研究大多聚焦于成年人,较少开展对青少年群体的针对性研究。研究显示,青少年CFS患者患病率逐年增高,由于诊断困难、治疗不当等原因导致部分患者预后不佳,加大对青少年CFS的研究力度极为必要。本文对青少年CFS的诊断标准、漏诊原因及研究进展进行总结,以期为青少年CFS的诊断及治疗提供新的思路。

关键词：慢性疲劳综合征青少年诊断治疗

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Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways

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SCIENTIFIC REPORTS 2017年第1期7卷 41082-41082页

作者： Zhang, Chao li, chuwen Chen, Shenghui li, Zhiping Ma, lijuan Jia, Xuejing Wang, Kai Bao, Jiaolin liang, Yeer Chen, Meiwan li, Peng Su, Huanxing Lee, Simon Ming Yuen liu, Kechun Wan, Jian-Bo He, Chengwei Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Macau 999078 Peoples R China Lees Pharmaceut Hong Kong Ltd Shatin 999077 Hong Kong Peoples R China Shandong Acad Sci Key Lab Drug Screening Technol Shandong Prov Key Lab Biosensor Inst Biol Jinan 250014 Peoples R China

Hormesis is an adaptive response of living organisms to a moderate stress. However, its biomedical implication and molecular mechanisms remain to be intensively investigated. Panaxatriol saponins (PTS) is the major bioactive components extracted from Panax notoginseng, a widely used herbal medicine for cerebrovascular diseases. This study aims to examine the hormetic and neuroprotective effects of PTS in PC12 cells and zebrafish Parkinson's disease (PD) models. Our results demonstrated that PTS stimulated PC12 cell growth by about 30% at low doses, while PTS at high doses inhibited cell growth, which is a typical hormetic effect. Moreover, we found that low dose PTS pretreatment significantly attenuated 6-OHDA-induced cytotoxicity and up-regulated PI3K/AKT/mTOR cell proliferation pathway and AMPK/SIRT1/FOXO3 cell survival pathway in PC12 cells. These results strongly suggested that neuroprotective effects of PTS may be attributable to the hormetic effect induced by PTS through activating adaptive response-related signaling pathways. Notably, low dose PTS could significantly prevent the 6-OHDA-induced dopaminergic neuron loss and improve the behavior movement deficiency in zebrafish, whereas relative high dose PTS exhibited neural toxicity, further supporting the hormetic and neuroprotective effects of PTS. This study indicates that PTS may have the potential in the development of future therapeutic medicines for PD.

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基于脑-肠轴理论探讨针灸的起效机制

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医学综述 2023年第19期29卷 3867-3872页

作者：鲁菁邵玉莹冯楚文屈媛媛郭述豪陈涛李彬彬杨添淞黑龙江中医药大学研究生学院哈尔滨150040 黑龙江中医药大学附属第一医院康复二科哈尔滨150040 黑龙江省中医药信息学重点实验室哈尔滨150040

脑-肠轴以肠道微生物为关键介质,通过动态调节大脑与肠道信息交流网络平衡,参与介导神经内分泌系统、免疫系统、消化系统等的生理及病理变化。针灸作为传统外治法,已被证实具有良性调节神经内分泌系统、炎症反应及肠道菌群等作用,为针... 详细信息

脑-肠轴以肠道微生物为关键介质,通过动态调节大脑与肠道信息交流网络平衡,参与介导神经内分泌系统、免疫系统、消化系统等的生理及病理变化。针灸作为传统外治法,已被证实具有良性调节神经内分泌系统、炎症反应及肠道菌群等作用,为针灸通过调节脑-肠轴防治疾病提供客观证据支持,但其对脑-肠轴的调控途径仍有待进一步明晰。因此,以经络循行为指导系统梳理针灸对脑-肠轴的调控效应,以期基于脑-肠轴为针灸效应机制研究提供新视角。

关键词：针灸脑-肠轴起效机制

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P³R: Realizing Robust Routing for VANET using Trajectory Prediction and Crossroad Recognition 25

P<SUP>3</SUP>R: Realizing Robust Routing for VANET using Tra...

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25th IEEE International Conference on Parallel and Distributed Systems (IEEE ICPADS)

作者： Zhang, chuwen Dai, Huichen Feng, Yong li, Yang Xu, Wenquan Ji, Xuefeng Wan, Ying Zhang, Gong liu, Bin Tsinghua Univ Dept Comp Sci & Technol Beijing Peoples R China Huawei Theory Lab Shenzhen Peoples R China

ISBN: (纸本)9781728125831

High topology dynamics and intermittent connectivity in Vehicular Ad hoc Network (VANET) bring huge challenges to end-to-end communication. Existing routing protocols for MANET such as AODV and OLSR work fine under modest mobility, but have a difficult time to handle frequent topology changes in VANET. This paper proposes Peeking at the Past and Present Routing ((PR)-R-3), a routing protocol that will calculate next-hops when the past forwarding is considered invalid. The nexthop calculation is based on the predicted locations of forwarder's neighbors and the packet's destination node, overcoming the inaccuracy caused by stale location information. Furthermore, we differentiate vehicles on crossroads as they have high connectivity in actual urban streets. In this way, (PR)-R-3 is able to deal with link breakages quickly and exploit new links. Simulation results show that (PR)-R-3 outperforms state-of-the-art alternatives in terms of packet delivery ratio, delay and cost, while maintaining strong scalability and robustness. We also implement (PR)-R-3 in a real vehicular testbed and the results reveal it has high connectivity on real streets.

关键词： VANET trajectory prediction crossroad recognition routing

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Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening

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MOLECULAR BIOSYSTEMS 2016年第9期12卷 2713-2721页

作者： Chong, Cheong-Meng Kou, Man-Teng Pan, Peichen Zhou, Hefeng Ai, Nana li, chuwen Zhong, Hai-Jing Leung, Chung-Hang Hou, Tingjun Lee, Simon Ming-Yuen Univ Macau State Key Lab Qual Res Chinese Med Macau Peoples R China Univ Macau Inst Chinese Med Sci Macau Peoples R China Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Soochow Univ Inst Funct Nano & Soft Mat FUNSOM Suzhou 215123 Jiangsu Peoples R China Soochow Univ Jiangsu Key Lab Carbon Based Funct Mat & Devices Suzhou 215123 Jiangsu Peoples R China

Rho-associated protein kinase (ROCK) mediated the reorganization of the actin cytoskeleton and has been implicated in the spread and metastatic process of cancer. In this study, structure-based high-throughput virtual screening was used to identify candidate compounds targeting ROCK2 from a chemical library. Moreover, high-content screening based on neurite outgrowth of SH-SY5Y cells (a human neuroblastoma cell line) was used for accelerating the identification of compounds with characteristics of ROCK2 inhibitors. The effects of bioactive ROCK2 inhibitor candidates were further validated using other bioassays including cell migration and wound healing in SH-SY5Y cells. Through the combined virtual and high-content drug screening, the compound 1,3-benzodioxol-5-yl[1-(5-isoquinolinylmethyl)-3-piperidinyl]-methanone (BIPM) was identified as a novel and potent ROCK2 inhibitor. Exposure of SH-SY5Y cells to BIPM led to significant changes in neurite length, cell migration and actin stress fibers. Further experiments demonstrated that BIPM was able to significantly inhibit phosphorylation of cofilin, a regulatory protein of actin cytoskeleton. These results suggest that BIPM could be considered as a promising scaffold for the further development of ROCK2 inhibitors for anti-cancer metastasis.

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针刺在阿尔茨海默病中调控多种类型自噬的机制研究进展

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针灸临床杂志 2022年第3期38卷 97-101页

作者：张菶杨添淞李孟孙晓伟冯楚文孙忠人周晓卿黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第一医院黑龙江哈尔滨150040 黑龙江中医药大学针灸临床神经生物学(脑病)重点实验室黑龙江哈尔滨150040 北京中医药大学深圳医院(龙岗) 广东深圳518172

阿尔茨海默病是以记忆、认知甚至人格改变为主要临床特征的中枢神经系统退行性疾病,目前发病机制以β淀粉样蛋白异常堆积形成老年斑和Tau蛋白异常积聚形成神经纤维结为主要因素。自噬作为哺乳动物清除异常细胞或蛋白的重要途径,近年发... 详细信息

阿尔茨海默病是以记忆、认知甚至人格改变为主要临床特征的中枢神经系统退行性疾病,目前发病机制以β淀粉样蛋白异常堆积形成老年斑和Tau蛋白异常积聚形成神经纤维结为主要因素。自噬作为哺乳动物清除异常细胞或蛋白的重要途径,近年发现其在阿尔茨海默病中可通过清除疾病过程产生的变性或错误折叠蛋白促进神经功能恢复,对该病的治疗意义重大。针刺作为传统中医疗法,在临床中治疗阿尔茨海默病患者有一定疗效。本研究通过在CNKI、Pubmed等网站搜索针刺、阿尔茨海默病和自噬等关键词,收集近8年文献,对针刺阿尔茨海默病中调控不同种类自噬机制作以综述,为阿尔茨海默病的针刺治疗效果提供有力证据,同时也为该病的治疗提供新思路。

关键词：针刺阿尔茨海默病自噬研究进展

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高质量视角下粤港澳大湾区公立医院数字转型的实践与思考

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现代医院 2023年第8期23卷 1149-1151,1155页

作者：张秋郑柏枫李伊玲邬楚雯陈义良吴颖芳姚立晴汤荧莹广东药科大学医药商学院广东广州510006 广东省药品监管科学研究基地广东广州510006 广东药科大学医药化工学院广东广州510006 广东药科大学生命科学与生物制药学院广东广州510006 广东药科大学附属第一医院广东广州510062 广州医科大学附属广州市妇女儿童医疗中心广东广州510623 澳门科技大学医学院中国澳门999078 香港岭南大学研究生院中国香港999077

数字技术的深化应用可为公立医院高质量发展赋予新动能。文章通过梳理公立医院信息化、数字化与智慧化的内部关系,分析大湾区公立医院在数字技术融合医疗服务实践中的主要特点与存在问题,并基于大湾区实践经验探析大湾区医院数字化转型... 详细信息

数字技术的深化应用可为公立医院高质量发展赋予新动能。文章通过梳理公立医院信息化、数字化与智慧化的内部关系,分析大湾区公立医院在数字技术融合医疗服务实践中的主要特点与存在问题,并基于大湾区实践经验探析大湾区医院数字化转型的经验启示。

关键词：公立医院数字化转型高质量发展粤港澳大湾区

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