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Predictors of mortality in patients with COVID-19-a systematic review

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE 2020年 40卷 101226-101226页

作者： Mehraeen, Esmaeil Karimi, Amirali Barzegary, Alireza Vahedi, Farzin Afsahi, Amir Masoud dadras, omid Moradmand-Badie, Banafsheh Alinaghi, Seyed Ahmad Seyed Jahanfar, Shayesteh Khalkhal Univ Med Sci Dept Hlth Informat Technol Khalkhal Iran Univ Tehran Med Sci Sch Med Tehran Iran Islamic Azad Univ Sch Med Tehran Iran Univ Calif San Diego Dept Radiol Sch Med La Jolla CA 92093 USA Kyoto Univ Grad Sch Med Dept Global Hlth & Socioepidemiol Kyoto Japan Univ New South Wales Black Dog Inst Sydney NSW Australia Univ Tehran Med Sci Iranian Inst Reduct High Risk Behav Iranian Res Ctr HIV AIDS Tehran Iran Cent Michigan Univ Sch Publ Hlth Mt Pleasant MI 48859 USA

Introduction: In the current COVID-19 pandemic, disease diagnosis is essential for optimal management and timely isolation of infected cases in order to prevent further spread. The aim of this study was to systematically review the assessment of risk and model the predictors of mortality in COVID-19 patients. Methods: A systematic search was conducted of PubMed, Scopus, Embase, Google Scholar, and Web of Science databases. Variables associated with hospital mortality using bivariate analysis were included as potential independent predictors associated with mortality at the p < 0.05 levels. Results: We included 114 studies accounting for 310,494 patients from various parts of the world. For the purpose of this analysis, we set a cutoff point of 10% for the mortality percentages. High mortality rates were defined as higher than 10% of confirmed positive cases and were given a score of two, while low mortality (<10%) was assigned the score of one. We then analyzed the associations between 72 variables and the observed mortality rates. These variables included a large range of related variables such as demographics, signs and symptoms and related morbidities, vital signs, laboratory findings, imaging studies, underlying diseases, and the status of countries' income, based on the United Nation's classifications. Conclusion: Findings suggest that older age, hypertension, and diabetes mellitus conferred a significant increased risk of mortality among patients with COVID-19. In the multivariate analysis, only diabetes mellitus demonstrated an independent relationship with increased mortality. Further studies are needed to ascertain the relationship between possible risk factors with COVID-19 mortality.

关键词： COVID-19 Modeling Mortality Risk factors Predictors Systematic review

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Internet of things in the management of chronic diseases during the COVID-19 pandemic: A systematic review

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Health science reports 2022年第2期5卷 e557页

作者： Ahmadreza Shamsabadi Zahra Pashaei Amirali Karimi Pegah Mirzapour Kowsar Qaderi Mahmoud Marhamati Alireza Barzegary Amirata Fakhfouri Esmaeil Mehraeen SeyedAhmad SeyedAlinaghi omid dadras Department of Health Information Technology Esfarayen Faculty of Medical Sciences Esfarayen Iran. Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors Tehran University of Medical Sciences Tehran Iran. School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Midwifery Kermanshah University of Medical Sciences Kermanshah Iran. Instructor of Medical Surgical Nursing Department of Nursing Esfarayen Faculty of Medical Sciences Esfarayen Iran. School of Medicine Islamic Azad University Tehran Iran. Department of Health Information Technology Khalkhal University of Medical Sciences Khalkhal Iran. School of Public Health Walailak University Thai Buri Nakhon Si Thammarat Thailand.

Introduction:The use of new technologies such as the Internet of Things (IoT) in the management of chronic diseases, especially in the COVID pandemics, could be a life-saving appliance for public health practice. The purpose of the current study is to identify the applications and capability of IoT and digital health in the management of the COVID-19 pandemic. Methods:This systematic review was conducted by searching the online databases of PubMed, Scopus, and Web of Science using selected keywords to retrieve the relevant literature published until December 25th, 2021. The most relevant original English studies were included after initial screening based on the inclusion criteria. Results:Overall, 18 studies were included. Most of the studies reported benefits and positive responses in the form of patients' and healthcare providers' satisfaction and trust in the online systems. Many services were provided to the patients, including but not limited to training the patients on their conditions; monitoring vital signs and required actions when vital signs were altered; ensuring treatment adherence; monitoring and consulting the patients regarding diet, physical activity, and lifestyle. Conclusion:IoT is a new technology, which can help us improve health care services during the COVID-19 pandemic. It has a network of various sensors, obtaining data from patients. We have found several applications for this technology. Future studies can be conducted for the capability of other technologies in the management of chronic diseases.

关键词： COVID‐19 IoT Sensor Telehealth chronic diseases

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Soluble biomarkers for diagnosis, monitoring, and therapeutic response assessment in psoriasis

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JOURNAL OF DERMATOLOGICAL TREATMENT 2022年第4期33卷 1967-1974页

作者： Pourani, Mohammad Reza Abdollahimajd, Fahimeh Zargari, omid Shahidi dadras, Mohammad Shahid Beheshti Univ Med Sci Skin Res Ctr Tehran Iran Shahid Beheshti Univ Med Sci Clin Res Dev Unit Shohada Tajrish Hosp Tehran Iran

Background Psoriasis is an inflammatory disease associated with multiple comorbidities. Biomarkers for the assessment of psoriasis, its associated comorbidities, and the therapeutic response are not well characterized. A number of possible biomarkers for the diagnosis and monitoring of psoriasis have been proposed. Purpose To assess potential biomarkers for diagnosis of psoriasis, its associated comorbidities and response to treatment. Methods We investigated medical databases from 2000 to 2021 and assessed relevant research. In this review, we evaluated the important biomarkers to help predict potential risk of psoriasis and disease activity (Beta-defensin-2, VEGF, Lipocalin-2, and YKL-40) and its possible inflammatory-related comorbidities like cardiovascular diseases (hs-CRP, GlycA, Psoriasin, IL-18, NT-proBNP, and Adipokines). In addition, we described the potential biomarkers for psoriatic arthritis (CXCL10, S100A8 and S100A9, and MicroRNA) and related manifestations such as enthesitis. Finally, we discussed novel markers for monitoring the response to specific treatments (HLA-C 06, PLC, TARC, NLR, and PLR) as well as potentially useful biomarkers for evaluation of therapy-associated adverse events (liver fibrosis-related markers). Conclusion A wide range of genetic, tissue, and serum markers have been investigated in psoriasis;however, most of them are not used in routine clinical practice;and thorough physical examination along with the appropriate application of clinical scoring systems like Psoriasis Area and Severity Index score are still of particular importance.

关键词： Arthritis biomarker comorbidity genetic inflammation psoriasis treatment review

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Evaluating the effects of air disinfectants in decontamination of COVID-19 aerosols

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Health science reports 2023年第1期6卷 e1042页

作者： Soheil Dehghani SeyedAhmad SeyedAlinaghi Amirali Karimi Fatemeh Afroughi Shayan Abshenas Kimia Azad Marcarious M Tantuoyir Parsa Mohammadi Seyed Mohammad Ghavam Hengameh Mojdeganlou omid dadras Newsha Nazarian Farzin Vahedi Alireza Barzegary Esmaeil Mehraeen School of medicine Tehran University of Medical Sciences Tehran Iran. Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High Risk Behaviors Tehran University of Medical Sciences Tehran Iran. Pars Hospital Iran University of Medical Sciences Tehran Iran. School of medicine Islamic Azad University Tehran Iran. School of medicine Kashan University of Medical Sciences Kashan Iran. Biomedical Engineering Unit University of Ghana Medical Center (UGMC) Accra Ghana. Department of Pathology The Johns Hopkins University School of Medicine Baltimore Maryland USA. Department of Global Public Health and Primary Care University of Bergen Bergen Norway. Department of Health Information Technology Khalkhal University of Medical Sciences Khalkhal Iran.

Introduction:Airborne transmission is the most  crucial mode of COVID-19 transmission. Therefore, disinfecting the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) aerosols float can have important implications in limiting COVID-19 transmission. Herein, we aimed to review the studies that utilized various disinfectants to decontaminate and inactivate the SARS-CoV-2 aerosols. Methods:This study was a review that studied related articles published between December 1, 2019 and August 23, 2022. We searched the online databases of PubMed, Scopus, Web of Science, Cochrane, on August 23, 2021. The studies were downloaded into the EndNote software, duplicates were removed, and then the studies were screened based on the inclusion/exclusion criteria. The screening process involved two steps; first, the studies were screened based on their title and abstract and then their full texts. The included studies were used for the qualitative analysis. Results:From 664 retrieved records, only 31 met the inclusion criteria and were included in the final qualitative analysis. Various materials like Ozone, HO, alcohol, and TiO and methods like heating and using Ultraviolet were described in these studies to disinfect places contaminated by COVID-19. It appeared that the efficacy of these disinfectants varies considerably depending on the situation, time, and ultimately their mode of application. Conclusion:Following reliable protocols in combination with the proper selection of disinfectant agents for each purpose would serve to achieve desired elimination of the SARS-CoV-2 transmission.

关键词： COVID‐19 SARS‐CoV‐2 aerosol decontamination disinfectants

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Reinfection risk of novel coronavirus(COVID-19):A systematic review of current evidence

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World Journal of Virology 2020年第5期9卷 79-90页

作者： SeyedAhmad SeyedAlinaghi Shahram Oliaei Shaghayegh Kianzad Amir Masoud Afsahi Mehrzad MohsseniPour Alireza Barzegary Pegah Mirzapour Farzane Behnezhad Tayebeh Noori Esmaeil Mehraeen omid dadras Fabricio Voltarelli Jean-Marc Sabatier Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High Risk BehaviorsTehran University of Medical SciencesTehran ***Iran HBOT Research Center Golestan HospitalIslamic Republic of IranNavy and AJA Medical UniversityTehran ***Iran School of Medicine Iran University of Medical SciencesTehran ***Iran Department of Radiology School of MedicineUniversity of CaliforniaSan Diego(UCSD)CaliforniaCA 587652458United States School of Medicine Islamic Azad UniversityTehran ***Iran Department of Virology School of Public HealthTehran University of Medical SciencesTehran ***Iran Department of Health Information Technology Zabol University of Medical SciencesZabol ***Iran Department of Health Information Technology Khalkhal University of Medical SciencesKhalkhal ***Iran Department of Global Health and Socioepidemiology Graduate School of MedicineKyoto UniversityKyoto 215789652Japan Graduation Program of Health Sciences Faculty of MedicineFederal University of Mato GrossoCuiaba 458796523Brazil UniversitéAix-Marseille Institutde Neuro-physiopathologie(INP)UMR 7051Facultéde Pharmacie27 Bd Jean MoulinMarseille 546789235France

BACKGROUND There is recently a concern regarding the reinfection and reactivation of previously reCoVered coronavirus disease 2019(CoVID-19)*** To summarize the recent findings and reports of CoVID-19 reinfection in patients previously reCoVered from the *** This study was a systematic review of current evidence conducted in August *** authors studied the probable reinfection risk of novel coronavirus(CoVID-19).We performed a systematic search using the keywords in online *** investigation adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)checklist to ensure the reliability and validity of this study and *** We reviewed 31 *** studies described reCoVered patients with *** one study reported reinfected patients who *** 26 studies,there was no information about the status of the *** studies indicated that reinfection is not probable and that post-infection immunity is at least temporary and *** Based on our review,we concluded that a positive polymerase chain reaction retest could be due to several reasons and should not always be considered as reinfection or reactivation of the *** relevant studies in positive retest patients have shown relative and probably temporary immunity after the reCoVery of the disease.

关键词： Reactivation Reinfection Postinfection Coronavirus CoVID-19 SARSCoV-2

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Gut microbiota and COVID-19: A systematic review

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Health science reports 2023年第2期6卷 e1080页

作者： SeyedAhmad SeyedAlinaghi Arian Afzalian Zahra Pashaei Sanaz Varshochi Amirali Karimi Hengameh Mojdeganlou Paniz Mojdeganlou Armin Razi Farzaneh Ghanadinezhad Alireza Shojaei Ava Amiri Mohsen Dashti Afsaneh Ghasemzadeh omid dadras Esmaeil Mehraeen Amir Masoud Afsahi Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High Risk Behaviors Tehran University of Medical Sciences Tehran Iran. School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Pathology Urmia University of Medical Sciences Urmia Iran. Shahid Beheshti University of Medical Sciences Tehran Iran. Shahid Chamran University of Ahvaz Ahvaz Iran. Department of Radiology Tabriz University of Medical Sciences Tabriz Iran. Department of Global Public Health and Primary Care University of Bergen Bergen Norway. Department of Health Information Technology Khalkhal University of Medical Sciences Khalkhal Iran. Department of Radiology University of California San Diego (UCSD) California USA.

Background and Aims:Alteration in humans' gut microbiota was reported in patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The gut and upper respiratory tract (URT) microbiota harbor a dynamic and complex population of microorganisms and have strong interaction with host immune system homeostasis. However, our knowledge about microbiota and its association with SARS-CoV-2 is still limited. We aimed to systematically review the effects of gut microbiota on the SARS-CoV-2 infection and its severity and the impact that SARS-CoV-2 could have on the gut microbiota. Methods:We searched the keywords in the online databases of Web of Science, Scopus, PubMed, and Cochrane on December 31, 2021. After duplicate removal, we performed the screening process in two stages; title/abstract and then full-text screening. The data of the eligible studies were extracted into a pre-designed word table. This study adhered to the PRISMA checklist and Newcastle-Ottawa Scale Bias Assessment tool. Results:Sixty-three publications were included in this review. Our study shows that among COVID-19 patients, particularly moderate to severe cases, the gut and lung microbiota was different compared to healthy individuals. In addition, the severity, and viral load of COVID-19 disease would probably also be influenced by the gut, and lung microbiota's composition. Conclusion:Our study concludes that there was a significant difference in the composition of the URT, and gut microbiota in COVID-19 patients compared to the general healthy individuals, with an increase in opportunistic pathogens. Further, research is needed to investigate the probable bidirectional association of COVID-19 and human microbiome.

关键词： COVID‐19 SARS‐CoV‐2 gut microbiota microbiome microbiota probiotics

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Prenatal and neonatal complications of COVID-19: A systematic review

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Health science reports 2022年第2期5卷 e510页

作者： Zahra Pashaei SeyedAhmad SeyedAlinaghi Kowsar Qaderi Alireza Barzegary Amirali Karimi Seyed Peyman Mirghaderi Pegah Mirzapour Marcarious M Tantuoyir omid dadras Zoha Ali Fabricio Voltarelli Esmaeil Mehraeen Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors Tehran University of Medical Sciences Tehran Iran. Department of Midwifery School of Nursing and Midwifery Kermanshah University of Medical Sciences Kermanshah Iran. School of Medicine Islamic Azad University Tehran Iran. School of Medicine Tehran University of Medical Sciences Tehran Iran. Biomedical Engineering Unit University of Ghana Medical Center (UGMC) Accra Ghana. School of Public Health Walailak University Nakhon Si Thammarat Thailand. Graduation Program of Health Sciences Faculty of Medicine Federal University of Mato Grosso Cuiabá Brazil. Department of Health Information Technology Khalkhal University of Medical Sciences Khalkhal Iran.

BACKGROUND AND AIMS:The outbreak of coronavirus disease 2019 (COVID-19) over the past year has affected public health worldwide. During pregnancy, the maternal immune system and inflammatory responses are widely suppressed. Pregnancy-related immune system suppression could make the mother vulnerable to infectious diseases like SARS-COV-2. However, current data suggest little to no possibility of COVID-19 transmission in pregnant women to the fetus during pregnancy or childbirth. This systematic review focused on the possible complications of COVID-19 infection in the fetus and newborn babies including the possibility and evidence of vertical transmission by reviewing articles published during the first year of the COVID-19 pandemic. METHODS:We conducted a systematic search using keywords on PubMed, Embase, and Scopus databases. The studies followed a title/abstract and a full-text screening process, and the eligible articles were included in the study. RESULTS:In total, 238 published papers were identified using a systematic search strategy (44 articles met the inclusion criteria and were included in the final review). In all studies, a total of 2375 women with signs and symptoms of COVID-19, who were in the second and third trimester of pregnancy, were assessed mild to moderate pneumonia was one of the most common symptoms. Seventy-three percent of the women did not present any comorbidity, 19% had a fever, 17% had to cough as the most frequent clinical signs and symptoms, 7.5% had pulmonary changes with chest scans, 8% had increased C reactive protein, and 9.4% had decreased lymphocytes (lymphocytopenia). A total of 2716 newborns and fetal were assessed; the delivery method of 1725 of them was reported, 913 (53%) through C-section delivery, and 812 through normal vaginal delivery (47%). Of total newborns, 13 died (five died along with the mother), and 1965 were tested for SARS-CoV-2:118 tested positive. In a study, vertical transmission in seven cases was reported

关键词： COVID‐19 SARS‐CoV‐2 fetus neonatal newborn prenatal

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A probable atypical skin manifestation of COVID-19 infection

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JOURNAL OF DERMATOLOGICAL TREATMENT 2022年第2期33卷 1188-1190页

作者： Shahidi dadras, Mohammad Zargari, omid Abolghasemi, Rozita Bahmanjahromi, Ayda Abdollahimajd, Fahimeh Shahid Beheshti Univ Med Sci Skin Res Ctr Tehran Iran Shahid Beheshti Univ Med Sci Shohada E Tajrish Hosp Dept Nephrol Tehran Iran Shahid Beheshti Univ Med Sci Shohada E Tajrish Hosp Clin Res Dev Unit Tehran Iran

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RETRACTED: Prevalence of sexually transmitted infections and associated risk behaviors in prisoners: A systematic review (Retracted Article)

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HEALTH SCIENCE REPORTS 2022年第5期5卷

作者： SeyedAlinaghi, SeyedAhmad Pashaei, Zahra Rahimi, Ensiyeh Saeidi, Solmaz Mirzapour, Pegah Noori, Tayebeh Ghasemzadeh, Afsaneh Afzalian, Arian Dashti, Mohsen Habibi, Pedram Farhoudi, Behnam Aghaie, Narjes Shamsabadi, Ahmadreza dadras, omid Mehraeen, Esmaeil Univ Tehran Med Sci Iranian Res Ctr HIV AIDS Iranian Inst Reduct High Risk Behav Tehran Iran Khalkha Univ Med Sci Dept Nursing Khalkha Iran Zabol Univ Med Sci Dept Hlth Informat Technol Zabol Iran Tabriz Univ Med Sci Dept Radiol Tabriz Iran Univ Tehran Med Sci Sch Med Tehran Iran Islamic Azad Univ Amiralmomenin Hosp Social Determinants Hlth Res Ctr Tehran Med Sci Tehran Iran Univ Tehran Med Sci Sch Nursing & Midwifery Tehran Iran Esfarayen Fac Med Sci Dept Hlth Informat Technol Esfarayen Iran Univ Bergen Dept Global Publ Hlth & Primary Care Bergen Norway Khalkha Univ Med Sci Dept Hlth Informat Technol Khalkha *** Iran

Background and Aims Sexually transmitted infections (STIs) are one of the major health concerns globally. Generally, prisoners are at higher risks for STIs due to risk factors including;drug-use, high-risk sexual behaviors, densely populated prisons, and poor living conditions. Therefore, we aimed to conduct a systematic review to evaluate the existing data on STI prevalence, and its associated risk factors among prisoners. Methods We conducted a systematic search of the literature using the keywords in Scopus, PubMed, Web of Science, and Google Scholar online databases. We selected all the relevant original studies in English through title/abstract and full-text screening ***-to-right mark Results Based on the inclusion and exclusion criteria, we selected and reviewed 32 studies out of 96 identified papers. The most important STI-associated risk factors among prisoners were drug use, low educational levels, and unsafe sex. The prevalence of STIs was heterogenous in selected studies and was reported as follows;Human Immunodeficiency Virus (HIV) (0%-14.5%), hepatitis B viruses (HBV) (0.04%-27.23%), hepatitis C viruses (HCV) (0.17%-49.7%), Syphilis (0.2%-22.1%), Chlamydia Trachomatis (CT) (1.02%-6.7%), Gonorrhea (0.6%-7.8%), and herpes simplex virus-2 (HSV-2) 22.4%. Conclusion This systematic review indicates that the prevalence of STIs (HIV, HBV, HCV, Syphilis, Chlamydia Trachomatis, Gonorrhea, and HSV-2) among prisoners appears to be higher than the general population, with drug abuse, low educational levels, and unsafe sex as major risk factors.

关键词： prisoners risk factors sexually transmitted disease

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RETRACTED: The relationship between C-reactive protein and levels of various cytokines in patients with COVID-19: A systematic review and correlation analysis (Retracted Article)

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HEALTH SCIENCE REPORTS 2022年第6期5卷

作者： SeyedAlinaghi, SeyedAhmad Karimi, Amirali Mirzapour, Pegah Afroughi, Fatemeh Noroozi, Alireza Arjmand, Ghazal Abshenas, Shayan Pashaei, Zahra Tantuoyir, Marcarious M. dadras, omid Qaderi, Kowsar Saeidi, Solmaz Dehghani, Soheil Shabanzadeh Pirsaraie, Ayda Mehraeen, Esmaeil Afsahi, Amir Masoud Univ Tehran Med Sci Iranian Inst Reduct High Risk Behav Iranian Res Ctr HIV AIDS Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Islamic Azad Univ Sch Med Tehran Iran Iran Univ Med Sci Pars Hosp Tehran Iran Shahid Beheshti Univ Med Sci Tehran Iran Kashan Univ Med Sci Sch Med Kashan Iran Univ Ghana Med Ctr UGMC Biomed Engn Unit Accra Ghana Bergen Univ Grad Sch Med Dept Global Publ Hlth & Primary Care Bergen Norway Kermanshah Univ Med Sci Sch Nursing & Midwifery Dept Midwifery Kermanshah Iran Khalkhal Univ Med Sci Dept Nursing Khalkhal Iran Islamic Azad Univ Karaj Branch Karaj Iran Khalkhal Univ Med Sci Dept Hlth Informat Technol Khalkhal *** Iran Univ Calif San Diego UCSD Sch Med Dept Radiol San Diego CA USA

Introduction C-reactive protein (CRP) and cytokines levels could alter in patients with coronavirus disease (COVID-19) due to the inflammatory response caused by the virus. This analysis aimed to assess the relationship between the CRP levels and the levels of various cytokines in COVID-19 patients. Materials and Methods We searched the databases of PubMed, Cochrane, and Web of Science for relevant articles on May 29th, 2021. Applying the inclusion/exclusion criteria, the retrieved records underwent two-phase screenings;first, a title/abstract screening process, and then, a full-text screening to find the eligible studies. Data for study variables were extracted, including the CRP levels and the levels of all reported cytokines. A strong and significant relationship between Interleukins and CRP was defined as: p <= 0.05, 0.7 <= r <= 1. Results In this study, 103 studies were included for systematic review and correlation analysis. The aggregate mean and SD of study variables were calculated and reported. The correlation between Interleukins and CRP was measured using correlation coefficient (r). It appeared that interleukin (IL)-10 has a moderate and significant relationship with CRP (p <= 0.05, r = 0.472). IL-10 predicted almost 10% of CRP changes. Conclusion This correlation analysis suggests IL-10 is moderately correlated with CRP levels in patients with COVID-19 infection. A better understanding of the pro-inflammatory markers could contribute to the implementation of therapeutic and preventive approaches. More prospective studies are suggested to explore the relationship between CRP and cytokines as potential markers for the early identification of COVID-19 progression and severity.

关键词： COVID-19 C-reactive protein CRP cytokines interleukin SARS-CoV-2

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