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Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway

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BIOMEDICINE & PHARMACOTHERAPY 2020年 127卷 110115-110115页

作者： Zhuo, Jianyi Chen, Baoyi Sun, Chaoyue Jiang, Tao Chen, Zhiwei liu, Yanlu Nie, Juan Yang, Hongmei Zheng, Jingna Lai, Xiaoping Su, Ziren li, chuwen li, Yucui Guangzhou Univ Chinese Med Math Engn Acad Chinese Med Guangdong Prov Key Lab New Drug Dev & Res Chinese Guangzhou 510006 Peoples R China Sun Yat Sen Univ Dept Expt Res State Key Lab Oncol South China Canc Ctr Guangzhou 510060 Peoples R China Guangdong Pharmaceut Univ Lab Anim Ctr Guangzhou 510006 Peoples R China Guangzhou Med Univ Sch Pharmaceut Sci Key Lab Mol Target & Clin Pharmacol Guangzhou 510006 Peoples R China

Patchouli alcohol (PA), a tricyclic sesquiterpene, is the major chemical component of patchouli oil. This study investigated the antidepressant-like effect and mechanism of PA in chronic unpredictable mild stress (CUMS). Our results showed that PA markedly attenuated CUMS-induced depressant-like behaviors, including an effective increase of sucrose preference and spontaneous exploratory capacity, as well as reduction of immobility time. In addition, PA markedly attenuated CUMS-induced mTOR, p70S6K, and 4E-BP-1 phosphorylation reduction in the hippocampus. Furthermore, PA reversed CUMS-induced increases in LC3-II and p62 levels and CUMS-induced decrease in PSD-95 and SYN-I levels. These results indicated that the antidepressant-like effect of PA was correlated with the activation of the mTOR signaling pathway. Moreover, behavioral experimental results showed that the antidepressant-like effect of PA was blocked by rapamycin (autophagy inducer and mTOR inhibitor) and chloroquine (autophagic flux inhibitor). These results suggest that PA exerted antidepressant-like effect in CUMS rats through inhibiting autophagy, repairing synapse, and restoring autophagic flux in the hippocampus by activating the mTOR signaling pathway. The results render PA a promising antidepressant agent worthy of further development into a pharmaceutical drug for the treatment of depression.

关键词： GUMS Antidepressant-like effect patchouli alcohol mTOR Autophagy Synaptic proteins

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Intraspecific DNA Barcoding and Variation Analysis for Citri Reticulatae Pericarpium of Citrus reticulata "Chachi"

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EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021年第1期2021卷 2609935页

作者： liu, Mengshi Wang, Kanghui Chen, Baizhong Cai, Yi li, chuwen Yang, Wanling Wei, Minyan Zheng, Guodong Guangzhou Med Univ Sch Pharmaceut Sci Key Lab Mol Target & Clin Pharmacol Guangzhou 511436 Peoples R China Guangzhou Med Univ Sch Pharmaceut Sci State Key Lab Resp Dis Guangzhou 511436 Peoples R China Guangzhou Med Univ Sch Pharmaceut Sci Affiliated Hosp 5 Guangzhou 511436 Peoples R China Guangdong Xinbaotang Biol Technol Co Ltd Jiangmen 529000 Guangdong Peoples R China

Citri Reticulatae Pericarpium, the desiccative mature peel of Citrus reticulata Blanco or its cultivated varieties, is a national geographical indicated product that has the concomitant function of both medicine and foodstuff. The primary source of Citri Reticulatae Pericarpium is Citrus reticulata "Chachi," called "Guang chenpi," while it differs in variety, propagation, grafting rootstock, and tree age, and the hereditary stability of its biological information between intraspecific plants is worthy of our attention. Homologous analysis result of 4 DNA barcodings in the ribosome or the chloroplast showed that the homology of them (ITS2, rbcl, matK, and psbA-trnH) of 22 samples was 100.00%, 99.97%, 99.99%, and 99.81%, respectively, which indicated that 4 DNA barcodes maintained a high degree of genetic stability in Citrus reticulata "Chachi." Also, ITS2 was considered to identify Citrus reticulata "Chachi" from other varieties because it presented not only low variability within a certain taxon but also a high level of interspecies variability. Simultaneously, variant site detection of Citrus reticulata "Chachi" was analyzed by comparing with the reference Citrus reticulata genome, and 2652697 SNP sites and 533906 InDel sites were detected from whole-genome resequencing data of 22 samples, providing the data resources and theoretical foundation for the future study about the relevant molecular makers of "Guang chenpi."

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Adrenal Insufficiency in Children With Eosinophilic Esophagitis Treated With Topical Corticosteroids

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JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 2020年第3期70卷 324-329页

作者： Bose, Paroma Kumar, Sanjay Nebesio, Todd D. li, chuwen Hon, Emily C. Atkins, Dan Furuta, Glenn T. Gupta, Sandeep K. Indiana Univ Sch Med Dept Pediat Riley Hosp Children Div Pediat Gastroenterol Hepatol & Nutr Indianapolis IN 46202 USA Ascens St John Hosp & Med Ctr Dept Pediat Gastroenterol Digest Hlth Detroit MI USA Indiana Univ Sch Med Dept Pediat Div Pediat Endocrinol & Diabetol Riley Hosp Children Indianapolis IN 46202 USA Indiana Univ Dept Stat Bloomington IN USA Cook Res Inc W Lafayette IN USA Univ Colorado Sch Med Childrens Hosp Colorado Gastrointestinal Eosinophil Dis ProgramDept Pedi Aurora CO USA Univ Colorado Sch Med Childrens Hosp ColoradoGastrointestinal Eosinoph Dept Pediat Gastroenterol Hepatol & NutrDigest H Aurora CO USA Univ Illinois Coll Med Div Pediat Gastroenterol Hepatol & Nutr Childrens Hosp Illinois 530 NE Glen Oak Ave Rm NB6646 Peoria IL 61603 USA

Objectives: The aim of the study was to identify practices of gastroenterologists screening for adrenal insufficiency (AI) and report prevalence of AI in children with eosinophilic esophagitis (EoE) treated with topical corticosteroids (TCS);compare serum dehydroepiandrosterone sulfate (DHEA-S) levels to morning serum cortisol (MSC) levels as screening tool for AI. Methods: A multipart study was conducted. In part 1, a survey about screening practices for AI in children with EoE on TCS was sent to gastroenterologists belonging to a PedsGI listserv and to EoE consortia. In part 2, children with EoE on TCS for >= 6 months were prospectively screened for AI with MSC levels. For subjects with a MSC level of <10 mu g/dL, a repeat MSC level and/or confirmatory adrenocorticotropic hormone (ACTH) stimulation testing was offered. AI was defined by peak serum cortisol level <18 mu g/dL. In part 3, DHEA-S levels were drawn with MSC levels. Results: Seven percent (16/238) of gastroenterologists screened for AI. Providers in EoE consortia were more likely to screen than nonconsortia providers [9/21(43%) vs 7/217(3%);P = 0.0001]. Thirty-seven children were prospectively screened for AI, and 51% (19/37) had a low MSC level. Ten patients had a low-dose ACTH stimulation test (LDST) after 1 or more low MSC levels. Five percent (2/37) of patients were diagnosed with AI. DHEA-S and MSC levels had a moderate correlation (r(s) = 0.44,P = 0.03). Conclusions: Gastroenterologists belonging to EoE consortia were more likely to screen for AI. Prevalence of AI in our prospective cohort was 5%. DHEA-S has a moderate correlation with MSC levels, but more data is required to assess utility as a screening tool for AI.

关键词： adrenal insufficiency adrenal suppression corticosteroids eosinophilic esophagitis

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Metal artifacts correction based on a physics-informed nonlinear sinogram completion model

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PHYSICS IN MEDICINE AND BIOLOGY 2025年第6期70卷 065010-065010页

作者： Fan, Shuqiong li, Mengfei Huang, chuwen Deng, Xiaojuan li, Hongwei Capital Normal Univ Sch Math Sci Beijing 100048 Peoples R China Beijing Higher Inst Engn Res Ctr Testing & Imaging Beijing 100048 Peoples R China Natl Inst Metrol Div Ionizat Radiat Beijing 100029 Peoples R China Beijing Informat Sci & Technol Univ Sch Comp Sci Beijing 102206 Peoples R China

Objective. Metal artifacts seriously deteriorate CT image quality. Current metal artifacts reduction (MAR) methods suffer from insufficient correction or easily introduce secondary artifacts. To better suppress metal artifacts, we propose a sinogram completion approach extracting and utilizing useful information that contained in the corrupted metal trace projections. Approach. Our method mainly contains two stages: sinogram interpolation by an improved normalization technique for initial correction and physics-informed nonlinear sinogram decomposition for further improvement. In the first stage, different from the popular normalized metal artifact reduction method, we propose a more meaningful normalization scheme for the interpolation procedure. In the second stage, instead of performing a linear sinogram decomposition as done in the physics-informed sinogram completion method, we introduce a nonlinear decomposition model that can accurately separate the sinogram into metal and non-metal contributions by better modeling the physical scanning process. The interpolated sinogram and physics-informed correction compensate each other to reach the optimal correction results. Main results. Experimental results on simulated and real data indicate that, in terms of both structures preservation and detail recovery, the proposed physics-informed nonlinear sinogram completion method achieves very competitive performance for MAR compared to existing methods. Significance. According to our knowledge, it is for the first time that a nonlinear sinogram decomposition model is proposed in the literature for metal artifacts correction. It might motivate further research exploring this idea for various sinogram processing tasks.

关键词： metal artifacts reduction computed tomography sinogram completion nonlinear sinogram decomposition

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Synthesis of Bi2O3@BiOI@UiO-66 composites with enhanced photocatalytic activity under visible light

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CHEMICAL PHYSICS LETTERS 2021年 768卷 138354-138354页

作者： Tang, Jijun Zhang, Tang Duan, Zhengzhou li, chuwen Meng, Chunfeng Zhang, Yamei Zhang, Qiyuan Hou, Dongmei Xv, Qinyun Zhu, Yu Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang 212003 Jiangsu Peoples R China Taizhou Univ Coll Pharm & Chem & Chem Engn Jiangsu Key Lab Chiral Pharmaceut Biomfg Taizhou 225300 Peoples R China

Bi2O3 is a photocatalyst with excellent performance;however, its applications are limited due to its wide bandgap. In this paper, by adding BiOI and the metal-organic framework UiO-66, a Bi2O3@BiOI@UiO-66 composite material is obtained with high adsorption capacity, in which the bandgap of Bi2O3 is reduced, the recombination of photogenerated electrons and holes is prevented, the photocatalytic efficiency and stability are improved. In visible light degradation experiments, Bi2O3@BiOI@UiO-66 has obvious degradation effects on Rhodamine B and tetracycline, which are 22.2 and 1.04 times that of pure Bi2O3, respectively. Bi2O3@-BiOI@UiO-66 demonstrats its potential as photocatalytic degradation material.

关键词： Bi-based compounds UiO-66 Composite material Photocatalysis degradation Persistence organic pollutions

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Correction to:NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3967-3968页

作者： Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan liang Sheng Jie Qing Wang chuwen li Guocai Tian Zhen Zhang Zhenhu Ren Bo li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical Sciences Department of Oral and Maxillofacial-Head Neck Oncology Shanghai China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293) Zhang Zhiyuan Academician Workstation Hainan Western Central Hospital Shanghai Ninth People’s Hospital Department of Oral and Maxillofacial Surgery Danzhou China (GRID:grid.412523.3) (ISNI:0000 0004 0386 9086) The Second Xiangya Hospital of Central South University Department of Oral and Maxillofacial Surgery Changsha China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical Sciences Department of Oral and Maxillofacial-Head Neck Oncology Shanghai China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293) Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Department of Oral Pathology Shanghai China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293) The Second Xiangya Hospital of Central South University Department of Oral and Maxillofacial Surgery Changsha China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) Third Military Medical University Department of Occupational Health Chongqing China (GRID:grid.410570.7) (ISNI:0000 0004 1760 6682) The Second Xiangya Hospital of Central South University Department of Pathology Changsha China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) Guangxi University School of Medicine Nanning China (GRID:grid.256609.e) (I

In the process of checking the raw data1,the authors noticed several inadvertent mistakes occurring in Fig.5a,b,c,d,f that need to be corrected after online publication of the *** the preparation of Fig.5,the representative image showing TFE3 overexpression antagonized the NUPR1 KD-induced inhibition of OSCC cell proliferation and metastasis,were pasted and placed by *** correct results should be as shown *** authors apologize for these oversights and declare that these corrections do not affect the description,interpretation,or conclusions detailed in the original manuscript.

关键词： metastasis correction paste

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SRCES: a simulation program for collective effects in electron storage rings

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JOURNAL OF INSTRUMENTATION 2025年第1期20卷

作者： Hu, Nan Luo, chuwen li, Weimin Wang, lin Univ Sci & Technol China Natl Synchrotron Radiat Lab Hezuohua South Rd Hefei Peoples R China

Collective effects are important in the physics design of electron storage rings, especially for the fourth-generation synchrotron light source, where the collective effects are more severe than before and limit maximum stored beam current. To estimate beam collective effects, besides theoretical analysis, numerical tracking methods are necessary for obtaining more accurate and comprehensive results. To systematically study the comprehensive influence of wakefields and various damping mechanisms, we developed a new code Storage Ring Collective Effects Simulator (SRCES), which is a tracking code based on macroparticle model in 6-dimensional phase space. Several models are employed to handle various processes of particle motion. The modified transfer matrix and high order Taylor transfer map are used to solve particle motion under external electro-magnetic fields. A simplified equivalent damping and excitation model is used to represent the effects of synchrotron radiation on particle motion. The kick model is used to represent the influence of wakefields and RF cavity. Furthermore, the wake function data can be input as numerical arrays directly or through specific impedance models. In this paper, we describe the basic theory foundation, functions and benchmarked results of the code SRCES. Then, SRCES is used to conduct preliminary research on the collective effects of the Hefei Advanced light Facility storage ring.

关键词： Simulation methods and programs Accelerator modelling and simulations (multi-particle dynamics, single-particle dynamics) Beam dynamics Coherent instabilities

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Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice

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FOOD & FUNCTION 2019年第2期10卷 1212-1224页

作者： Wu, Xiaoli Tang, Benqin liao, Xian Su, Ziren Lee, Simon Ming-Yuen Cai, Yefeng li, chuwen Guangzhou Med Univ Sch Pharmaceut Sci Key Lab Mol Target & Clin Pharmacol Guangzhou Guangdong Peoples R China Guangzhou Univ Chinese Med Affiliated Hosp 2 Guangzhou Guangdong Peoples R China Guangdong Prov Hosp Chinese Med Dept Neurol Guangzhou Guangdong Peoples R China Guangzhou Univ Chinese Med Postdoctoral Programme Guangzhou Guangdong Peoples R China Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Macau Peoples R China Guangzhou Univ Chinese Med Affiliated Hosp 1 Guangzhou Guangdong Peoples R China Guangzhou Univ Chinese Med Math Engn Acad Chinese Med Guangdong Prov Key Lab New Drug Dev & Res Chinese Guangzhou Guangdong Peoples R China

The aim of the present study was to explore whether the supercritical-carbon dioxide fluid extract from flowers and buds of Chrysanthemum indicum (SEC) exhibits antidepressant-like effects in a chronic unpredictable mild stress (CUMS)-induced mice model. Firstly, SEC was found to reverse a CUMS-induced decrease in the body weight gain in mice. Next, SEC was found to alleviate CUMS-induced depressive-like behavior, evidenced by the reversal of the decrease in the sucrose consumption in the sucrose preference test (SPT), the increase in the locomotor activity in the open field test (OPF), and the alleviation of immobility duration in both the forced swimming test (FST), and tail-suspension test (TST). SEC also attenuated CUMS-induced hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis by decreasing the levels of serum corticosterone and (CORT) and adrenocorticotropic hormone (ACTH), and hypothalamus corticotrophin-releasing hormone (CRH). In addition, SEC was found to suppress the expression of pro-inflammatory cytokines, including the tumor necrosis factor (TNF)-, interleukin (IL)-1, and IL-6 in the hippocampal of CUMS mice. Interestingly, further investigations demonstrated that SEC inhibited CUMS-induced activation of the nuclear factor kappa B (NF-B) and NOD-like receptor protein 3 (NLRP3) inflammasomes pathways but upregulated brain-derived neurotrophic factor (BDNF) expression and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element-binding protein (CREB) in hippocampal. In summary, SEC was able to alleviate depressive-like behavior in a CUMS-induced mice model, accompanied by inhibitory roles in the hyperactivity of the HPA axis and pro-inflammatory cytokine expression. Modulating the NF-B/NLRP3 and BDNF/CREB/ERK pathways contributed to SEC-mediated antidepressant-like effects.

关键词： Sugar (sucrose)

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In-situ growth UiO-66 on Bi₂O₃ to fabrication p-p heterojunction with enhanced visible-light degradation of tetracycline

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JOURNAL OF SOliD STATE CHEMISTRY 2021年 302卷 122353-122353页

作者： Tang, Jijun Zhang, Tang Zhang, Qiyuan Duan, Zhengzhou li, chuwen Hou, Dongmei Xv, Qinyun Meng, Chunfeng Zhang, Yamei Zhu, Yu Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang 212003 Jiangsu Peoples R China Taizhou Univ Coll Pharm & Chem & Chem Engn Jiangsu Key Lab Chiral Pharmaceut Biomfg Taizhou 225300 Peoples R China

A p-p heterostructure has been constructed through loading UiO-66 on Bi2O3 as a composite photocatalyst to degrade the antibiotic tetracycline (TC) under visible light. The Bi2O3@UiO-66 composites were characterized by XRD, SEM, UV, BET, PL and FTIR. The formed p-p heterojunction improves the separation efficiency of electrons and holes, which caused the degradation rate constant of the composite photocatalyst for TC reaching 0.0492 min(-1). The UiO-66 is added to improve the TC adsorption capacity and photocatalytic stability of the composite photocatalyst, so that the composite photocatalyst can have a photodegradation effect on TC under different anion and cation environments or a strong acid-base solution environment with the pH value of 1-13. The photoelectrochemical analyses is the evidence of the fast transfer of electron and hole pairs with inhibiting recombination.

关键词： Bi2O3 UiO-66 Composite material Photocatalytic degradation

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Synthetic biology approaches to improve Rubisco carboxylation efficiency in C3 Plants: Direct and Indirect Strategies

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JOURNAL OF PLANT PHYSIOLOGY 2025年 307卷 154470页

作者： Cui, chuwen Shang, Mengting li, Zhigang Xiao, Jianwei Beijing Forestry Univ Coll Biol Sci & Biotechnol Beijing 100083 Peoples R China Chinese Acad Trop Agr Sci Spice & Beverage Res Inst Wanning 571500 Peoples R China Beijing Forestry Univ State Key Lab Efficient Prod Forest Resources Beijing 100083 Peoples R China

Food security remains a pressing issue due to the growing global population and climate change, including the global warming along with increased atmospheric CO2 levels, which can negatively impact C3 crop yields. A major limitation in C3 plants is the inefficiency of Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) due to its low carboxylation activity and competing oxygenase activity. Improving Rubisco efficiency in C3 plants is thus essential for improving photosynthetic performance. Recent advances in synthetic biology have introduced promising strategies to overcome these limitations. This review highlights the latest synthetic biology and gene transformation techniques aimed at optimizing Rubsico carboxylation efficiency. Next, direct approaches such as engineering Rubisco subunits by replacing plant Rubisco with proteins from other organisms are discussed. Additionally, indirect strategies involve modifications of Rubisco-interacting proteins and adjustment of Rubisco environment. We explore CO2-concentrating mechanisms (CCMs) based on pyrenoids and carboxysomes, which increase local CO2 concentrations around Rubisco thus favouring the carboxylation reaction. Lastly, photorespiratory bypasses are also covered in this review.

关键词： Rubisco Photosynthesis C 3 plant synthetic biology techniques

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