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忻州师范学院学报 2021年第5期37卷 11-18页

作者：张建华冯琳张晓璐霍巧丽刘兴华赵旭文忻州师范学院生物系山西忻州034000 山西省管涔山国有林管理局山西宁武036000

对北京东灵山的荆条灌丛进行氮添加试验,设置4个氮沉降水平:对照(0 N_(0))、低氮(20 N_(1))、中氮(50 N_(2))、高氮(100 N_(3))kg N·hm^(-2)·a^(-1),研究灌丛凋落物量和养分输入量对模拟氮沉降的响应。结果显示:氮沉降表现出... 详细信息

对北京东灵山的荆条灌丛进行氮添加试验,设置4个氮沉降水平:对照(0 N_(0))、低氮(20 N_(1))、中氮(50 N_(2))、高氮(100 N_(3))kg N·hm^(-2)·a^(-1),研究灌丛凋落物量和养分输入量对模拟氮沉降的响应。结果显示:氮沉降表现出增加凋落物凋落产量的趋势,但处理之间差异不显著。氮沉降增加叶、枝和花果凋落物中N元素含量,但对其他元素没有显著影响。5年的模拟氮沉降处理对荆条灌丛凋落物养分归还量的影响不明显。

关键词：氮沉降凋落物量养分归还量荆条灌丛华北地区

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合并动眼神经麻痹的颈内动脉后交通动脉段动脉瘤血管内治疗及预后分析

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中华介入放射学电子杂志 2020年第3期8卷 205-210页

作者：吴邯刘永晟王旭文王峰大连医科大学附属第一医院介入治疗科辽宁大连116000

目的探讨合并动眼神经麻痹(oculomotor nerve palsy,ONP)的颈内动脉后交通动脉段动脉瘤的不同血管内治疗方式的恢复情况差异及影响因素。方法回顾性分析我院2011至2018年收治的35例合并动眼神经麻痹的颈内动脉后交通动脉段动脉瘤并经血... 详细信息

目的探讨合并动眼神经麻痹(oculomotor nerve palsy,ONP)的颈内动脉后交通动脉段动脉瘤的不同血管内治疗方式的恢复情况差异及影响因素。方法回顾性分析我院2011至2018年收治的35例合并动眼神经麻痹的颈内动脉后交通动脉段动脉瘤并经血管内治疗的病例。随访观察术后动眼神经麻痹的恢复情况,分析不同治疗方式ONP恢复情况的差异性,分析术后数字减影血管造影(digital subtraction angiography,DSA)即刻评价的栓塞与否及程度对ONP恢复的差异性,分析ONP恢复与否与年龄、动眼神经麻痹程度、蛛网膜下腔出血(subarachnoid hemorrhage,SAH)、动脉瘤大小、自发病至接受治疗的时长的关系。结果35例后交通动脉瘤患者,动眼神经麻痹完全恢复25例(71.4%),部分恢复6例(17.1%),未缓解4例(11.4%);不同的血管内治疗方式,ONP的恢复没有统计学差异(P=1.00);术后DSA即刻评价的栓塞与否及程度对ONP恢复的存在统计学差异(P<0.01),单纯支架治疗和致密栓塞后动眼神经功能恢复得更好;年龄、ONP程度、动脉瘤大小、是否SAH、治疗时间均不是ONP恢复的影响因素(P>0.05)。结论不同治疗方式患者的ONP恢复状态没有差异;术后即刻评价的致密栓塞及单纯支架置入,相较部分栓塞及栓塞后瘤腔显影,动眼神经恢复更好。

关键词：颅内动脉瘤动眼神经麻痹血管内治疗后交通动脉瘤

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IK1 channel agonist zacopride suppresses ventricular arrhythmias in conscious rats with healing myocardial infarction

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LIFE SCIENCES 2019年第0期239卷 117075-000页

作者： Zhai, xuwen Qiao, Xi Zhang, Li Wang, Dongming Zhang, Lijun feng, Qilong Wu, Bowei Cao, Jimin Liu, Qinghua Shanxi Med Univ Clin Skills Teaching Simulat Hosp Taiyuan Shanxi Peoples R China Shanxi Med Univ Dept Pathophysiol 56 Xinjian South Rd Taiyuan 030001 Shanxi Peoples R China Childrens Hosp Shanxi Clin Lab Taiyuan Shanxi Peoples R China Shanxi Med Univ Hosp 2 Taiyuan Shanxi Peoples R China Shanxi Med Univ Minist Educ Key Lab Cellular Physiol 56 Xinjian South Rd Taiyuan 030001 Shanxi Peoples R China Shanxi Med Univ Dept Physiol 56 Xinjian South Rd Taiyuan 030001 Shanxi Peoples R China

Aims: Arrhythmogenesis of chronic myocardial infarction (MI) is associated with the prolongation of action potential, reduction of inward rectifier potassium (I-K1, Kir) channels and hyper-activity of Calcium/calmodulin-dependent kinase II (CaMKII) in cardiomyocytes. Zacopride, a selective I-K1 agonist, was applied to clarify the cardioprotection of I-K1 agonism via a CaMKII signaling on arrhythmias post-MI. Methods: Male SD rats were implanted wireless transmitter in the abdominal cavity and subjected to left main coronary artery ligation or sham operation. The telemetric ECGs were monitored per day throughout 4 weeks. At the endpoint, isoproterenol (1.28 mg/kg, i.v.) was administered for provocation test. The expressions of Kir2.1 (dominant subunit of I-K1 in ventricle) and CaMKII were detected by Western-blotting. Key findings: In the telemetric rats post-MI, zacopride significantly reduced the episodes of atrioventricular conduction block (AVB), premature ventricular contraction (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF), without significant effect on superventricular premature contraction (SPVC). In provocation test, zacopride suppressed the onset of ventricular arrhythmias in conscious PMI or sham rats. The expression of Kir2.1 was significantly downregulated and p-CaMKII was upregulated post-MI, whereas both were restored by zacopride treatment. Significance: I-K1/Kir2.1 might be an attractive target for pharmacological controlling of lethal arrhythmias post MI.

关键词： Inward rectifier potassium channel Zacopride Myocardial infarction Arrhythmias Calcium/calmodulin-dependent kinase II

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Sedimentary organic and inorganic records of eutrophication and hypoxia in and off the Changjiang Estuary over the last century

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MARINE POLLUTION BULLETIN 2015年第1-2期99卷 76-84页

作者： Zhao, Jun feng, xuwen Shi, Xiaolai Bai, Youcheng Yu, Xiaoguo Shi, Xuefa Zhang, Weiyan Zhang, Rongping State Ocean Adm Inst Oceanog 2 Hangzhou 310012 Zhejiang Peoples R China SOA Key Lab Marine Ecosyst & Biogeochem Hangzhou 310012 Zhejiang Peoples R China SOA Key Lab Submarine Geosci Hangzhou 310012 Zhejiang Peoples R China SOA Inst Oceanog 1 Key Lab Marine Sedimentol & Environm Geol Qingdao 266061 Peoples R China Ocean Univ China Minist Educ Key Lab Marine Chem Theory & Technol Qingdao 266100 Peoples R China

Organic and inorganic sedimentary parameters in and off the Changjiang Estuary have been analyzed to reconstruct historical trends in eutrophication and hypoxia over the last century. The lipid biomarker concentrations in the Changjiang Estuary mud area,(CEMA) indicated eutrophication accelerated after the 1970s. Meanwhile, Mo/Al indicated hypoxia has increased since 1960s. Eutrophication and hypoxia in the CEMA are primarily a result of the dramatically increased load of terrestrial nutrients from the Changjiang to the East China Sea. The lipid biomarker concentrations in the southwest Cheju Island mud area (SCIMA) showed primary production is controlled mainly by changes in regional climate and marine current. No significant hypoxia occurred in the SCIMA over the past century as indicated by Mo/Al. Therefore, geochemical indicators of eutrophication and hypoxia revealed different patterns between the CEMA and SCIMA, suggesting the role of river-derived nutrients in sustaining eutrophication and hypoxia in the CEMA since the 1960s. (C) 2015 Elsevier Ltd. All rights reserved.

关键词： Changjiang Estuary Eutrophication Hypoxia Biomarker Redox sensitive element Sediments

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Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

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JOURNAL OF MEDICINAL CHEMISTRY 2018年第19期61卷 8613-8624页

作者： Pang, Peichen Chen, Jiean Li, Xijian Li, Miyang Yu, Huidong Zhao, Jean J. Ni, Jing Wang, xuwen Sun, Huiyong Tian, Sheng Zhu, feng Liu, feng Huang, Yong Hou, Tingjun Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Peking Univ State Key Lab Chem Oncogen Key Lab Chem Genom Shenzhen Grad Sch Shenzhen 518055 Guangdong Peoples R China Rongene Pharma Co Ltd Guangzhou 510663 Guandong Peoples R China Dana Farber Canc Inst Dept Canc Biol Boston MA 02215 USA Harvard Med Sch Dept Biol Chem & Mol Pharmacol Boston MA 02215 USA Soochow Univ Coll Pharmaceut Sci Suzhou 215123 Jiangsu Peoples R China

Camptothecin (CPT) has been shown to block disassembly of the topoisomerase I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic instability, and severe toxicity of CPTs have limited their clinical applications. Herein, we report the design and synthesis of H2O-soluble and orally bioavailable hexacyclic CPT derivatives. By analysis of a virtual chemical library and cytotoxicity screening in vitro, 9 and 11 were identified as potential prodrugs and chosen for further characterization in vivo. Both compounds exhibited remarkable anticancer and anti-inflammation efficacies in animals and improved drug-like profiles.

关键词： Mixtures Rodent models Solubility Genetics Toxicity

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ISAR Imaging Based on Block Sparse Smoothed L0 Norm Recovery Algorithm

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Journal of Physics: Conference Series 2019年第3期1213卷

作者： Junjie feng xuwen Zhang Yonghui Wang School of Electrical engineering Liupanshui Normal University Liupanshui Guizhou 553004 China College of Electronic and Information Engineering Nanjing University of Aeronautics and Astronautics Nanjing 211106 China

In order to obtain high resolution inverse synthetic aperture radar (ISAR) sparse images, a block sparse signal recovery ISAR imaging algorithm is proposed by considering the cluster characteristics of target in this paper. Firstly, the ISAR sparse imaging model is established, the imaging is converted to L0 norm optimization problem. Secondly, one negative exponential function sequence is used as smoothed function to approach the block L0 norm. Finally, the revised step is added to ensure solving the optimization problem along the steepest descent gradient direction and the cost function is updated for the next loop. Simulation results verify the proposed algorithm is effective.

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Dual priming oligonucleotide (DPO)-based real-time RT-PCR assay for accurate differentiation of four major viruses causing porcine viral diarrhea

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MOLECULAR AND CELLULAR PROBES 2019年 47卷 101435-000页

作者： Jia, Shuo feng, Baohua Wang, Zhuo Ma, Yingying Gao, xuwen Jiang, Yanping Cui, Wen Qiao, Xinyuan Tang, Lijie Li, Yijing Wang, Li Xu, Yigang Northeast Agr Univ Heilongjiang Key Lab Anim Dis Control & Pharmaceu Coll Vet Med Harbin Heilongjiang Peoples R China China Minist Agr Key Lab Anim Pathogen Biol Northeastern Sci Inspect Stn Harbin Heilongjiang Peoples R China

Currently in China, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine rotavirus (PoRV), and porcine deltacoronavirus (PDCoV) are the major causes of porcine viral diarrhea, and mixed infections in clinics are common, resulting in significant economic losses in pig industry. Here, a dual priming oligonucleotide (DPO)-based multiplex real-time SYBR Green RT-PCR assay were developed for accurately differentiating PEDV, TGEV, PoRV, and PDCoV in clinical specimens targeting the N gene of TGEV, PEDV, and PDCoV, and the VP7 gene of PoRV. Results showed that the DPO primer allowed a wider annealing temperature range (40-65 degrees C) and had a higher priming specificity compared to conventional primer, in which more than 3 nucleotides in the 3'- or 5'-segment of DPO primer mismatched with DNA template, PCR amplification efficiency would decrease substantially or extension would not proceed. DPO-based multiplex real-time RT-PCR method had analytical detection limit of 8.63 x 10(2) copies/mu L, 1.92 x 10(2) copies/mu L, 1.74 x 10(2) copies/mu L, and 1.76 x 10(2) copies/mu L for PEDV, TGEV, PoRV, and PDCoV in clinical specimens, respectively. A total of 672 clinical specimens of piglets with diarrhea) symptoms were collected in Northeastern China from 2017 to 2018 followed by analysis using the assay, and epidemiological investigation results showed that PEDV, TGEV, PoRV, and PDCoV prevalence was 19.05%, 5.21%, 4.32%, and 3.87%, respectively. The assay developed in this study showed higher detection accuracy than conventional RT-PCR method, suggesting a useful tool for the accurate differentiation of the four major viruses causing porcine viral diarrhea in practice.

关键词： Porcine viral diarrhea Dual priming oligonucleotide (DPO) Real-time RT-PCR assay Accurate differentiation

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同构型知识基础合作研发伙伴的优势

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科技管理研究 2018年第2期38卷 131-138页

作者：曾德明赵旭雯冯科湖南大学工商管理学院湖南长沙410082

在专利竞赛的压力下,企业普遍选择知识基础多元化、网络化路线。基于汽车产业1999—2010年专利数据和负二项混合回归模型的实证研究表明,企业自身知识基础多元化与创新产出正相关,而自身知识基础网络密度与创新产出负相关;合作研发伙伴... 详细信息

在专利竞赛的压力下,企业普遍选择知识基础多元化、网络化路线。基于汽车产业1999—2010年专利数据和负二项混合回归模型的实证研究表明,企业自身知识基础多元化与创新产出正相关,而自身知识基础网络密度与创新产出负相关;合作研发伙伴知识基础多元化正向调节自身知识基础多元化,合作研发伙伴知识基础网络密度正向调节自身知识基础网络密度。同构型合作研发伙伴有利于企业自身吸收能力的释放,对于提升其创新产出更有优势。

关键词：合作研发知识基础多元化知识基础网络创新产出

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我国BIM推进现状与发展趋势探析

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施工技术 2019年第12期48卷 4-7页

作者：冯大阔肖绪文焦安亮刘会超中国建筑第七工程局有限公司河南郑州450004 中国建筑股份有限公司北京100037

结合国内外BIM研究和发展,详细阐述BIM的概念和内涵,介绍我国在BIM应用、软件、标准等方面的发展现状及存在问题。同时结合国家政策和行业发展需求,对BIM未来发展趋势进行探析,包括协同管理模式优化与创新、建筑全生命周期应用、一体化... 详细信息

结合国内外BIM研究和发展,详细阐述BIM的概念和内涵,介绍我国在BIM应用、软件、标准等方面的发展现状及存在问题。同时结合国家政策和行业发展需求,对BIM未来发展趋势进行探析,包括协同管理模式优化与创新、建筑全生命周期应用、一体化信息集成标准与平台、多种信息化技术融合、与移动终端的结合及具有自主知识产权的软件系统6个方面;并建议在该6个方面开展重点工作,以全面推进BIM应用。

关键词：建筑业建筑信息模型标准大数据物联网施工技术

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含铜镍尾矿重金属溶出特性试验研究

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材料与冶金学报 2019年第2期18卷 147-152页

作者：夏瑜冯泽珅张清孙桂容张淳关曙雷何绪文中国矿业大学(北京)化学与环境工程学院北京100083

本研究以位于我国东北典型铜镍矿区为研究对象,对其进行尾矿重金属溶出特性分析,通过静态浸出实验研究尾矿粒径和固液比对尾矿中镍(Ni)释放浓度及溶液pH的影响;并研究模拟酸雨条件下尾矿中Ni和铜(Cu)的溶解释放规律;此外,也分析了微生... 详细信息

本研究以位于我国东北典型铜镍矿区为研究对象,对其进行尾矿重金属溶出特性分析,通过静态浸出实验研究尾矿粒径和固液比对尾矿中镍(Ni)释放浓度及溶液pH的影响;并研究模拟酸雨条件下尾矿中Ni和铜(Cu)的溶解释放规律;此外,也分析了微生物对尾矿中重金属的溶出特性的影响.结果表明:在初始pH=7. 0的浸出液中,尾矿中的Ni在第1天就释放得较为完全,其质量浓度达到0. 85～1. 73 mg/L。减小尾矿粒径会增加Ni释放量,固液比过高会减小Ni的浸出;模拟酸雨(pH=4. 0和6. 0)条件下,淋溶液pH值相对较稳定,说明尾矿的缓冲能力较强,低pH条件利于Ni和Cu的溶出.静态浸出和动态淋溶实验初期,Ni的质量浓度基本高于《污水综合排放标准》(GB8978-1996)中的Ni排放限值(1. 0 mg/L),说明铜镍尾矿具有污染水环境的风险.微生物溶出试验结果表明:35 d后Ni和Cu浸出率达到了38. 4%和32. 7%,较酸浸条件下分别提高了74. 5%和28. 7%,说明微生物作用会加剧重金属Ni和Cu的释放,从而增加其环境风险.

关键词：含铜镍尾矿重金属静态浸出动态淋溶

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