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The relationship between geometry and hemodynamics of the stenotic carotid artery based on computational fluid dynamics

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CLINICAL NEUROLOGY AND NEUROSURGERY 2023年第1期231卷 107860-107860页

作者： Liu, Yongsheng Jiang, Guinan Wang, xuwen An, Xiangbo Wang, feng Dalian Med Univ Dept Pathol Affiliated Hosp 1 Dalian Peoples R China 222 Zhongshan Rd Dalian Peoples R China

Objective: The purpose of this work was to investigate the relationship between the geometric factors and the hemodynamics of the stenotic carotid ***: We retrospectively reviewed data of patients with carotid stenosis (40%-95%). The Navier-Stokes equations were solved using ANSYS CFX 18.0. Correlation analysis was based on Spearman's test. Geometric variables (p < 0.1 in the univariate analysis) were entered into the logistical regression. A receiver-operating characteristics analysis was used to detect hemodynamically significant lesions. Results: 81 patients (96 arteries) were evaluated. The logistic regression analysis revealed that the translesional pressure ratio was significantly correlated with the stenosis degree (OR = 1.147, p < 0.001) and the angle between internal carotid artery and external carotid artery (angle ?) (OR = 0.933, p = 0.01). The translesional wall shear stress ratio was significantly correlated with stenosis degree (OR = 1.094, p < 0.001), lesion length (OR = 0.873, p = 0.01), lumen area of internal carotid artery (OR = 0.867, p = 0.002), and lumen area of common carotid artery (OR = 1.058, p = 0.01). For predicting low translesional pressure ratio, the AUC was 0.71 (p < 0.001) for angle ?, and was 0.87 (p < 0.001) for stenosis degree. For predicting high translesional wall shear stress ratio, the AUC was 0.62 (p = 0.04) for lumen area of internal carotid artery, and was 0.77 (p < 0.001) for stenosis ***: Apart from stenosis degree, other geometric characteristics of lesions may also have an influence on hemodynamics of the stenotic carotid artery.

关键词： Carotid artery Computational fluid dynamics Geometry Hemodynamics Stenosis

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装配式混凝土建筑防水技术与措施

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施工技术（中英文） 2024年第17期53卷 7-14,66页

作者：冯大阔肖绪文中国建筑第七工程局有限公司河南郑州450004 郑州大学水利科学与工程学院河南郑州450001 中国建筑股份有限公司北京100029

通过大量工程实践和文献调研,深入分析装配式建筑防水的重要性,系统梳理并划分装配式混凝土建筑的防水技术和措施。重点阐述3类常用的防水结构体系和5种构造防水措施,明确装配式混凝土建筑防水工程工作重点。装配式混凝土建筑防水措施... 详细信息

通过大量工程实践和文献调研,深入分析装配式建筑防水的重要性,系统梳理并划分装配式混凝土建筑的防水技术和措施。重点阐述3类常用的防水结构体系和5种构造防水措施,明确装配式混凝土建筑防水工程工作重点。装配式混凝土建筑防水措施分为结构防水、构造防水和材料防水3类,结构防水是基础,构造防水是关键,材料防水最直接。从这3方面入手,选用整体性好的结构体系、合适的防水构造、生产质量好的预制构件,并加强储存运输过程成品保护,强化预制构件安装精度和质量,关注拼缝防水处理和密封材料施工措施,注重技术联合和产品集成应用,以切实增强装配式建筑整体性和防水性能。

关键词：装配式混凝土防水工程防水材料构造

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Altered levels of circulating CD8⁺CXCR5⁺PD-1⁺T follicular cytotoxic cells in primary Sjogren's syndrome

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CLINICAL RHEUMATOLOGY 2022年第6期41卷 1697-1708页

作者： Zhai, xuwen Wang, Yanlin Guo, Hui Liang, Zhaojun feng, Min Wu, Yanyao Qin, Yan Zhao, Xiangcong Gao, Chong Luo, Jing Shanxi Med Univ Simulat Hosp Clin Skills Teaching Jinzhong 030600 Shanxi Peoples R China Shanxi Med Univ Dept Med Div Rheumatol Hosp 2 Taiyuan 030001 Shanxi Peoples R China Shanxi Med Univ Dept Med Div Nephrol Hosp 2 Taiyuan 030001 Shanxi Peoples R China Shenzhen Baoan Shiyan Peoples Hosp Dept Med Div Nephrol Shenzhen 518005 Guangdong Peoples R China Harvard Med Sch Brigham & Womens Hosp Dept Pathol Boston MA 02115 USA

Background Circulating CD8(+)T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) (CD8(+)CXCR5(+)T), a recently identified follicular cytotoxic T cell subset, are involved in antiviral immunity and autoimmunity, but their abundance and role in the pathogenesis of primary Sjogren syndrome (pSS) are unknown. Methods Circulating CD8(+)CXCR5(+)T cell and CD8(+) regulatory T cells (CD8(+)Treg) were evaluated in 49 pSS patients (19 patients with pulmonary involvement) and 24 age- and sex-matched healthy controls (HCs) by flow cytometry. Orthogonal partial least squares discriminant analysis (OPLS-DA) was performed, and receiver operating characteristic curves (ROC) were generated to identify characteristic cell subsets. Spearman's correlation analysis was conducted to examine the relationships between CD8(+)T cell subsets and clinical features. Results The proportions and numbers of CD8(+)CXCR5(+) , CD8(+)CXCR5(+) programmed death 1-positive (PD-1(+)), and CD8(+)CXCR5 PD-1(+)T cells were significantly higher, whereas those of CD8 +/- Treg were markedly lower, in pSS patients than HCs. The CD8(+)CXCR5(+)PD-1(+)T cell to CD8(+)Treg ratio had the greatest discriminatory power for pSS and HCs according to OPLS-DA and ROC analyses. The increased numbers of CD8(+)CXCR5(+)T cells and CD8(+)CXCR5(+)PD-1(+)T cells were strongly associated with those of CD4(+)CXCR5(+)T and B cells. The proportions and numbers of CD8(+)CXCR5(+)PD-1(+)T cells were increased in pSS patients with lung involvement. Conclusions We identified a new CD8(+)CXCR5(+)PD-1(+)T subset, which was increased in abundance in pSS patients, particularly those with lung involvement, compared with HCs. Also, the CD8(+)CXCR5(+)PD-1(+)T to CD8(+)Treg ratio may be useful for identifying pSS. Our findings suggest that targeting follicular CD8(+)T cell subsets has therapeutic potential for pSS.

关键词： CD8(+)CXCR5(+) follicular cytotoxic T subsets CD8(+) regulatory T cells Lung involvement OPLS-DA Primary Sjogren's syndrome

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Improved Eagle Perching Optimizer Based P2P Energy Trading for Smart Homes

Improved Eagle Perching Optimizer Based P2P Energy Trading f...

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Power and Electrical Engineering (ACPEE), 5th Asia Conference on

作者： Yu Jiang Yingchun feng Jie Fan Bo Gao Yang Wang xuwen Liu Jiangsu Electric Power Trading Center State Grid Jiangsu Electric Power Co. LTD Nanjing China

ISBN: (数字)9798350309638

ISBN: (纸本)9798350309645

The purpose of the study is to optimize power price in smart homes that connect to share energy. A Demand Side Management (DSM) system is used to coordinate P2P energy trading between smart homes using the improved eagle perching optimizer (IEPO). The IEPO algorithm produces optimum solutions for 99% of actual datasets, according to the outcomes. It is possible that consumer price distribution in the microgrid (MG) could be unequal as a result of P2P energy trading. The Pareto optimality principle addresses the issue of unequal price distribution, preventing households from being harmed by improving the costs of others. A final evaluation is performed on the effect of renewable energy and the penetration of storage within the MG. As the renewable energy and the penetration of storage increases, savings cannot necessarily be linear. As the saturation point approaches, they slowly begin to decline.

关键词： Electrical engineering Renewable energy sources Demand side management Costs Electricity Asia Optimization methods

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Deep Reinforcement Learning Home Energy Management Based Local Energy Trading in a Blockchain Platform

Deep Reinforcement Learning Home Energy Management Based Loc...

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Power and Electrical Engineering (ACPEE), 5th Asia Conference on

作者： Yu Jiang Yingchun feng Jie Fan Bo Gao Yang Wang xuwen Liu Jiangsu Electric Power Trading Center State Grid Jiangsu Electric Power Co. LTD Nanjing China

ISBN: (数字)9798350309638

ISBN: (纸本)9798350309645

Decentralized peer-to-peer Local Energy Markets (LEMs) are gaining popularity as local power production from Renewable Energy Sources (RESs) increases. The study investigates a blockchain-driven LEM in which prosumers and consumers buy and sell energy independently of the involvement of a third party. The suggested scheme involves Home Energy Management (HEM) and demurrage mechanisms that enable both consumers and prosumers to reduce their power prices and improve their power usage. The end-user can likewise move the load to off-peak periods and benefit from lower energy costs from the LEM through the approach. In this solution, HEM and demurrage mechanisms are used to optimize power usage as well as energy costs. As well as providing adequate power for the LEM, it is economically beneficial for end users and the community. The proposed system in the study utilizes the Deep Deterministic Policy Gradient (DDPG) algorithm and demurrage mechanisms to optimize electricity usage and energy costs. Meanwhile, smart contract on the Ethereum blockchain regulate and safeguard the electricity trading process.

关键词： Renewable energy sources Costs Simulation Smart contracts Production Power markets Blockchains

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A Two-level Learning Approach for Achieving the Sustainable Development of Service Ecosystem

A Two-level Learning Approach for Achieving the Sustainable ...

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IEEE International Conference on Web Services (ICWS)

作者： Chao Peng Xiao Xue xuwen Zhang Peilin Ji Yifan Shen Li Fang Zhiyong feng College of Intelligence and Computing Tianjin University Tianjin China Tianjin Key Laboratory of Healthy Habitat and Smart Technology Tianjin China School of Information Xi’an University of Finance and Economics Xi’an China

ISBN: (数字)9798350368550

ISBN: (纸本)9798350368567

The governance of service ecosystem needs to balance efficiency and fairness to promote the sustainable development of the system, making it an important topic. However, service entities in the service ecosystem have autonomy and engage in dynamic game with governance strategies, leading to governance challenges. To address this issue, we model the governance process as a repeated sequential game between the governance algorithm and service entities, and propose a novel two-level learning algorithm. This algorithm considers the learning evolution of service entities and the co-evolutionary of the governance algorithm, using reinforcement learning to learn effective governance strategies while also considering the response function of service entities to balance efficiency and fairness. Combining the ideas of bilevel optimization and online learning, this algorithm effectively balances exploration (understanding the service entities’ responses function) and exploitation (choosing efficient actions). We apply the algorithm to a classic service ecosystem, the ride-hailing service system, and empirically demonstrate its effectiveness in the governance task of order dispatching.

关键词： Web services Heuristic algorithms Ecosystems Games Reinforcement learning Dispatching Robustness Sustainable development Optimization

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Development of a Synthesis Process for a Novel HCV NS5A Inhibitor, Emitasvir

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ORGANIC PROCESS RESEARCH & DEVELOPMENT 2021年第4期25卷 838-848页

作者： Xie, Hongming Liu, Haiwang Zhang, Yingjun Huang, Enhuo feng, Yahui Xiang, xuwen Fang, Qinghong Peng, Zhihong Dong, Wanrong An, Delie Hunan Univ Coll Chem & Chem Engn State Key Lab Chemo Biosensing & Chemometr Changsha 410082 Hunan Peoples R China Sunshine Lake Pharma Co Ltd State Key Lab Antiinfect Drug Dev 2015DQ780357 Dongguan 523871 Peoples R China HEC Pharm Grp HEC Res & Dev Ctr Dongguan 523871 Peoples R China

A new approach to the synthesis of Emitasvir (DAG181), a small molecule hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor, is described. Enantioselective enzymatic desymmetrization with hydrolases in the synthetical approach can significantly avoid the loss of chiral raw materials in the resolution process. The synthesis route is further optimized and scaled-up to establish a new process that is applied to the preparation of kilogram scales of target active pharmaceutical ingredients (APIs). Compared with our initial process, the overall yield of target API was dramatically improved from 17 to 40%.

关键词： hepatitis C virus inhibitor Emitasvir enantioselective synthesis process development

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Screening and Expression Analysis of POD Gene in POD-H2O2 Pathway on Bud Dormancy of Pear (Pyrus pyrifolia)

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FORESTS 2024年第3期15卷 434页

作者： Xiang, xuwen Song, Keke Li, Yinyin Zhang, Chenyu Zhou, Ruiqi feng, Yu You, Jingnan Wu, Jingdong Zhang, Yanhui Jiang, Cuicui Li, Yongyu Fujian Agr & Forestry Univ Coll Hort Key Lab Minist Educ Genet Breeding & Multiple Utilizat Cro Fuzhou 350002 Peoples R China Fujian Agr & Forestry Univ Inst Nat Prod Hort Plants Fuzhou 350002 Peoples R China Agr & Rural Bur Jianning Cty Econ Crop Stn Sanming 354500 Peoples R China Agr & Rural Bur Yongtai Cty Econ Crop Stn Fuzhou 350700 Peoples R China Fujian Acad Agr Sci Fruit Res Inst Fuzhou 350002 Peoples R China

Bud endodormancy represents a pivotal and intricate biological process influenced by both genetic and epigenetic factors, the exact mechanism of which remains elusive. Hydrogen peroxide (H2O2) functions as a signalling molecule in the regulation of dormancy, with peroxidase (POD) playing a crucial role in governing H2O2 levels. Our prior transcriptomic and metabolomic investigations into diverse pear dormancy phases posited that POD predominantly oversees pear bud dormancy. In this study, we utilised qRT-PCR to screen the most significantly expressed gene, Pyrus pyrifolia POD4-like (PpPOD4-like), from seven POD genes. Subsequently, H2O2 test kits, overexpression methods, and subcellular localisation techniques were employed to assess changes in H2O2 content, POD activity, PpPOD4-like expression, and its cellular positioning during pear bud dormancy. Subcellular localisation experiments revealed that PpPOD4-like is situated on the cell membranes. Notably, H2O2 content exhibited a rapid increase during endodormancy and decreased swiftly after ecodormancy. The fluctuation pattern of POD activity aligned with that of H2O2 content. Additionally, PpPOD4-like expression was markedly upregulated, displaying an overall upward trajectory. Our findings indicate that PpPOD4-like modulates H2O2 levels by regulating POD activity, thereby actively participating in the intricate regulation of pear dormancy processes.

关键词： endodormancy overexpression H2O2 POD genes

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Recent advances in the synthesis of biodegradable polyesters by sustainable polymerization: lipase-catalyzed polymerization

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RSC ADVANCES 2020年第59期10卷 36230-36240页

作者： Liu, Ying Song, Lijie feng, Na Jiang, Wei Jin, Yongri Li, xuwen Jilin Univ Coll Chem 2699 Qianjin Rd Changchun 130012 Jilin Peoples R China Jilin Prov Acad Tradit Chinese Med Clin Hosp 1 Changchun 130021 Peoples R China Zhengzhou Univ Acad Med Sci Dept Mol Pathol Applicat Ctr Precis MedAffiliated Hosp 2 Zhengzhou 450052 Henan Peoples R China

Over the past three decades, enzymatic polymerization has dramatically developed and gradually broadened as a creative methodology in the construction of polymeric materials with tailor-made structures and properties. Compared with transition metal catalyst polymerizations, enzymatic polymerization is more attractive in the biomedicine field due to the metal-free residue, good biocompatibility, and few by-products. Meanwhile, enzymatic polymerization has far more activity towards macrolides. In this review, the synthesis of lipase-catalyzed polymer materials is systematically summarized, focusing on the synthesis of the complex and well-defined polymers. The enzymatic polyester synthesis was then discussed concerning the different reaction types, including ring-opening polymerization, polycondensation, a combination of ring-opening polymerization with polycondensation, and chemoenzymatic polymerization. Besides, exploration of novel biocatalysts and reaction media was also described, with particular emphasis on the enzymes obtainedviaimmobilization or protein engineering strategies, green solvents, and reactors. Finally, recent developments in catalytic kinetics and mechanistic studies through the use of spectroscopy, mathematics, and computer techniques have been introduced. Besides, we addressed the remaining central issues in enzymatic polymerization and discussed current studies aimed at providing answers.

关键词： Ring opening polymerization

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Zeolite biofilm aeration filter plays a pre-nitritation role in autotrophic nitrogen removal from iron oxide red wastewater

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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 2020年第12期95卷 3261-3269页

作者： feng, Xinghui Wang, Xiaojun Wang, Ruixin Zheng, xuwen Zhong, Zhong Chen, Xiaozhen South China Univ Technol Sch Environm & Energy Guangzhou Peoples R China Minist Educ Key Lab Pollut Control & Ecosyst Restorat Ind Clu Guangzhou Peoples R China Hua An Biotech Co Ltd Foshan Peoples R China

BACKGROUND The completely autotrophic nitrogen removal over nitrite (CANON) system has excellent performance in treating ammonium-rich wastewater and it depends on ammonia oxidizing bacteria (AOB) working together with anammox bacteria in a reactor. Higher ammonium nitrogen loading requires higher aeration to provide sufficient dissolved oxygen (DO) for nitritation, whereas high-strength aeration in theCANON will destroy the sludge structure and inhibit the activity of anammox bacteria. The present study uses a stable pre-nitritation system to reduce a part of nitritation and also decrease aeration intensity in the CANON. RESULTS Continuous aeration to maintain the DO concentration between 1.5 and 4.3 mg L(-1)in the CANON achieved a stable nitrogen removal rate (1.22 kg N m(-3)d(-1)) from iron oxide red wastewater with 400-1016 mg N L(-1)after 183 days of operation. Using a mixed alkalinity donor [sodium carbonate (Na2CO3) and bicarbonate (NaHCO3)] in the combined system can save approximate to 14.1-28.2% of the alkalinity cost compared with using NaHCO(3)only. CONCLUSIONS A zeolite biofilm aeration filter (ZBAF) used in a pre-nitritation process can tolerate high DO concentration of <= 6.5 mg L(-1)for nitritation and avoid all of the nitritation taking place in the CANON system. This can protect the sludge structure and anammox bacteria from high-strength aeration erosion. (c) 2020 Society of Chemical Industry

关键词： pre-nitritation zeolite dissolved oxygen control Anammox granular sludge

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