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A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living

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NEUROLOGICAL SCIENCES 2022年第10期43卷 5821-5837页

作者： Sun, Weibo Wang, Qingyong Yang, Tiansong Feng, chuwen Qu, Yuanyuan Yang, Yan li, Chaoran Sun, Zhongren Asakawa, Tetsuya Harbin Med Univ Harbin Peoples R China Heilongjiang Univ Chinese Med Harbin Peoples R China Heilongjiang Univ Chinese Med Affiliated Hosp 1 24 Heping Rd Harbin 150040 Peoples R China Third Peoples Hosp Shenzhen Inst Neurol 29 Buji Bulan Rd Shenzhen 518112 Guangdong Peoples R China Fujian Univ Tradit Chinese Med Res Base Tradit Chinese Med Syndrome Fuzhou 350122 Peoples R China Sun Yat Sen Univ Affiliated Hosp 8 Dept Neurol Shenzhen 518033 Peoples R China

Background Rotigotine transdermal patch (TP) is a useful dopaminergic medication for Parkinson's disease (PD). This meta-analysis attempted to evaluate the effects of rotigotine TP on motor performance, activities of daily living (ADL) limitations, and sleep disturbances in patients with PD. Methods Only randomized controlled clinical trials (RCTs) with placebo design were included in this study. The clinical outcomes, evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS III), UPDRS-II, UPDRS Part II + III, Parkinson's Disease Sleep Scale (PDSS)-2, and adverse events (AEs) were evaluated. The Jadad scale was used to evaluate study quality. Results A total of 16 RCTs with 4682 patients with PD were enrolled in this study. We found that rotigotine TP significantly reduced the UPDRS-III, UPDRS-II, and UPDRS Part II + III scores, indicating that rotigotine TP led to a significant amelioration of movement symptoms and ADL limitations. Moreover, we found that rotigotine TP significantly reduced PDSS-2 scores, suggesting that rotigotine TP led to a remarkable improvement in sleep quality. Meanwhile, compared with the placebo group, patients taking rotigotine TP did not have added incidence of AEs. Conclusion This study verified the efficacy and safety of rotigotine TP in treating PD. The findings of the present study provide compelling evidence concerning and insight into clinical usage of rotigotine TP. Future studies will focus on more non-motor symptoms affected by rotigotine TP.

关键词： Rotigotine transdermal patch Parkinson's disease Motor symptoms ADL Sleep disturbances Adverse events

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Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2019年第1期2019卷 8169125-8169125页

作者： Zhou, Hefeng Shao, Min Yang, Xuanjun li, chuwen Cui, David Gao, Cheng Di, lijun Zhong, Hanbing Wang, Yuqiang Zhang, Zaijun Lee, Simon Ming-Yuen Zunyi Med Univ Dept Bioengn Zhuhai Campus Zhuhai Peoples R China Univ Macau State Key Lab Qual Res Chinese Med Macau Peoples R China Univ Macau Inst Chinese Med Sci Macau Peoples R China South Univ Sci & Technol Dept Biol Shenzhen Guangdong Peoples R China Guangzhou Med Univ Sch Pharmaceut Sci Key Lab Mol Target & Clin Pharmacol Guangzhou Guangdong Peoples R China Univ Macau Fac Hlth Sci Canc Ctr Macau Peoples R China Jinan Univ Coll Pharm Inst New Drug Res Guangzhou Guangdong Peoples R China

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and there is no cure for it at present. We have previously reported that the tetramethylpyrazine (TMP) derivative T-006 exhibited beneficial effects in Alzheimer's disease (AD) models. However, its effect on PD remains unclear. In the present study, we investigated the neuroprotective effects and underlying mechanisms of T-006 against 6-hydroxydopamine- (6-OHDA-) induced lesions in in vivo and in vitro PD models. Our results demonstrated that T-006 alleviated mitochondrial membrane potential loss and restored the energy metabolism and mitochondrial biogenesis that were induced by 6-OHDA in PC12 cells. In addition, animal experiments showed that administration of T-006 significantly attenuated the 6-OHDA-induced loss of tyrosine hydroxylase- (TH-) positive neurons in the SNpc, as well as dopaminergic nerve fibers in the striatum, and also increased the concentration of dopamine and its metabolites (DOPAC, HVA) in the striatum. Functional deficits were restored following T-006 treatment in 6-OHDA-lesioned mice, as demonstrated by improved motor coordination and rotational behavior. In addition, we found that the neuroprotective effects of T-006 were mediated, at least in part, by the activation of both the PKA/Akt/GSK-3 beta and CREB/PGC-1 alpha/NRF-1/TFAM pathways. In summary, our findings demonstrate that T-006 could be developed as a novel neuroprotective agent for PD, and the two pathways might be promising therapeutic targets for PD.

关键词： Neurons

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Research on the co-combustion characteristics and kinetics of rice husk hydrochar with anthracite

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ENERGY 2024年 299卷

作者： Ding, Yan li, Debo Zhang, Xiaowei Lv, Maochao Qin, Shiru Zhao, Peitao Guo, chuwen China Univ Min & Technol Xuhai Coll Xuzhou 221008 Peoples R China China Univ Min & Technol Sch Low Carbon Energy & Power Engn Xuzhou 221116 Peoples R China China Southern Power Grid Power Technol Co Ltd Guangzhou 510080 Peoples R China Jiaozuo Qianye New Mat Co Ltd Jiaozuo 454000 Peoples R China China Univ Min & Technol Sch Informat & Control Engn Xuzhou Peoples R China

Co-combustion of anthracite and hydrochar derived from hydrothermal carbonization with process water recirculation was proposed as an effective way to achieve a transition to low-carbon energy in industries that rely heavily on coal combustion. In this study, thermogravimetric analysis and model-free methods were employed to investigate the co-combustion characteristics and kinetics of anthracite and hydrochar. The results demonstrate that the carbon content of hydrochar is lower than that of anthracite, but the volatile content is higher than that of anthracite, indicating that hydrochar has better combustion performance. There is a synergistic effect in the co-combustion reaction of hydrochar and anthracite. With the increase of the hydrochar addition ratio, the ignition and burnout temperatures of anthracite decrease gradually. With the increase of temperature rise rate, the combustion reaction is enhanced and the combustion performance of anthracite is improved under the fixed mixing ratio. According to the calculation of combustion activation energy by Flynn-Wall-Ozawa and KissengerAkahira-Sunose methods, the apparent activation energy of the mixed samples gradually decreases with the increase of combustion conversion rate. When the addition of hydrochar is 60 %, the average apparent activation energy of the mixed sample is the lowest, which is 66.51 kJ mol(-1) and 54.62 kJ mol(-1), respectively.

关键词： Process water recirculation Combustion characteristic Rice husk Anthracite Kinetics

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Galectin-1 ameliorates perioperative neurocognitive disorders in aged mice

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CNS NEUROSCIENCE & THERAPEUTICS 2021年第7期27卷 842-856页

作者： Shen, Zhiwen Xu, Hui Song, Wen Hu, chuwen Guo, Mingyan li, Jinfeng li, Junhua Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Anesthesiol Guangzhou 510120 Peoples R China Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet & Guangzhou Peoples R China Guangzhou Univ Chinese Med Affiliated Hosp 2 Dept Anesthesiol Guangzhou 510120 Peoples R China Sun Yat Sen Univ Zhongshan Sch Med Guangdong Prov Key Lab Brain Funct & Dis Guangzhou Peoples R China

Introduction The incidence of perioperative neurocognitive disorders (PND) is higher in the elderly patients undergoing surgery. Microglia activation-mediated neuroinflammation is one of the hallmarks of PND. Galectin-1 has been identified as a pivotal modulator in the central nervous system (CNS), while the role of galectin-1 in PND induced by microglia-mediated neuroinflammation is still undetermined. Methods An exploratory laparotomy model anesthetized with isoflurane was employed to investigate the role of galectin-1 on PND in aged mice. Open field test and Morris water maze were used to test the cognitive function 3- or 7-days post-surgery. The activation of microglia in the hippocampus of aged mice was tested by immunohistochemistry. Western blot, enzyme-linked immunosorbent assay (EliSA), and quantitative real-time polymerase chain reaction (qRT-PCR) were employed to elucidate the underlying mechanisms. Results Galectin-1 attenuated the cognitive dysfunction induced by surgery in aged mice and inhibited microglial activity. Moreover, galectin-1 decreased the expression level of inflammatory proteins (interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha), and prevented neuronal loss in the hippocampus. Galectin-1 inhibited the inflammation of BV2 microglial cells induced by lipopolysaccharide via decreasing the translocation of NF-kappa B p65 and c-Jun, while this kind of inhibition was rescued when overexpressing IRAK1. Conclusion Our findings provide evidence that galectin-1 may inhibit IRAK1 expression, thus suppressing inflammatory response, inhibiting neuroinflammation, and improving ensuing cognitive dysfunction. Collectively, these findings unveil that galectin-1 may elicit protective effects on surgery-induced neuroinflammation and neurocognitive disorders.

关键词： galectin-1 IRAK1 microglia activation neuroinflammation perioperative neurocognitive disorders

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GNSS Receiver Fingerprinting Based on Time Skew of Embedded CSAC Clock

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SENSORS 2024年第15期24卷 4897页

作者： Gui, Sibo Dai, li Shi, Meng Wang, Junchao Tang, chuwen Wu, Haitao Zhao, Jianye Peking Univ Sch Elect Beijing 100871 Peoples R China ZhongkeQidi Optoelect Technol Co Beijing 100083 Peoples R China

GNSS spoofing has become a significant security vulnerability threatening remote sensing systems. Hardware fingerprint-based GNSS receiver identification is one of the solutions to address this security issue. However, existing research has not provided a solution for distinguishing GNSS receivers of the same specification. This paper first theoretically proves that the CSACs (Chip-Scale Atomic Clocks) used in GNSS receivers have unique hardware noise and then proposes a fingerprinting scheme based on this hardware noise. Experiments based on the neural network method demonstrate that this fingerprint achieved an identification accuracy of 94.60% for commercial GNSS receivers of the same specification and performed excellently in anomaly detection, confirming the robustness of the fingerprinting method. This method shows a new real-time GNSS security monitoring method based on CSACs and can be easily used with any commercial GNSS receivers.

关键词： GNSS receiver chip-scale atomic clock device fingerprint

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Collision characteristics and breakage evolution of particles in fluidizing processes

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FUEL PROCESSING TECHNOLOGY 2023年第1期243卷

作者： Yang, li Song, Chen Ai, Lun liu, Fang li, Caifu Zhu, Dan Guo, chuwen China Univ Min & Technol Sch Low Carbon Energy & Power Engn Xuzhou 22108 Jiangsu Peoples R China

Fluidized beds are widely used in chemical reactors. Particles in fluidized bed usually circulate between reactors, and therefore, particle attrition cannot be avoided. Catalyst particle attrition in the fluidized bed significantly shortens their lifespan and raises operating costs. This study established an irregular polyhedron model of the particles to acquire their motion and force characteristics by the Euler-Lagrangian method and then employed the Ab-T10 breakage model to predict the particle's breakage process. The collision frequency and stress characteristics of the three-dimensional surface of a single particle were explored, as well as the time-dependent variations in the collision frequency and impact power between particles. The breakage and elutriation processes of a single particle were observed. The investigation found that the velocity differential between particles was the main factor that caused impact power. The particles were typically crushed one to six times before becoming completely fine powder, and their size evolution can be summarized in three stages. The complete process of particle breakage was revealed by tracing the size evolution of a single particle. This work would contribute to a deeper understanding of particle collision behavior and breakage mechanisms in fluidized beds.

关键词： Fluidized bed Particulate solids Breakage evolution Collision characteristics

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Deep sea cold seeps are a sink for mercury and source for methylmercury

COMMUNICATIONS EARTH & ENVIRONMENT

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COMMUNICATIONS EARTH & ENVIRONMENT 2024年第1期5卷 1-10页

作者： li, Jiwei Dong, Xiyang Tang, Yongjie Zhang, chuwen Yang, Yali Zhang, Wei liu, Shanshan Yuan, Wei Feng, Xinbin Heimbuerger-Boavida, Lars-Eric Wang, Feiyue Shang, lihai Peng, Xiaotong Chinese Acad Sci Inst Deep Sea Sci & Engn Sanya Peoples R China Minist Nat Resources Inst Oceanog 3 Key Lab Marine Genet Resources Xiamen Peoples R China Chinese Acad Sci Inst Geochem State Key Lab Environm Geochem Guiyang Peoples R China BGI Qingdao Qingdao Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Univ Toulon & Var Aix Marseille Univ Mediterranean Inst Oceanog MIO CNRS INSUIRD Marseille France Univ Manitoba Ctr Earth Observat Sci Dept Environm & Geog Winnipeg MB Canada

The effect of seafloor cold seeps on the biogeochemical cycling of mercury (Hg) remains enigmatic. Here we demonstrate substantial enrichments of mercury and methylmercury, along with the presence of microbes capable of metabolizing mercury in sediments of the Haima cold seep, South China Sea, by analyzing mercury and methylmercury concentrations, mercury isotopic composition analyses and metagenomic analyses of sediment cores. Compared to the reference area, the sediments in the upper sediment column of the active-seep area were 2.4 times enriched in Hg and 10.5 times in methylmercury. The slope of the capital delta ratio of mercury 199 to mercury 201 (Delta 199Hg/Delta 201Hg) with 1.23 +/- 0.10 in the active-seep area indicate the occurrence of dark redox reactions. Genes related to mercury methylation (hgcA), demethylation (merB) and reduction (merA) were phylogenetically associated with several bacterial and archaeal linages. We roughly estimated an additional 2,835 Mg mercury and 9 Mg methylmercury are stored in cold seep globally. In summary, we propose that cold seeps globally function as a previously unrecognized sink for mercury and source for methylmercury in the deep ocean. Seafloor cold seeps can act as a sink for mercury and a source for methylmercury in the deep ocean, according to the results from geochemical and geomicrobiological analysis of sediments of the Haima cold seep in the South China Sea.

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CmMYB9a activates floral coloration by positively regulating anthocyanin biosynthesis in chrysanthemum

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PLANT MOLECULAR BIOLOGY 2022年第1-2期108卷 51-63页

作者： Wang, Yiguang Zhou, li-Jie Wang, Yuxi Geng, Zhiqiang liu, Shenhui Chen, chuwen Chen, Sumei Jiang, Jiafu Chen, Fadi Nanjing Agr Univ State Key Lab Crop Genet & Germplasm Enhancement Key Lab Landscaping Minist Agr & Rural AffairsColl Hort Weigang 1 Nanjing 210095 Jiangsu Peoples R China

Key message An R2R3-MYB transcription factor, CmMYB9a, activates floral coloration in chrysanthemum by positively regulating CmCHS, CmDFR and CmFNS, but inhibiting the expression of CmFLS. Chrysanthemum is one of the most popular ornamental plants worldwide. Flavonoids, such as anthocyanins, flavones, and flavonols, are important secondary metabolites for coloration and are involved in many biological processes in plants, like petunia, snapdragon, Gerbera hybrida, as well as chrysanthemum. However, the metabolic regulation of flavonoids contributing to chrysanthemum floral coloration remains largely unexplored. Here, an R2R3-MYB transcription factor, CmMYB9a, was found to be involved in flavonoid biosynthesis. Phylogenetic analysis and amino acid sequence analysis suggested that CmMYB9a belonged to subgroup 7. Transient overexpression of CmMYB9a in flowers of chrysanthemum cultivar 'Anastasia Pink' upregulated the anthocyanin-related and flavone-related genes and downregulated CmFLS, which led to the accumulation of anthocyanins and flavones. We further demonstrated that CmMYB9a independently activates the expression of CmCHS, CmDFR and CmFNS, but inhibits the expression of CmFLS. Overexpression of CmMYB9a in tobacco resulted in increased anthocyanins and decreased flavonols in the petals by upregulating NtDFR and downregulating NtFLS. These results suggest that CmMYB9a facilitates metabolic flux into anthocyanin and flavone biosynthesis. Taken together, this study functionally characterizes the role of CmMYB9a in regulating the branched pathways of flavonoids in chrysanthemum flowers.

关键词： Chrysanthemum Flavonoids Floral coloration CmMYB9a Branched pathways

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FASTeller: A Hardware Partial Aggregator for Accurate Flow Counting in Cloud Networks 31

FASTeller: A Hardware Partial Aggregator for Accurate Flow C...

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31st IEEE International Conference on Network Protocols (ICNP)

作者： Yun, Tong Kuang, Yinxin ling, Zhuang Song, Haoyu Wang, Peilong Zhang, chuwen Miao, Mao li, Zhaogeng Huang, Donghua liu, Bin Tsinghua Univ Beijing Peoples R China Futurewei Technol Santa Clara CA USA Baidu Inc Beijing Peoples R China

ISBN: (纸本)9798350303223

Accurate per-flow counting is beyond the capability of network switches due to the sheer flow number. The conventional divide-and-conquer method by distributing the traffic to multiple servers for software processing is costly. The solution therefore quests for a combination of hardware and software where the hardware with limited resources aims to undertake a part of the job and reduce the workload of software, achieving a desirable balance of cost and performance. To this end we design FASTeller to be deployed on SmartNlCs. It is tuned to maximize the counting aggregation level in hardware, leaving the server a much lower workload for accurate per-flow counting and sparing the server capacity for post-counting functions such as network intrusion detection. The novelty lies in the multi-tier hardware caching data structure which is tailored for the flow distribution properties of real traffic. We build an FPGA-based prototype and evaluate the performance of FASTeller. The low-cost implementation achieves the highest performance among the methods in comparison and can easily sustain the accurate perflow counting for 100Gbps traffic with the least software load.

关键词： Intrusion detection

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Functional characterization of porcine nucleophosmin (NPM1) gene in promoting the replication of Japanese encephalitis virus and induction of inflammatory cytokines

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DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2023年第1期148卷 104902页

作者： liu, Ying Zhang, linjie Chen, Xuan Sun, chuwen Zhang, Yanbing li, Yanhua li, Chenxi Yangzhou Univ Coll Vet Med Yangzhou 225009 Jiangsu Peoples R China Yangzhou Univ Comparat Med Res Inst Yangzhou 225009 Jiangsu Peoples R China Jiangsu Coinnovat Ctr Prevent & Control Important Yangzhou 225009 Jiangsu Peoples R China Shihezi Univ Coll Anim Sci & Technol Shihezi 832003 Peoples R China

Nucleophosmin (NPM1) is a multifunctional nucleolar protein that plays a role in cell cycle control, tumorigenesis, induction of the inflammatory cytokine, virus replication, as well as the cellular responses to a variety of stress stimuli. However, its physiological functions in pigs have not been well understood. Here, we cloned the porcine NPM1 (porNPM1) gene and analyzed the functions of the porNPM1 protein in pigs. The full-length porNPM1 gene encoded a 294-amino acid protein with 94.5%-99.3% sequence identity to its orthologues in mammals and was extensively expressed in various pig tissues at the mRNA level. The porNPM1 primarily localizes in the nucleus of ST cells, while it translocates from the nucleus to nucleoplasm upon UV irradiation or H2O2 treatment. Notably, JEV infection blocked the translocation of porNPM1 from the nucleolus to the nucleoplasm. Furthermore, porNPM1 interacted with the JEV C protein and facilitated JEV replication in ST cells. The overexpression and knockdown of porNPM1 respectively enhanced or impaired JEV replication, suggesting the important role of porNPM1 in JEV replication. Additionally, the purified ectodomain of porNPM1 induced the production of inflammatory cytokines (TNF-& alpha;, IL-6, and IL-8). Together, these data demonstrated that porNPM1 is involved in cellular stress stimuli, JEV replication, and induction of inflammatory cytokines.

关键词： Porcine NPM1 Cell stress Japanese encephalitis virus Inflammatory cytokines

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