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Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 2000 to 2020

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EYE 2024年第11期38卷 2047-2057页

作者： Curran, Katie Peto, Tunde Jonas, Jost B. Friedman, David Kim, Judy E. Leasher, Janet Tapply, Ian Fernandes, Arthur G. Cicinelli, Maria Vittoria Arrigo, Alessandro Leveziel, Nicolas Resnikoff, Serge Taylor, Hugh R. Sedighi, Tabassom Flaxman, Seth Bikbov, Mukkharram M. Braithwaite, Tasanee Bron, Alain Cheng, Ching-Yu Del Monte, Monte A. Ehrlich, Joshua R. Furtado, Joao M. Gazzard, Gus Hartnett, M. Elizabeth Kahloun, Rim Kempen, John H. Khairallah, Moncef Khanna, Rohit C. Lansingh, Van Charles Naidoo, Kovin S. Nangia, Vinay Nowak, Michal Pesudovs, Konrad Ramulu, Pradeep Topouzis, Fotis Tsilimbaris, Mitiadis Wang, Ya Xing Wang, Ningli Bourne, Rupert R. A. Curran, Katie Peto, Tunde Bourne, Rupert Leasher, Janet L. Jonas, Jost B. Sedighi, Tabassom Friedman, David S. Kim, Judy E. Fernandes, Arthur G. Ahinkorah, Bright Opoku Ahmadieh, Hamid Ahmed, Ayman Alfaar, Ahmad Samir Almidani, Louay Amu, Hubert Androudi, Sofia Arabloo, Jalal Aravkin, Aleksandr Y. Asemu, Mulu Tiruneh Azzam, Ahmed Y. Baghcheghi, Nayereh Bailey, Freddie Baran, Mehmet Firat Bardhan, Mainak Barnighausen, Till Winfried Barrow, Amadou Bhardwaj, Pankaj Bikbov, Mukharram Braithwaite, Tasanee Briant, Paul Svitil Burkart, Katrin Camera, Luis Alberto Coberly, Kaleb dadras, omid Dai, Xiaochen Dehghan, Amin Demessa, Berecha Hundessa Diress, Mengistie Thanh Chi Do Thao Huynh Phuong Do Dokova, Klara Georgieva Duncan, Bruce B. Ekholuenetale, Michael Elhadi, Muhammed Emamian, Mohammad Hassan Emamverdi, Mehdi Farrokhpour, Hossein Fatehizadeh, Ali Desideri, Lorenzo Ferro Furtado, Joao M. Gebrehiwot, Mesfin Ghassemi, Fariba Gudeta, Mesay Dechasa Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Hammond, Billy Randall Harorani, Mehdi Hasani, Hamidreza Heidari, Golnaz Hosseinzadeh, Mehdi Huang, John J. Islam, Sheikh Mohammed Shariful Javadi, Nilofer Jimenez-Corona, Aida Jokar, Mohammad Joshua, Charity Ehimwenma Kadashetti, Vidya Kandel, Himal Kasraei, Hengameh Kaur, Rimple Jeet Khanal, Sudarshan Khorrami, Zahra Koohestani, Hamid Reza Krishan, Kewal Lim, Stephen S. Abd El Queens Univ Belfast Ctr Publ Hlth Belfast Antrim North Ireland Heidelberg Univ Med Fac Mannheim Dept Ophthalmol Heidelberg Germany Harvard Med Sch Mass Eye & Ear Boston MA USA Univ Texas Southwestern Med Ctr Dallas Dallas TX USA Nova Southeastern Univ Coll Optometry Ft Lauderdale FL USA Cambridge Univ Hosp Dept Ophthalmol Cambridge England Fed Univ Sao Paolo Sao Paulo SP Brazil Univ Calgary Calgary AB Canada Univ Vita Salute San Raffaele Sch Med Milan Italy IRCCS San Raffaele Sci Inst Dept Ophthalmol Milan Italy Univ Vita Salute San Raffaele Sci Inst San Raffaele Hosp Milan Italy Univ Poitiers Poitiers France CHU Poitiers Poitiers France Brien Holden Vis Inst Sydney NSW Australia Univ New South Wales Sch Optometry & Vis Sci Fac Med Sydney NSW Australia Univ Melbourne Sch Populat & Global Hlth Carlton Vic Australia Anglia Ruskin Univ Vis & Eye Res Inst Cambridge England Univ Oxford Dept Comp Sci Oxford England Ufa Eye Res Inst Ufa Russia Kings Coll London Sch Life Course & Populat Sci London England Guys & St Thomas NHS Fdn Trust Med Eye Unit London England Univ Hosp Dijon France Natl Univ Singapore Singapore Singapore Singapore Eye Res Inst Singapore Singapore Univ Michigan Ann Arbor MI USA Kellogg Eye Ctr Ann Arbor MI USA Univ Michigan Inst Social Res Ann Arbor MI USA Univ Michigan Dept Ophthalmol & Visual Sci Ann Arbor MI USA Univ Sao Paulo Ribeirao Preto Med Sch Sao Paulo Brazil UCL Inst Ophthalmol London England NIHR Biomed Res Ctr London England Stanford Univ Stanford CA USA Associated Ophthalmol Monastir Monastir Tunisia Harvard Univ Dept Ophthalmol Boston MA USA MyungSung Med Coll Eye Unit Addis Ababa Ethiopia Addis Ababa Univ Dept Ophthalmol Addis Ababa Ethiopia Sight Souls Bellevue WA USA Univ Monastir Fattouma Bourguiba Univ Hosp Monastir Tunisia LV Prasad Eye Inst Gullapalli Pratibha Rao Int Ctr Adv Rural Eye Car Allen Foster Community Eye Hlth Res Ctr Hyderabad India LV Prasad Eye Inst Brien H

OBJECTIVES: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by diabetic retinopathy and their proportion of the total number of vision-impaired individuals. METHODS:... 详细信息

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Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021

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The Lancet Infectious Diseases 2025年第5期25卷 519-536页

作者： Kyu, Hmwe Hmwe Vongpradith, Avina Dominguez, Regina-Mae Villanueva Ma, Jianing Albertson, Samuel B Novotney, Amanda Khalil, Ibrahim A Troeger, Christopher E Doxey, Matthew C Ledesma, Jorge R Sirota, Sarah Brooke Bender, Rose Grace Swetschinski, Lucien R Cunningham, Matthew Spearman, Sandra Abate, Yohannes Habtegiorgis Abd Al Magied, Abdallah H A Abd ElHafeez, Samar Abdoun, Meriem Abera, Bayeh Abidi, Hassan Aboagye, Richard Gyan Abtew, Yonas Derso Abualruz, Hasan Abu-Gharbieh, Eman Abukhadijah, Hana J Aburuz, Salahdein Addo, Isaac Yeboah Adekanmbi, Victor Adetunji, Charles Oluwaseun Oluwaseun Adeyeoluwa, Temitayo Esther Adhikary, Ripon Kumar Adnani, Qorinah Estiningtyas Sakilah Adra, Saryia Adzigbli, Leticia Akua Afolabi, Aanuoluwapo Adeyimika Afzal, Muhammad Sohail Afzal, Saira Agampodi, Suneth Buddhika Agide, Feleke Doyore Ahinkorah, Bright Opoku Ahmad, Aqeel Ahmad, Sajjad Ahmed, Ayman Ahmed, Ayman Ahmed, Haroon Ahmed, Saeed Akinosoglou, Karolina Akter, Ema Al Awaidy, Salah Alajlani, Muaaz M Alam, Khurshid Albakri, Almaza Albashtawy, Mohammed Aldhaleei, Wafa A Algammal, Abdelazeem M Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Syed Shujait Ali, Waad Alif, Sheikh Mohammad Aljunid, Syed Mohamed Al-Marwani, Sabah Almazan, Joseph Uy Al-Mekhlafi, Hesham M Almustanyir, Sami Alqahatni, Saleh A Alrawashdeh, Ahmad Al-Rifai, Rami H Alsabri, Mohammed A Altaf, Awais Altirkawi, Khalid A Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J Alyahya, Mohammad Sharif Ibrahim Al-Zyoud, Walid A Amugsi, Dickson A Andrei, Catalina Liliana Antoni, Sebastien Anuoluwa, Boluwatife Stephen Anuoluwa, Iyadunni Adesola Anwar, Saleha Anwari, Palwasha Apostol, Geminn Louis Carace Arabloo, Jalal Arafat, Mosab Aravkin, Aleksandr Y Areda, Demelash Aregawi, Brhane Berhe Aremu, Abdulfatai Arndt, Michael Benjamin Asgedom, Akeza Awealom Ashraf, Tahira Athari, Seyyed Shamsadin Atreya, Alok Ayele, Firayad Azadi, Davood Azhar, Gulrez Shah Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Bahrami Taghanaki, Pegah Bahramian, Saeed Balakrishnan, Senthilkumar B

Background: Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific ...

Background: Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk factors, in children and adults in 204 countries and territories from 1990 to 2021. Methods: We used the Cause of Death Ensemble modelling strategy to analyse vital registration data, verbal autopsy data, mortality surveillance data, and minimally invasive tissue sampling data. We used DisMod-MR (version 2.1), a Bayesian meta-regression tool, to analyse incidence and prevalence data identified via systematic reviews, population-based surveys, and claims and inpatient data. We calculated diarrhoeal disability-adjusted life-years (DALYs) as the sum of years of life lost (YLLs) and years lived with disability (YLDs) for each location, year, and age–sex group. For aetiology estimation, we used a counterfactual approach to quantify population-attributable fractions (PAFs). Additionally, we estimated the diarrhoeal disease burden attributable to the independent effects of risk factors using the comparative risk assessment framework. Findings: In 2021, diarrhoeal diseases caused an estimated 1·17 million (95% uncertainty interval 0·793–1·62) deaths globally, representing a 60·3% (50·6–69·0) decrease since 1990 (2·93 million [2·31–3·73] deaths). The most pronounced decline was in children younger than 5 years, with a 79·2% (72·4–84·6) decrease in diarrhoeal deaths. Global YLLs also decreased substantially, from 186 million (147–221) in 1990 to 51·4 million (39·9–65·9) in 2021. In 2021, an e

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Global, regional, and national burden of spinal cord injury, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

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LANCET NEUROLOGY 2023年第11期22卷 1026-1047页

作者： Safdarian, Mahdi Trinka, Eugen Rahimi-Movaghar, Vafa Thomschewski, Aljoscha Aali, Amirali Abady, Gdiom Gebreheat Abate, Semagn Mekonnen Abd-Allah, Foad Abedi, Aidin Adane, Denberu Eshetie Afzal, Saira Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmed, Haroon Amanat, Nasir Angappan, Dhanalakshmi Arabloo, Jalal Aryannejad, Armin Athari, Seyyed Shamsadin Atreya, Alok Azadnajafabad, Sina Azzam, Ahmed Y. Babamohamadi, Hassan Banik, Palash Chandra Bardhan, Mainak Bashiri, Azadeh Berhie, Alemshet Yirga Bhat, Ajay Nagesh Brown, Julie Champs, Ana Paula Charalampous, Periklis Chukwu, Isaac Sunday Coberly, Kaleb dadras, omid Yada, Dereje Y. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi Dessalegn, Fikadu Nugusu Desta, Abebaw Alemayehu Dhingra, Sameer Diao, Nancy Diaz, Daniel Dibas, Mahmoud Dongarwar, Deepa Dsouza, Haneil Larson Ekholuenetale, Michael El Nahas, Nevine Elhadi, Muhammed Eskandarieh, Sharareh Fagbamigbe, Adeniyi Francis Fares, Jawad Fatehizadeh, Ali Fereshtehnejad, Seyed-Mohammad Fischer, Florian Franklin, Richard Charles Garg, Tushar Getachew, Melaku Ghaffarpasand, Fariborz Gholamrezanezhad, Ali Mesgarha, Milad Gholizadeh Ghozy, Sherief Golechha, Mahaveer Goleij, Pouya Graham, Simon Matthew Gupta, Vivek Kumar Haagsma, Juanita A. Hamidi, Samer Harlianto, Netanja I. Harorani, Mehdi Hasanian, Mohammad Hassan, Amr Hassen, Mohammed Bheser Hoveidaei, Amir Human Iravanpour, Farideh Irilouzadian, Rana Iwu, Chidozie C. D. Jacob, Louis Jaja, Chinwe Juliana Joseph, Nitin Joshua, Charity Ehimwenma Jozwiak, Jacek Jerzy Kadashetti, Vidya Kandel, Amit Kantar, Rami S. Karaye, Ibraheem M. Karkhah, Samad Khader, Yousef Saleh Khan, Ejaz Ahmad Khan, Jobair Kashani, Hamid Reza Khayat Khonji, Mohammad Saeid Khormali, Moein Kim, Grace Krishnamoorthy, Vijay Kumaran, Senthil D. Malekpour, Mohammad-Reza Meretoja, Tuomo J. Mesregah, Mohamed Kamal Mestrovic, Tomislav de Sa, Ana Carolina Micheletti Gomide Nogueira Mirahmadi, Alireza Mirghaderi, Seyed Peyman Mirza, Moonis Misganaw, Awoke Misra, Sanjeev Mohammad, Yousef Mohammadi, Esmaeil Mokdad, Al Paracelsus Med Univ Christian Doppler Univ Hosp Dept Neurol Ctr Cognit Neurosci A-5020 Salzburg Austria Paracelsus Med Univ Spinal Cord Injury & Tissue Regenerat Ctr SCI TRe Salzburg Austria Paracelsus Med Univ Christian Doppler Univ Hosp Neurosci Inst Ctr Cognit Neurosci Salzburg Austria Karl Landsteiner Inst Neurorehabil & Space Neurol Salzburg Austria UMIT Univ Hlth Sci Med Informat & Technol Dept Publ Hlth Hlth Serv Res & Hlth Technol Asses Hall In Tirol Austria Univ Tehran Med Sci Sina Trauma & Surg Res Ctr Tehran Iran Univ Tehran Med Sci Noncommunicable Dis Res Ctr Tehran Iran Univ Tehran Med Sci Expt Med Res Ctr Tehran Iran Univ Tehran Med Sci Multiple Sclerosis Res Ctr Tehran Iran Univ Tehran Med Sci Students Sci Res Ctr SSRC Tehran Iran Univ Tehran Med Sci Fac Med Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Univ Tehran Med Sci Dept Neurol Tehran Iran Univ Tehran Med Sci Sina Trauma & Surg Res Ctr Tehran Iran Univ Tehran Med Sci Dept Pediat Allergy & Immunol Tehran Iran Univ Tehran Med Sci Tehran Iran Mashhad Univ Med Sci Fac Med Mashhad Razavi Khorasan Iran Mashhad Univ Med Sci Neurosci Dept Mashhad Razavi Khorasan Iran Adigrat Univ Dept Nursing Adigrat Ethiopia Dilla Univ Dept Anesthesiol Addis Ababa Ethiopia Cairo Univ Dept Neurol Cairo Egypt Univ Southern Calif Dept Neurosurg Los Angeles CA 90007 USA Univ Southern Calif Keck Sch Med Los Angeles CA 90007 USA Univ Southern Calif Dept Radiol Los Angeles CA 90007 USA Debre Tabor Univ Dept Anesthesia & Crit Care Debre Tabor Ethiopia King Edward Mem Hosp Dept Community Med Lahore Pakistan Publ Hlth Inst Dept Publ Hlth Lahore Pakistan Univ Technol Sydney Sch Publ Hlth Sydney NSW Australia Abasyn Univ Dept Hlth & Biol Sci Peshawar Pakistan COMSATS Inst Informat Technol Dept Biosci Islamabad Pakistan Semnan Univ Med Sci & Hlth Serv Nursing Care Res Ctr Semnan Iran Semnan Univ Med Sci & Hlth Serv Dept Nursing Semnan Iran Oregon Hlth & Sci Univ Dept Chil

Background Spinal cord injury (SCI) is a major cause of health loss due to premature mortality and long-term disability. We aimed to report on the global, regional, and national incidence, prevalence, and years of lif...

Background Spinal cord injury (SCI) is a major cause of health loss due to premature mortality and long-term disability. We aimed to report on the global, regional, and national incidence, prevalence, and years of life lived with disability (YLDs) for SCI from 1990 to 2019, using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods Using GBD 2019 data pooled in DisMod-MR 2.1, a Bayesian meta-regression tool, we systematically derived numbers and age-standardised rate changes with 95% uncertainty intervals (95% UIs) for the incidence, prevalence, and YLDs for SCI from 1990 to 2019 for the whole world, 21 GBD regions, and 204 countries and territories. We report trends based on age, sex, year, cause of injury, and level of injury. Findings Globally, 20 center dot 6 million (95% UI 18 center dot 9 to 23 center dot 6) individuals were living with SCI in 2019. The incidence of SCI was 0 center dot 9 million (0 center dot 7 to 1 center dot 2) cases with an estimated 6 center dot 2 million (4 center dot 5 to 8 center dot 2) YLDs. SCI rates increased substantially from 1990 to 2019 for global prevalence (81 center dot 5%, 74 center dot 2 to 87 center dot 1), incidence (52 center dot 7%, 30 center dot 3 to 69 center dot 8), and YLDs (65 center dot 4%, 56 center dot 3 to 76 center dot 0). However, global age-standardised rates per 100 000 population showed small changes in prevalence (5 center dot 8%, 2 center dot 6 to 9 center dot 5), incidence (-6 center dot 1%, -17 center dot 2 to 1 center dot 5), and YLDs (-1 center dot 5%, -5 center dot 5 to 3 center dot 2). Data for 2019 shows that the incidence of SCI increases sharply until age 15-19 years, where it remains reasonably constant until 85 years of age and older. By contrast, prevalence and YLDs showed similar patterns to each other, with one peak at around age 45-54 years. The incidence, prevalence, and YLDs of SCI have consistently been higher in men than in women globally, with

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Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990-2019: results from the Global Burden of Disease Study 2019

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LANCET INFECTIOUS DISEASES 2022年第2期22卷 222-241页

作者： Ledesma, Jorge R. Ma, Jianing Vongpradith, Avina Maddison, Emilie R. Novotney, Amanda Biehl, Molly H. LeGrand, Kate E. Ross, Jennifer M. Jahagirdar, Deepa Bryazka, Dana Feldman, Rachel Abolhassani, Hassan Abosetugn, Akine Eshete Abu-Gharbieh, Eman Adebayo, Oladimeji M. Adnani, Qorinah Estiningtyas Sakilah Afzal, Saira Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmad Ahmadi, Sepideh Rashid, Tarik Ahmed Salih, Yusra Ahmed Aklilu, Addis Akunna, Chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Alemayehu, Yosef Alene, Kefyalew Addis Ali, Beriwan Abdulqadir Ali, Liaqat Alipour, Vahid Alizade, Hesam Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Amini, Saeed Amit, Arianna Maever L. Anderson, Jason A. Androudi, Sofia Antonio, Carl Abelardo T. Antony, Catherine M. Anwer, Razique Arabloo, Jalal Arja, Asrat Asemahagn, Mulusew A. Atre, Sachin R. Azhar, Gulrez Shah Darshan, B. B. Babar, Zaheer-Ud-Din Baig, Atif Amin Banach, Maciej Barqawi, Hiba Jawdat Barra, Fabio Barrow, Amadou Basu, Sanjay Belgaumi, Uzma Iqbal Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharjee, Natalia, V Bhattacharyya, Krittika Bijani, Ali Bikbov, Boris Boloor, Archith Briko, Nikolay Ivanovich Buonsenso, Danilo Nagaraja, Sharath Burugina Butt, Zahid A. Carter, Austin Carvalho, Felix Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Christopher, Devasahayam J. Chu, Dinh-Toi Claassens, Mareli M. dadras, omid Dagnew, Amare Belachew Dai, Xiaochen Dandona, Lalit Dandona, Rakhi Daneshpajouhnejad, Parnaz Darwesh, Aso Mohammad Dhamnetiya, Deepak Dianatinasab, Mostafa Diaz, Daniel Linh Phuong Doan Eftekharzadeh, Sahar Elhadi, Muhammed Emami, Amir Enany, Shymaa Faraon, Emerito Jose A. Farzadfar, Farshad Fernandes, Eduarda Desideri, Lorenzo Ferro Filip, Irina Fischer, Florian Foroutan, Masoud Frank, Tahvi D. Garcia-Basteiro, Alberto L. Garcia-Calavaro, Christian Garg, Tushar Geberemariyam, Biniyam Sahiledengle Ghadiri, Keyghobad Ghashghaee, Ahmad Golechha, Mahaveer Goodridge, Amador Gupta, Bhawna Gupta, Sapna Gupta, Univ Washington Inst Hlth Metr & Evaluat Seattle WA 98195 USA Univ Washington Dept Global Hlth Seattle WA 98195 USA Univ Washington Dept Med Seattle WA 98195 USA Univ Washington Dept Hlth Metr Sci Seattle WA 98195 USA World Hlth Org WHO Div Data Analyt & Delivery Impact Geneva Switzerland Karolinska Univ Hosp Dept Lab Med Huddinge Sweden Univ Tehran Med Sci Res Ctr Immunodeficiencies Tehran Iran Univ Tehran Med Sci Noncommunicable Dis Res Ctr Tehran Iran Univ Tehran Med Sci Digest Dis Res Inst Tehran Iran Univ Tehran Med Sci Metabol & Genom Res Ctr Tehran Iran Univ Tehran Med Sci Sina Trauma & Surg Res Ctr Tehran Iran Debre Berhan Univ Dept Publ Hlth Debre Brehan Ethiopia Univ Sharjah Dept Clin Sci Sharjah U Arab Emirates Univ Sharjah Clin Sci Dept Sharjah U Arab Emirates Univ Coll Hosp Coll Med Ibadan Nigeria Karya Husada Inst Hlth Sci Dept Midwifery Kediri Indonesia Auckland Univ Technol Dept Midwifery Auckland New Zealand King Edward Mem Hosp Dept Community Med Lahore Pakistan Publ Hlth Inst Dept Publ Hlth Lahore Pakistan Univ Technol Sydney Australian Ctr Publ & Populat Hlth Res ACPPHR Sydney NSW Australia Fdn Univ Islamabad Fdn Univ Med Coll Islamabad Pakistan Shahid Beheshti Univ Med Sci Sch Adv Technol Med Tehran Iran Shahid Beheshti Univ Med Sci Dept Epidemiol Tehran Iran Univ Kurdistan Hewler Dept Comp Sci & Engn Erbil Iraq Sulaimani Polytech Univ Database Technol Dept Sulaymaniyah Iraq Sulaimani Polytech Univ Coll Informat Sulaymaniyah Iraq Arba Minch Univ Dept Med Lab Sci Arba Minch Ethiopia Arba Minch Univ Dept Midwifery Arba Minch Ethiopia Arba Minch Univ Dept Biomed Sci Arba Minch Ethiopia Intercountry Ctr Oral Hlth ICOH Africa Dept Publ Hlth Jos Nigeria Fed Minist Hlth Dept Publ Hlth Garki Nigeria Hamad Med Corp Geriatr & Long Term Care Dept Doha Qatar Hamad Med Corp Rumailah Hosp Doha Qatar Mayo Clin Fdn Med Educ & Res Mayo Evidence Based Practice Ctr Rochester MN USA Curtin Univ Fac Hlth Sci P

Background Tuberculosis is a major contributor to the global burden of disease, causing more than a million deaths annually. Given an emphasis on equity in access to diagnosis and treatment of tuberculosis in global h...

Background Tuberculosis is a major contributor to the global burden of disease, causing more than a million deaths annually. Given an emphasis on equity in access to diagnosis and treatment of tuberculosis in global health targets, evaluations of differences in tuberculosis burden by sex are crucial. We aimed to assess the levels and trends of the global burden of tuberculosis, with an emphasis on investigating differences in sex by HIV status for 204 countries and territories from 1990 to 2019. Methods We used a Bayesian hierarchical Cause of Death Ensemble model (CODEm) platform to analyse 21 505 site-years of vital registration data, 705 site-years of verbal autopsy data, 825 site-years of sample-based vital registration data, and 680 site-years of mortality surveillance data to estimate mortality due to tuberculosis among HIV-negative individuals. We used a population attributable fraction approach to estimate mortality related to HIV and tuberculosis coinfection. A compartmental meta-regression tool (DisMod-MR 2.1) was then used to synthesise all available data sources, including prevalence surveys, annual case notifications, population-based tuberculin surveys, and tuberculosis cause-specific mortality, to produce estimates of incidence, prevalence, and mortality that were internally consistent. We further estimated the fraction of tuberculosis mortality that is attributable to independent effects of risk factors, including smoking, alcohol use, and diabetes, for HIV-negative individuals. For individuals with HIV and tuberculosis coinfection, we assessed mortality attributable to HIV risk factors including unsafe sex, intimate partner violence (only estimated among females), and injection drug use. We present 95% uncertainty intervals for all estimates. Findings Globally, in 2019, among HIV-negative individuals, there were 1.18 million (95% uncertainty interval 1.08-1.29) deaths due to tuberculosis and 8.50 million (7.45-9.73) incident cases of tuberculosis. A

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Global estimates on the number of people blind or visually impaired by glaucoma: A meta-analysis from 2000 to 2020

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EYE 2024年第11期38卷 2036-2046页

作者： Bourne, Rupert R. A. Jonas, Jost B. Friedman, David Nangia, Vinay Bron, Alain Tapply, Ian Fernandes, Arthur G. Cicinelli, Maria Vittoria Arrigo, Alessandro Leveziel, Nicolas Resnikoff, Serge Taylor, Hugh R. Sedighi, Tabassom Bikbov, Mukkharram M. Braithwaite, Tasanee Cheng, Ching-Yu Congdon, Nathan Del Monte, Monte A. Ehrlich, Joshua R. Fricke, Tim Furtado, Joao M. Gazzard, Gus George, Ronnie Hartnett, M. Elizabeth Kahloun, Rim Kempen, John H. Khairallah, Moncef Khanna, Rohit C. Kim, Judy E. Lansingh, Van Charles Leasher, Janet Naidoo, Kovin S. Nowak, Michal Pesudovs, Konrad Peto, Tunde Ramulu, Pradeep Topouzis, Fotis Tsilimbaris, Mitiadis Wang, Ya Xing Wang, Ningli Flaxman, Seth Casson, Robert James Friedman, David S. Bron, Alain M. Briant, Paul Svitil Vos, Theo Abate, Yohannes Habtegiorgis Abate, Melsew Dagne Dolatabadi, Zahra Abbasi Abdollahi, Mozhan Aboagye, Richard Gyan Abu-Gharbieh, Eman Aburuz, Salahdein Adnani, Qorinah Estiningtyas Sakilah Aghamiri, Shahin Ahinkorah, Bright Opoku Ahmad, Danish Ahmadieh, Hamid Ahmadzadeh, Hooman Ahmed, Ayman Alfaar, Ahmad Samir Alinia, Cyrus Almidani, Louay Amu, Hubert Androudi, Sofia Anil, Abhishek Arabloo, Jalal Areda, Damelash Ashraf, Tahira Bagherieh, Sara Baltatu, Ovidiu Constantin Baran, Mehmet Firat Barrow, Amadou Bashiri, Azadeh Bayileyegn, Nebiyou Simegnew Bazvand, Fatemeh Berhie, Alemshet Yirga Bhatti, Jasvinder Singh Bikbov, Mukharram Birck, Marina G. Bitra, Veera R. Bozic, Marija M. Braithwaite, Tasanee Burkart, Katrin Bustanji, Yasser Butt, Zahid A. Cenderadewi, Muthia Chattu, Vijay Kumar Coberly, Kaleb dadras, omid Dai, Xiaochen Dascalu, Ana Maria Dastiridou, Anna Devanbu, Vinoth Gnana Chellaiyan Dhimal, Meghnath Diaz, Daniel Thao Huynh Phuong Do Thanh Chi Do Dziedzic, Arkadiusz Marian Ehrlich, Joshua R. Ekholuenetale, Michael Elhadi, Muhammed Emamian, Mohammad Hassan Emamverdi, Mehdi Farrokhpour, Hossein Fetensa, Getahun Fischer, Florian Forouhari, Ali Fowobaje, Kayode Raphael Furtado, Joao M. Gandhi, Aravind P. Gebregergis, Miglas W. W. Garcia Goulart, Barb Anglia Ruskin Univ Vis & Eye Res Inst Cambridge England Heidelberg Univ Med Fac Mannheim Dept Ophthalmol Heidelberg Germany Harvard Med Sch Massachusetts Eye & Ear Boston MA 02115 USA Suraj Eye Inst 559 New Colony Nagpur Maharashtra India Univ Hosp Dijon France Addenbrookes Hosp Cambridge England Fed Univ Sao Paolo Sao Paulo SP Brazil Univ Calgary Calgary AB Canada Univ Vita Salute San Raffaele Sch Med Milan Italy IRCCS San Raffaele Sci Inst Dept Ophthalmol Milan Italy Univ Vita Salute San Raffaele Sci Inst San Raffaele Hosp Milan Italy Univ Poitiers Poitiers France CHU Poitiers Poitiers France Brien Holden Vis Inst Sydney NSW Australia Univ New South Wales Sch Optometry & Vis Sci Fac Med Sydney NSW Australia Univ Melbourne Sch Populat & Global Hlth Carlton Vic Australia Ufa Eye Res Inst Ufa Russia Kings Coll London Sch Life Course & Populat Sci London England Guys & St Thomas NHS Fdn Trust Med Eye Unit London England Natl Univ Singapore Singapore Singapore Singapore Eye Res Inst Singapore Singapore Queens Univ Belfast Belfast Antrim North Ireland Orbis Int New York NY USA Sun Yat Sen Univ Zhongshan Ophthalm Ctr Guangzhou Peoples R China Univ Michigan Ann Arbor MI 48109 USA Kellogg Eye Ctr Ann Arbor MI USA Univ Michigan Inst Social Res Ann Arbor MI USA Univ Michigan Dept Ophthalmol & Visual Sci Ann Arbor MI 48109 USA Australian Coll Optometry Melbourne Vic Australia Univ Melbourne Melbourne Vic Australia UNSW Sydney Sydney NSW Australia Univ Sao Paulo Ribeirao Preto Med Sch Sao Paulo Brazil UCL Inst Ophthalmol London England NIHR Biomed Res Ctr London England Sankara Nethralaya Med Res Fdn Chennai Tamil Nadu India Stanford Univ Stanford CA 94305 USA Assoc Ophthalmologists Monastir Monastir Tunisia Harvard Univ Dept Ophthalmol Boston MA 02115 USA MyungSung Med Coll Eye Unit Addis Ababa Ethiopia Addis Ababa Univ Dept Ophthalmol Addis Ababa Ethiopia Sight Souls Bellevue WA USA Univ Monastir Fattouma Bo

OBJECTIVES: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by glaucoma and their proportion of the total number of vision-impaired individuals. METHODS: A systemati... 详细信息

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Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021

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The Lancet 2025年第10481期405卷 785-812页

作者： Kerr, Jessica A Patton, George C Cini, Karly I Abate, Yohannes Habtegiorgis Abbas, Nasir Abd Al Magied, Abdallah H A Abd ElHafeez, Samar Abd-Elsalam, Sherief Abdollahi, Arash Abdoun, Meriem Abdulah, Deldar Morad Abdulkader, Rizwan Suliankatchi Abdullahi, Auwal Abeywickrama, Hansani Madushika Abie, Alemwork Abiodun, Olumide Abohashem, Shady Abtahi, Dariush Abualruz, Hasan Abubakar, Bilyaminu Abu-Gharbieh, Eman Abukhadijah, Hana J Abu-Rmeileh, Niveen ME Aburuz, Salahdein Abu-Zaid, Ahmed Adams, Lisa C. Adane, Mesafint Molla Addo, Isaac Yeboah Adedokun, Kamoru Ademola Adegoke, Nurudeen A Adesola, Ridwan Olamilekan Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Adiga, Usha Adnani, Qorinah Estiningtyas Sakilah Afify, Abdelrahman Yousry Afolabi, Aanuoluwapo Adeyimika Afzal, Muhammad Sohail Afzal, Saira Agampodi, Suneth Buddhika Aghamiri, Shahin Agostinis Sobrinho, César Agyemang-Duah, Williams Ahinkorah, Bright Opoku Ahlstrom, Austin J Ahmad, Aqeel Ahmad, Danish Ahmad, Fuzail Ahmad, Muayyad M Ahmad, Noah Ahmad, Sajjad Ahmed, Ayman Ahmed, Haroon Ahmed, Luai A Ahmed, Meqdad Saleh Ahmed, Meqdad Saleh Ahmed, Syed Anees Ajami, Marjan Akkaif, Mohammed Ahmed Akrami, Ashley E Al Hamad, Hanadi Al Hasan, Syed Mahfuz Al Ta'ani, Zain Al Thaher, Yazan Alalwan, Tariq A Al-Aly, Ziyad Alam, Khurshid Al-amer, Rasmieh Mustafa Alansari, Amani Al-Ashwal, Fahmi Y. Albashtawy, Mohammed Alemayehu, Bezawit Abeje Algammal, Abdelazeem M Alhabib, Khalid F Alhuwail, Dari Ali, Abid Ali, Endale Alemayehu Ali, Mohammad Daud Ali, Mohammed Usman Ali, Rafat Ali, Waad Alif, Sheikh Mohammad Alimohamadi, Yousef Al-Jabi, Samah W Aljofan, Mohamad Aljunid, Syed Mohamed Alkhatib, Ahmad Almahmeed, Wael Al-Marwani, Sabah Alomari, Mahmoud A Alqahtani, Saleh A Alqarni, Abdullah A Alrawashdeh, Ahmad Alrimawi, Intima Alrousan, Sahel Majed Alshahrani, Najim Z Altaany, Zaid Altaf, Awais Alvi, Farrukh Jawad Alvis-Guzman, Nelson Al-Wardat, Mohammad Al-Worafi, Yaser Mohammed Aly, Hany Aly, Safwat Alzoubi, Karem H Aman Mohammadi, Masoud Amera, Tewodros Getnet Amiri,

Background: Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-communicable diseases in adulthood, coordinated global action on excess body...

Background: Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-communicable diseases in adulthood, coordinated global action on excess body mass in early life is still insufficient. Inconsistent measurement and reporting are a barrier to specific targets, resource allocation, and interventions. In this Article we report current estimates of overweight and obesity across childhood and adolescence, progress over time, and forecasts to inform specific actions. Methods: Using established methodology from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we modelled overweight and obesity across childhood and adolescence from 1990 to 2021, and then forecasted to 2050. Primary data for our models included 1321 unique measured and self-reported anthropometric data sources from 180 countries and territories from survey microdata, reports, and published literature. These data were used to estimate age-standardised global, regional, and national overweight prevalence and obesity prevalence (separately) for children and young adolescents (aged 5–14 years, typically in school and cared for by child health services) and older adolescents (aged 15–24 years, increasingly out of school and cared for by adult services) by sex for 204 countries and territories from 1990 to 2021. Prevalence estimates from 1990 to 2021 were generated using spatiotemporal Gaussian process regression models, which leveraged temporal and spatial correlation in epidemiological trends to ensure comparability of results across time and geography. Prevalence forecasts from 2022 to 2050 were generated using a generalised ensemble modelling approach assuming continuation of current trends. For every age-sex-location population across time (1990–2050), we estimated obesity (vs overweight) predominance using the log ratio of obesity percentage to overweight percentage. Findings: Between 1990 and 2021, the combined pr

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Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021

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The Lancet 2025年第10481期405卷 813-838页

作者： Ng, Marie Gakidou, Emmanuela Lo, Justin Abate, Yohannes Habtegiorgis Abbafati, Cristiana Abbas, Nasir Abbasian, Mohammadreza Abd ElHafeez, Samar Abdel-Rahman, Wael M Abd-Elsalam, Sherief Abdollahi, Arash Abdoun, Meriem Abdulah, Deldar Morad Abdulkader, Rizwan Suliankatchi Abdullahi, Auwal Abedi, Armita Abeywickrama, Hansani Madushika Abie, Alemwork Aboagye, Richard Gyan Abohashem, Shady Abtahi, Dariush Abualruz, Hasan Abubakar, Bilyaminu Abu Farha, Rana Kamal Abukhadijah, Hana J Abu-Rmeileh, Niveen ME Aburuz, Salahdein Abu-Zaid, Ahmed Adams, Lisa C Adane, Mesafint Molla Addo, Isaac Yeboah Adedokun, Kamoru Ademola Adegoke, Nurudeen A Adepoju, Abiola Victor Victor Adesola, Ridwan Olamilekan Adeyeoluwa, Temitayo Esther Adiga, Usha Adnani, Qorinah Estiningtyas Sakilah Afaghi, Siamak Afzal, Saira Afzal, Muhammad Sohail Agampodi, Thilini Chanchala Aghamiri, Shahin Agostinis Sobrinho, César Agyemang-Duah, Williams Ahlstrom, Austin J Ahmad, Danish Ahmad, Sajjad Ahmad, Aqeel Ahmad, Muayyad M Ahmad, Fuzail Ahmad, Noah Ahmed, Haroon Ahmed, Muktar Beshir Ahmed, Ayman Ahmed, Mehrunnisha Sharif Ahmed, Mehrunnisha Sharif Ahmed, Syed Anees Ajami, Marjan Akhtar, Samina Akkaif, Mohammed Ahmed Akrami, Ashley E Alalwan, Tariq A Al-Aly, Ziyad Alam, Khurshid Al-amer, Rasmieh Mustafa Alansari, Amani Al-Ashwal, Fahmi Y Albashtawy, Mohammed Aldhaleei, Wafa A Alemayehu, Bezawit Abeje Algammal, Abdelazeem M Alhabib, Khalid F Al Hamad, Hanadi Al Hasan, Syed Mahfuz Alhuwail, Dari Ali, Rafat Ali, Abid Ali, Waad Ali, Mohammed Usman Alif, Sheikh Mohammad Al-Jabi, Samah W Aljunid, Syed Mohamed Alkhatib, Ahmad Al-Marwani, Sabah Alomari, Mahmoud A Alqahtani, Saleh A Al-Raddadi, Rajaa M Mohammad Alrawashdeh, Ahmad Alrimawi, Intima Alrousan, Sahel Majed Alshahrani, Najim Z Al Ta'ani, Omar Al Ta'ani, Zain Altaany, Zaid Altaf, Awais Al Thaher, Yazan Alvis-Guzman, Nelson Al-Wardat, Mohammad Al-Worafi, Yaser Mohammed Aly, Safwat Aly, Hany Alzahrani, Hosam Alzoubi, Abdallah Alzoubi, Karem H Al-Zubayer, Md. Akib Amiri, Sohrab Amu, Hubert Amugsi, Dickson A

Background: Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of ...

Background: Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories to 2050. Methods: Leveraging established methodology from the Global Burden of Diseases, Injuries, and Risk Factors Study, we estimated the prevalence of overweight and obesity among individuals aged 25 years and older by age and sex for 204 countries and territories from 1990 to 2050. Retrospective and current prevalence trends were derived based on both self-reported and measured anthropometric data extracted from 1350 unique sources, which include survey microdata and reports, as well as published literature. Specific adjustment was applied to correct for self-report bias. Spatiotemporal Gaussian process regression models were used to synthesise data, leveraging both spatial and temporal correlation in epidemiological trends, to optimise the comparability of results across time and geographies. To generate forecast estimates, we used forecasts of the Socio-demographic Index and temporal correlation patterns presented as annualised rate of change to inform future trajectories. We considered a reference scenario assuming the continuation of historical trends. Findings: Rates of overweight and obesity increased at the global and regional levels, and in all nations, between 1990 and 2021. In 2021, an estimated 1·00 billion (95% uncertainty interval [UI] 0·989–1·01) adult males and 1·11 billion (1·10–1·12) adult females had overweight and obesity. China had the largest population of adults with overweight and obesity (402 million [397–407] individuals), followed by India (180 million [167–194]) and the USA (172 million [169–174]). The highest age-standardised prevalence of overweight and obesity was observed in countries in

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Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000-2021: a systematic analysis from the Global Burden of Disease Study 2021

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LANCET HAEMATOLOGY 2023年第8期10卷 E585-E599页

作者： Thomson, Azalea M. McHugh, Theresa A. Oron, Assaf P. Teply, Corey Lonberg, Nikhil Tella, Victor M. Vilchis Wilner, Lauren B. Fuller, Kia Hagins, Hailey Aboagye, Richard Gyan Aboye, Melka Biratu Abu-Gharbieh, Eman Abu-Zaid, Ahmed Addo, Isaac Yeboah Ahinkorah, Bright Opoku Ahmad, Aqeel AlRyalat, Saif Aldeen S. Amu, Hubert Aravkin, Aleksandr Y. Arulappan, Judie Atout, Maha Moh'd Wahbi Badiye, Ashish D. Bagherieh, Sara Banach, Maciej Banakar, Morteza Bardhan, Mainak Barrow, Amadou Bedane, Deriba Abera Bensenor, Isabela M. Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhardwaj, Prarthna, V Bhat, Ajay Nagesh Bhutta, Zulfiqar A. Bilalaga, Mariah Malak Bishai, Jessica Devin Bitaraf, Saeid Boloor, Archith Butt, Muhammad Hammad Chattu, Vijay Kumar Chu, Dinh-Toi dadras, omid Dai, Xiaochen Danaei, Bardia Dang, Anh Kim Demisse, Fitsum Wolde Dhimal, Meghnath Diaz, Daniel Djalalinia, Shirin Dongarwar, Deepa Elhadi, Muhammed Elmonem, Mohamed A. Esezobor, Christopher Imokhuede Etaee, Farshid Eyawo, Oghenowede Fagbamigbe, Adeniyi Francis Fatehizadeh, Ali Force, Lisa M. Gardner, William M. Ghaffari, Kazem Gill, Paramjit Singh Golechha, Mahaveer Goleij, Pouya Gupta, Vivek Kumar Hasani, Hamidreza Hassan, Treska S. Hassen, Mohammed Bheser Ibitoye, Segun Emmanuel Ikiroma, Adalia I. Iwu, Chidozie C. D. James, Peter Bai Jayaram, Shubha Jebai, Rime Jha, Ravi Prakash Joseph, Nitin Kalantar, Farnaz Kandel, Himal Karaye, Ibraheem M. Kassahun, Woldeteklehaymanot Dagne Khan, Imteyaz A. Khanmohammadi, Shaghayegh Kisa, Adnan Kompani, Farzad Krishan, Kewal Landires, Ivan Lim, Stephen S. Mahajan, Preetam Bhalchandra Mahjoub, Soleiman Majeed, Azeem Marasini, Bishnu P. Meresa, Haftu Asmerom Mestrovic, Tomislav Minhas, Sonica Misganaw, Awoke Mokdad, Ali H. Monasta, Lorenzo Mustafa, Ghulam Nair, Tapas Sadasivan Swamy, Sreenivas Narasimha Nassereldine, Hasan Natto, Zuhair S. Naveed, Muhammad Nayak, Biswa Prakash Noubiap, Jean Jacques Noyes, Taylor Nri-ezedi, Chisom Adaobi Nwatah, Vincent Ebuka Nzoputam, Chimezie Igwegbe Nzoputam, Ogochukwu Janet Okon Univ Washington Inst Hlth Metr & Evaluat Seattle WA 98195 USA Univ Washington Dept Appl Math Seattle WA 98195 USA Univ Washington Sch Med Dept Hlth Metr Sci Seattle WA USA Univ Washington Div Pediat Hematol Oncol Seattle WA 98195 USA Univ Washington Dept Anesthesiol & Pain Med Seattle WA 98195 USA Univ Hlth & Allied Sci Dept Family & Community Hlth Ho Ghana Univ Hlth & Allied Sci Dept Populat & Behav Sci Ho Ghana Jimma Univ Dept Anesthesia Jimma Ethiopia Jimma Univ Dept Biomed Sci Jimma Ethiopia Univ Sharjah Dept Clin Sci Sharjah U Arab Emirates Univ Sharjah Res Inst Med & Hlth Sci Sharjah U Arab Emirates Alfaisal Univ Dept Surg Dept Obstet & Gynecol Dept Med Riyadh Saudi Arabia Univ Tennessee Coll Grad Hlth Sci Memphis TN USA Univ New South Wales Ctr Social Res Hlth Sydney NSW Australia Canc Inst New South Wales Qual & Syst Performance Unit Sydney NSW Australia Univ Technol Sydney Sch Publ Hlth Sydney NSW Australia Shaqra Univ Dept Med Biochem Shaqra Saudi Arabia Shaqra Univ Dept Pediat Shaqra Saudi Arabia Univ Jordan Dept Special Surg Amman Jordan Sultan Qaboos Univ Dept Maternal & Child Hlth Muscat Oman Philadelphia Univ Fac Nursing Amman Jordan Govt Inst Forens Sci Dept Forens Sci Nagpur Maharashtra India Isfahan Univ Med Sci Sch Med Esfahan Iran Isfahan Univ Med Sci Dept Environm Hlth Engn Esfahan Iran Med Univ Lodz Dept Hypertens Lodz Poland Polish Mothers Mem Hosp Res Inst Lodz Poland Univ Tehran Med Sci Dent Res Ctr Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Univ Tehran Med Sci Childrens Med Ctr Tehran Iran Univ Tehran Med Sci Noncommunicable Dis Res Ctr Tehran Iran Univ Tehran Med Sci Fac Med Tehran Iran Shiraz Univ Med Sci Ctr Hlth Policy Res Shiraz Iran Natl Inst Cholera & Enter Dis Mol Microbiol & Bacteriol Kolkata India Indian Council Med Res Dept Mol Microbiol New Delhi India Univ Gambia Dept Publ & Environm Hlth Brikama Gambia Minist Hlth Epidemiol & Dis Control Unit Kotu Gambi

Background Previous global analyses, with known underdiagnosis and single cause per death attribution systems, provide only a small insight into the suspected high population health effect of sickle cell disease. Comp...

Background Previous global analyses, with known underdiagnosis and single cause per death attribution systems, provide only a small insight into the suspected high population health effect of sickle cell disease. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this study delivers a comprehensive global assessment of prevalence of sickle cell disease and mortality burden by age and sex for 204 countries and territories from 2000 to 2021. Methods We estimated cause-specific sickle cell disease mortality using standardised GBD approaches, in which each death is assigned to a single underlying cause, to estimate mortality rates from the International Classification of Diseases (ICD)-coded vital registration, surveillance, and verbal autopsy data. In parallel, our goal was to estimate a more accurate account of sickle cell disease health burden using four types of epidemiological data on sickle cell disease: birth incidence, age-specific prevalence, with-condition mortality (total deaths), and excess mortality (excess deaths). Systematic reviews, supplemented with ICD-coded hospital discharge and insurance claims data, informed this modelling approach. We employed DisMod-MR 2.1 to triangulate between these measures-borrowing strength from predictive covariates and across age, time, and geography-and generated internally consistent estimates of incidence, prevalence, and mortality for three distinct genotypes of sickle cell disease: homozygous sickle cell disease and severe sickle cell 13-thalassaemia, sickle-haemoglobin C disease, and mild sickle cell 13-thalassaemia. Summing the three models yielded final estimates of incidence at birth, prevalence by age and sex, and total sickle cell disease mortality, the latter of which was compared directly against cause-specific mortality estimates to evaluate differences in mortality burden assessment and implications for the Sustainable Development Goals (SDGs). Findings Between 2

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Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

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LANCET RHEUMATOLOGY 2023年第9期5卷 E508-E522页

作者： Steinmetz, Jaimie D. Culbreth, Garland T. Haile, Lydia M. Rafferty, Quinn Lo, Justin Fukutaki, Kai Glenn Cruz, Jessica A. Smith, Amanda E. Vollset, Stein Emil Brooks, Peter M. Cross, Marita Woolf, Anthony Hagins, Hailey Abbasi-Kangevari, Mohsen Abedi, Aidin Ackerman, Ilana N. Amu, Hubert Antony, Benny Arabloo, Jalal Aravkin, Aleksandr Y. Argaw, Ayele Mamo Artamonov, Anton A. Ashraf, Tahira Barrow, Amadou Bearne, Lindsay M. Bensenor, Isabela M. Berhie, Alemshet Yirga Bhardwaj, Nikha Bhardwaj, Pankaj Bhojaraja, Vijayalakshmi S. Bijani, Ali Briant, Paul Svitil Briggs, Andrew M. Butt, Nadeem Shafique Charan, Jaykaran Chattu, Vijay Kumar Cicuttini, Flavia M. Coberly, Kaleb dadras, omid Dai, Xiaochen Dandona, Lalit Dandona, Rakhi de Luca, Katie Denova-Gutierrez, Edgar Dharmaratne, Samath Dhamminda Dhimal, Meghnath Dianatinasab, Mostafa Dreinhoefer, Karsten E. Elhadi, Muhammed Farooque, Umar Farpour, Hamid Reza Filip, Irina Fischer, Florian Freitas, Marisa Ganesan, Balasankar Gemeda, Belete Negese Belete Getachew, Tamiru Ghamari, Seyyed-Hadi Ghashghaee, Ahmad Gill, Tiffany K. Golechha, Mahaveer Golinelli, Davide Gupta, Bhawna Gupta, Veer Bala Gupta, Vivek Kumar Haddadi, Rasool Hafezi-Nejad, Nima Halwani, Rabih Hamidi, Samer Hanif, Asif Harlianto, Netanja, I Haro, Josep Maria Hartvigsen, Jan Hay, Simon, I Hebert, Jeffrey J. Heidari, Golnaz Hosseini, Mohammad-Salar Hosseinzadeh, Mehdi Hsiao, Alexander Kevin Ilic, Irena M. Ilic, Milena Jacob, Louis Jayawardena, Ranil Jha, Ravi Prakash Jonas, Jost B. Joseph, Nitin Kandel, Himal Karaye, Ibraheem M. Khan, Md Jobair Kim, Yun Jin Kolahi, Ali-Asghar Korzh, Oleksii Koteeswaran, Rajasekaran Krishnamoorthy, Vijay Kumar, G. Anil Kumar, Narinder Lee, Sang-woong Lim, Stephen S. Lobo, Stany W. Lucchetti, Giancarlo Malekpour, Mohammad-Reza Malik, Ahmad Azam Mandarano-Filho, Luiz Garcia Garcia Martini, Santi Mentis, Alexios-Fotios A. Mesregah, Mohamed Kamal Mestrovic, Tomislav Mirrakhimov, Erkin M. Misganaw, Awoke Mohammadpourhodki, Reza Mokdad, Ali H. Momtazmanesh, Sara Morrison, Shane Univ Washington Inst Hlth Metr & Evaluat Seattle WA 98195 USA Univ Washington Sch Med Dept Hlth Metr Sci Seattle WA USA Univ Washington Dept Appl Math Seattle WA USA Univ Washington Dept Anesthesiol & Pain Med Seattle WA USA Univ Washington Div Plast & Reconstruct Surg Seattle WA USA Dept Publ Hlth Seattle WA USA Univ Melbourne Ctr Hlth Policy Melbourne Vic Australia Univ Sydney Fac Med & Hlth Sydney NSW Australia Univ Sydney Save Sight Inst Sydney NSW Australia Univ Sydney Inst Bone & Joint Res Sydney NSW Australia Global Alliance Musculoskeletal Hlth Sydney NSW Australia Royal Cornwall Hosp Bone & Joint Res Grp Truro England Univ Tehran Med Sci Noncommunicable Dis Res Ctr Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Univ Tehran Med Sci Fac Med Tehran Iran Univ Southern Calif Dept Neurosurg Los Angeles CA USA Univ Southern Calif Keck Sch Med Los Angeles CA USA Univ Southern Calif Mark & Mary Stevens Neuroimaging & Informat Inst Los Angeles CA USA Monash Univ Sch Publ Hlth & Prevent Med Melbourne Vic Australia Univ Hlth & Allied Sci Dept Populat & Behav Sci Ho Ghana Univ Tasmania Menzies Inst Med Res Hobart Tas Australia Iran Univ Med Sci Hlth Management & Econ Res Ctr Tehran Iran Iran Univ Med Sci Prevent Med & Publ Hlth Res Ctr Tehran Iran Iran Univ Med Sci Dept Community & Family Med Tehran Iran Madda Walabu Univ Dept Clin Pharm Goba Ethiopia Russian Acad Sci Dept Biophys Moscow Russia Univ Lahore Univ Inst Radiol Sci & Med Imaging Technol Lahore Pakistan Univ Lahore Univ Inst Publ Hlth Lahore Pakistan Univ Gambia Dept Publ & Environm Hlth Brikama Gambia Minist Hlth Epidemiol & Dis Control Unit Kotu Gambia Univ London Populat Hlth Res Inst London England Natl Inst Hlth Res Ctr Engagement & Disseminat Twickenham England Univ Sao Paulo Dept Internal Med Sao Paulo Brazil Univ Sao Paulo Dept Psychiat Sao Paulo Brazil Bahir Dar Univ Sch Hlth Sci Bahir Dar Ethiopia All India Inst Med Sci Dept Anat

Background Osteoarthritis is the most common form of arthritis in adults, characterised by chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years and prevalence increases steeply w...

Background Osteoarthritis is the most common form of arthritis in adults, characterised by chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years and prevalence increases steeply with age. WHO has designated 2021-30 the decade of healthy ageing, which highlights the need to address diseases such as osteoarthritis, which strongly affect functional ability and quality of life. Osteoarthritis can coexist with, and negatively effect, other chronic conditions. Here we estimate the burden of hand, hip, knee, and other sites of osteoarthritis across geographies, age, sex, and time, with forecasts of prevalence to 2050. Methods In this systematic analysis for the Global Burden of Disease Study, osteoarthritis prevalence in 204 countries and territories from 1990 to 2020 was estimated using data from population-based surveys from 26 countries for knee osteoarthritis, 23 countries for hip osteoarthritis, 42 countries for hand osteoarthritis, and US insurance claims for all of the osteoarthritis sites, including the other types of osteoarthritis category. The reference case definition was symptomatic, radiographically confirmed osteoarthritis. Studies using alternative definitions from the reference case definition (for example self-reported osteoarthritis) were adjusted to reference using regression models. Osteoarthritis severity distribution was obtained from a pooled meta-analysis of sources using the Western Ontario and McMaster Universities Arthritis Index. Final prevalence estimates were multiplied by disability weights to calculate years lived with disability (YLDs). Prevalence was forecast to 2050 using a mixed-effects model. Findings Globally, 595 million (95% uncertainty interval 535-656) people had osteoarthritis in 2020, equal to 7 center dot 6% (95% UI 6 center dot 8-8 center dot 4) of the global population, and an increase of 132 center dot 2% (130 center dot 3-134 center dot 1) in total cases since 1990. Compared with 2020,

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Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

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LANCET GASTROENTEROLOGY & HEPATOLOGY 2022年第9期7卷 796-829页

作者： Sheena, Brittney S. Hiebert, Lindsey Han, Hannah Ippolito, Helen Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abbastabar, Hedayat Abdoli, Amir Ali, Hiwa Abubaker Adane, Mesafint Molla Adegboye, Oyelola A. Adnani, Qorinah Estiningtyas Sakilah Advani, Shailesh M. Afzal, Muhammad Sohail Afzal, Saira Meybodi, Mohamad Aghaie Ahadinezhad, Bahman Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmad, Tauseef Ahmadi, Sepideh Ahmed, Haroon Ahmed, Muktar Beshir Rashid, Tarik Ahmed Akalu, Gizachew Taddesse Aklilu, Addis Akram, Tayyaba Al Hamad, Hanadi Alahdab, Fares Alem, Adugnaw Zeleke Alem, Dejene Tsegaye Alhalaiqa, Fadwa Alhalaiqa Naji Alhassan, Robert Kaba Ali, Liaqat Ali, Muhammad Ashar Alimohamadi, Yousef Alipour, Vahid Alkhayyat, Motasem Almustanyir, Sami Al-Raddadi, Rajaa M. Altawalah, Haya Amini, Saeed Amu, Hubert Ancuceanu, Robert Andrei, Catalina Liliana Andrei, Tudorel Anoushiravani, Amir Ansar, Adnan Anyasodor, Anayochukwu Edward Arabloo, Jalal Arab-Zozani, Morteza Argaw, Ayele Mamo Argaw, Zeleke Gebru Arshad, Muhammad Artamonov, Anton A. Ashraf, Tahira Atlaw, Daniel Ausloos, Floriane Ausloos, Marcel Azadnajafabad, Sina Azangou-Khyavy, Mohammadreza Jafari, Amirhossein Azari Azarian, Ghasem Bagheri, Sayna Bahadory, Saeed Baig, Atif Amin Banach, Maciej Barati, Nastaran Barrow, Amadou Batiha, Abdul-Monim Mohammad Ramirez, Diana Fernanda Bejarano Belgaumi, Uzma Iqbal Berhie, Alemshet Yirga Bhagat, Devidas S. Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bhojaraja, Vijayalakshmi S. Bijani, Ali Biondi, Antonio Bodicha, Belay Boda Abule Bojia, Hunduma Amensisa Boloor, Archith Bosetti, Cristina Braithwaite, Dejana Briko, Nikolay Ivanovich Butt, Zahid A. Camera, Luis Alberto Chakinala, Raja Chandra Chakraborty, Promit Ananyo Charan, Jaykaran Chen, Shu Choi, Jee-Young Jasmine Choudhari, Sonali Gajanan Chowdhury, Fazle Rabbi Chu, Dinh-Toi Chung, Sheng-Chia Cortesi, Paolo Angelo Cowie, Benjamin C. Culbreth, Garland T. dadras, omid Dai, Xiaochen Dandona, Lalit Dandona, Rakhi De la Hoz, Fernando Pio Debela, Sisay Abebe Univ Washington Inst Hlth Metr & Evaluat Seattle WA USA Univ Washington Evans Sch Publ Policy & Governance Seattle WA USA Univ Washington Sch Med Dept Hlth Metr Sci Seattle WA USA Univ Washington Sch Med Dept Family Med Seattle WA USA Task Force Global Hlth Coalit Global Hepatitis Eliminat Decatur GA USA Hiroshima Univ Dept Epidemiol Infect Dis Control & Prevent Hiroshima Japan Shahid Beheshti Univ Med Sci Social Determinants Hlth Res Ctr Tehran Iran Shahid Beheshti Univ Med Sci Sch Adv Technol Med Tehran Iran Shahid Beheshti Univ Med Sci Dept Parasitol Tehran Iran Shahid Beheshti Univ Med Sci Dept Hlth & Community Med Tehran Iran Shahid Beheshti Univ Med Sci Sch Med Tehran Iran Shahid Beheshti Univ Med Sci Dept Epidemiol Tehran Iran Shahid Beheshti Univ Med Sci Med Eth & Law Res Ctr Tehran Iran Shahid Beheshti Univ Med Sci Ophthalm Res Ctr Tehran Iran Univ Tehran Med Sci Noncommunicable Dis Res Ctr Tehran Iran Univ Tehran Med Sci Adv Diagnost & Intervent Radiol Res Ctr Tehran Iran Univ Tehran Med Sci Dept Epidemiol & Biostat Tehran Iran Univ Tehran Med Sci Digest Dis Res Inst Tehran Iran Univ Tehran Med Sci Expt Med Res Ctr Tehran Iran Univ Tehran Med Sci Paediat Ctr Excellence Tehran Iran Univ Tehran Med Sci Multiple Sclerosis Res Ctr Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Univ Tehran Med Sci Pediat Chron Kidney Dis Res Ctr Tehran Iran Univ Tehran Med Sci Students Sci Res Ctr SSRC Tehran Iran Univ Tehran Med Sci Endocrinol & Metab Res Ctr Tehran Iran Univ Tehran Med Sci Fac Med Tehran Iran Univ Tehran Med Sci Dept Pharmacol Tehran Iran Jahrom Univ Med Sci Zoonoses Res Ctr Jahrom Iran Univ Human Dev Sulaymaniyah Iraq Univ Human Dev Dept Comp Sci Sulaymaniyah Iraq Univ Human Dev Diplomacy & Publ Relat Dept Sulaymaniyah Iraq Bahir Dar Univ Coll Med & Hlth Sci Bahir Dar Ethiopia Bahir Dar Univ Sch Hlth Sci Bahir Dar Ethiopia Bahir Dar Univ Dept Med Lab Sci Bahir Dar Ethiopia James Cook Univ Publ Hlth

Background Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and...

Background Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-ofsample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4 center dot 1% (95% uncertainty interval [UI] 3 center dot 7 to 4 center dot 5), corresponding to 316 million (284 to 351) infected people. There was a 31 center dot 3% (29 center dot 0 to 33 center dot 9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76 center dot 8% (76 center dot 2 to 77 cente

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