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Ocular manifestations of COVID-19: A systematic review of current evidence

PREVENTIVE MEDICINE REPORTS 2024年 38卷 102608-102608页

作者： Seyedalinaghi, SeyedAhmad Mehraeen, Esmaeil Afzalian, Arian Dashti, Mohsen Ghasemzadeh, Afsaneh Pashaei, Ava Afsahi, Amir Masoud Zadeh, Seyed Saeed Tamehri Fard, Iman Amiri Vafaee, Amirmohammad Molla, Ayoob Shahidi, Ramin Dadjou, Ali Habibi, Mohammad Amin Mirzapour, Pegah dadras, omid Univ Tehran Med Sci Iranian Inst Reduct High Risk Behav Iranian Res Ctr HIV AIDS Tehran Iran Khalkhal Univ Med Sci Dept Hlth Informat Technol Khalkhal Iran Univ Tehran Med Sci Sch Med Tehran Iran Tabriz Univ Med Sci Dept Radiol Tabriz Iran Univ British Columbia Sch Nursing Vancouver BC Canada Univ Calif San Diego UCSD Sch Med Dept Radiol San Diego CA USA Iran Univ Med Sci Sch Nursing & Midwifery Dept Community Hlth Nursing & Geriatr Nursing Geriatr Nursing Tehran Iran Bushehr Univ Med Sci Sch Med Bushehr Iran Qom Univ Med Sci Clin Res Dev Ctr Qom Iran Univ Bergen Dept Global Publ Hlth & Primary Care Bergen Norway

Introduction: COVID-19 caused by SARS-CoV-2, commonly presents with symptoms such as fever and shortness of breath but can also affect other organs. There is growing evidence pointing to potential eye complications. In this article, we aim to systematically review the ocular manifestations of COVID-19. Methods: We conducted a systematic review to explore the ocular manifestations of COVID-19. We searched online databases including PubMed, Embase, Scopus, and Web of Science up to September 4, 2023. After a twostage screening process and applying inclusion/exclusion criteria, eligible articles were advanced to the data extraction phase. The PRISMA checklist and Newcastle -Ottawa Scale (NOS) were used for quality and bias risk assessments. Results: We selected and extracted data from 42 articles. Most of the studies were cross-sectional (n = 33), with the highest number conducted in Turkey (n = 10). The most frequent ocular manifestation was conjunctivitis, reported in 24 articles, followed by photophobia, burning, chemosis, itching, and ocular pain. Most studies reported complete recovery from these manifestations;however, one study mentioned visual loss in two patients. Conclusion: In general, ocular manifestations of COVID-19 appear to resolve either spontaneously or with supportive treatments. For more severe cases, both medical treatment and surgery have been employed, with the outcomes suggesting that complete recoveries are attainable.

关键词： COVID-19 Ocular manifestations Ophthalmic complication Eye involvement

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Evaluation of heroin-assisted treatment in Norway: protocol for a mixed methods study

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BMC HEALTH SERVICES RESEARCH 2024年第1期24卷 1页

作者： Myklebust, Lars Henrik Eide, Desiree Arnevik, Espen A. dadras, omid De Pirro, Silvana Ellefsen, Rune Fadnes, Lars T. Hesse, Morten Kvamme, Timo L. Melis, Francesca Oldervoll, Ann Thylstrup, Birgitte Wusthoff, Linda E. C. Clausen, Thomas Univ Oslo Fac Med Norwegian Ctr Addict Res Kirkevegen 166Bldg 45 NO-0407 Oslo Norway Haukeland Hosp Dept Addict Med Bergen Addict Res Grp Pb 1400 NO-5021 Bergen Norway Univ Bergen Dept Global Publ Hlth & Primary Care Pb 7804 NO-5020 Bergen Norway Oslo Univ Hosp Sect Clin Addict Res Pb 4950 Nydalen NO-0424 Oslo Norway Aarhus Univ Ctr Alcohol & Drug Res Bartholins Alle 10 DK-8000 Aarhus Denmark Univ Roma La Sapienza Dept Physiol & Pharmacol V Erspamer Ple Aldo Moro 5 I-00185 Rome Italy

Background Opioid agonist treatment (OAT) for patients with opioid use disorder (OUD) has a convincing evidence base, although variable retention rates suggest that it may not be beneficial for all. One of the options to include more patients is the introduction of heroin-assisted treatment (HAT), which involves the prescribing of pharmaceutical heroin in a clinical supervised setting. Clinical trials suggest that HAT positively affects illicit drug use, criminal behavior, quality of life, and health. The results are less clear for longer-term outcomes such as mortality, level of function and social integration. This protocol describes a longitudinal evaluation of the introduction of HAT into the OAT services in Norway over a 5-year period. The main aim of the project is to study the individual, organizational and societal effects of implementing HAT in the specialized healthcare services for *** The project adopts a multidisciplinary approach, where the primary cohort for analysis will consist of approximately 250 patients in Norway, observed during the period of 2022-2026. Cohorts for comparative analysis will include all HAT-patients in Denmark from 2010 to 2022 (N = 500) and all Norwegian patients in conventional OAT (N = 8300). Data comes from individual in-depth and semi-structured interviews, self-report questionnaires, clinical records, and national registries, collected at several time points throughout patients' courses of treatment. Qualitative analyses will use a flexible inductive thematic approach. Quantitative analyses will employ a wide array of methods including bi-variate parametric and non-parametric tests, and various forms of multivariate *** The project's primary strength lies in its comprehensive and longitudinal approach. It has the potential to reveal new insights on whether pharmaceutical heroin should be an integral part of integrated conventional OAT services to individually tailor treatments for patients with OUD.

关键词： Heroin assisted treatment Opioid maintenance treatment Protocol Health services Mixed methods Longitudinal

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The relationship between COVID-19 viral load and disease severity: A systematic review

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IMMUNITY INFLAMMATION AND DISEASE 2022年第3期10卷 e580页

作者： dadras, omid Afsahi, Amir M. Pashaei, Zahra Mojdeganlou, Hengameh Karimi, Amirali Habibi, Pedram Barzegary, Alireza Fakhfouri, Amirata Mirzapour, Pegah Janfaza, Nazanin Dehghani, Soheil Afroughi, Fatemeh Dashti, Mohsen Khodaei, Sepideh Mehraeen, Esmaeil Voltarelli, Fabricio Sabatier, Jean-Marc SeyedAlinaghi, SeyedAhmad Walailak Univ Sch Publ Hlth Excellent Ctr Dengue & Community Publ Hlth EC DAC Nakhon Si Thammarat Thailand Univ Calif San Diego UCSD Sch Med Dept Radiol La Jolla CA USA Univ Tehran Med Sci Iranian Inst Reduct High Risk Behav Iranian Res Ctr HIV AIDS Tehran Iran Urmia Univ Med Sci Dept Pathol Orumiyeh Iran Univ Tehran Med Sci Sch Med Tehran Iran Islamic Azad Univ Sch Med Tehran Iran Univ Tehran Med Sci Sch Med Imam Khomeini Hosp Complex Internal Med Dept Tehran Iran Iran Univ Med Sci Pars Hosp Tehran Iran Tabriz Univ Med Sci Dept Radiol Tabriz Iran Khalkhal Univ Med Sci Dept Hlth Informat Technol Khalkhal *** Iran Univ Fed Mato Grosso Grad Program Hlth Sci Fac Med Cuiaba Brazil Univ Aix Marseille Inst Neurophysiopathol INP Fac Pharm UMR 7051 Marseille France

Introduction: Patients with COVID-19 may present different viral loads levels. However, the relationship between viral load and disease severity in COVID-19 is still unknown. Therefore, this study aimed to systematically review the association between SARS-CoV-2 viral load and COVID-19 severity. Methods: The relevant studies using the keywords of "COVID-19" and "viral load" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. A two-step title/abstract screening process was carried out and the eligible studies were included in the study. Results: Thirty-four studies were included from the initial 1015 records. The vast majority of studies have utilized real-time reverse transcription-polymerase chain reaction of the nasopharyngeal/respiratory swabs to report viral load. Viral loads were commonly reported either as cycle threshold (C-t) or log(10) RNA copies/ml. Conclusion: The results were inconclusive about the relationship between COVID-19 severity and viral load, as a similar number of studies either approved or opposed this hypothesis. However, the studies denote the direct relationship between older age and higher SARS-CoV-2 viral load, which is a known risk factor for COVID-19 mortality. The higher viral load in older patients may serve as a mechanism for any possible relationships between COVID-19 viral load and disease severity. There was a positive correlation between SARS-CoV-2 viral load and its transmissibility. Nonetheless, further studies are recommended to precisely characterize this matter.

关键词： COVID-19 prognosis SARS-CoV-2 severity viral load

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Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021

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The Lancet 2025年第10482期405卷 897-910页

作者： Bernabe, Eduardo Marcenes, Wagner Abdulkader, Rizwan Suliankatchi Abreu, Lucas Guimarães Afzal, Saira Alhalaiqa, Fadwa Naji Al-Maweri, Sadeq Alsharif, Ubai Anyasodor, Anayochukwu Edward Arora, Amit Asgary, Saeed Ashraf, Tahira Balasubramanian, Madhan Banakar, Morteza Barrow, Amadou Bashiri, Azadeh Belay, Sefealem Assefa Belgaumi, Uzma Iqbal Berhie, Alemshet Yirga Bhardwaj, Pankaj Bhaskar, Sonu Bijani, Ali Bouaoud, Souad Cao, Yin Chaurasia, Akhilanand Chen, Meng Xuan Chu, Dinh-Toi Cruz-Martins, Natalia dadras, omid Dai, Xiaochen Diaz, Daniel Du, Mi Ekholuenetale, Michael Ekundayo, Temitope Cyrus El Tantawi, Maha Elhadi, Muhammed Fagbamigbe, Adeniyi Francis Farshidfar, Nima Fatehizadeh, Ali Fischer, Florian Folayan, Morenike Oluwatoyin Gaewkhiew, Piyada Gajdács, Márió Golechha, Mahaveer Gupta, Bhawna Gupta, Sapna Hagins, Hailey Halboub, Esam S Hamidi, Samer Hariyani, Ninuk Hay, Simon I Heidari, Mohammad Herrera-Serna, Brenda Yuliana Heyi, Demisu Zenbaba Hostiuc, Sorin Humphrey, Kyle Matthew Ibitoye, Segun Emmanuel Ilic, Milena D Isola, Gaetano Kandaswamy, Eswar Kantar, Rami S Kaur, Navjot Kemmer, Laura Khader, Yousef Saleh Khateri, Sorour Kisa, Adnan Krishan, Kewal Kruger, Estie Lalloo, Ratilal Li, An Lim, Stephen S Mestrovic, Tomislav Mokdad, Ali H Moreira, Rafael Silveira Morrison, Shane Douglas Murray, Christopher J L Natto, Zuhair S Nayak, Biswa Prakash Nguyen, Trang Nguyen, Van Thanh Omotayo, Abiodun Olusola Padron-Monedero, Alicia Patel, Jay Patil, Shankargouda Pawar, Shrikant Petcu, Ionela-Roxana Qattea, Ibrahim Rahman, Mosiur Ratan, Zubair Ahmed Riad, Abanoub S, Manjula S N, Chandan Sabour, Siamak Saheb Sharif-Askari, Fatemeh Sahebkar, Amirhossein Sakshaug, Joseph W Samy, Abdallah M Sarode, Sachin C Sawhney, Monika Schwendicke, Falk Shaikh, Masood Ali Tadakamadla, Santosh Kumar Tesler, Riki Thiyagarajan, Arulmani Tovani-Palone, Marcos Roberto Umair, Muhammad Unnikrishnan, Bhaskaran Valadan Tahbaz, Sahel Varma, Siddhartha Alluri Vukovic, Ana Petar Wang, Cong Wickramasinghe, Nuwan Darshana Yadav, Lalit Yiğit,

Background: The WHO Global Oral Health Action Plan has set an overarching global target of achieving a 10% reduction in the prevalence of oral conditions by 2030. Robust and up-to-date information on the global burden of oral conditions is paramount to monitor progress towards this target. The aim of this systematic data analysis was to produce global, WHO region, and country-level estimates of the prevalence of, and disability-adjusted life-years (DALYs) attributed to, untreated caries, severe periodontitis, edentulism, other oral disorders, lip and oral cavity cancer, and orofacial clefts from 1990 to 2021. Methods: This report is based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. Input data were extracted from epidemiological surveys, population-based registries, and vital statistics. Data were modelled with DisMod-MR 2.1, a Bayesian meta-regression modelling tool, to ensure consistency between prevalence, incidence, remission, and mortality estimates for oral conditions. DALYs were estimated as the aggregation of the years of life lost (YLLs) due to premature mortality and years lived with disability (YLDs). YLDs were calculated by multiplying prevalence estimates, the severity of the oral condition's sequelae (disability weight) and duration of the sequelae. Although all oral conditions lead to YLDs, only lip and oral cavity cancer and orofacial clefts lead to YLLs as well. 95% uncertainty intervals (UIs) were generated for every metric with the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: The combined global age-standardised prevalence of the main oral conditions (untreated caries, severe periodontitis, edentulism, and other oral disorders) was 45 900 (95% UI 42 300 to 49 800) per 100 000 population in 2021, with 3·69 billion (3·40 to 4·00) people affected globally. Untreated dental caries of permanent teeth and severe periodontitis were the most common oral conditions, with a global age-sta

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COVID-19 mortality and its predictors in the elderly: A systematic review

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Health Science Reports 2022年第3期5卷 e657页

作者： dadras, omid SeyedAlinaghi, SeyedAhmad Karimi, Amirali Shamsabadi, Ahmadreza Qaderi, Kowsar Ramezani, Maryam Mirghaderi, Seyed Peyman Mahdiabadi, Sara Vahedi, Farzin Saeidi, Solmaz Shojaei, Alireza Mehrtak, Mohammad Azar, Shiva A. Mehraeen, Esmaeil Voltarelli, Fabrício A. Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors Tehran Iran Department of Global Public Health and Primary Care University of Bergen Bergen Norway School of Medicine Tehran University of Medical Sciences Tehran Iran Department of Health Information Technology Esfarayen Faculty of Medical Sciences Esfarayen Iran Kermanshah University of Medical Sciences Kermanshah Iran Department of Health Management Policy and Economics School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Nursing University of Medical Sciences Khalkhal Khalkhal Iran School of Medicine and Allied Medical Sciences Ardabil University of Medical Sciences Ardabil Iran School of Pharmacy Shiraz University of Medical Sciences Shiraz Iran Department of Health Information Technology Khalkhal University of Medical Sciences Khalkhal Iran Graduation Program in Health Sciences Faculty of Medicine Federal University of Mato Grosso Mato Grosso Cuiabá Brazil

Background and Aims: Older people have higher rates of comorbidities and may experience more severe inflammatory responses;therefore, are at higher risk of death. Herein, we aimed to systematically review the mortality in coronavirus disease 2019 (COVID-19) patients and its predictors in this age group. Methods: We searched PubMed, Web of Science, and Science Direct using relevant keywords. Retrieved records underwent a two-step screening process consisting of title/abstract and full-text screenings to identify the eligible studies. Results: Summarizing findings of 35 studies demonstrated that older patients have higher mortality rates compared to the younger population. A review of articles revealed that increasing age, body mass index, a male gender, dementia, impairment or dependency in daily activities, presence of consolidations on chest X-ray, hypoxemic respiratory failure, and lower oxygen saturation at admission were risk factors for death. High d-dimer levels, 25-hydroxy vitamin D serum deficiencies, high C-reactive protein (≥5 mg/L) levels plus any other abnormalities of lymphocyte, higher blood urea nitrogen or lactate dehydrogenase, and higher platelet count were predictors of poor prognosis and mortality in the elderly. Studies have also shown that previous treatment with renin–angiotensin–aldosterone system inhibitors, pharmacological treatments of respiratory disorders, antibiotics, corticosteroids, vitamin K antagonist, antihistamines, azithromycin, Itolizumab (an anti-CD6 monoclonal antibody) in combination with other antivirals reduces COVID-19 worsening and mortality. Vaccination against seasonal influenza might also reduce COVID-19 mortality. Conclusion: Overall, a critical consideration is necessary for the care and management of COVID-19 in the aged population considering the drastic contrasts in manifestation and prognosis compared to other age groups. Mortality from COVID-19 is independently associated with the patient's age. Elderly patients

关键词： aging COVID-19 elderly older people SARS-CoV-2

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Can serum level of N-terminal pro B-type natriuretic peptide be used in patients with psoriasis as a predictor of cardiovascular disease?

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DERMATOLOGIC THERAPY 2019年第3期32卷 e12865-e12865页

作者： Shahidi-dadras, Mohammad Niknezhad, Nasim Niknejad, Nakisa Zargari, omid Shahid Beheshti Univ Med Sci Shohada E Tajrish Hosp Skin Res Ctr Shahrdari St Tehran *** Iran Univ Tehran Med Sci Canc Inst Imam Khomeini Hosp Complex Dept Pathol Tehran Iran

Past studies have reported associations between psoriasis, metabolic syndrome, and atherosclerotic cardiovascular disease. According to studies, N-terminal pro B-type natriuretic peptide (NT-proBNP) is a useful screening test for cardiac disease. We examined the serum NT-proBNP level in patients with psoriasis and compared them with nonpsoriatic healthy control subjects. Sixty-one patients with psoriasis were enrolled, along with 61 age, sex, and body mass index (BMI) matched control subjects. In both groups, NT-proBNP serum levels and lipid profile parameters were investigated. Means and 95% confidence intervals (CIs) were reported. The median serum concentration of NT-proBNP was higher in psoriatic patients than the control group (26.67 [interquartile range (IQR): 15.15-43.03 and range: 5-250] vs. 17.45 [IQR: 12.35-20.80 and range: 5-45.09, p < 0.0001). NT-proBNP serum level in psoriatic arthritis patients (11%;55.6 +/- 25.7 pg/mL, 95% CI: 31.9-79.4 pg/mL) was higher than psoriasis patients without arthritis (35.8 +/- 40.6 pg/mL, CI: 24.7-46.9, p < 0.001). NT-proBNP levels were also positively correlated with BMI, lipid profile, and disease duration. NT-proBNP is elevated in patients with psoriasis, consistent with the high risk of cardiovascular disease associated with psoriasis.

关键词： psoriasis NT-proBNP cardiovascular

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Internet of things in the management of chronic diseases during the COVID-19 pandemic: A systematic review

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Health science reports 2022年第2期5卷 e557页

作者： Ahmadreza Shamsabadi Zahra Pashaei Amirali Karimi Pegah Mirzapour Kowsar Qaderi Mahmoud Marhamati Alireza Barzegary Amirata Fakhfouri Esmaeil Mehraeen SeyedAhmad SeyedAlinaghi omid dadras Department of Health Information Technology Esfarayen Faculty of Medical Sciences Esfarayen Iran. Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors Tehran University of Medical Sciences Tehran Iran. School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Midwifery Kermanshah University of Medical Sciences Kermanshah Iran. Instructor of Medical Surgical Nursing Department of Nursing Esfarayen Faculty of Medical Sciences Esfarayen Iran. School of Medicine Islamic Azad University Tehran Iran. Department of Health Information Technology Khalkhal University of Medical Sciences Khalkhal Iran. School of Public Health Walailak University Thai Buri Nakhon Si Thammarat Thailand.

Introduction:The use of new technologies such as the Internet of Things (IoT) in the management of chronic diseases, especially in the COVID pandemics, could be a life-saving appliance for public health practice. The purpose of the current study is to identify the applications and capability of IoT and digital health in the management of the COVID-19 pandemic. Methods:This systematic review was conducted by searching the online databases of PubMed, Scopus, and Web of Science using selected keywords to retrieve the relevant literature published until December 25th, 2021. The most relevant original English studies were included after initial screening based on the inclusion criteria. Results:Overall, 18 studies were included. Most of the studies reported benefits and positive responses in the form of patients' and healthcare providers' satisfaction and trust in the online systems. Many services were provided to the patients, including but not limited to training the patients on their conditions; monitoring vital signs and required actions when vital signs were altered; ensuring treatment adherence; monitoring and consulting the patients regarding diet, physical activity, and lifestyle. Conclusion:IoT is a new technology, which can help us improve health care services during the COVID-19 pandemic. It has a network of various sensors, obtaining data from patients. We have found several applications for this technology. Future studies can be conducted for the capability of other technologies in the management of chronic diseases.

关键词： COVID‐19 IoT Sensor Telehealth chronic diseases

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Soluble biomarkers for diagnosis, monitoring, and therapeutic response assessment in psoriasis

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JOURNAL OF DERMATOLOGICAL TREATMENT 2022年第4期33卷 1967-1974页

作者： Pourani, Mohammad Reza Abdollahimajd, Fahimeh Zargari, omid Shahidi dadras, Mohammad Shahid Beheshti Univ Med Sci Skin Res Ctr Tehran Iran Shahid Beheshti Univ Med Sci Clin Res Dev Unit Shohada Tajrish Hosp Tehran Iran

Background Psoriasis is an inflammatory disease associated with multiple comorbidities. Biomarkers for the assessment of psoriasis, its associated comorbidities, and the therapeutic response are not well characterized. A number of possible biomarkers for the diagnosis and monitoring of psoriasis have been proposed. Purpose To assess potential biomarkers for diagnosis of psoriasis, its associated comorbidities and response to treatment. Methods We investigated medical databases from 2000 to 2021 and assessed relevant research. In this review, we evaluated the important biomarkers to help predict potential risk of psoriasis and disease activity (Beta-defensin-2, VEGF, Lipocalin-2, and YKL-40) and its possible inflammatory-related comorbidities like cardiovascular diseases (hs-CRP, GlycA, Psoriasin, IL-18, NT-proBNP, and Adipokines). In addition, we described the potential biomarkers for psoriatic arthritis (CXCL10, S100A8 and S100A9, and MicroRNA) and related manifestations such as enthesitis. Finally, we discussed novel markers for monitoring the response to specific treatments (HLA-C 06, PLC, TARC, NLR, and PLR) as well as potentially useful biomarkers for evaluation of therapy-associated adverse events (liver fibrosis-related markers). Conclusion A wide range of genetic, tissue, and serum markers have been investigated in psoriasis;however, most of them are not used in routine clinical practice;and thorough physical examination along with the appropriate application of clinical scoring systems like Psoriasis Area and Severity Index score are still of particular importance.

关键词： Arthritis biomarker comorbidity genetic inflammation psoriasis treatment review

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Prenatal and neonatal complications of COVID-19: A systematic review

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Health science reports 2022年第2期5卷 e510页

作者： Zahra Pashaei SeyedAhmad SeyedAlinaghi Kowsar Qaderi Alireza Barzegary Amirali Karimi Seyed Peyman Mirghaderi Pegah Mirzapour Marcarious M Tantuoyir omid dadras Zoha Ali Fabricio Voltarelli Esmaeil Mehraeen Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors Tehran University of Medical Sciences Tehran Iran. Department of Midwifery School of Nursing and Midwifery Kermanshah University of Medical Sciences Kermanshah Iran. School of Medicine Islamic Azad University Tehran Iran. School of Medicine Tehran University of Medical Sciences Tehran Iran. Biomedical Engineering Unit University of Ghana Medical Center (UGMC) Accra Ghana. School of Public Health Walailak University Nakhon Si Thammarat Thailand. Graduation Program of Health Sciences Faculty of Medicine Federal University of Mato Grosso Cuiabá Brazil. Department of Health Information Technology Khalkhal University of Medical Sciences Khalkhal Iran.

BACKGROUND AND AIMS:The outbreak of coronavirus disease 2019 (COVID-19) over the past year has affected public health worldwide. During pregnancy, the maternal immune system and inflammatory responses are widely suppressed. Pregnancy-related immune system suppression could make the mother vulnerable to infectious diseases like SARS-COV-2. However, current data suggest little to no possibility of COVID-19 transmission in pregnant women to the fetus during pregnancy or childbirth. This systematic review focused on the possible complications of COVID-19 infection in the fetus and newborn babies including the possibility and evidence of vertical transmission by reviewing articles published during the first year of the COVID-19 pandemic. METHODS:We conducted a systematic search using keywords on PubMed, Embase, and Scopus databases. The studies followed a title/abstract and a full-text screening process, and the eligible articles were included in the study. RESULTS:In total, 238 published papers were identified using a systematic search strategy (44 articles met the inclusion criteria and were included in the final review). In all studies, a total of 2375 women with signs and symptoms of COVID-19, who were in the second and third trimester of pregnancy, were assessed mild to moderate pneumonia was one of the most common symptoms. Seventy-three percent of the women did not present any comorbidity, 19% had a fever, 17% had to cough as the most frequent clinical signs and symptoms, 7.5% had pulmonary changes with chest scans, 8% had increased C reactive protein, and 9.4% had decreased lymphocytes (lymphocytopenia). A total of 2716 newborns and fetal were assessed; the delivery method of 1725 of them was reported, 913 (53%) through C-section delivery, and 812 through normal vaginal delivery (47%). Of total newborns, 13 died (five died along with the mother), and 1965 were tested for SARS-CoV-2:118 tested positive. In a study, vertical transmission in seven cases was reported

关键词： COVID‐19 SARS‐CoV‐2 fetus neonatal newborn prenatal

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A probable atypical skin manifestation of COVID-19 infection

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JOURNAL OF DERMATOLOGICAL TREATMENT 2022年第2期33卷 1188-1190页

作者： Shahidi dadras, Mohammad Zargari, omid Abolghasemi, Rozita Bahmanjahromi, Ayda Abdollahimajd, Fahimeh Shahid Beheshti Univ Med Sci Skin Res Ctr Tehran Iran Shahid Beheshti Univ Med Sci Shohada E Tajrish Hosp Dept Nephrol Tehran Iran Shahid Beheshti Univ Med Sci Shohada E Tajrish Hosp Clin Res Dev Unit Tehran Iran

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