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应用激光 2022年第5期42卷 109-119页

作者：崔缙郭华玲郑宾刘辉张钰龙邓祎昕贺旭文中北大学电气与控制工程学院山西太原030051

小口径金属圆柱体的缺陷检测是无损检测领域的一个难题。通过有限元方法对金属圆柱中横波传播特性以及与缺陷作用机理进行数值模拟。探究了横波的方向性变化、圆孔缺陷半径对横波传播影响、不同位置和不同长度的缺陷对横波传播的影响。... 详细信息

小口径金属圆柱体的缺陷检测是无损检测领域的一个难题。通过有限元方法对金属圆柱中横波传播特性以及与缺陷作用机理进行数值模拟。探究了横波的方向性变化、圆孔缺陷半径对横波传播影响、不同位置和不同长度的缺陷对横波传播的影响。研究表明横波在传播过程中主要能量范围由15°~36°变为20°~35°,提出了近似正三角形的传播路径并进行验证,发现横波到达表面后发生模态转换,一部分声波以略面纵波的速度沿表面传播;对于圆孔缺陷,圆孔半径在3.4~4.6mm范围内可通过幅值变化判断孔径信息,半径在4.6~5.8mm范围内可通过接收时间判断孔径信息;对于不同位置的矩形缺陷,当缺陷进入到横波主要能量范围内,C扫图中出现近似线性的高能量区域,探测角度随着缺陷位置增加而增大,此范围内的缺陷可通过反射信号的探测角度判断位置信息;对于不同长度的矩形缺陷,随着缺陷长度增加,透射波能量减弱并且探测角度减小,呈现出近似线性的能量分布,通过探测透射波到达外表面的角度可判断缺陷长度信息。提出了相应的传播路径和长度计算公式,计算结果得到的误差百分比控制在6.5%以内,验证了该缺陷长度检测方法的有效性。

关键词：横波柱状材料激光超声内部缺陷数值模拟

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Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

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NATURE COMMUNICATIONS 2021年第1期12卷 308页

作者： Yan, Zhengzheng Luo, Haihua Xie, Bingyao Tian, Tian Li, Shan Chen, Zhixia Liu, Jinghua Zhao, xuwen Zhang, Liyong deng, Yongqiang Billiar, Timothy R. Jiang, Yong Southern Med Univ State Key Lab Organ Failure Res Guangdong Prov Key Lab Prote Sch Basic Med SciDept Pathophysiol Guangzhou 510515 Peoples R China Univ Pittsburgh Sch Med Dept Surg Pittsburgh PA 15213 USA Southern Med Univ Nanfang Hosp Dept Anesthesiol Guangzhou 510515 Peoples R China

Accumulating evidence shows that RAGE has an important function in the pathogenesis of sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase cascades during septic shock are not clear. Here, we identify SLP76 as a binding partner for the cytosolic tail of RAGE both in vitro and in vivo and demonstrate that SLP76 binds RAGE through its sterile alpha motif (SAM) to mediate downstream signaling. Genetic deficiency of RAGE or SLP76 reduces AGE-induced phosphorylation of p38 MAPK, ERK1/2 and IKK alpha/beta, as well as cytokine release. Delivery of the SAM domain into macrophages via the TAT cell-penetrating peptide blocks proinflammatory cytokine production. Furthermore, administration of TAT-SAM attenuates inflammatory cytokine release and tissue damage in mice subjected to cecal ligation and puncture (CLP) and protects these mice from the lethality of sepsis. These findings reveal an important function for SLP76 in RAGE-mediated pro-inflammatory signaling and shed light on the development of SLP76-targeted therapeutics for sepsis.

关键词： Bacterial infection Cell signalling Monocytes and macrophages

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Strong positive allosteric cooperativity in ternary complexes based on hydrogen-bonded aromatic amide macrocycles

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CHEMICAL COMMUNICATIONS 2019年第33期55卷 4869-4872页

作者： Peng, Zhiyong Guo, xuwen Xu, Weitao Li, Jian deng, Pengchi Xiao, Xin Feng, Wen Yuan, Lihua Sichuan Univ Analyt & Testing Ctr Minist Educ Coll ChemKey Lab Radiat Phys & Technol Chengdu 610064 Sichuan Peoples R China Guizhou Univ Key Lab Macrocycl & Supramol Chem Guizhou Prov Guiyang 550025 Guizhou Peoples R China

Three new hydrogen-bonded aromatic amide macrocycles with eight residues were synthesized. The first single crystal structure of this class of larger macrocycles was obtained, which reveals a saddle-like conformation. Interestingly, in sharp contrast to previous negative cooperativity in binding paraquat with cyclo[6]aramide, strong positive allosteric cooperativity in ternary complexes was observed. This may open an avenue for the construction of mechanically interlocked molecules with these larger H-bonded macrocycles.

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A High-Performance n-Type Thermoelectric Polymer from C−H/C−H Oxidative Direct Arylation Polycondensation

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Angewandte Chemie 2023年第20期135卷

作者： Yibo Shi xuwen Zhang Tian Du Prof. Yang Han Prof. Yunfeng deng Prof. Yanhou Geng School of Materials Science and Engineering and Tianjin Key Laboratory of Molecular Optoelectronic Science Tianjin University and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) 300072 Tianjin P. R. China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University 350207 Binhai New City Fuzhou China

n-Type conjugated polymers (CPs) are crucial in the applications of organic electronics. Direct coupling of electron-deficient C−H monomer via selective C−H activation, namely C−H/C−H oxidative direct arylation polycondensation (Oxi-DArP), is an ideal approach toward such CPs. Herein, Oxi-DArP is firstly adopted to synthesize a high-performance n-type CP using a newly developed monomer, i.e., 3,6-di(thiazol-5-yl)-diketopyrrolopyrrole (Tz-5-DPP). Tz-5-DPP based homopolymer PTz - 5 - DPP with a molecular weight of 22 kDa has been synthesized via Oxi-DArP. After n-doping, PTz - 5 - DPP films exhibited electric conductivity values up to 8 S cm −1 and power factors ( PFs ) up to 106 μW m −1 K −2 . Notably, this PF value is the highest for n-type polymer thermoelectric materials to date. The Oxi-DArP synthesis and the excellent n-type performance of the polymer make this work an important step toward the straightforward and sustainable preparation of high-performance n-type polymer semiconductors.

关键词： Conjugated Polymer Diketopyrrolopyrrole Direct Arylation Polycondensation Electron Transport Organic Thermoelectrics

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妊娠期糖尿病围手术期血糖水平与产后出血量及新生儿血糖关系

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广州医科大学学报 2022年第2期50卷 35-39页

作者：郭蓝蓝张学真狄小丹汤栩文邓雯锋广州市妇女儿童医疗中心广东广州510623

目的:探讨妊娠期糖尿病孕妇围手术期血糖水平与产后出血量及新生儿血糖的关系。方法:前瞻性收集2020年4月⁃2021年4月在广州市妇女儿童医疗中心行剖宫产妊娠期糖尿病孕妇175例,按照孕期血糖控制状况分为控制良好的研究A组和控制不佳的研... 详细信息

目的:探讨妊娠期糖尿病孕妇围手术期血糖水平与产后出血量及新生儿血糖的关系。方法:前瞻性收集2020年4月⁃2021年4月在广州市妇女儿童医疗中心行剖宫产妊娠期糖尿病孕妇175例,按照孕期血糖控制状况分为控制良好的研究A组和控制不佳的研究B组;将同时期剖宫产的非糖尿病孕妇设为对照C组,分析3组孕妇围手术期血糖与产后出血量及新生儿血糖关系。结果:3组的术后2 h血糖、术后24 h出血量、新生儿血糖均有统计学差异(P<0.05),术后2 h血糖为A组(5.1±1.0)mmol/L,B组(5.7±1.3)mmol/L,C组(5.5±1.0)mmol/L;24 h出血量为A组440(410,500)mL,B组480(404,578)mL,C组420(370,506)mL;新生儿血糖为A组(3.1±0.8)mmol/L,B组(2.8±0.8)mmol/L,C组(3.7±0.9)mmol/L。术后24 h出血量与术后2 h血糖相关(P<0.05)。通过曲线拟合分析得出妊娠期糖尿病术后血糖的理想范围为4.4~6.7 mmol/L。结论:做好妊娠糖尿病孕妇孕期及围手术期血糖的科学管理,可能减少产后出血量及降低新生儿低血糖发生率。

关键词：妊娠糖尿病围手术期血糖产后出血量新生儿血糖

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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds

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JOURNAL OF IMMUNOLOGY RESEARCH 2018年第1期2018卷 1-13页

作者： deng, Zhuo Wang, Jing Lyu, Wentao Wieneke, xuwen Matts, Robert Ma, Xi Zhang, Guolong Oklahoma State Univ Dept Anim & Food Sci Stillwater OK 74078 USA Beijing Acad Agr & Forestry Sci Inst Anim Husb & Vet Med Beijing 100097 Peoples R China Oklahoma State Univ Dept Biochem & Mol Biol Stillwater OK 74078 USA China Agr Univ State Key Lab Anim Nutr Beijing 100193 Peoples R China Oklahoma State Univ Ctr Vet Hlth Sci Dept Physiol Sci Stillwater OK 74078 USA

Novel alternatives to antibiotics are needed for the swine industry, given increasing restrictions on subtherapeutic use of antibiotics. Augmenting the synthesis of endogenous host defense peptides (HDPs) has emerged as a promising antibiotic-alternative approach to disease control and prevention. To facilitate the identification of HDP inducers for swine use, we developed a stable luciferase reporter cell line, IPEC-J2/PBD3-luc, through permanent integration of a luciferase reporter gene driven by a 1.1 kb porcine beta-defensin 3 (PBD3) gene promoter in porcine IPEC-J2 intestinal epithelial cells. Such a stable reporter cell line was employed in a high-throughput screening of 148 epigenetic compounds and 584 natural products, resulting in the identification of 41 unique hits with a minimum strictly standardized mean difference (SSMD) value of 3.0. Among them, 13 compounds were further confirmed to give at least a 5-fold increase in the luciferase activity in the stable reporter cell line, with 12 being histone deacetylase (HDAC) inhibitors. Eight compounds were subsequently observed to be comparable to sodium butyrate in inducing PBD3 mRNA expression in parental IPEC-J2 cells in the low micromolar range. Six HDAC inhibitors including suberoylanilide hydroxamine (SAHA), HC toxin, apicidin, panobinostat, SB939, and LAQ824 were additionally found to be highly effective HDP inducers in a porcine 3D4/31 macrophage cell line. Besides PBD3, other HDP genes such as PBD2 and cathelicidins (PG1-5) were concentration-dependently induced by those compounds in both IPEC-J2 and 3D4/31 cells. Furthermore, the antibacterial activities of 3D4/31 cells were augmented following 24 h exposure to HDAC inhibitors. In conclusion, a cell-based high-throughput screening assay was developed for the discovery of porcine HDP inducers, and newly identified HDP-inducing compounds may have potential to be developed as alternatives to antibiotics for applications in swine and possibly other anima

关键词： ANTIBIOTICS PEPTIDES LUCIFERASES DEFENSINS EPITHELIAL cells HISTONE deacetylase inhibitors HIGH throughput screening (Drug development)

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CEPC Technical Design Report - Accelerator (v2)

arXiv

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arXiv 2023年

作者： Abdallah, Waleed De Freitas, Tiago Carlos Adorno Afanaciev, Konstantin Ahmad, Shakeel Ahmed, Ijaz Ai, Xiaocong Aleem, Abid Altmannshofer, Wolfgang Alves, Fabio An, Weiming An, Rui Anderle, Daniele Paolo Antusch, Stefan Arai, Yasuo Arbuzov, Andrej Arhrib, Abdesslam Ashry, Mustafa Bai, Sha Bai, Yu Bai, Yang Bairathi, Vipul Balazs, Csaba Bambade, Philip Ban, Yong Bandyopadhyay, Triparno Bao, Shou-Shan Barber, Desmond P. Bat, Ayse Batozskaya, Varvara Behera, Subash Chandra Belyaev, Alexander Bertucci, Michele Bi, Xiao-Jun Bi, Yuanjie Bian, Tianjian Bianchi, Fabrizio Biekötter, Thomas Biglietti, Michela Bilanishvili, Shalva Binglin, deng Bodrov, Denis Bogomyagkov, Anton Bondarenko, Serge Boogert, Stewart Boonekamp, Maarten Borri, Marcello Bosotti, Angelo Boudry, Vincent Boukidi, Mohammed Boyko, Igor Bozovic, Ivanka Bozzi, Giuseppe Brient, Jean-Claude Budzinskaya, Anastasiia Bukhari, Masroor Bytev, Vladimir Cacciapaglia, Giacomo Cai, Hua Cai, Wenyong Cai, Wujun Cai, Yijian Cai, Yizhou Cai, Yuchen Cai, Haiying Cai, Huacheng Calibbi, Lorenzo Cang, Junsong Cao, Guofu Cao, Jianshe Chance, Antoine Chang, Xuejun Chang, Yue Chang, Zhe Chang, Xinyuan Chao, Wei Chatrabhuti, Auttakit Che, Yimin Che, Yuzhi Chen, Bin Chen, Danping Chen, Fuqing Chen, Fusan Chen, Gang Chen, Guoming Chen, Hua-Xing Chen, Huirun Chen, Jinhui Chen, Ji-Yuan Chen, Kai Chen, Mali Chen, Mingjun Chen, Mingshui Chen, Ning Chen, Shanhong Chen, Shanzhen Chen, Shao-Long Chen, Shaomin Chen, Shiqiang Chen, Tianlu Chen, Wei Chen, Xiang Chen, Xiaoyu Chen, Xin Chen, Xun Chen, Xurong Chen, Ye Chen, Ying Chen, Yukai Chen, Zelin Chen, Zilin Chen, Boping Chen, Chunhui Cheng, Hok Chuen Cheng, Huajie Cheng, Shan Cheng, Tongguang Chi, Yunlong Chimenti, Pietro Chiu, Wen Han Cho, Guk Chu, Ming-Chung Chu, Xiaotong Chu, Ziliang Coloretti, Guglielmo Crivellin, Andreas Cui, Hanhua Cui, Xiaohao Cui, Zhaoyuan D'Anzi, Brunella Dai, Ling-Yun Dai, Xinchen Dai, xuwen De Maria, Antonio De Filippis, Nicola De La Taille, Christophe De Mori, Francesca De Sio, Chiara Del Core, Elisa deng, S Agh University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Anhui University Anhui Hefei China Applied Physics Department Federal Urdu University of Arts Science and Technology Islamabad Pakistan Banaras Hindu University Institute of Science Varanasi India Bandirma Onyedi Eylul University Bandirma Turkey Beihang University Beijing China Beijing Computational Science Research Center Beijing China Beijing Conveyi Ltd Beijing China Beijing Glass Research Institute Co. Ltd Beijing China Beijing Institute of Technology Beijing China Beijing Normal University Beijing China Brown University ProvidenceRI United States Budker Institute of Nuclear Physics Novosibirsk Russia Cadi Ayyad University Laboratory of Fundamental and Applied Physics Polydisciplinary Faculty Marrakech Morocco Cairo University Giza Egypt Center for Theory and Computation National Tsing Hua University Hsinchu Taiwan Central China Normal University Hubei Wuhan China Central South University Hunan Changsha China Centro de Fisica Teorica de Particulas Universidade Tecnica de Lisboa Lisboa Portugal Chengdu KaitengSifang Digital Radio & Tv Equipment Co. Ltd Sichuan Chengdu China China Academy of Engineering Physics Sichuan Mianyang China China Building Materials Academy Beijing China China Center of Advanced Science and Technology Beijing China China Institute of Atomic Energy Beijing China China Jiliang University Zhejiang Hangzhou China China Nuclear Instrument CO. Ltd Beijing China China University of Geosciences Beijing China China University of Geosciences Hubei Wuhan China China University of Mining and Technology Jiangsu Xuzhou China China West Normal University Sichuan Nanchong China Chongqing University Department of Physics Chongqing China Chulalongkorn University Bangkok Thailand City University of Hong Kong Department of Physics Hong Kong Cockcroft Institute Daresbury United Kingdom Cornell University IthacaNY

The Circular Electron Positron Collider (CEPC) is a large scientific projectinitiated and hosted by China, fostered through extensive collaboration withinternational partners. The complex comprises four accelerators: a 30 GeVLinac, a 1.1 GeV Damping Ring, a Booster capable of achieving energies up to180 GeV, and a Collider operating at varying energy modes (Z, W, H, and ttbar).The Linac and Damping Ring are situated on the surface, while the Booster andCollider are housed in a 100 km circumference underground tunnel, strategicallyaccommodating future expansion with provisions for a Super Proton ProtonCollider (SPPC). The CEPC primarily serves as a Higgs factory. In its baselinedesign with synchrotron radiation (SR) power of 30 MW per beam, it can achievea luminosity of 5e34 /cm^2/s^1, resulting in an integrated luminosity of 13 /abfor two interaction points over a decade, producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC\'s capability togenerate 4.3 million Higgs bosons, facilitating precise measurements of Higgscoupling at sub-percent levels, exceeding the precision expected from theHL-LHC by an order of magnitude. This Technical Design Report (TDR) follows thePreliminary Conceptual Design Report (Pre-CDR, 2015) and the Conceptual DesignReport (CDR, 2018), comprehensively detailing the machine\'s layout andperformance, physical design and analysis, technical systems design, R&D andprototyping efforts, and associated civil engineering aspects. Additionally, itincludes a cost estimate and a preliminary construction timeline, establishinga framework for forthcoming engineering design phase and site selectionprocedures. Construction is anticipated to begin around 2027-2028, pendinggovernment approval, with an estimated duration of 8 years. The commencement ofexperiments could potentially initiate in the mid-2030s. © 2023, CC BY-NC-SA.

关键词： Synchrotron radiation

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热应激对银鲫生化指标和HSP70 mRNA表达的影响

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渔业科学进展 2018年第6期39卷 65-71页

作者：周朝伟胡续雯雷骆刘晓庆任胜杰杨旻珉曹高祥陈国梁邓星星李岩李路宽西南大学动物科学学院水产系重庆402460

本研究旨在探讨热应激对银鲫(Carassius auratus gibelio)生化指标及肝脏HSP70 mRNA表达的影响,选取平均体重为(72.8±10.1) g的银鲫,分别在热应激前(25℃,对照组)、热应激后(32℃,0 h、2 h、6 h、10 h)和恢复适温后6 h (25℃,恢复... 详细信息

本研究旨在探讨热应激对银鲫(Carassius auratus gibelio)生化指标及肝脏HSP70 mRNA表达的影响,选取平均体重为(72.8±10.1) g的银鲫,分别在热应激前(25℃,对照组)、热应激后(32℃,0 h、2 h、6 h、10 h)和恢复适温后6 h (25℃,恢复组)的条件下,测定机体血浆乳酸(LD)、血浆葡萄糖(Glu)、肝糖原(Gly)、己糖激酶(HK)、丙酮酸激酶(PK)和肝脏HSP70 m RNA表达量变化。研究表明,实验组乳酸含量从热应激开始至恢复期,差异始终不显著(P>0.05);实验组血浆葡萄糖水平在热应激后0 h、2 h、6 h,极显著高于对照组(P<0.01);实验组肝糖原水平在热应激0 h时,极显著高于对照组(P<0.01),其余时间点差异不显著(P>0.05);己糖激酶活力在热应激后2 h,显著高于对照组(P>0.05);丙酮酸激酶活力在热应激后6h,极显著高于对照组(P<0.01);热应激后2h,肝脏中HSP70 m RNA表达量达到最高(P<0.01),恢复至适温后,表达量与应激前无差异(P>0.05)。本研究为进一步探究银鲫的高温应激作用机制及调控机理提供参考数据,同时,也为银鲫养殖和育种等生产实践提供相应参考依据。

关键词：银鲫热应激生化指标 HSP70

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广西水牛唾液和血清生殖激素在发情周期的变化规律及相关性分析

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中国牛业科学 2018年第4期44卷 17-20页

作者：贾银海莫志辉潘能庆徐文文蒋世强邓辉杨秀荣蒋和生广西大学动物科技学院广西南宁530001 广西巴弗罗牧业投资有限公司广西南宁530003

[目的]对广西水牛发情周期唾液和血液中雌激素(E2)和孕酮(P4)的浓度变化规律及相关性进行了分析,为进一步探讨水牛发情规律来指导生产提供依据。[方法]采用酶联免疫分析方法(ELISA)测定发情母水牛血液和唾液中E2(雌二醇)和P4(孕酮)的浓... 详细信息

[目的]对广西水牛发情周期唾液和血液中雌激素(E2)和孕酮(P4)的浓度变化规律及相关性进行了分析,为进一步探讨水牛发情规律来指导生产提供依据。[方法]采用酶联免疫分析方法(ELISA)测定发情母水牛血液和唾液中E2(雌二醇)和P4(孕酮)的浓度变化,并对血液和唾液的激素变化规律进行了相关性分析。[结果]广西水牛血液和唾液中的E2和P4呈波动性变化,结果表明,发情前期,唾液中P4浓度一直维持在6.57.1ng/mL,第13天达到11.09ng/mL以上,随后快速下降。唾液中E2浓度在发情前期第35天出现一个峰值178.528pg/mL,在1417d唾液中E2浓度显著升高,出现第二个峰值达到120.57pg/mL。唾液E2和P4浓度的变化趋势和血清E2和P4浓度的变化趋势基本一致,相关性较好。母水牛唾液和血清样品的P4浓度相关性显著(R=0.4080;P<0.05),母水牛唾液和血清标本的E2浓度相关性显著(R=0.5113;P<0.05)母水牛唾液E2和P4浓度相关性非常显著(R=0.7754;P<0.01)。[结论]唾液和血液中的这两种激素水平起伏变化基本趋于一致,其相关性显著,可以作为监测水牛发情及预测排卵的可靠指标之一。

关键词：水牛唾液血清生殖激素相关性

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue deng Wei-Tian deng Zhi deng Ziyan deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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