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地质通报 2024年第4期43卷 489-502页

作者：秦绪文戴意蕴张耀阳肖都方慧裴发根何大双冯斌中国地质调查局北京100037 中国地质科学院地球物理地球化学勘查研究所河北廊坊065000 国家现代地质勘查技术研究中心河北廊坊065000 自然资源部地球物理电磁法探测技术重点实验室河北廊坊065000

阵列式大地电磁测深是区域地球物理调查的重点发展方向之一,对标国外先进水平和国家社会的基础性需求,中国阵列式大地电磁测深工作程度依然较低,缺乏整体规划,开展全国性观测计划亟需提上日程。系统总结了当前区域地球物理学的发展趋势... 详细信息

阵列式大地电磁测深是区域地球物理调查的重点发展方向之一,对标国外先进水平和国家社会的基础性需求,中国阵列式大地电磁测深工作程度依然较低,缺乏整体规划,开展全国性观测计划亟需提上日程。系统总结了当前区域地球物理学的发展趋势及国内外大地电磁网建设现状,提出了合作共建陆域多层级大地电磁基础网和大数据中心的顶层设计和规划布局,并对中国大地电磁基础网未来的重点发展方向进行了展望和思考。相关工作的顺利开展将为中国的区域地球物理调查拓展一项新属性参数,推动构建物性地球、结构地球和地球物理场四维模型,进而变革区域地球物理研究范式和工作模式,支撑中国深地探测走向世界前列。

关键词：区域地球物理大地电磁测深深地探测基础网建设观测监测体系数据库

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Process knowledge graph modeling techniques and application methods for ship heterogeneous models

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SCIENTIFIC REPORTS 2022年第1期12卷 1-14页

作者： Dong, Jianwei Jing, xuwen Lu, Xiang Liu, Jinfeng Li, Haipeng Cao, Xuwu du, Chenxiao Li, Jun Li, Lei Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212100 Jiangsu Peoples R China China Merchants Cruise Shipbldg Co LTD Nantong 226000 Peoples R China

In the process design and reuse of marine component products, there are a lot of heterogeneous models, causing the problem that the process knowledge and process design experience contained in them are difficult to express and reuse. Therefore, a process knowledge representation model for ship heterogeneous model is proposed in this paper. Firstly, the multi-element process knowledge graph is constructed, and the heterogeneous ship model is described in a unified way. Then, the multi-strategy ontology mapping method is applied, and the semantic expression between the process knowledge graph and the entity model is realized. Finally, by obtaining implicit semantics based on case-based reasoning and checking the similarity of the matching results, the case knowledge reuse is achieved, to achieve rapid design of the process. This method provides reliable technical support for the design of ship component assembly and welding process, greatly shortens the design cycle, and improves the working efficiency. In addition, taking the double-deck bottom segment of a ship as an example, the process knowledge map of the heterogeneous model is constructed to realize the rapid design of ship process, which shows that the method can effectively acquire the process knowledge in the design case and improve the efficiency and intelligence of knowledge reuse in the process design of the heterogeneous model of a ship.

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Advances in Multimodal Imaging Techniques for Evaluating and Predicting the Efficacy of Immunotherapy for NSCLC

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Cancer Management and Research 2025年 17卷 1073-1086页

作者： Jingyi Liu Mei Xie Jing Shen Jie Yao xuwen Lin Xinyu Bao Xin Zhang Yiran Liang Yun Yang Gege Jiang Ximeng Diao Wenya Han Hai du Xinying Xue Jianlin Wu Department of Radiology Affiliated Zhongshan Hospital of Dalian University Dalian 116001 People’s Republic of China Department of Respiratory and Critical Care Emergency and Critical Care Medical Center Beijing Shijitan Hospital Capital Medical University Beijing 100038 People’s Republic of China Department of Respiratory and Critical Care Affiliated Hospital of Shandong Second Medical University Weifang People’s Republic of China Department of Respiratory and Critical Care Medicine Taihe Hospital Hubei University of Medicine Shiyan 442000 People’s Republic of China Ordos Central Hospital Ordos City 017000 People’s Republic of China Department of Respiratory and Critical Care Xuanwu Hospital Capital Medical University Beijing 100038 People’s Republic of China

Immunotherapy has emerged as a transformative treatment for non-small cell lung cancer (NSCLC), yet its clinical benefits remain variable among patients. Early and accurate evaluation of treatment response is critical to guide therapeutic adjustments and improve outcomes. This review synthesizes recent advancements in multimodal imaging techniques—computed tomography (CT), positron emission tomography (PET)/CT, magnetic resonance imaging (MRI), and radiomics—for evaluating and predicting immunotherapy efficacy in NSCLC. We analyze the strengths and limitations of conventional morphological criteria (eg, RECIST, iRECIST) and highlight emerging quantitative biomarkers, including CT texture analysis, metabolic parameters (MTV, TLG), and diffusion-weighted MRI metrics. Notably, radiomics demonstrates promise in decoding tumor heterogeneity, PD-L1 expression, and immune microenvironment features, while immuno-PET probes targeting immune checkpoints offer novel insights into immune activity in vivo. Challenges such as pseudo-progression, nodal immune flare, and discrepancies between imaging responses and pathological responses are critically discussed. By integrating morphological, metabolic, and microenvironmental data, multimodal imaging enhances precision in patient stratification and therapeutic monitoring. Future research should prioritize multicenter, AI-driven radiomics validation and targeted tracer development to optimize NSCLC immunotherapy management. This review provides clinicians and researchers with new directions for utilizing multimodal imaging techniques in developing personalized treatment strategies.

关键词： non-small cell lung cancer immunotherapy efficacy prediction CT PET MRI

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Numerical Prediction of the Migrating Diurnal Tide Total Variability in the Mesosphere and Lower Thermosphere

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JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS 2021年第11期126卷 e2021JA029588-e2021JA029588页

作者： Vitharana, Ashan du, Jian Zhu, xuwen Oberheide, Jens Ward, William E. Univ Louisville Dept Phys & Astron Louisville KY 40292 USA Univ Alabama Dept Informat Syst Stat & Management Sci Tuscaloosa AL USA Clemson Univ Dept Phys & Astron Clemson SC 29634 USA Univ New Brunswick Dept Phys Fredericton NB Canada

We present a forecast model for the total variability of DW1 and study its prediction accuracy against the actual variability from the extended Canadian Middle Atmospheric Model (eCMAM) simulations and Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) observations in the mesosphere and lower thermosphere region. To account for the long-term variability (periods >30 days), we fit the data with a multi-linear regression model that contains the solar cycle, El Nino Southern Oscillation, quasi-biennial oscillation, and the seasonal harmonics at 12, 6, 4, and 3 months. The fitting coefficients/amplitudes from each deterministic variability are examined between the eCMAM and SABER. To predict the short-term tidal variability, we adopted an auto-regression (AR) model from Vitharana et al. (2019, ). The forecast model is a combination of the multi-linear regression model and the AR model. The forecast model can predict the total tidal variability of DW1 with high accuracy. The prediction accuracy (correlation coefficient) ranges between 0.81 and 0.98 (average 0.93) for eCMAM and 0.76 and 0.92 (average 0.82) for SABER. The prediction accuracy for the short-term tidal variability is very high for both eCMAM and SABER and shows little variation with correlation coefficients at similar to 0.95. The prediction accuracy for the total tidal variability follows that for the long-term tidal variability. The discrepancy between the forecast model and the actual total tidal variability is mainly because the forecast model cannot capture all the long-term tidal variability (periods >30 days). Besides the well-known periods for long-term variability, the other periods change on a year-to-year basis.

关键词： atmospheric tide short term tidal variability tidal variability migrating diurnal tide tidal weather

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Hyponatremia as a Specific Marker of Perforation in Infants with Necrotizing Enterocolitis

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INDIAN JOURNAL OF PEDIATRICS 2022年第7期89卷 725-725页

作者： Li, Yifan du, Xiaobin Zhao, xuwen Wang, Jinhu Yang, Fujiang Zhang, Ao Dai, Chunjuan Hu, Bo Tianjin Childrens Hosp Neonatal Surg Dept Tianjin 300074 Peoples R China

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WRKY15 Suppresses Tracheary Element Differentiation Upstream of VND7 during Xylem Formation

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PLANT CELL 2020年第7期32卷 2307-2324页

作者： Ge, Shating Han, Xiaofei Xu, xuwen Shao, Yiming Zhu, Qiankun Liu, Yidong du, Juan Xu, Juan Zhang, Shuqun Zhejiang Univ Coll Life Sci State Key Lab Plant Physiol & Biochem Hangzhou 310058 Zhejiang Peoples R China Nanjing Agr Univ Coll Plant Protect Nanjing 210095 Jiangsu Peoples R China Univ Missouri Div Biochem Columbia MO 65211 USA

Arabidopsis WRKY15 functions upstream of VND7, an important regulator of tracheary element (TE) differentiation, to suppress TE formation during plant vascular development. Formation of the vascular cylinder, a structure critical to water and nutrient transport in higher plants, is highly regulated. Here we identify WRKY15 as an important regulator that suppresses tracheary element (TE) differentiation in Arabidopsis (Arabidopsis thaliana). Overexpression of WRKY15 resulted in discontinuous protoxylem vessel files and TEs with reduced spiral wall thickening/lignification. Expression of a dominant-negative WRKY15 variant, WRKY15-EAR, led to extra protoxylem vessels and ectopic TEs with increased spiral wall thickening/lignification. Ectopic TE formation in the root cortex and hypocotyl/leaf epidermis reveals that the suppression of WRKY15 is sufficient to trigger the transdifferentiation of other types of cells to TEs. Expression profiling, RT-qPCR, and reporter analyses revealed that WRKY15 suppresses the expression of VASCULAR-RELATED NAC DOMAIN7 (VND7), a master transcriptional regulator that promotes TE differentiation. We propose that WRKY15 negatively regulates VND7 expression indirectly based on (1) the absence of a W-box in the promoter of VND7 and (2) the observation that WRKY15 and VND7 are expressed in different cells in the vascular cylinder, with WRKY15 expressed in the procambial cells and VND7 in the protoxylem poles of procambium and differentiating TEs. Future research is needed to reveal the details underlying the interaction of WRKY15 and VND7 in plant vascular development.

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不同鼻胃管喂养模式对食管闭锁术后恢复的影响

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中华小儿外科杂志 2023年第11期44卷 968-974页

作者：杨福江胡博戴春娟马林赵绪稳王金虎杜晓斌天津市儿童医院(天津大学儿童医院)新生儿外科天津300074

目的探讨食管闭锁术后经鼻胃管进行高能量密度的早期肠内营养模式对术后恢复的影响。方法收集2016年1月至2022年12月在天津市儿童医院一期食管吻合手术治疗的Ⅲb型先天性食管闭锁36例患儿的资料,所有患儿均于术后早期经鼻胃管进行肠内营... 详细信息

目的探讨食管闭锁术后经鼻胃管进行高能量密度的早期肠内营养模式对术后恢复的影响。方法收集2016年1月至2022年12月在天津市儿童医院一期食管吻合手术治疗的Ⅲb型先天性食管闭锁36例患儿的资料,所有患儿均于术后早期经鼻胃管进行肠内营养(enteral nutrition,EN)。根据所使用配方奶能量密度分为两组:一组为早期微量EN组17例,其中男11例,女6例,胎龄为(38.8±1.3)周,出生体重为(2.6±0.3)kg,术后早期给予深度水解配方奶微量喂养;另一组早期强化EN组19例,其中男13例,女6例,胎龄为(38.5±1.8)周,出生体重为(2.8±0.4)kg,术后早期给予高能量密度深度水解配方奶喂养。两组均根据胃肠道耐受情况,逐步增加肠内营养量,最终过渡至完全经口喂养。采用IBM SPSS Statistics 26软件处理所有数据,符合正态分布的定量资料用独立样本t检验,非正态分布用非参数检验。结果两组在术前一般指标、手术方式、喂养不耐受、术后首次排便时间、术后14 d血清前白蛋白水平及术后1个月年龄别体重Z值(weight for age z score,WAZ)方面差异无统计学意义(P>0.05);早期强化EN组术后7 d血清前白蛋白水平、日均体重增长、达到全肠内营养时间、住院时长、住院总费用方面明显优于早期微量EN组,差异均有统计学意义(P<0.05)。结论新生儿食管闭锁术后早期高能量密度的肠内营养有助于改善围手术期营养状态,缩短住院时间及减少医疗花费,值得临床推广。

关键词：食管闭锁肠内营养高能量密度奶

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Process Knowledge Graph Modeling Techniques and Application Methods for Ship Heterogeneous Models

Research Square

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Research Square 2021年

作者： Liu, Jinfeng Dong, Jianwei Jing, xuwen Cao, Xuwu du, Chenxiao Li, Lei School of Mechanical Engineering Jiangsu University of Science and Technology Zhenjiang212100 China

In the process design and reuse of marine component products, there are a lot of heterogeneous models, causing the problem that the process knowledge and process design experience contained in them are difficult to express and reuse. Therefore, a process knowledge representation model for ship heterogeneous model is proposed in this paper. Firstly, the multi-element process knowledge graph is constructed, and the heterogeneous ship model is described in a unified way. Then, the multi-strategy ontology mapping method is applied, and the semantic expression between the process knowledge graph and the entity model is realized. Finally, by obtaining implicit semantics based on case-based reasoning and checking the similarity of the matching results, the case knowledge reuse is achieved, to achieve rapid design of the process. This method provides reliable technical support for the design of ship component assembly and welding process, greatly shortens the design cycle, and improves the working efficiency. In addition, a case study of the test model is carried out to verify the feasibility and efficiency of the proposed method. © 2021, CC BY.

关键词： Case based reasoning

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股骨颈动力交叉钉系统与空心螺钉固定治疗65~75岁年龄段患者股骨颈骨折的效果比较

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中华创伤骨科杂志 2024年第3期26卷 228-233页

作者：张成栋王开李绪文王天瑞刘国明杜现法叶发刚扈延龄青岛大学附属医院创伤外科青岛266000

目的比较股骨颈动力交叉钉系统(FNS)与空心螺钉(CCS)固定治疗65~75岁年龄段患者股骨颈骨折的临床效果。方法回顾性分析2015年1月至2022年9月期间青岛大学附属医院创伤外科收治的39例65~75岁年龄段股骨颈骨折患者资料。按内固定方式不同... 详细信息

目的比较股骨颈动力交叉钉系统(FNS)与空心螺钉(CCS)固定治疗65~75岁年龄段患者股骨颈骨折的临床效果。方法回顾性分析2015年1月至2022年9月期间青岛大学附属医院创伤外科收治的39例65~75岁年龄段股骨颈骨折患者资料。按内固定方式不同分为两组:FNS组18例,男8例,女10例;年龄(71.1±2.8)岁;采用FNS固定治疗。CCS组21例,男7例,女14例;年龄(70.1±2.9)岁;采用CCS固定治疗。比较两组患者的术中透视次数、手术时间、术中出血量、住院费用、骨折愈合时间、内固定失败情况,以及术后1年髋关节Harris评分、颈干角变化、股骨颈短缩程度。结果两组患者术前一般资料及随访时间比较差异均无统计学意义(P>0.05),具有可比性。FNS组患者的术中透视次数[(15.1±2.3)次]显著少于CCS组患者[(19.5±3.5)次]、手术时间[(49.2±5.2) min]显著短于CCS组患者[(62.4±11.2)min],术中出血量[(74.2±15.6) mL]、住院费用[(39 928.7±1 438.3)元]显著多于CCS组患者[(53.1±17.3)mL、(23 527.9±2 126.3)元],差异均有统计学意义(P<0.05)。而两组患者的骨折愈合时间比较差异无统计学意义(P>0.05)。FNS组患者术后1年颈干角减小角度(2.65°±1.66°)、股骨颈短缩程度[(3.9±1.3)mm]均显著小于CCS组患者[4.18°±2.13°、(6.3±2.5)mm],髋关节Harris评分[(82.2±7.2)分]显著高于CCS组患者[(76.4±5.9)分],差异均有统计学意义(P<0.05)。FNS组和CCS组分别有1、4例患者发生内固定失败,差异无统计学意义(P>0.05)。结论与CCS比较,FNS固定治疗65~75岁年龄段患者股骨颈骨折的疗效更好,但也要考虑内固定失败的发生风险。

关键词：股骨颈骨折骨折固定术,内骨钉股骨颈动力交叉钉系统老年人

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全肠无神经节细胞症合并新的 SOX10突变1例

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临床小儿外科杂志 2025年第4期24卷 386-388页

作者：张骜戴春娟赵绪稳王金虎杜晓斌杨福江胡博天津市儿童医院新生儿外科天津

全肠无神经节细胞症是先天性巨结肠中十分罕见的类型, 其临床表现不典型, 诊疗上存在一定困难。SOX10基因突变被认为与先天性巨结肠症有关。本文报道1例合并新的SOX10突变的全肠无神经节细胞症患儿, 以提高临床对此罕见疾病的认识。

关键词：先天性巨结肠全肠无神经节细胞症 SOX10

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