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Estima.e of circRNa. a.d microRNa. synergies on clinica. a.va.ce of psoria.is

Journa. of Immunoa.sa. a.d Immunochemistry 2025年第2期46卷 147-168页

作者： Sa.eh, a.a.y a. Ta.el, Sa.a. I. Sheha.a. Wa.a. a. el-masry, eman a. a.d-elha.iz, Huda.I. elhelba.y, Moha.med G. el-Na.da.y, Sherin S. Medical Biochemistry and Molecular Biology Department Faculty of Medicine Menoufia University Al Minufiyah Egypt Medical Surgical Nursing Department College of Nursing Taibah University KSA Medina Saudi Arabia Medical Biochemistry Unit College of Medicine Albaha University Albaha Saudi Arabia Dermatology and Andrology & STDs Department Faculty of Medicine Menoufia University Al Minufiyah Egypt Department of Medical Microbiology and Immunology Faculty of Medicine Menoufia University Al Minufiya Egypt Microbiology and Immunology Unit Department of Pathology College of Medicine Jouf University Sakaka Saudi Arabia Clinical Pharmacology Department Faculty of Medicine Menoufia University Al Minufiyah Egypt Clinical Pathology Department Faculty of Medicine Menoufia University Al Minufiyah Egypt

Ba.kground: Noncoding RNa. ha.e recently proven their contributing role in the pa.hogenesis of numerous disea.es. The etiology of psoria.is is still not well defined, a.d genetic a.d environmenta. fa.tors a.e bla.ed. We mea.t to explore the a.socia.ion of circRNa./microRNa. in psoria.is a.d inspect their correla.ion with the clinica. fea.ures of the disea.e. Design a.d Methods: This study included 166 subjects: 83 ca.es with pla.ue psoria.is a.d 83 a.e- a.d sex-ma.ched hea.thy persons a. the control group. The expression levels of circRNa.00102, circRNa.045272, circRNa.084764, a.d microRNa. -93,181, 16a. a.d 21 were estima.ed by qua.tita.ive rea.-time PCR. Results: CircRNa.045272 wa. ten-fold up-regula.ed, wherea. circRNa.084764 a.d circRNa.00102 were a.out two-fold downregula.ed in pa.ients vs. control. MicroRNa. −93 a.d 181 were significa.tly downregula.ed in pa.ients vs. control, wherea. microRNa.−16a.a.d 21 were up-regula.ed in pa.ients vs. control. CircRNa.045272 wa. positively correla.ed with microRNa.181, a.d circRNa.084764 wa. positively correla.ed with microRNa.93 a.d microRNa.181. CircRNa.045272 ha. the highest sensitivity (98.8%) a.d specificity (93.98%), a.d microRNa.16a.ha. sensitivity (98.80%) with specificity (93.98%). Conclusion: We a.sume tha. circRNa. ca. predict psoria.is occurrence a.d progression by sponging a.set of microRNa. a.d ca. modula.e severa. genes tha. disturb immune cell ba.a.ce a.d infla.ma.ory elements in psoria.is. © 2024 Ta.lor & Fra.cis Group, LLC.

关键词： CircRNa. immune microRNa. PCR psoria.is

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Cha.a.teriza.ion of a.tigen Esca.e Muta.ions in Chronic HBV-Infected Pa.ients in Upper Egypt

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INFECTION a.D DRUG RESISTa.CE 2021年 14卷 2419-2427页

作者： el-Mokhta., Moha.ed a. Hetta. Hela. F. Mekky, Moha.ed a. a.d el-Ka.eem, Doa. M. Ra.a.a., Moha.med Sa.a., Moha.med Moha.ed, Na.ed a. el-masry, eman a. a.el, Sa.a.Sa.ed, Ibra.im M. Assiut Univ Fac Med Dept Med Microbiol & Immunol Assiut 71515 Egypt Assiut Univ Hosp Dept Trop Med & Gastroenterol Assiut Egypt Assiut Univ Fac Med Dept Clin Pathol Assiut Egypt Al Azhar Univ Branch Fac Pharm Microbiol & Immunol Dept Assiut 71526 Egypt Port Said Univ Fac Pharm Microbiol & Immunol Dept Port Said 42526 Egypt Assiut Univ Fac Med Dept Med Biochem Assiut Egypt Assiut Univ Fac Med Dept Med Biochem Al Jouf Saudi Arabia Menoufia Univ Coll Med Dept Med Microbiol & Immunol Menoufia Egypt Al Azhar Univ Fac Med Dept Clin Pathol Assiut 71515 Egypt Univ Calif San Diego Sch Med Dept Pathol San Diego CA 92093 USA

Ba.kground: Muta.ions within the "a.quot; determina.t region (position 124-147) tha. is present in the ma.or hydrophilic region (MHR, position 99-160) of the hepa.itis B surfa.e a.tigen (HBsa.) a.e a.socia.ed wit... 详细信息

Ba.kground: Muta.ions within the "a. determina.t region (position 124-147) tha. is present in the ma.or hydrophilic region (MHR, position 99-160) of the hepa.itis B surfa.e a.tigen (HBsa.) a.e a.socia.ed with va.cine-esca.e, la.k of dia.nosis, a.d fa.lure to hepa.itis B immunoglobulin (HBIG) thera.y. Da.a.rega.ding the a.ino a.id cha.ges of "a. determina.t region of HBsa. a.e limited in Egypt. The preva.ence a.d muta.ions in this region a.ong chronic HBV (CHB)infected pa.ients in Upper Egypt a.e not known. Ma.eria. a.d Methods: Blood sa.ples were collected from HBsa.-positive CHB-infected pa.ients (n=123) a.mitted to a.siut University Hospita.s. Serum sa.ples were screened for HBsa., HBea., a.ti-HBs a.d a.ti-HBe a.tibodies using commercia.ly a.a.la.le elISa.kits. Vira. loa. wa. determined by qPCR. In a.dition, muta.iona. a.a.ysis wa. ca.ried out ta.geting the HBV surfa.e gene to determine the HBV genotype a.d va.cine esca.e muta.ions. Results: Sequencing a.a.ysis of HBV DNa.revea.ed tha. genotype D is the ma.or circula.ing type (81.3%), followed by genotype E (18.7%). a.a.ysis of the HBV genome revea.ed tha. 103/123 (83.7%) pa.ients showed wild-type sequences a.d 20/123 (16.3%) showed muta.ions in the HBsa. gene. Muta.ion in seventeen pa.ients (17/20, 85%) showed only one muta.ion, a.d three pa.ients showed two muta.ions (3/20, 15%) in the "a. determina.t region. The observed muta.ions were T115S (3/20, 15%), P120T/S (3/20, 15%), T126S (1/ 20, 5%), Q129R (2/20, 10%), M133T (2/20, 10%), S143L (5/20, 25%), D144E/a.(3/20, 15%), a.d G145R/a.(4/20, 20%). Muta.ions in the "a. determina.t region were detected in genotype D isola.es only. Conclusion: We described for the first time the preva.ence a.d cha.a.teriza.ion of va.cine esca.e muta.ts in CHB pa.ients in Upper Egypt. Muta.iona. a.a.ysis of the "a. determina.t region revea.ed the presence of a.wide spectrum of muta.ts in the circula.ing HBV isola.es tha. could be a.potentia. threa. to HBV dia.nosis, thera.y success, a

关键词： HBV "a. determina.t muta.iona. a.a.ysis va.cine esca.e Upper Egypt

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Morphologica. a.d meta.olomics impa.t of subletha. doses of na.ura. compounds a.d its na.oemulsions in Ba.illus cereus

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FOOD RESEa.CH INTERNa.IONa. 2021年 149卷 110658-110658页

作者： Pa.nossa. Jorge Pa.plona.Rocchetti, Ga.riele de a.reu Ma.tins, Heloisa.Helena.Pereira.Bezerra. Ja.son Diogo Ba.iha. Ga.er el-Sa.er el-masry, eman a. Cocconcelli, Pier Sa.dro Sa.tos, Cledir Lucini, Luigi Piccoli, Roberta.Hilsdorf Univ Fed Lavras Food Sci Dept Univ Campus BR-37200000 Lavras MG Brazil Univ Cattolica Sacro Cuore Dept Sustainable Food Proc Via Emilia Parmense 84 I-29122 Piacenza Italy Univ Fed Goias Inst Patol Trop & Saude Publ Dept Biociencias & Tecnol Setor Micol BR-7460505 Goiania Go Brazil Damanhour Univ Fac Vet Med Dept Pharmacol & Therapeut Damanhour 22511 Albeheira Egypt Jouf Univ Coll Med Dept Pathol Microbiol & Immunol Unit Al Jouf Sakaka Saudi Arabia Menoufia Univ Coll Med Dept Med Microbiol & Immunol Menoufia Egypt Univ La Frontera Dept Chem Sci & Nat Resources Temuco 4811230 Chile

Microbiologica. sa.ety in food industry a.e a.wa.s a.concern rega.ding subletha. tolera.ce in ba.teria.for common a.d na.ura. sa.itizers. Na.ura. ba.teriocins, such a. nisin (NIS), ma. nega.ively interfere in the efficiency of ma.or compounds of essentia. oils a.a.nst foodborne pa.hogenic ba.teria. However, na.oemulsioned forms increa.e the ba.tericida. potentia. of na.ura. compounds a.ting synergistica.ly. In this study, cinna.a.dehyde (CIN), citra. (CIT), a.d lina.ool (LIN) were eva.ua.ed independently, a.socia.ed with NIS, a.d in na.oemulsions (NEs) a.a.nst Ba.illus cereus using unta.geted-meta.olomics. Results revea.ed morphologica. cha.ges in the structure of B. cereus trea.ed with NEs of CIN a.d CIT, both NIS-a.socia.ed. In a.dition, sensibility tests a.d UHPLC-QTOF-MS a.a.yses indica.ed tha. NIS might rea.t together with CIT reducing the ba.tericida. efficiency, while the na.oemulsion of CIT effect wa. enha.ced by NIS in na.oemulsioned forms. This study highlights the importa.ce of prudent a.ministra.ion of na.ura. compounds a. a.timicrobia. a.ents to prevent subletha. tolera.ce in pa.hogenic ba.teria.

关键词： Subletha. stress Ma.or compounds Ba.teriocin Na.otechnology Meta.olomics

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In vitro a.ti-HIV a.d cytotoxic effects of pure compounds isola.ed from Croton ma.rosta.hyus Hochst. Ex Delile

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BMC COMPLEMENTa.Y MEDICINE a.D THERa.IES 2022年第1期22卷 159-159页

作者： Terefe, Ermia. Mergia.Oka.ebo, Fa.th a. Derese, Solomon La.ga., Moses K. Ma.-Cla.et, Edua.d a.ja.ba. Na.a.H. a.ka.ta.i, Sa.d Ba.iha. Ga.er el-Sa.er Ghosh, a.a.inda.el-masry, eman a. Muriuki, Joseph US Int Univ Africa Sch Pharm & Hlth Sci Dept Pharmacol & Pharmacognosy POB 14634-00800 Nairobi Kenya Univ Nairobi Coll Hlth Sci Dept Pharmacol & Pharmacognosy Nairobi Kenya Univ Nairobi Dept Chem Nairobi Kenya Royal Bot Gardens Richmond TW9 3AE Surrey England Princess Nourah Bint Abdulrahman Univ Coll Sci Dept Biol POB 84428 Riyadh 11671 Saudi Arabia King Saud Univ Coll Sci Dept Zool POB 2455 Riyadh 11451 Saudi Arabia Damanhour Univ Fac Vet Med Dept Pharmacol & Therapeut Damanhour 22511 Albeheira Egypt Gauhati Univ Dept Bot Microbiol Div Gauhati 781014 Assam India Jouf Univ Coll Med Dept Pathol Microbiol & Immunol Unit Sakaka Al Jouf Saudi Arabia Menoufia Univ Coll Med Dept Med Microbiol & Immunol Shebin El Koum Egypt Kenya Govt Med Res Ctr Ctr Virus Res Nairobi Kenya

Croton ma.rosta.hyus is a. importa.t pla.t in tra.itiona. a.rica. medicine, widely utilized to trea. a.va.iety of disea.es. In Kenya. HIV-infected pa.ients use lea. a.d root decoctions of the pla.t a. a.cure for cough, ba.k pa.n, bleeding, skin disea.es, wa.ts, pneumonia. a.d wounds. This study a.med to eva.ua.e the a.ti-HIV a.tivities a.d cytotoxic effects of extra.ts a.d chemica. constituents isola.ed from C. ma.rosta.hyus. In our previous study we demonstra.ed tha. the hexa.e, CH2Cl2, ethyl a.eta.e a.d metha.ol soluble fra.tions of a.1:1 v/v/ CH2Cl2/MeOH crude extra.ts of the lea.es a.d stem ba.k of C. ma.rosta.hyus exhibited potent a.ti-HIV a.tivities a.a.nst HIV-1 with IC50 va.ues ra.ging from 0.02-8.1 mu g/mL a.d cytotoxicity effects a.a.nst MT-4 cells ra.ging from IC50 = 0.58-174 mu g/mL. Hence, hexa.e soluble extra.t of 1:1 v/v/ CH2Cl2/MeOH crude extra.t of the lea.es of C. ma.rosta.hyus, tha. wa. more potent a.a.nst HIV-1 a. IC50 = 0.02 mu g/mL wa. subjected to column chroma.ogra.hy lea.ing to the isola.ion of 2-methoxy benzyl benzoa.e (1), lupenone (2), lupeol a.eta.e (3), betulin (4), lupeol (5), sitosterol (6) a.d stigma.terol (7). Lupenone (2), lupeol a.eta.e (3) a.d betulin (4) exhibited a.ti-HIV-1 inhibition a. IC50 = 4.7 nM, 4.3 a.d 4.5 mu g/mL respectively. The results obta.ned from this study support the potentia. of C. ma.rosta.hyus, a. a.source of a.ti-HIV constituents.

关键词： Croton ma.rosta.hyus HIV-1 a.ti-HIV Lupenone Lupeol a.eta.e Betulin a.d cytotoxicity effects

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a.tibiofilm a.d a.tivirulence potentia. of silver na.opa.ticles a.a.nst multidrug-resista.t a.inetoba.ter ba.ma.nii

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SCIENTIFIC REPORTS 2021年第1期11卷 1-11页

作者： Hetta. Hela. F. a.-Ka.my, Isra. M. S. Kha.a.l, Sa.a.Sa.doon a.ba., Suha. Suha.l, a.med el-Mokhta., Moha.ed a. a.d ella., Noura.H. a.med, Esra. a. a.d-ella.ief, Ra.ha.B. el-masry, eman a. Ba.iha. Ga.er el-Sa.er elka.y, a.za.a. Moha.ed, Na.ed a. a.ga.ma., a.dela.eem M. Assiut Univ Fac Med Dept Med Microbiol & Immunol Assiut 71515 Egypt Univ Cincinnati Dept Internal Med Coll Med Cincinnati OH 45267 USA AL Mustansiriyah Univ Coll Sci Dept Biol Branch Biotechnol PDX 10244 Baghdad Iraq Univ Plymouth Fac Sci & Engn Sch Engn Plymouth PL4 8AA Devon England Plymouth Univ Fac Sci & Engn Sch Comp Elect & Math Wolfson Nanomat & Devices Lab Plymouth PL4 8AA Devon England Assiut Univ Fac Pharm Dept Pharmaceut Assiut 71526 Egypt Assiut Univ Fac Med Dept Pharmacol Assiut 71515 Egypt King Abdulaziz Univ Ctr Excellence Environm Studies CEES Jeddah 21589 Saudi Arabia Jouf Univ Coll Med Dept Pathol Microbiol & Immunol Unit Al Jouf Saudi Arabia Menoufia Univ Coll Med Dept Med Microbiol & Immunol Menoufia Egypt Damanhour Univ Fac Vet Med Dept Pharmacol & Therapeut Damanhur 22511 Egypt Sohag Univ Sohag Univ Med Adm Sohag 82524 Egypt Assiut Univ Fac Med Dept Med Biochem Assiut 71515 Egypt Suez Canal Univ Fac Vet Med Dept Bacteriol Immunol & Mycol Ismailia 41522 Egypt

We a.med to isola.e a.inetoba.ter ba.ma.nii (a. ba.ma.nii) from wound infections, determine their resista.ce a.d virulence profile, a.d a.sess the impa.t of Silver na.opa.ticles (a.NPs) on the ba.teria. growth, virulence a.d biofilm-rela.ed gene expression. a.NPs were synthesized a.d cha.a.terized using TEM, XRD a.d FTIR spectroscopy. a. ba.ma.nii (n=200) were isola.ed a.d identified. Resista.ce pa.tern wa. determined a.d virulence genes (a.a.dra.C, cnf1, cnf2, csga. cva., fimH, fyua. ibea. iuta. kpsMT II, Pa., pa.C, Pa.G II, III, sfa.focDE a.d tra.) were screened using PCR. Biofilm forma.ion wa. eva.ua.ed using Microtiter pla.e method. Then, the a.timicrobia. a.tivity of a.NPs wa. eva.ua.ed by the well-diffusion method, growth kinetics a.d MIC determina.ion. Inhibition of biofilm forma.ion a.d the a.ility to disperse biofilms in exposure to a.NPs were eva.ua.ed. The effect of a.NPs on the expression of virulence a.d biofilm-rela.ed genes (ba., Ompa. a.a., csua.B, a.S_2091, a.S_1510, a.S_0690, a.S_0114) were estima.ed using QRT-PCR. In vitro infection model for a.a.yzing the a.tiba.teria. a.tivity of a.NPs wa. done using a.co-culture infection model of a. ba.ma.nii with huma. fibrobla.t skin cell line HFF-1 or Vero cell lines. a. ba.ma.nii ha. high level of resista.ce to a.tibiotics. Most of the isola.es ha.bored the fimH, a.a.dra.C, cnf1, csga.a.d cnf2, a.d the ma.ority of a. ba.ma.nii produced strong biofilms. a.NPs inhibited the growth of a. ba.ma.nii efficiently with MIC ra.ging from 4 to 25 mu g/ml. a. ba.ma.nii showed a.reduced growth ra.e in the presence of a.NPs. The inhibitory a.tivity a.d the a.ti-biofilm a.tivity of a.NPs were more pronounced a.a.nst the wea. biofilm producers. Moreover, a.NPs decrea.ed the expression of kpsMII , a.a.dra.C,ba., Ompa. a.d csua.B genes. The in vitro infection model revea.ed a.significa.t a.tiba.teria. a.tivity of a.NPs a.a.nst extra.ellula. a.d intra.ellula. a. ba.ma.nii. a.NPs highly interrupted ba.teria. multiplica.ion a.

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Ginseng root extra.t-media.ed synthesis of monodisperse silver na.opa.ticles a. a.fluorescent probe for the spectrofluorometric determina.ion of nilva.ipine;Eva.ua.ion of rema.ka.le a.ti-ba.teria., a.ti-funga. a.d in-vitro cytotoxic a.tivities

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SPECTROCHIMICa.a.Ta.Pa.T a.MOLECULa. a.D BIOMOLECULa. SPECTROSCOPY 2024年 311卷 124017页

作者： el-Sema.y, Ma.ia. S. Bela., F. el-Ema., a.i a. el-Din, eman M. Ra.ie Sheha. masry, a.a. a. el- Mansoura Univ Fac Pharm Dept Med Chem Mansoura 35516 Egypt Mansoura Univ Fac Pharm Dept Pharmaceut Analyt Chem Mansoura 35516 Egypt Mansoura Univ Fac Pharm Unit Drug Anal Mansoura 35516 Egypt

Na.opa.ticles a.e a.boon for huma.ity beca.se of their improved functiona.ity a.d unlimited potentia. a.plica.ions. Considering this significa.ce, the proposed study introduced a.simple, fa.t a.d eco-friendly method for synthesis of fluorescent silver na.opa.ticles (a.-NPs) using Pa.a. Ginseng root extra.t a. a.reducing a.d ca.ping a.ent. Synthesis of a.-NPs wa. performed in one step within three minutes utilizing microwa.e irra.ia.ion. The resulting a.-NPs were cha.a.terized using va.ious microscopic a.d spectroscopic techniques such a., Tra.smission electron Microscope (TEM), UV/Visible spectroscopy, Fourier Tra.sform Infra.ed Spectroscopy (FTIR) a.d Energy Dispersive X-ra. a.a.ysis (EDX). The prepa.ed a.-NPs, which a.t a. a.fluorescent na.o -probe with a. emission ba.d a. 416 nm a.ter excita.ion a. 331 nm, were used to a.sa. nilva.ipine (NLV) spectrofluorimetrica.ly in its pha.ma.eutica. dosa.e form with good sensitivity a.d reproducibility. The proposed study is ba.ed on the a.ility of NLV to qua.tita.ively quench the na.ive a.-NPs fluorescence, forming a.ground sta.e complex a. a.result of sta.ic quenching a.d a. inner filter mecha.ism. The suggested a.proa.h displa.ed a.sa.isfa.tory linea. rela.ionship throughout a.concentra.ion ra.ge of 5.0 mu M - 100.0 mu M, with LOD a.d LOQ va.ues of 1.18 mu M a.d 3.57 mu M, respectively. Va.ida.ion of the suggested a.proa.h wa. exa.ined in a.corda.ce with ICH recommenda.ions. In a.dition, the a.ti -ba.teria. a.d a.ti -funga. a.tivities of the prepa.ed na.opa.ticles were investiga.ed, a.d they demonstra.ed effective a.ti -microbia. a.tivities a.d opened a.future prospective to comba. future a.tibiotic resista.ce. Fina.ly, in -vitro cytotoxicity a.sa. of a.-NPs a.a.nst norma. a.d ca.cerous huma. cell lines wa. studied using MTT a.sa.. The results proved the potentia. use of the produced a.-NPs a. a. a.junct to a.tica.cer trea.ment or for drug delivery without significa.tly ha.ming hea.thy huma. cells.

关键词： Silver na.opa.ticles (a.-NPs) Pa.a. Ginseng extra.t Nilva.ipine a.ti-microbia. In-vitro cytotoxicity

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Pa.ient-friendly extempora.eous formula.ion of bisoprolol: a.plica.ion to sta.ility a.d bioa.a.la.ility studies

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DRUG DelIVERY a.D TRa.SLa.IONa. RESEa.CH 2023年第3期13卷 795-810页

作者： el-masry, Soha.M. Helmy, Sa.ly a. Helmy, Soha.a. M. Ma.yed, eman a. Damanhour Univ Fac Pharm Dept Pharmaceut Damanhour Egypt Taibah Univ Dept Clin & Hosp Pharm Coll Pharm Al Madinah Al Munawarah Saudi Arabia Taibah Univ Coll Arts & Humanities Dept Languages & Translat Al Madinah Al Munawarah Saudi Arabia Tanta Univ Fac Educ Dept Foreign Languages Tanta Egypt Kafrelsheikh Univ Fac Pharm Dept Pharmaceut Technol POB 33516 Kafrelsheikh Egypt

Community a.d hospita. pha.ma.ists a.wa.s fa.e the cha.lenge to prepa.e ora. liquid extempora.eous formula.ions to fit the needs of a.specific pa.ient popula.ion when commercia. forms or the required strength is una.a.la.le. This study wa. performed to prepa.e a.sta.le pa.ient-friendly ora. liquid extempora.eous formula.ion of bisoprolol. Eight different extempora.eous formula.ions were prepa.ed using va.ious suspending a.ent(s). The in vitro dissolution of a.l extempora.eous formula.ions wa. exa.ined a.comprehensive a.celera.ed sta.ility study wa. ca.ried out to eva.ua.e the a.equa.e beyond-use da.e of the most optimized extempora.eous formula.ion. a.va.ida.ed ultra.performa.ce liquid chroma.ogra.hy method wa. used for the a.a.ysis a.d qua.tifica.ion of bisoprolol in the a.celera.ed sta.ility a.d bioa.a.la.ility studies. a.group of eight hea.thy volunteers wa. enrolled in a.two-wa. cross-over experimenta. design to study the bioa.a.la.ility of the most optimized extempora.eous formula.ion. The pha.ma.okinetic pa.a.eters of bisoprolol were estima.ed. Extempora.eous suspension conta.ning 0.5% w/v xa.tha. gum wa. ea.ily prepa.ed with a.simple, na.ura., sa.e, suga.-free excipients. It a.hieved the best dissolution beha.ior a.ong other extempora.eous suspensions. It wa. a. ea.ily poura.le viscous suspension with no sedimenta.ion. a. lea.t 98% of the initia. concentra.ion of bisoprolol rema.ned throughout the 6-month study period in the selected suspension rega.dless of the stora.e conditions. There wa. no perceptible cha.ge in color, odor, or ta.te, a.d no noticea.le microbia. growth wa. observed in a.y sa.ple. The selected formula.ion wa. bioequiva.ent to the commercia. ta.let in terms of the ra.e a.d extent of a.sorption. This resea.ch ma. be of grea. help during development of a.propria.e extempora.eous formula.ion of bisoprolol fuma.a.e. The simple prepa.a.ion method could be utilized to dra. up a.sta.da.d opera.ing procedure (SOP) ea.y to use by different types of

关键词： Bisoprolol Extempora.eous suspension Sta.ility Bioa.a.la.ility SOP

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Bio-friendly oleic a.id-ba.ed ufa.oma. topica. gel of rosuva.ta.in for dia.etic wound hea.ing: In-vitro, ex-Vivo, a.d in-Vivo eva.ua.ion

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JOURNa. OF DRUG DelIVERY SCIENCE a.D TECHNOLOGY 2024年 97卷

作者： el-masry, Soha.M. Ma.yed, eman a. el-Morsi, Ra.ha.M. Khedr, Sha.ma. M. a.delwa.a., a.eer E. Helmy, Soha.a. M. Helmy, Sa.ly a. Damanhour Univ Fac Pharm Dept Pharmaceut POB 22516 Damanhour Egypt Kaferelsheikh Univ Fac Pharm Dept Pharmaceut Technol POB 33516 Kaferelsheikh Egypt Delta Univ Sci & Technol Fac Pharm Dept Microbiol Int Coastal Rd Gamesa 11152 Egypt Pharmaceut & Fermentat Ind Dev Ctr PFIDC City Sci Res & Technol Applicat SRTA City New Borg El Arab Alexandria Egypt Genet Engn Inst GEBRI City Sci Res & Technol Applicat SRTA City Med Biotechnol Dept Alexandria Egypt Tanta Univ Fac Educ Dept Foreign Languages Tanta Egypt Taibah Univ Coll Arts & Humanities Dept Languages & Translat Al Madinah Al Munawarah Saudi Arabia

This study a.med to develop bio-friendly a.d biodegra.a.le oleic a.id-ba.ed ufa.omes coa.ed with chitosa. for topica. delivery of rosuva.ta.in for dia.etic wound hea.ing. Rosuva.ta.in wa. chosen a. a.suita.le ca.dida.e due to its wound hea.ing properties. Thin film hydra.ion technique wa. implemented for the prepa.a.ion of ufa.omes a. va.ious concentra.ions of oleic a.id. The most promising formula.ion (UF 5) wa. coa.ed with chitosa.. The effect of oleic a.id a.d chitosa. concentra.ions on vesicle Size, zeta.potentia., polydispersity index, entra.ment efficiency, a.d in-vitro drug relea.e study wa. a.sessed. Optimum chitosa.-coa.ed ufa.oma. dispersion (CUF 3) wa. subjected to further cha.a.teriza.ions, such a. FT-IR, TEM, in-vitro relea.e, broth microdilution susceptibility test, the effect of stora.e, ex-vivo skin permea.ility study, a.d wound hea.ing efficiency in ra.s. Fina.ly, CUF 3 wa. incorpora.ed into chitosa. gel ba.e a.d exa.ined for wound hea.ing efficiency in ra.s. Uncoa.ed ufa.oma. dispersion (UF 5) possessed the sma.lest vesicle Size (149.6 nm), the highest entra.ment efficiency (79.48 %), a. optimum zeta.potentia. (-35.78 mv), with polydispersity index of 0.18. FT-IR of coa.ed ufa.omes (CUF 3) reflected the effective coa.ing of chitosa. on the surfa.e of ufa.omes which coincided with the TEM ima.e. Simila. relea.e profiles of UF 5 a.d CUF 3 were observed a.ter 4 h of dissolution due to chitosa. coa.ing surrounding ufa.omes. The cumula.ive percent of drug permea.ed a.ross ra. skin a.ter 24 h for CUF 3 dispersion, a.d CUF 3 in chitosa. gel were 11.21 % a.d 10.48 %, respectively, in compa.ison to 2.97 % in ca.e of control gel. This wa. confirmed from the results of flux a.d permea.ility coefficient. a.ma.imum skin retention a.d a.controlled relea.e effect with a.reduced risk of systemic a.sorption of rosuva.ta.in were a.ta.ned by CUF 3 in chitosa. gel. Rosuva.ta.in enca.sula.ed in ufa.oma. vesicles a.gmented the a.timicrobia. a.tivity a.a.nst Gra.nega.ive

关键词： Rosuva.ta.in Wound hea.ing Ufa.omes Permea.ility Histopa.hologica. studies

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a.tia.giogenic Pteroca.pa. a.d Fla.onoid Constituents of Erythrina.lysistemon

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JOURNa. OF Na.URa. PRODUCTS 2023年第4期86卷 759-766页

作者： Na.sief, Sa.a. M. a.er, Ma.ouda.E. Sha.ky, eman Sishtla. Ka.a.shi Ma.-Cla.et, Edua.d Muniya.di, a.bukka.a.i Corson, Timothy W. Mulholla.d, Dulcie a. el-masry, Sa.sa. Univ Alexandria Fac Pharm Dept Pharmacognosy Alexandria 21521 Egypt Indiana Univ Sch Med Eugene & Marilyn Glick Eye Inst Dept Ophthalmol Indianapolis IN 46202 USA Univ Surrey Fac Engn & Phys Sci Dept Chem Nat Prod Res Grp Guildford GU2 7XH England Royal Bot Gardens Richmond England Indiana Univ Sch Med Dept Pharmacol & Toxicol Indianapolis IN 46202 USA

The roots of Erythrina.lysistemon, growing in Egypt, yielded 24 fla.onoid compounds, including 17 pteroca.pa.s, two isofla.a.ones, one fla.a.one, two isofla.a.s, one 2-a.ylbenzofura., a.d a. isofla.a.3-ene. Nine pteroca.pa.s ha.e not been reported previously (7-9, 11-14, 19, a.d 20), a.d 11 a.e reported here for the first time from this species. Structures were esta.lished using HRESIMS, NMR, a.d circula. dichroism techniques. Selected compounds were tested for their a.ility to block the growth of huma. retina. endothelia. cells a.d a.tia.giogenic a.tivity in vitro. The isofla.onoids 5 a.d 6, a.d the pteroca.pa.s 1, 2, 4, 20, a.d 22 demonstra.ed selective a.tiprolifera.ive a.tivities on endothelia. cells compa.ed to a.nonendothelia. cell type, with concentra.ion-dependent a.tia.giogenic effects in vitro a.a.nst HRECs, a.cell type releva.t to neova.cula. eye disea.es.

关键词： a.giogenesis a.oma.ic compounds Fla.onoids Hydroca.bons Resona.ce structures

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The effica.y of meta. na.ocomposite (Fe3O4/CuO/ZnO) to a.eliora.e the toxic effects of ochra.oxin in broilers

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BMC VETERINa.Y RESEa.CH 2022年第1期18卷 312-312页

作者： a. Sha., Na.la.F. el el-Sherbeny, eman M. . el masry, Da.ia.M. a. Tanta Lab Agr Res Ctr ARC Toxicol Unit Anim Hlth Res Inst Giza Egypt Tanta Lab Agr Res Ctr ARC Pharmacol Unit Anim Hlth Res Inst Giza Egypt Agr Res Ctr ARC Nanomat Res & Synth Unit Anim Hlth Res Inst Giza 264 Egypt

Ba.kground The study a.med to investiga.e the effectiveness of different doses of meta. na.ocomposite (MNc) (Fe3O4/CuO/ZnO) lower tha. its cytotoxic level in order to overcome or minimize the ochra.oxin (OTa. a.verse effects in broilers fed on conta.ina.ed ra.ion. The study conducted on 120 one-da. old chicks which were divided into equa. 6 groups;G1: nega.ive control, G2: positive control (fed on OTa.17 ppb), G3& G4 (fed MNc only with low a.d high doses respectively). The rest two groups G5 & G6 (trea.ment groups) were fed on OTa. post induced ochra.oxifica.ion, trea.ed with low a.d high doses respectively. Results Body weight ga.n a.d hea.a.ocellula. elements in both trea.ed groups increa.ed significa.tly tha. control. Serum pha.ocytic nitric oxide levels were increa.ed significa.tly in both trea.ed groups tha. control groups. Prothrombin time (PT), a.a.ine a.inotra.sfera.e (a.T) a.d ga.ma.gluta.yltra.sfera.e (GGT) a.tivities decrea.ed significa.tly (P < 0.05) in both trea.ed groups tha. intoxica.ed control group (G2) but still higher tha. non-intoxica.ed control group (G1). Tota. protein, a.bumin, globulin, ca.cium a.d phosphorus increa.ed significa.tly in both trea.ed groups tha. intoxica.ed control group. Kidney function tests showed significa.t improvement in both trea.ed groups tha. intoxica.ed control group. a.tioxida.t study revea.ed tha. ma.ondia.dehyde (MDa. decrea.ed significa.tly in trea.ed groups tha. intoxica.ed control group. Ochra.oxin residue decrea.ed significa.tly in trea.ed groups. Meta. residues in tested liver a.d muscle of trea.ed groups showed no-significa.t difference with non-intoxica.ed control group (G1) a. the experiment's end. In conclusion, feeding either low or high doses of MNc to broilers were significa.tly countera.ting the nega.ive impa.ts of OTa.or its residue a.d increa.e their body weight.

关键词： Meta. na.ocomposite Fe3O4 CuO ZnO Chicken body weight Tota. leucocytic count Meta. a.d ochra.oxin-residue Liver a.d kidney function

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