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COVID-19 mortality in patients with immunodeficiency and its predictors: a systematic review

EUROPEAN JOURNAL OF MEDICAL RESEARCH 2022年第1期27卷 1页

作者： SeyedAlinaghi, SeyedAhmad Karimi, Amirali Barzegary, Alireza Mojdeganlou, Hengameh Vahedi, Farzin Mirghaderi, Seyed Peyman Shobeiri, Parnian Ramezani, Maryam Yousefi Konjdar, Parisa Mirzapour, Pegah Tantuoyir, Marcarious M. Mehraeen, Esmaeil dadras, omid Voltarelli, Fabricio Univ Tehran Med Sci Iranian Inst Reduct High Risk Behav Iranian Res Ctr HIV AIDS Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Islamic Azad Univ Sch Med Tehran Iran Urmia Univ Med Sci Dept Pathol Orumiyeh Iran Univ Tehran Med Sci Sch Publ Hlth Dept Hlth Management Policy & Econ Tehran Iran Kashan Univ Med Sci Fac Paramed Dept Hlth Informat Management Kashan Iran Univ Ghana Med Ctr UGMC Biomed Engn Unit Accra Ghana Khalkhal Univ Med Sci Dept Hlth Informat Technol Khalkhal Iran Univ Bergen Dept Global Publ Hlth & Primary Care Bergen Norway Univ Fed Mato Grosso Fac Med Grad Program Hlth Sci Cuiaba Mato Grosso Brazil

Introduction Patients with immunodeficiency are usually more prone to worse outcomes of infectious diseases. However, there are some disagreements in the context of COVID-19, for example, in patients with human immunodeficiency virus (HIV). Herein, we aimed to systematically review the risk and predictors of COVID-19 mortality in people with primary or secondary immunodeficiency. Methods PubMed, Scopus, Web of Science, and Science Direct were searched. We followed a two-step screening process to identify eligible results. We first reviewed the title and abstract of the records and the unqualified studies were removed. Then, their full texts were evaluated based on their coherence with the purpose and inclusion/exclusion criteria, and those eligible for qualitative synthesis were included. Results Twenty-two articles were included, which investigated a total of 109,326 with primary or secondary immunodeficiencies. Three studies investigated the pediatric and infant population, while other studies were conducted on the adult population. Overall, studies on both primary and secondary immunodeficiency conflicted as some reported higher and some mentioned lower mortality rates in patients with immunodeficiency. Conclusions Overall, there were two points of view in both types of immunodeficiencies. The first is the classical viewpoint that all immunodeficient patients are at a higher risk of infection leading to a higher mortality rate. The second types of studies found that immunodeficiency might play a less important or even an inverse role in mortality rates by lowering the severity of the inflammatory response. However, it is important to take note to comorbidities, such as DM, HTN, CAD, ESRD, history of lower respiratory infection, etc., and demographic factors, such as obesity and age > 70 years, as they appear to influence the mortality rate, especially in patients with secondary immunodeficiency.

关键词： COVID-19 Immunocompromised Immunodeficiency Immunosuppression Impaired immune response SARS-CoV-2 Comorbidities

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Epidemiology of Occupational Injuries in Hospital Personnel: Findings from a Hospital Registry in Tehran, Iran

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国际转化医学杂志（英文版） 2019年第1期7卷 44-47页

作者： Saeedreza Jamali Moghadam SIYAHKALI SeyedAhmad SEYEDALINAGHI Zoha ALI Mohammad Reza SALEHI omid dadras Ziaeian Hospital Tehran University of Medical Sciences Tehran Iran Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors Tehran University of Medical Sciences Tehran Iran Department of Global Health and Socioepidemiology Graduate School of Medicine Kyoto University Japan

Background: Occupational injuries can expose healthcare workers (HCWs) to blood infectious diseases such as hepatitis B, C and HIV and other blood borne diseases. These could be prevented by implementing the precaution and safety procedures in workplace. This study explored the prevalence of occupational injuries among HCWs in Tehran, Iran, in ***: A cross-sectional study was conducted among 55 HCWs at Ziaeian Hospital in Tehran. Data for HCWs with a history of occupational injuries in 2016 were retrieved from the Hospital registry and analyzed by SPSS version 22. Results: The occupational injuries were observed in 19 (34.6％) registered nurses (RNs), 8 (14.5％) licensed practical nurses (LPNs), and 7 (12.7％) doctors. The most common injuries were needle stick injuries (87.7％) and splashing blood and secretions into the eyes (12.7％). Needle stick injuries were mostly caused by drawing blood 18 (32.8％), suturing 14 (25.5％) and blood sugar testing 8 (14.5％). Conclusion: Needle stick is the most common injury among healthcare workers which may cause serious and life-threatening infectious diseases such as Hepatitis B and C and HIV. This could be prevented by risk reduction through safety measures such as vaccination, precaution in handling of sharp and contaminated objects and safe disposal of infectious waste. Furthermore, post exposure prophylaxis, psychological support and counselling should be provided for the affected HCWs.

关键词： Epidemiology Occupational injuries Hospital personnel

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Hematologic and Hepatic Enzymes Abnormalities and Associated Factors among Patients with Swine Influenza (H1N1) Admitted in Two Hospitals, Tehran, 2014-2016

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国际转化医学杂志（英文版） 2018年第3期6卷 121-124页

作者： Saeedreza Jamali Moghadam SIYAHKALI SeyedAhmad SEYEDALINAGHI omid dadras Zoha ALI Samira ARMANPOUR Ziaeian Hospital Tehran University of Medical Sciences Tehran Iran Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors Tehran University of Medical Sciences Tehran Iran Department of Global Health and Socioepidemiology Graduate School of Medicine Kyoto University Japan

Background: Influenza A is a single-stranded ribonucleic acid (RNA) virus that belongs to orthomyxoviridae family. The virus usually invades the respiratory tract endothelium, and the period of contagiousness is up to 5 days after the onset of symptoms. Influenza is an important cause of lower respiratory tract infections (LRTIs) and approximately 8％-10％ of all patients with pneumonia are positive for influenza. In this study, we aimed to evaluate hematologic and hepatic enzymes disorders in patients with swine influenza (H1N1) admitted in two hospitals, Tehran. Methods: This is a cross-sectional study identifying the hematologic and hepatic enzymes abnormalities and influencing factors conducted among patients with swine influenza (H1N1) admitted in Imam Khomeini and Ziaeiyan Hospitals in 2014-2016. Onehundred eighteen people with suspected or confirmed influenza were evaluated for hematologic and hepatic enzymes disorders. Results: In this study, the total number of individuals was 118, including 58 (49％) women and 60 (51％) men. Thirty-seven (31％) of patients had pneumonia, 51 (43％) of them had hypertension and diabetes, 5 (5％) of them expired. PCR of 28 (33％) nasopharynx samples were positive. The mean ratio of neutrophil to lymphocyte at the time of admission was 3.4 and the mean ratio of neutrophil to lymphocyte at the time of discharge was 2.1, which indicated lymphopenia. Conclusion: H1N1 is associated with more hematologic and liver enzyme abnormalities than non-H1N1 subtypes thus if we notice these changes on lab tests, we should suspect more to H1N1 than non-H1N1.

关键词： Influenza A Lower respiratory tract infections Swine influenza (H1N1)

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Evaluation of Sensitivity and Specificity of the Method Cefoxitin-disk Diffusion in Detection of Methicillin-resistant Staphylococcus Aureus in Clinical Samples of Two Hospitals, Tehran, Iran

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国际转化医学杂志（英文版） 2018年第3期6卷 141-143页

作者： Saeedreza Jamali Moghadam SIYAHKALI omid dadras Zoha ALI SeyedAhmad SEYEDALINAGHI Nilofar HEJAZI Ziaeian Hospital Tehran University of Medical Sciences Tehran Iran Department of Global Health and Socioepidemiology Graduate School of Medicine Kyoto University Japan Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors Tehran University of Medical Sciences Tehran Iran

Background: The rapid growing rate of Methicillin-resistant Staphylococcus aureus (MRSA) infection is a noticeable phenomenon worldwide and has become a global concern of substantial emphasis. A reliable, accurate and rapid test for the detection of MRSA is important for both therapeutic as well as control measures. This study aimed at comparing the phenotypic (disk diffusion) and genotypic (polymerase chain reaction) methods for the expeditious diagnosis of methicillin-resistant strain samples isolated from patients admitted at Tehran Central Hospitals. Materials and methods: Through a cross-sectional study a total of 150 samples were collected and tested from the patients admitted at Tehran hospitals located in central Tehran between 2014-2015. The isolated samples sensitivity to Cefoxitin disks was confirmed through disk diffusion. Polymerase chain reaction (PCR) method was performed as the "Gold Standard" test to identify the specimens with mecA gene presence. Results were compared based on sensitivity and specificity by application of chi-square test in SPSS software (version 22). Results: Eighty-three percent of 150 collected samples tested resistance for Cefoxitin applying Cefoxitin disk diffusion *** of the resistant samples to Cefoxitin were negative for the mecA gene; whereas 80％ of the samples were proven positive for mecA gene using PCR. Sensitivity, specificity and positive and negative predictive values of disk diffusion in comparison to PCR were 100％, 85％, 96％ and 100％, respectively. Conclusion: Findings indicated that Cefoxitin disk diffusion method is a simple phenotypic method; however, it has an acceptable sensitivity compared to the PCR method. Therefore, it is recommended for the detection of MRSA. The existence of strains resistant to Cefoxitin without mecA gene suggests the emergence of either a new resistance strain or mutation in MRSA.

关键词： Staphylococcus aureus Methicillin-resistant Disk diffusion Polymerase chain reaction

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Gradients of Surface-Bound Laminin on Conducting Polymer Films for Potential Nerve Regeneration**Research supported by National Institute of Health, R01 NS087224.

Gradients of Surface-Bound Laminin on Conducting Polymer Fil...

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International IEEE/EMBS Conference on Neural Engineering, CNE

作者： omid dadras-Toussi Milad Khorrami Sheereen Majd Mohammad Reza Abidian Dept. of Biomedical Engineering University of Houston Houston TX USA University of Houston Houston TX USA

Functional nerve recovery after the injury is crucial in the field of neural interfaces. Although numerous technologies have already been established to promote nerve regeneration, effective nerve guidance in long distances (over 10 mm) still remains challenging. Herein, we report a novel technique to fabricate long gradients of substrate-bound laminin protein on conducting polymer films of poly(3,4-ethylenedioxythiophene) (PEDOT). The developed methodology allows for creation of various gradient profiles of laminin on PEDOT films to modulate axonal regeneration. These bioactive and conductive platforms can potentially be employed to promote axonal regeneration in the long nerve gaps.

关键词： Proteins Printing Correlation Neural engineering Polymer films National Institutes of Health Surface treatment

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Prevalence and correlates of diabetes and impaired fasting glucose among adults in Afghanistan: Insights from a national survey

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SAGE OPEN MEDICINE 2024年 12卷

作者： dadras, omid Ongosi, Anita Nyaboke Wang, Chia-Wen Univ Bergen Dept Global Publ Hlth & Primary Care Bergen Norway Int Inst Socio Epidemiol Kyoto Japan Natl Univ Singapore Saw Swee Hock Sch Publ Hlth Singapore City Singapore Natl Univ Hlth Syst Singapore City Singapore Natl Univ Singapore Lloyds Register Fdn Inst Publ Understanding Risk Singapore City Singapore Univ Bergen Dept Global Publ Hlth & Primary Care Arstadveien 17 N-5009 Bergen Norway

Objectives: Afghanistan is experiencing an escalating burden of noncommunicable diseases, with diabetes and impaired fasting glucose being of particular concern. To explore the prevalence of diabetes and impaired fasting glucose and associated factors among adult ***: This cross-sectional study used secondary data from a nationally representative survey, conducted in 2018 in Afghanistan. A blood sample was collected from the fingertip and tested through a strip to measure blood glucose. The complex sampling design and sampling weights were accounted for in all analyses to produce representative estimates of the target population in ***: Of 3890 Afghan adults aged 18-69 years who participated in this survey, 11.07% and 10.32% had diabetes and impaired fasting glucose, respectively. For overweight individuals with abdominal obesity, the risk for diabetes became significantly elevated, with an adjusted relative risk ratio of 2.12 (95% CI: 1.10-4.09). However, the most pronounced effect was observed among individuals classified as having obesity with abdominal obesity with an adjusted relative risk ratio of 2.54 (95% CI: 1.37-4.70). Moreover, high cholesterol level was significantly associated with both impaired fasting glucose (ARRR: 2.52, 95% CI: 1.55-4.12) and diabetes (ARRR: 4.12, 95% CI: 2.59-6.56), whereas high blood pressure was significantly associated with only diabetes (ARRR: 1.82, 95% CI: 1.16-2.86).Conclusions: This investigation provides critical insight into the prevalence of diabetes and IFG among Afghan adults aged 18-69 years. Relative to the global average, the higher prevalence observed calls for specifically designed interventions targeting individuals with cardiometabolic risk factors, such as elevated body mass index, abdominal obesity, hypertension, and hypercholesterolemia.

关键词： Diabetes impaired fasting glucose risk factors Afghanistan

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Multiphoton Lithography of Organic Semiconductor Devices for 3D Printing of Flexible Electronic Circuits, Biosensors, and Bioelectronics

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ADVANCED MATERIALS 2022年第30期34卷 2270220-2270220页

作者： dadras-Toussi, omid Khorrami, Milad Louis Sam Titus, Anto Sam Crosslee Majd, Sheereen Mohan, Chandra Abidian, Mohammad Reza Univ Houston Dept Biomed Engn 3517 Cullen Blvd Houston TX 77204 USA

In recent years, 3D printing of electronics have received growing attention due to their potential applications in emerging fields such as nanoelectronics and nanophotonics. Multiphoton lithography (MPL) is considered the state-of-the-art amongst the microfabrication techniques with true 3D fabrication capability owing to its excellent level of spatial and temporal control. Here, a homogenous and transparent photosensitive resin doped with an organic semiconductor material (OS), which is compatible with MPL process, is introduced to fabricate a variety of 3D OS composite microstructures (OSCMs) and microelectronic devices. Inclusion of 0.5 wt% OS in the resin enhances the electrical conductivity of the composite polymer about 10 orders of magnitude and compared to other MPL-based methods, the resultant OSCMs offer high specific electrical conductivity. As a model protein, laminin is incorporated into these OSCMs without a significant loss of activity. The OSCMs are biocompatible and support cell adhesion and growth. Glucose-oxidase-encapsulated OSCMs offer a highly sensitive glucose sensing platform with nearly tenfold higher sensitivity compared to previous glucose biosensors. In addition, this biosensor exhibits excellent specificity and high reproducibility. Overall, these results demonstrate the great potential of these novel MPL-fabricated OSCM devices for a wide range of applications from flexible bioelectronics/biosensors, to nanoelectronics and organ-on-a-chip devices.

关键词： bioelectronics biosensors electronics multiphoton lithography organic semiconductors

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A systematic review of sarcopenia prevalence and associated factors in people living with human immunodeficiency virus

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JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE 2023年第3期14卷 1168-1182页

作者： SeyedAlinaghi, SeyedAhmad Ghayomzadeh, Morteza Mirzapour, Pegah Maroufi, Seyed Farzad Pashaei, Zahra Ali, Zoha Tantuoyir, Marcarious M. Aghaie, Narjes Vahedi, Farzin Salmani, Roghayeh MohsseniPour, Mehrzad Qaderi, Kowsar Shahidi, Ramin Peyman, Akram Varshochi, Sanaz Afzalian, Arian Maroufi, Seyede Parmis Mehraeen, Esmaeil dadras, omid Hackett, Daniel Univ Tehran Med Sci Iranian Inst Reduct High Risk Behav Iranian Res Ctr HIV AIDS Tehran Iran Univ Sydney Phys Activ Lifestyle Ageing & Wellbeing Fac Res Gr Fac Med & Hlth Sch Hlth Sci Sydney NSW Australia Univ Tehran Med Sci Sch Med Tehran Iran Univ Ghana Med Ctr UGMC Biomed Engn Unit Accra Ghana Univ Tehran Med Sci Sch Nursing & Midwifery Tehran Iran Khalkhal Univ Med Sci Dept Midwifery Khalkhal Iran Kermanshah Univ Med Sci Sch Nursing & Midwifery Dept Midwifery Kermanshah Iran Bushehr Univ Med Sci Sch Med Bushehr Iran Islamic Azad Univ Fac Nursing & Midwifery Dept Midwifery Tehran Med Sci Tehran Iran Semnan Univ Med Sci Fac Med Semnan Iran Khalkhal Univ Med Sci Dept Hlth Informat Technol Khalkhal Iran Univ Bergen Dept Global Publ Hlth & Primary Care Bergen Norway

People living with human immunodeficiency virus (HIV) (PLWH) appear to be at an increased risk of sarcopenia, which can have a devastating effect on their life due to consequences such as physical disability, poor quality of life, and finally death. This systematic review examined sarcopenia prevalence and its associated factors in PLWH. A systematic search was conducted using the keywords in the online databases including Scopus, PubMed, Web of Science, Embase and Cochrane databases from the dates of inception up to May 2022. The retrieved articles underwent a two-step title/abstract and full-text review process, and the eligible papers were selected and included in the qualitative synthesis. Data relating to the study population, purpose of study, gender, age, race, body mass index, medical history, paraclinical results and antiretroviral therapy as associated factors of sarcopenia were extracted. In addition, the prevalence of sarcopenia in PLWH and its promoting and reducing factors were also extracted. We reviewed the 14 related studies for identifying of sarcopenia prevalence and its associated factors in PLWH. The total number of PLWH in all the reviewed studies was 2592. There was no criterion for the minimum number of people with HIV and the lowest number of PLWH was 27, and the highest number was 860. Some studies reported a significantly higher prevalence of sarcopenia in HIV-infected individuals compared with HIV-negative controls as follows: 24.2-6.7%, 15-4% and 10-6%, respectively. We showed that, age (30-50 years), being female, >5 years post-HIV diagnosis, multiple vertebral fractures, cocaine/heroin use and lower gamma-glutamyl transferase level were the main promoting factors of sarcopenia. Higher educational level, employment, physical exercise, calf circumference >31 cm, and gait speed >0.8 m/s were also factors to reduce sarcopenia. Sarcopenia prevalence in PLWH is higher than HIV-negative population. Given the importance and prevalence of sarco

关键词： human immunodeficiency virus acquired immunodeficiency syndrome sarcopenia wasting syndrome

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Predictors of mortality in patients with COVID-19-a systematic review

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EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE 2020年 40卷 101226-101226页

作者： Mehraeen, Esmaeil Karimi, Amirali Barzegary, Alireza Vahedi, Farzin Afsahi, Amir Masoud dadras, omid Moradmand-Badie, Banafsheh Alinaghi, Seyed Ahmad Seyed Jahanfar, Shayesteh Khalkhal Univ Med Sci Dept Hlth Informat Technol Khalkhal Iran Univ Tehran Med Sci Sch Med Tehran Iran Islamic Azad Univ Sch Med Tehran Iran Univ Calif San Diego Dept Radiol Sch Med La Jolla CA 92093 USA Kyoto Univ Grad Sch Med Dept Global Hlth & Socioepidemiol Kyoto Japan Univ New South Wales Black Dog Inst Sydney NSW Australia Univ Tehran Med Sci Iranian Inst Reduct High Risk Behav Iranian Res Ctr HIV AIDS Tehran Iran Cent Michigan Univ Sch Publ Hlth Mt Pleasant MI 48859 USA

Introduction: In the current COVID-19 pandemic, disease diagnosis is essential for optimal management and timely isolation of infected cases in order to prevent further spread. The aim of this study was to systematically review the assessment of risk and model the predictors of mortality in COVID-19 patients. Methods: A systematic search was conducted of PubMed, Scopus, Embase, Google Scholar, and Web of Science databases. Variables associated with hospital mortality using bivariate analysis were included as potential independent predictors associated with mortality at the p < 0.05 levels. Results: We included 114 studies accounting for 310,494 patients from various parts of the world. For the purpose of this analysis, we set a cutoff point of 10% for the mortality percentages. High mortality rates were defined as higher than 10% of confirmed positive cases and were given a score of two, while low mortality (<10%) was assigned the score of one. We then analyzed the associations between 72 variables and the observed mortality rates. These variables included a large range of related variables such as demographics, signs and symptoms and related morbidities, vital signs, laboratory findings, imaging studies, underlying diseases, and the status of countries' income, based on the United Nation's classifications. Conclusion: Findings suggest that older age, hypertension, and diabetes mellitus conferred a significant increased risk of mortality among patients with COVID-19. In the multivariate analysis, only diabetes mellitus demonstrated an independent relationship with increased mortality. Further studies are needed to ascertain the relationship between possible risk factors with COVID-19 mortality.

关键词： COVID-19 Modeling Mortality Risk factors Predictors Systematic review

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Prevalence of COVID-19 in prison population: a meta-analysis of 35 studies

International journal of prison health

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International journal of prison health 2024年第4期20卷 393-409页

作者： SeyedAhmad SeyedAlinaghi Soudabeh Yarmohammadi Farid Farahani Rad Muhammad Ali Rasheed Mohammad Javaherian Amir Masoud Afsahi Haleh Siami AmirBehzad Bagheri Ali Zand omid dadras Esmaeil Mehraeen Iranian Research Center for HIV/AIDS Tehran University of Medical Sciences Tehran Iran. Kashan University of Medical Sciences Kashan Iran. Tehran University of Medical Sciences Tehran Iran. Department of Radiology University of California San Diego CA USA. Islamic Azad University Shahreza Iran. Baylor College of Medicine Houston Texas USA. Ardabil University of Medical Sciences Ardabil Iran and Department of Health Information Technology Khalkhal University of Medical Sciences Khalkhal Iran.

PURPOSE:COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Considering the restricted and enclosed nature of prisons and closed environments and the prolonged and close contact between individuals, COVID-19 is more likely to have a higher incidence in these settings. This study aims to assess the prevalence of COVID-19 among prisoners. DESIGN/METHODOLOGY/APPROACH:Papers published in English from 2019 to July 7, 2023, were identified using relevant keywords such as prevalence, COVID-19 and prisoner in the following databases: PubMed/MEDLINE, Scopus and Google Scholar. For the meta-analysis of the prevalence, Cochrane's statistics were calculated. A random effect model was used due to the heterogeneity in COVID-19 prevalence across included studies in the meta-analysis. All analyses were performed in STATA-13. FINDINGS:The pooled data presented a COVID-19 prevalence of 20% [95%CI: 0.13, 0.26] and 24% [95%CI: 0.07, 0.41], respectively, in studies that used PCR and antibody tests. Furthermore, two study designs, cross-sectional and cohort, were used. The results of the meta-analysis showed studies with cross-sectional and cohort designs reported 20% [95%CI: 0.11, 0.29] and 25% [95%CI: 0.13, 0.38], respectively. ORIGINALITY/VALUE:Through more meticulous planning, it is feasible to reduce the number of individuals in prison cells, thereby preventing the further spread of COVID-19.

关键词： COVID-19 Prevalence Prisoners SARS-CoV-2

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