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Effects of raloxifene on cognition in postmenopausal women with schizophrenia: a 24-week double-blind, randomized, parallel, placebo-controlled trial

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EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 2020年第6期270卷 729-737页

作者： Huerta-Ramos, Elena Labad, Javier Cobo, Jesus Nunez, Christian Creus, Marta Garcia-Pares, Gemma cuadras, daniel Franco, Jose Miquel, Eva Reyes, Julio-Cesar Marco-Garcia, Silvia Rodriguez, Carolina Rodriguez, Carolina Beneitez, Isabel Costa, Joan Castro, Lourdes Teba, Silvia Milian, Laura Foix, Alexandrina Rivero, Sonia Cavero, Marian Argemi, Maria Teba, Fernando Arranz, Belen Rubio, Elena Coromina, Marta Santos, Angeles Bogas, Jose Luis Barber, Ana Romans, Carlota Marquez, Manel Sabata, Anna Nieto, Lourdes Willikens, Eva Blanch, Enrich Acebillo, Siddharta Coronas, Ramon Ortega, Laura Coll, Ignasi Valero, Joaquin Rodriguez, Jesus Perez, Modesto Niubo, Ines Tost, Montse Monfort, Mari Pau Martorell, Lourdes Vilella, Elisabet Usall, Judith Huerta-Ramos, Elena Labad, Javier Cobo, Jesus Nunez, Christian Creus, Marta Garcia-Pares, Gemma cuadras, daniel Franco, Jose Miquel, Eva Reyes, Julio-Cesar Roca, Mercedes Usall, Judith Parc Sanitari Sant Joan Deu C/Antoni Pujadas 42. Sant Boi Llobregat 08830 Barcelona Spain Fundacio Sant Joan Deu Barcelona Spain Centro Investigac Red Salud Mental Instituto Salud Carlos 3 CIBERSAM Madrid Spain Institut Recerca Sant Joan Deu Barcelona Spain Corporacio Sanitaria Parc Tauli Barcelona Spain Institut Pere Mata Tarragona Spain Hosp Nostra Senyora Meritxell Escaldes-engordany Andorra

We assessed the utility of raloxifene (60 mg/day) as an adjuvant treatment for cognitive symptoms in postmenopausal women with schizophrenia in a 24-week, double-blind, randomized, placebo-controlled study. Patients were recruited from the inpatient and outpatient services of Parc Sanitari Sant Joan de Deu, Hospital Universitari Institut Pere Mata, and Corporacio Sanitaria Parc Tauli. Seventy eight postmenopausal women with schizophrenia were randomized to either adjunctive raloxifene or placebo. Sixty-eight began the clinical trial (37 women on raloxifene adjunct) and 31 on placebo adjunct. The outcome measures were: memory, attention and executive function. Assessment was conducted at baseline and at week 24. Between groups homogeneity was tested with the Student'sttest for continuous variables and/or the Mann-WhitneyUtest for ordinal variables and the chi(2)test or Fisher's exact test for categorical variables. The differences between the two groups in neuropsychological test scores were compared using the Student'sttest. The sample was homogenous with respect to age, formal education, illness duration and previous pharmacological treatment. The addition of raloxifene to antipsychotic treatment as usual showed no differences in cognitive function. The daily use of 60 mg raloxifene as an adjuvant treatment in postmenopausal women with schizophrenia has no appreciable effect. *** Identifier: NCT01573637.

关键词： Raloxifene Schizophrenia Cognition Clinical trial

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Gamma-aminobutyric acid levels in cerebrospinal fluid in neuropaediatric disorders

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DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY 2018年第8期60卷 780-+页

作者： Cortes-Saladelafont, Elisenda Molero-Luis, Marta cuadras, daniel Casado, Mercedes Armstrong-Moron, Judith Yubero, Delia Montoya, Julio Artuch, Rafael Garcia-Cazorla, Angels Hosp St Joan de Deu Dept Neurol Neurometab Unit Barcelona Spain Hosp St Joan de Deu Synapt Metab Lab Barcelona Spain Inst Recerca St Joan de Deu Barcelona Spain Inst Salud Carlos III Ctr Invest Biomed Red Enfermedades Raras CIBERER Madrid Spain Hosp St Joan de Deu Dept Genet & Biochem Barcelona Spain Inst Recerca St Joan de Deu Stat Dept Barcelona Spain Univ Zaragoza Dept Biochem Mol & Cellular Biol Zaragoza Spain

AimGamma-aminobutyric acid (GABA) is a major modulator in brain maturation and its role in many different neurodevelopmental disorders has been widely reported. Although the involvement of GABA in different disorders has been related to its regulatory function as an inhibitory neurotransmitter in the mature brain, co-transmitter, and signalling molecule, little is known about its role as a clinical biomarker in neuropaediatric disorders. The aim of this study is to report the cerebrospinal fluid (CSF) free-GABA concentrations in a large cohort of patients (n=85) with different neurological disorders. MethodGABA was measured in the CSF of neuropaediatric patients using capillary electrophoresis with laser-induced fluorescence detection. Other neurotransmitters (amino acids and monoamines) were also analysed. ResultsGABA concentrations in CSF were abnormal, with a greater frequency (44%) than monoamines (20%) in neuropaediatric patients compared with our reference values. Although we included a few patients with inborn errors of metabolism, GABA levels in CSF were more frequently abnormal in metabolic disorders than in other nosological groups. InterpretationOur work suggests further research into brain GABAergic status in neuropaediatric disorders, which could also lead to new therapeutic strategies.

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AZATAX: Acetazolamide safety and efficacy in cerebellar syndrome in PMM2 congenital disorder of glycosylation (PMM2-CDG)

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ANNALS OF NEUROLOGY 2019年第5期85卷 740-751页

作者： Martinez-Monseny, Antonio F. Bolasell, Merce Callejon-Poo, Laura cuadras, daniel Freniche, Veronica Itzep, Debora C. Gassiot, Susanna Arango, Pedro Casas-Alba, Didac de la Morena, Eugenia Corral, Javier Montero, Raquel Perez-Cerda, Celia Perez, Belen Artuch, Rafael Jaeken, Jaak Serrano, Mercedes St Joan Deu Hosp Genet Med Dept Res Inst Barcelona Spain St Joan Deu Hosp Pediat Inst Rare Dis Res Inst Barcelona Spain Neuroesplugues Neuropsychol Unit Barcelona Spain St Joan Deu Fdn Stat Dept Barcelona Spain St Joan Deu Hosp Neuropediat Dept Res Inst Barcelona Spain St Joan Deu Hosp Hematol Lab Res Inst Barcelona Spain St Joan Deu Hosp Nephrol Dept Res Inst Barcelona Spain Murcia Univ Morales Meseguer Univ Hosp Hematol & Med Oncol ServIMIB Arrixaca Reg Blood Donat CtrCtr Biomed Res Rare Dis U-765 Murcia Spain St Joan Deu Hosp Clin Biochem Dept Res Inst Barcelona Spain Inst Salud Carlos III St Joan Deu Hosp Ctr Biomed Res Rare Dis U-703 Barcelona Spain Autonomous Univ Madrid Inst Salud Carlos III Diag Mol Dis Ctr Ctr Biomed Res Rare DisIdiPAZ U-746 Madrid Spain Katholieke Univ Leuven Univ Hosp Gasthuisberg Ctr Metab Dis Leuven Belgium

Objective Phosphomannomutase deficiency (PMM2 congenital disorder of glycosylation [PMM2-CDG]) causes cerebellar syndrome and strokelike episodes (SLEs). SLEs are also described in patients with gain-of-function mutations in the CaV2.1 channel, for which acetazolamide therapy is suggested. Impairment in N-glycosylation of CaV2.1 promotes gain-of-function effects and may participate in cerebellar syndrome in PMM2-CDG. AZATAX was designed to establish whether acetazolamide is safe and improves cerebellar syndrome in PMM2-CDG. Methods A clinical trial included PMM2-CDG patients, with a 6-month first-phase single acetazolamide therapy group, followed by a randomized 5-week withdrawal phase. Safety was assessed. The primary outcome measure was improvement in the International Cooperative Ataxia Rating Scale (ICARS). Other measures were the Nijmegen Pediatric CDG Rating Scale (NPCRS), a syllable repetition test (PATA test), and cognitive scores. Results Twenty-four patients (mean age = 12.3 +/- 4.5 years) were included, showing no serious adverse events. Thirteen patients required dose adjustment due to low bicarbonate or asthenia. There were improvements on ICARS (34.9 +/- 23.2 vs 40.7 +/- 24.8, effect size = 1.48, 95% confidence interval [CI] = 4.0-7.6, p < 0.001), detected at 6 weeks in 18 patients among the 20 responders, on NPCRS (95% CI = 0.3-1.6, p = 0.013) and on the PATA test (95% CI = 0.5-3.0, p = 0.006). Acetazolamide improved prothrombin time, factor X, and antithrombin. Clinical severity, epilepsy, and lipodystrophy predicted greater response. The randomized withdrawal phase showed ICARS worsening in the withdrawal group (effect size = 1.46, 95% CI = 2.65-7.52, p = 0.001). Interpretation AZATAX is the first clinical trial of PMM2-CDG. Acetazolamide is well tolerated and effective for motor cerebellar syndrome. Its ability to prevent SLEs and its long-term effects on kidney function should be addressed in future studies. Ann Neurol 2019;85:740-751

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Lifestyle Intervention Decreases Urine Trimethylamine N-Oxide Levels in Prepubertal Children with Obesity

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OBESITY 2018年第10期26卷 1603-1610页

作者： Leal-Witt, Maria J. Llobet, Marina Samino, Sara Castellano, Pol cuadras, daniel Jimenez-Chillaron, Josep C. Yanes, Oscar Ramon-Krauel, Marta Lerin, Carles Inst Recerca St Joan de Deu Endocrinol Dept Barcelona Spain Hosp St Joan de Deu Barcelona Spain Univ Rovira & Virgili Dept Elect Engn DEEEA Metabol Platform Tarragona Spain Biomed Res Ctr Diabet & Associated Metab Disorder Madrid Spain St Joan de Deu Res Fdn Stat Dept Barcelona Spain

Objective: Early lifestyle interventions in children with obesity decrease risk of obesity and metabolic disorders during adulthood. This study aimed to identify metabolic signatures associated with lifestyle intervention in urine samples from prepubertal children with obesity. Methods: Thirty-four prepubertal children with obesity were studied before and after a 6-month lifestyle intervention program, and anthropometric, metabolic, and nutritional variables were collected. A nuclear magnetic resonance approach was applied to obtain the metabolomic profile from urine samples. Partial least squares-discriminant analysis (PLS-DA) was used to achieve group classification and variable importance on projection (VIP) for biomarker selection. Results: The intervention reduced caloric intake by 10% (P<0.05) and BMI standard deviation score by 0.47 SD (P<0.001). PLS-DA identified trimethylamine N-oxide (TMAO, VIP=2.21) as the metabolite with the highest discrimination properties between groups. Urine TMAO levels were reduced after the intervention (P<0.05). TMAO is a biomarker of cardiovascular disease risk and is a product of gut microbiota-dependent metabolism of certain dietary compounds, including choline. Notably, changes in TMAO levels after the intervention did not correlate to differences in choline intake but were inversely associated with fiber intake (P<0.05). Conclusions: These results indicate that lifestyle intervention decreases TMAO levels in children with obesity.

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Clinical Assessment of Dysarthria in Children with Cerebellar Syndrome Associated with PMM2-CDG

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NEUROPEDIATRICS 2018年第6期49卷 408-413页

作者： Itzep, Debora Martinez-Monseny, Antonio F. Bolasell, Merce cuadras, daniel Velazquez-Fragua, Ramon Gutierrez-Solana, Luis G. Macaya, Alfons Perez-Duenas, Belen Serrano, Mercedes Hosp St Joan de Deu Neuropediat Dept Barcelona Spain Hosp St Joan de Deu Radiol Dept Barcelona Spain Hosp St Joan de Deu Clin Biochem Dept Barcelona Spain Inst Salud Carlos III Ctr Biomed Res Rare Dis CIBER ER U 703 Passeig St Joan de Deu 2 Barcelona 08950 Spain Hosp St Joan de Deu Pediat Inst Rare Dis IPER Barcelona Spain Hosp St Joan de Deu Genet Med Dept Barcelona Spain Fundacio St Joan de Deu Stat Dept Barcelona Spain Hosp Univ La Paz Pediat Neurol Dept Madrid Spain Hosp Infantil Univ Nino Jesus Madrid Dept Pediat Unit Child Neurol Madrid Spain Univ Autonoma Barcelona Hosp Univ Vall dHebron Inst Recerca Vall dHebron Grp Recerca Neurol Pediat Barcelona Spain

Phosphomannomutase deficiency (PMM2-CDG) causes a cerebellar syndrome that has been evaluated using the International Cooperative Ataxia Rating Scale (ICARS). However, no particular dysarthria tests have been used. Speech ICARS subscore subjectively assesses fluency and clarity of speech with two items. Repetition of syllables, traditionally used for characterization of ataxic speech, was validated in earlyonset ataxia conditions. We assess the validity of the PATA test (SCA Functional Index [SCAN]) in PMM2-CDG patients. PATA rates from 20 patients were compared with a control population were and correlated with ICARS and neuroimaging. There was a difference between the PATA rate in patients and controls. PATA rate increased with age in controls. In patients, the improvement of PATA rate with age was not significant. In patients, the PATA rate was negatively correlated with the total ICARS score and the Speech ICARS subscore. Regarding neuroimaging, midsaggital vermin relative diameter was positively correlated with PATA results. These last differences were also significant when the results are corrected by age. PATA rate provides an easy measure for a quantitative assessment of dysarthria that may help clinicians to monitor patients' evolution in a regular consultation. It could also be used in PMM2-CDG clinical trials implementing ICARS speech subscore information.

关键词： cerebellar syndrome congenital disorders of glycosylation dysarthria magnetic resonance imaging PMM2-CDG

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Cerebrospinal fluid neopterin as a biomarker of neuroinflammatory diseases

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SCIENTIFIC REPORTS 2020年第1期10卷 1-9页

作者： Molero-Luis, Marta Casas-Alba, Didac Orellana, Gabriela Ormazabal, Aida Sierra, Cristina Oliva, Clara Valls, Anna Velasco, Jesus Launes, Cristian cuadras, daniel Perez-Duenas, Belen Jordan, Iolanda Cambra, Francisco J. Ortigoza-Escobar, Juan D. Munoz-Almagro, Carmen Garcia-Cazorla, Angels Armangu, Thais Artuch, Rafael Inst Recerca St Joan de Deu Barcelona Spain Hosp St Joan de Deu Clin Biochem Dept Passeig St Jan de Deu 2 Barcelona 08950 Spain Hosp St Joan de Deu Pediat Neurol Dept Barcelona Spain Hosp St Joan de Deu Pediat Dept Barcelona Spain Fundacio St Joan Deu Barcelona Spain Hosp Valle De Hebron Pediat Neurol Res Grp Inst Recerca VHIR Barcelona Spain Hosp St Joan de Deu Pediat Intens Care Unit Barcelona Spain Inst Recerca Hosp St Joan de Deu Pediat Infect Dis Res Grp CIBERESP Barcelona Spain Hosp St Joan de Deu Movement Disorder Unit ERN RND Barcelona Spain CIBERER Inst Salud Carlos III Barcelona Spain ISCIII CIBER Epidemiol & Salud PUbl CIBERESP Barcelona Spain Univ Int Catalunya Dept Med Barcelona Spain Univ Barcelona Inst Invest Biomed August Pi i Sunyer IDIBAPS Hosp Clin Neuroimmunol Program Barcelona Spain Univ Barcelona Pediat Neuroinmunol Unit St Joan de Deu Childrens Hosp Barcelona Spain

The elevation of neopterin in cerebrospinal fluid (CSF) has been reported in several neuroinflammatory disorders. However, it is not expected that neopterin alone can discriminate among different neuroinflammatory etiologies. We conducted an observational retrospective and case-control study to analyze the CSF biomarkers neopterin, total proteins, and leukocytes in a large cohort of pediatric patients with neuroinflammatory disorders. CSF samples from 277 subjects were included and classified into four groups: Viral meningoencephalitis, bacterial meningitis, acquired immune-mediated disorders, and patients with no-immune diseases (control group). CSF neopterin was analyzed with high-performance liquid chromatography. Microbiological diagnosis included bacterial CSF cultures and several specific real-time polymerase chain reactions. Molecular testing for multiple respiratory pathogens was also included. Antibodies against neuronal and glial proteins were tested. Canonical discriminant analysis of the three biomarkers was conducted to establish the best discriminant functions for the classification of the different clinical groups. Model validation was done by biomarker analyses in a new cohort of 95 pediatric patients. CSF neopterin displayed the highest values in the viral and bacterial infection groups. By applying canonical discriminant analysis, it was possible to classify the patients into the different groups. Validation analyses displayed good results for neuropediatric patients with no-immune diseases and for viral meningitis patients, followed by the other groups. This study provides initial evidence of a more efficient approach to promote the timely classification of patients with viral and bacterial infections and acquired autoimmune disorders. Through canonical equations, we have validated a new tool that aids in the early and differential diagnosis of these neuroinflammatory conditions.

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A mouthwash formulated with o-cymen-5-ol and zinc chloride specifically targets potential pathogens without impairing the native oral microbiome in healthy individuals

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JOURNAL OF ORAL MICROBIOLOGY 2023年第1期15卷 2185962页

作者： Pascual, Javier Mira Otal, Javier Torrent-Silla, daniel Porcar, Manuel Vilanova, Cristina Vivancos cuadras, Fernando Darwin Bioprospecting Excellence SL Paterna Spain Lacer SA Barcelona Spain Univ Valencia CSIC Inst Integrat Syst Biol I2SysBio Paterna Spain Darwin Bioprospecting Excellence SL Catedrat Agustin Escardino 9 Paterna 46980 Valencia Spain

Background Many antimicrobial compounds in mouthwashes can have a negative impact on the oral microbiome. O-cymen-5-ol, a compound derived from a phytochemical, has a targeted mode of action and is being used as an alternative. However, its effect on the native oral microbiome is unknown. Aim To assess the effect of a mouthwash formulated with o-cymen-5-ol and zinc chloride on the oral microbiome of healthy individuals. Methods A mouthwash formulated with o-cymen-5-ol and zinc chloride was administered to a cohort of 51 volunteers for 14 days, while another cohort of 49 volunteers received a placebo. The evolution of the oral microbiome in both groups was analysed using a metataxonomic approach. Results Analysis of the oral microbiome showed that the mouthwash selectively targeted potential oral pathogens while maintaining the integrity of the rest of the microbiome. Specifically, the relative abundance of several potentially pathogenic bacterial taxa, namely Fusobacteriota, Prevotella, Actinomyces, Granulicatella, Abiotrophia, Lautropia, Lachnoanaerobaculum, Eubacterium (nodatum group) and Absconditabacteriales (SR1) decreased, while the growth of Rothia, a nitrate-reducing bacterium beneficial for blood pressure, was stimulated. Conclusions The use of o-cymen-5-ol and zinc chloride as antimicrobial agents in oral mouthwashes is a valuable alternative to classical antimicrobial agents.

关键词： Mouthwash cymen-5-ol zinc chloride pathogens oral microbiome

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Estimated fetal weight percentile as a tool to predict collection of cord blood units with higher cellular content: implications for prenatal selection of cord blood donors

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TRANSFUSION 2018年第7期58卷 1732-1738页

作者： Lin, Xinxin Torrabadella, Marta Amat, Lluis Gomez, Susana Azqueta, Carmen Sanchez, Mar cuadras, daniel Martinez Lorenzo, Maria Jose Maria Brull, Jose Gaya, Antoni Cemborain, Arantxa Perez Garcia, Cristina Arroyo, JoseLuis Querol, Sergi Gomez Roig, Maria Dolores Hosp St Joan de Deu BCNatal Barcelona Ctr Maternal Fetal & Neonatal M Barcelona Spain Hosp Clin Barcelona Barcelona Spain Fundacio St Joan de Deu Programa Concordia Banc Sang & Teixits Barcelona Spain Fundacio St Joan de Deu Dept Stat Barcelona Spain Banco Sangre & Tejidos Aragon Zaragoza Spain Banco Sangre Extremadura Merida Spain Fundacio Banc Sang & Teixits Illes Balears Inst Invest Sanitaria Illes Balears Palma De Mallorca Spain Banco Sangre & Tejidos Navarra Pamplona Spain Hosp Nostra Senyora de Meritxell Escaldes Engordany Andorra Banco Sangre & Tejidos Santander Spain Maternal & Child Hlth & Dev Network II SAMID II Madrid Spain

BACKGROUNDThe need for high-cellular-content cord blood units (CBUs) for allogenic transplantation is evident to improve clinical outcomes. In our environment and with current donation programs, very few collected units meet suggested clinical thresholds, making collection programs highly inefficient. To increase the clinical conversion rate, we have assessed factors influencing the cellular content of the cord blood collection and established the estimated fetal weight percentile (EFWp) as a tool to predict which deliveries will obtain higher cellular counts. STUDY DESIGN AND METHODSWe conducted a retrospective analysis of 11,349 collected CBUs. An analysis of diagnostic efficiency (receiver operating characteristic [ROC] curve) was performed to establish the cutoffs of several obstetric and perinatal variables from which we would obtain more than 1500x10(6) total nucleated cells and 4x10(6) CD34 cells. We then calculated the optimal EFWp cutoff to increase efficiency. RESULTSIn the univariate analysis, factors positively and significantly associated were a greater neonatal and placental weight and longer weeks of gestation. In the multivariate analysis only neonatal and placental weight remain significant (p<0.001). The ROC curve analysis showed that the optimal EFWp cutoff is 60, which has the maximum area under the curve. Applying this, donations meeting clinical cellular numbers will increase more than 30% with respect to not using any threshold. CONCLUSIONThe EFWp predicts the quality of the collected CBUs and can be used to make a prenatal selection of the donors, therefore increasing the efficiency of umbilical cord blood collection programs.

关键词： CORD blood transplantation BLOOD collection HEALTH programs GESTATIONAL age CLINICAL trials

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Anterior iris-claw intraocular lens implantation for the management of nontraumatic ectopia lentis: long-term outcomes in a paediatric cohort

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ACTA OPHTHALMOLOGICA 2017年第2期95卷 170-174页

作者： Catala-Mora, Jaume cuadras, daniel Diaz-Cascajosa, Jesus Castany-Aregall, Marta Prat-Bartomeu, Joan Garcia-Arumi, Jose Hosp St Joan de Deu Barcelona Spain Ophthalmol Inst Pilar Barcelona Spain Univ Autonoma Barcelona Dept Surg Barcelona Spain Fundacio St Joan de Deu Advisory Serv Barcelona Spain Fundacio St Joan de Deu Stat Methodol Res Barcelona Spain Hosp Valle De Hebron Barcelona Spain

Purpose: To report the feasibility and long-term safety of lensectomy and iris-claw intraocular lens (IOL) implantation to treat children with severe ectopia lentis in a paediatric tertiary hospital. Methods: Prospective cohort study of 21 eyes from 12 patients with severe ectopia lentis and visual acuity < 20/63. All eyes underwent 23-gauge pars plana vitrectomy, lensectomy, iridectomy and Artisan IOL implantation in the anterior chamber with iris-claw enclavation via pars plana. Mean age at surgery was 8.0 +/- 5.3 yo (range 3-17 years). A full ophthalmologic examination including best-corrected visual acuity (BCVA), biomicroscopy, intraocular pressure (IOP) measurement, fundus evaluation and central endothelial cell count (cECC) was performed pretreatment, at 3 months' postsurgery, and every 6 months thereafter. Ultrasound biomicroscopy (UBM) was performed 12 months after surgery. Results: Mean follow-up was 39.3 +/- 13.0 months. Best-corrected visual acuity (BCVA) (mean +/- SD) improved from 0.91 +/- 0.29 logMar preoperatively to 0.18 +/- 0.23 logMar at final follow-up (p < 0.0001). Mean distance from the endothelium to the anterior IOL surface after surgery was 3.11 +/- 0.61 mm. Postsurgically, cECC loss was 5.04% +/- 9.58% with an annual cECC loss rate of 3.16% +/- 4.46%. One patient developed IOL dislocation and retinal detachment after severe ocular contusion requiring vitrectomy, IOL refixation and gas tamponade. Another patient developed cystoid macular oedema, managed with intravitreal dexamethasone. Conclusion: This technique is both feasible and effective to manage severe ectopia lentis in children. Lifetime ophthalmic follow-up including cECC measurement, IOL position monitoring and fundus examination is mandatory in these patients.

关键词： corneal endothelial cells ectopia lentis intraocular lens lensectomy Marfan's syndrome paediatric aphakia

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Saltatory pattern vs Zigzag pattern on the CTG, and perinatal outcomes

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European Journal of Obstetrics & Gynecology and Reproductive Biology 2019年 234卷 e55-e55页

作者： Gracia-Perez-Bonfils, Anna cuadras, daniel Whelehan, Virginia Archer, Abigail Del Río, Maria Chandraharan, Edwin Hospital General de l’Hospitalet Hospitalet Barcelona Spain Hospital Quiron Barcelona Spain Sant Joan de Deu Research Foundation Statistical Service Esplugues de Llobregat Barcelona Spain St. George's University Hospitals NHS Foundation Trust London United Kingdom

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