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新医科背景下基于课程思政建设和科教融合育人的《天然药物化学》教学改革研究与实践

广东化工 2024年第8期51卷 195-197页

作者：党元野陶移文郑国栋黄洪波李楚文张建业广州医科大学广东广州511436

新医科建设作为时代要求,需要创新医学人才教育模式,实现医学自身科学、人文与工程的交叉融合,打造中国特色的“新医科”教育新体系,培养适应和服务于信息时代的医学研究和医疗实践复合型人才。《天然药物化学》作为医药领域的重要学科... 详细信息

新医科建设作为时代要求,需要创新医学人才教育模式,实现医学自身科学、人文与工程的交叉融合,打造中国特色的“新医科”教育新体系,培养适应和服务于信息时代的医学研究和医疗实践复合型人才。《天然药物化学》作为医药领域的重要学科,本身兼有人文属性和自然属性,在其教学过程中,于课堂之中引入思政教育、于课堂之外引导科研创新具有极强的可行性和科学性,能够同时满足科学、人文与工程实践的融合教学。同时,辅以现代互联网技术,充分应用线上资源结合线下教学,积极开展线上线下相结合的教学能够发挥学生主动性,提高教学效果。

关键词：天然药物化学新医科课程思政科教融合线上线下结合教学

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Inhibition of YAP1 activity ameliorates acute lung injury through promotion of M2 macrophage polarization

MEDCOMM

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MEDCOMM 2023年第3期4卷 e293页

作者： liang, Lu Xu, Wenyan Shen, Ao Fu, Xiaomei Cen, Huiyu Wang, Siran lin, Zhongxiao Zhang, lingmin lin, Fangyu Zhang, Xin Zhou, Na Chang, Jishuo Chen, Zhe-Sheng li, chuwen Yu, Xiyong Guangzhou Med Univ Affiliated Hosp 5 Guangzhou Peoples R China Guangzhou Med Univ Sch Pharmaceut Sci Guangzhou Municipal & Guangdong Prov Key Lab Mol T State & NMPA Key Laboratoryof Resp Dis Guangzhou Peoples R China Guangzhou Med Univ Guangdong Engn Res Ctr Oral Restorat & Reconstruct Dept Prevent Dent Guangzhou Key Lab Basic & Appl Res Oral Regenerat Guangzhou Peoples R China Macau Univ Sci & Technol State Key Lab Qual Res Chinese Med Ave Wailong Taipa Macau Peoples R China Emory Univ Dept Ophthalmol B5500 Clin B1365B Clifton Rd NE Atlanta GA USA St Johns Univ Inst Biotechnol Coll Pharm & Hlth Sci Dept Pharmaceut Sci Queens NY USA Guangzhou Med Univ Sch Pharmaceut Sci Guangzhou Municipal & Guangdong Prov Key Lab Mol T State & NMPA Key Lab Resp Dis Guangzhou 511436 Peoples R China Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 511436 Peoples R China St Johns Univ Inst Biotechnol Coll Pharm & Hlth Sci Dept Pharmaceut Sci Queens NY 11439 USA

The balance of M1/M2 macrophage polarization plays an important role in regulating inflammation during acute lung injury (Ali). Yes-associated protein (YAP1) is a key protein in the Hippo-YAP1 signaling pathway and is involved in macrophage polarization. We aimed to determine the role of YAP1 in pulmonary inflammation following Ali and regulation of M1/M2 polarization. Pulmonary inflammation and injury with upregulation of YAP1 were observed in lipopolysaccharide (LPS)-induced Ali. The YAP1 inhibitor, verteporfin, attenuated pulmonary inflammation and improved lung function in Ali mice. Moreover, verteporfin promoted M2 polarization and inhibited M1 polarization in the lung tissues of Ali mice and LPS-treated bone marrow-derived macrophages (BMMs). Additionally, siRNA knockdown confirmed that silencing Yap1 decreased chemokine ligand 2 (CCL2) expression and promoted M2 polarization, whereas silencing large tumor suppressor 1 (Lats1) increased CCL2 expression and induced M1 polarization in LPS-treated BMMs. To investigate the role of inflammatory macrophages in Ali mice, we performed single-cell RNA sequencing of macrophages isolated from the lungs. Thus, verteporfin could activate the immune-inflammatory response, promote the potential of M2 macrophages, and alleviate LPS-induced Ali. Our results reveal a novel mechanism where YAP1-mediated M2 polarization alleviates Ali. Therefore, inhibition of YAP1 may be a target for the treatment of Ali.

关键词： Yes-associated protein 1 macrophage polarization acute lung injury pulmonary inflammation

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A numerical study of PCM battery thermal management performance enhancement with fin structures

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ENERGY REPORTS 2023年 9卷 1793-1802页

作者： liu, Huaqiang Jin, chuwen li, Hao Ji, Yulong Dalian Maritime Univ Naval Architecture & Ocean Engn Coll Liaoning Peoples R China Dalian Maritime Univ Marine Engn Coll Liaoning Peoples R China

Phase change material (PCM) cooling is regarded as a promising thermal management technique to realize a proper battery working temperature. However, the low thermal conductivity of PCM restricts its practical applications. In this study, the impact of aluminum fin insertion on the thermal performance of PCM thermal management is explored. Couples of fin structure shapes were adopted and their performances were compared. It is demonstrated from the simulation results that, among the fin structures investigated in this study, the bifurcated fin structures achieved the lowest battery maximum temperatures, specifically, the battery temperature was reduced by 6.16 K compared to the pure PCM case under 5C discharge (5C means that battery is discharged from full of charge to 0% state of charge in 1/5 h). The 2-branch bifurcated fin structure could realize a further 0.50 K temperature drop than the single-branch counterpart. Besides, the impacts of various parameters were investigated. The maximum temperature at the end of 5C discharge process was reduced from 314.30 K to 311.36 K when the fin quantity increased from 3 to 8. The maximum battery temperature reaches up to 313.80 K if the thermal contact resistance between the battery and fin structure grows to 0.0025 W/(m2 center dot K) with 8 fins while it could be decreased by 1.21 K if the contact resistance reduced half to 0.00125 ((m2 center dot K)/W. The maximum battery temperature was found to decrease by 0.27 K with PCM width enlarged from 28 mm to 29 mm. (c) 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Battery thermal management Phase change materials Bifurcated fin CFD simulation

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Investigation on the attrition behavior and reactivity characteristic of Fe-based oxygen carriers in long-term chemical looping catalytic oxidation process

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CHEMICAL ENGINEERING JOURNAL 2024年 480卷

作者： Song, Chen liu, Yang Cao, Yunqi li, Caifu Yang, li Guo, chuwen liu, Fang China Univ Min & Technol Sch Low carbon Energy & Power Engn Xuzhou 221008 Jiangsu Peoples R China

Human activities and industrial processes result in substantial methane emissions, predominantly at low concentration. This is particularly evident in coal mining where the gas concentration is notably low, posing challenges for effective utilization. Chemical looping catalytic oxidation (CLCO) is believed to be a potential approach for the disposal of ultra-low concentration methane (UCM) and the capture of CO2. Unlike pure air, which is generally used to oxidize OC in air reactor, UCM typically contains 0.1 similar to 1 %CH4 and less than 60 ppm H2S, therefore, the introduction of UCM into the air reactor would potentially threaten oxygen carrier (OC). In this study, the evolution of OC in CLCO process was investigated in terms of reaction performance and physicochemical parameters compared to traditional chemical looping process. XRD showed that the phase compositions of OC remained stable over 300 cycles and no sulfur-containing compounds were detected. The comparison showed that CLCO process negatively affected the performance of OC, especially for attrition. The attrition behavior of OC can be summarized in three stages: fines blowing out, steady-state attrition and intenseattrition stage. The main reason for increased attrition was attributed to methane oxidation, which released a large amount of heat and would impose a heat shock on OC. Contrary to the commonly reported "L"-shape, our data showed a "U"-shaped attrition rate trend in long-term cycles. The difference was that the attrition rate would suddenly increase after a certain number of cycles, indicating that the actual service life of OC may be significantly lower than predicted.

关键词： Chemical looping Oxygen carrier Attrition Methane

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A Non-Gaussian Adaptive Importance Sampling Method for High-Dimensional and Multi-Failure-Region Yield Analysis

A Non-Gaussian Adaptive Importance Sampling Method for High-...

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IEEE International Conference on Computer-Aided Design

作者： Xiao Shi Hao Yan chuwen li Jianli Chen Longxing Shi Lei He University of California Los Angeles CA USA Southeast University China State Key Lab of ASIC & System Fudan University China

ISBN: (数字)9781665423243

Rare-event yield analysis is challenging for high-dimensional circuit cases. In this paper, we propose a non-Gaussian adaptive importance sampling (NGAIS) method. In order to approximate the failure region in high-dimensional space, we model it as a mixture of von Mises-Fisher distributions. We formulate the parameter estimation problem as a maximum likelihood estimation problem, and then solve with expectation-maximization algorithm. Experiments on bit cell, amplifier and SRAM column circuit validate that the proposed NGAIS method outperforms other state-of-the-art approaches in terms of accuracy and efficiency.

关键词： Approximation algorithms Monte Carlo methods Gaussian distribution Random access memory Parameter estimation Maximum likelihood estimation Mathematical model

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Whole-genome resequencing reveals melanin deposition candidate genes of Luning chicken

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BMC GENOMICS 2024年第1期25卷 1-16页

作者： Chen, chuwen li, Jie li, Zhiyi Nong, Yi Wang, Jiayan Wang, Zi li, Zhixiong Southwest Minzu Univ Key Lab Qinghai Tibetan Plateau Anim Genet Resourc Minist Educ Chengdu Peoples R China Southwest Minzu Univ Key Lab Anim Sci Natl Ethn Affairs Commiss China Chengdu Peoples R China Southwest Minzu Univ Coll Anim & Vet Sci Chengdu Peoples R China

BackgroundMelanin in the black-bone chicken's body is considered the material basis for its medicinal effects and is an economically important trait. Therefore, improving the melanin content is a crucial focus in the breeding process of black-bone chickens. Luning chickens are black-bone chickens, with black beaks, skin, and meat. To investigate the genetic diversity and molecular mechanisms of melanin deposition in Luning chickens, we conducted whole-genome resequencing to analyze their breeding history and identify candidate genes influencing their black phenotype, along with transcriptome sequencing of dorsal skin tissues of male Luning *** structure analysis revealed that Luning chickens tend to cluster independently and are closely related to Tibetan chickens. Runs of homozygosity analysis suggested potential inbreeding in the Luning chicken and Tibetan chicken population. By combining genetic differentiation index (Fst) and nucleotide diversity (theta pi) ratios, we pinpointed selected regions associated with melanin deposition. Gene annotation identified 540 genes with the highest Fst value in LOC101750371 and LOC121108313, located on the 68.24-68.58 Mb interval of chromosome Z. Combining genomic and transcriptomic data, we identified ATP5E, EDN3, and LOC101750371 as candidate genes influencing skin color traits in black-bone *** study characterized the evolutionary history of Luning chickens and preliminarily excavated candidate genes influencing the genetic mechanism of pigmentation in black-bone chickens, providing valuable insights for the study of animal melanin deposition.

关键词： Luning chicken Genetic diversity Integration of whole-genome and transcriptome Selective sweep Melanin

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Understand relations between mechanical/thermal/chemical stresses and attrition of oxygen carrier in chemical looping process

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CHEMICAL ENGINEERING JOURNAL 2024年 494卷

作者： Song, Chen liu, Yang Zhu, Dan li, Caifu Yang, li Guo, chuwen liu, Fang China Univ Min & Technol Sch Low Carbon Energy & Power Engn Xuzhou 221008 Jiangsu Peoples R China

During the chemical looping process, oxygen carriers are subjected to extremely challenging conditions, such as high temperatures, fluidization, and redox reactions, which significantly increase their susceptibility to attrition. Overall, particle attrition is caused by mechanical, thermal, and chemical stresses, but their exact contribution and mechanism are unclear. In this work, five distinct experimental conditions and cold jet attrition tests were established to discern the contributions of different stresses to attrition and their impact on performance. Particle size versus strength was obtained for up to 1320 particles, and hotspot plots were used to reveal the relationship between the two. It was found that thermal stress was the dominant factor only during the pre-attrition phase, contributing 45 % to attrition. And then swiftly superseded by mechanical stress. Chemical stress emerged as the primary cause of attrition during the middle and late stages of the experiments, contributing up to 90 % of attrition. OC's strength typically ranged between 6 and 8 N without chemical stress and, conversely, dropped to below 1 N. Furthermore, chemical stress was found to induce an increase in particle volume and oxygen transport capacity, primarily achieved by reducing apparent density. The volume of particles can be enlarged by a factor of 1.56, and the oxygen release rate was increased from 4 % to 5.6 % under chemical stress. And a correlation was observed between apparent density and both attrition rate and strength.

关键词： Chemical looping Oxygen carrier Chemical stress Attrition

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Synthesis, Antifungal Activity, and Action Mechanism of Anethole-Derived Amide-Urea Compounds

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CHEMISTRY & BIODIVERSITY 2025年第5期22卷 e202402938页

作者： liu, chuwen Duan, Wengui Ma, Xianli lin, Guishan li, Baoyu Deng, Huan Guangxi Univ Sch Chem & Chem Engn Nanning Peoples R China Guilin Med Univ Sch Pharm Guangxi Key Lab Pharmaceut Mol Discovery & Druggab Guilin Peoples R China

In order to develop new antifungal molecules and explore further applications of natural products, 25 novel amide-urea compounds were synthesized from anethole in this work by a few simple reactions, and structural confirmation was conducted using 1H-nuclear magnetic resonance (1H-NMR), 13C-NMR, high-resolution mass spectrometry, and Fourier transform infrared spectroscopy. Preliminary bioactivity tests were performed against eight plant pathogens. The results demonstrated that all compounds exhibited antifungal activity against the tested fungi, and 5p exhibited the most potent antifungal activity. To explore the action mechanism of the antifungal compounds, the inhibitory activity of 5p against succinate dehydrogenase (SDH) was evaluated and found to be comparable to that of boscalid. Furthermore, the binding mode of the compound to SDH was simulated by molecular docking, and similarities between 5p and boscalid's binding with SDH were identified. The results indicate that further investigation of compound 5p may prove beneficial in determining its potential as a fungicide.

关键词： anethole amide-urea antifungal activity SDHI

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Nrf2 Ameliorates Sevoflurane-Induced Cognitive Deficits in Aged Mice by Inhibiting Neuroinflammation in the Hippocampus

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MOLECULAR NEUROBIOLOGY 2025年第6期62卷 8048-8064页

作者： li, Junhua li, Jinfeng liu, Yafang Hu, chuwen Xu, Hui Cao, Dong Zhang, Rong Zhang, Kun Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Anesthesiol 107 Yanjiang West Rd Guangzhou 510120 Peoples R China Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet & Guangzhou 510120 Peoples R China Sun Yat Sen Univ Zhongshan Sch Med Guangdong Prov Key Lab Brain Funct & Dis Guangzhou 510080 Peoples R China Guangzhou Univ Chinese Med Clin Med Coll 2 Dept Anesthesiol Affiliated Hosp 2 Guangzhou Peoples R China

Perioperative neurocognitive disorders (PND), common complications that occur after anesthetized surgery in elderly patients, are major challenges to our rapidly growing aging population. The transcription factor known as nuclear factor erythroid-2-related factor 2 (Nrf2) is an essential component of the cellular antioxidant response, purportedly contributing to the preservation of cognitive functions such as learning and memory. Nevertheless, the function and intracellular processes involving Nrf2 in PND remain largely unknown. Therefore, we evaluate the influence and fundamental mechanism of Nrf2 on PND in aged mice. To establish the postoperative neurocognitive dysfunction (PND) model, aged mice were subjected to anesthesia via inhalation of 3% sevoflurane for a duration of 2 h. The role of Nrf2 in PND was investigated by administering microinjections of either the adeno-associated virus (AAV)-Nrf2 vector or a null virus vector into the hippocampal CA1 region of aged mice 28 days before exposure to sevoflurane. Various assays including enzyme-linked immunosorbent assay (EliSA), immunofluorescence staining, and western blotting were employed to assess levels of pro-inflammatory cytokines, microglial activation, and the oxidative stress response. Furthermore, synaptic plasticity was evaluated through long-term potentiation (LTP) recording and Golgi staining techniques. Elevated expression of Nrf2 within the hippocampal CA1 region ameliorated sevoflurane-induced cognitive deficits, synaptic plasticity anomalies, and the oxidative stress reaction in aged mice. Furthermore, the activation of microglia and the release of pro-inflammatory cytokines (including IL-6, TNF-alpha, and IL-1 beta) within the hippocampus post-sevoflurane exposure were modulated in an Nrf2-dependent fashion. Based on the findings from present research, we conclude that Nrf2 ameliorates sevoflurane-induced cognitive dysfunction by inhibiting hippocampal neuroinflammation, thereby proposing a pote

关键词： Sevoflurane Nrf2 Mitochondrial oxidative stress Neuroinflammation Microglia Synaptic plasticity

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Simulation study of intra-beam scattering effect in the HALF storage ring with Piwinski model

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Radiation Detection Technology and Methods 2024年第3期8卷 1496-1504页

作者： chuwen Luo Penghui Yang Weiwei li Nan Hu Gangwen liu Weimin li lin Wang National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230029China

Background The Hefei Advanced light Facility(HALF)will be a VUV and soft X-ray diffraction-limited storage ring(DLSR),and its high density of electron bunches makes the intra-beam scattering(IBS)effect very *** An IBS module used in the IMPACT code is developed,where the scattering process of IBS is described by the Piwinski model in Monte Carlo *** the IMPACT code with IBS module,the macroparticle beam in storage ring is numerically tracked,including motion under external electromagnetic field and the IBS scattering *** the long-term tracking results of macroparticle beam are statistically *** and conclusions The results of IBS effect in the HALF storage ring studied by this new code are *** benchmarking,the IMPACT code with IBS module is compared with the ELEGANT code and a semi-analytic code using Bane’s model,and the results agree well with each *** various countermeasures,the IBS impact can be controlled to a certain extent,and the expected beam emittance is approximately 59 pm·rad.

关键词： Diffraction-limited storage ring Intra-beam scattering Piwinski model-Monte Carlo Macroparticle beam Equilibriumemittance

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