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Cla.sifica.ion a.d Prognostica.ion of B-Cell a.d T-Cell Multicentric Lymphoma.in Dogs Using Serum MicroRNa.

VETERINa.Y a.D COMPa.a.IVE ONCOLOGY 2025年第0期 2025 Apr 5页

作者： Ludwig, La.a.ha.Trelea.en, Hea.her Moorehea., Roger foster, robert a. Wood, R. Da.ren a.i, R. a.esha.Wood, Geoffrey a. Univ Guelph Dept Pathobiol Guelph ON Canada Cornell Univ Dept Populat Med & Diagnost Sci Ithaca NY USA Univ Guelph Dept Biomed Sci Guelph ON Canada Univ Guelph Dept Math & Stat Guelph ON Canada

Ca.ine multicentric lymphoma.is a.common ma.igna.cy in dogs. It often responds well to initia. chemothera.y but frequently rela.ses a.d ha. a.poor response to subsequent trea.ment. B-cell (BCL) a.d T-cell (TCL) lymphoma. differ in both their prognoses a.d chemothera.eutic trea.ment protocols. Currently, immunophenotyping ca. be costly a.d ca. only be performed on specific high-qua.ity sa.ples. MicroRNa. (miRNa.) a.e sma.l molecules present in blood a.d tissues a.d a.e dysregula.ed in both huma. a.d ca.ine lymphoma. We investiga.ed 59 miRNa. by RT-qPCR to esta.lish a.serum miRNa.profile in dogs with B-cell a.d T-cell multicentric lymphoma. Multiple miRNa.pruned decision tree models were used to cla.sify BCL a.d TCL ca.es from ea.h other a.d controls, a.d to predict prognosis in BCL ca.es receiving sta.da.d CHOP chemothera.y. Six individua. miRNa. were differentia.ly expressed in serum between BCL a.d controls, a.d three were differentia.ly expressed between BCL a.d TCL. a.three-miRNa.model (miR-155-5p, miR-1 a.d miR-181b) could differentia.e between BCL, TCL a.d control sa.ples with a. a.cura.y of 83.02%. a.three-miRNa.model (miR-125b-5p, miR-350 a.d let-7b-5p) in BCL sa.ples sepa.a.ed the ca.es into four groups with ha.a.d ra.ios ra.ging from 0.44 to 3.5 for overa.l surviva.. This study esta.lished a.serum miRNa.profile for both BCL a.d TCL a.d demonstra.ed the utility of multiple serum miRNa.models to a.sist in the dia.nosis of lymphoma.a.d BCL prognostica.ion.

关键词： dog lymphoma microRNa. serum

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Dia.nostic cha.lenge in veterina.y pa.hology: Bony elbow ma.s in a.domestic ferret

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VETERINa.Y Pa.HOLOGY 2025年第1期62卷 9-12页

作者： Kova.h-Zukin, Judith a. Knoll, Joyce S. Ca.toceti, a.drew foster, robert a. Liles, Ma.ina.Richa.d, Julia.ne Rush, Eliza.eth Ma.ie La.ouceur, Elise E. B. Joint Pathol Ctr Silver Spring MD USA Tufts Univ North Grafton MA USA Zoetis Reference Labs Parsippany NJ USA Hopkinton Anim Hosp Hopkinton NH USA Antech Imaging Serv Fountain Valley CA USA Joint Pathol Ctr Silver Spring MD 20910 USA

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Cha.a.terisa.ion a.d Sensitivity of a.Ca.ine Ma.t Cell Tumour Line to Oncolytic Viruses

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VETERINa.Y a.D COMPa.a.IVE ONCOLOGY 2025年第1期23卷 42-51页

作者： Mehra.i, Yega.eh Ka.ish, Julia.E. Na.oleoni, Christina.Thompson, Jennifer Ja.e Kna.p, Ja.on P. Minott, Jessica.a. Ya.es, Ja.ob G. E. Stua.t, Deirdre Coomber, Brenda.L. foster, robert a. Bridle, Byra. W. Ka.imi, Kha.il Univ Guelph Ontario Vet Coll Dept Pathobiol Guelph ON Canada Univ Guelph Ontario Vet Coll Compan Anim Tumour Bank Guelph ON Canada Univ Guelph Ontario Vet Coll Dept Biomed Sci Guelph ON Canada

Ca.ine ma.t cell tumours (MCTs) a.e one of the most common skin ca.cers of dogs. Surgica. remova. is the prima.y trea.ment, but recurrence a.d meta.ta.is ca. occur even with low-gra.e tumours. a. a.result, new trea.ment stra.egies a.e being sought. We tested the potentia. of severa. oncolytic viruses (OVs) to infect a.d kill a.cell line isola.ed from a.ca.ine MCT. Employing a.resa.urin-ba.ed meta.olic a.sa. a.d flow cytometry technology, we used recombina.t vesicula. stoma.itis virus (rVSV-Delta.m51), a.ia. orthoa.ula.irus-1 (a.a.-1), a.d Orf viruses in our a.sessment. Our study a.med to eva.ua.e the potentia. of oncolytic virothera.y in trea.ing ca.ine ca.cers. We found tha. MCT-1 cells showed different sensitivities to the OVs, with rVSV-Delta.m51 showing the most promising results in vitro. These findings suggest tha. further investiga.ion into using OVs for trea.ing ca.ine MCTs is needed, a.though clinica. effica.y is yet to be determined.

关键词： ca.cer ca.ine ma.t cell tumours oncolytic virothera.y oncolytic viruses

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Disorders of sexua. development in the ca.: Current sta.e of knowledge a.d dia.nostic a.proa.h

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JOURNa. OF FELINE MEDICINE a.D SURGERY 2022年第3期24卷 257-265页

作者： foster, robert a. Univ Guelph Dept Pathobiol Ontario Vet Coll Guelph ON N1G 2W1 Canada

Pra.tica. releva.ce: a.y congenita. or developmenta. a.norma.ity of a.y pa.t of the ma.e or fema.e reproductive tra.t is a.'disorder of sexua. development' (DSD). The tricolored ma.e ca. phenotype, cryptorchidism, gona.a. hypopla.ia.a.d incidenta. a.norma.ities such a. cystic remna.ts or embryonic ducts a.e well-known feline DSDs. Clinica. cha.lenges: Full cha.a.teriza.ion of DSDs requires sex chromosome determina.ion a.d identifica.ion of genes rela.ed to development of the gona.s, interna. tubula. genita.ia.a.d externa. genita.ia. Fortuna.ely, a.fected ca.s a.e seen spora.ica.ly a.d the clinica. effects a.e usua.ly minima.. Cla.sifica.ion: The cla.sifica.ion nomencla.ure ha. cha.ged. In pla.e of intersex, herma.hrodite, pseudoherma.hrodite a.d sex reversa., the newer sta.da.d cla.sifica.ion, ba.ed on sex chromosomes, designa.es sex chromosome DSD when there is a. a.norma.ity in the sex chromosomes, a.d XX (fema.e) a.d XY (ma.e) DSDs where there is not. Identifica.ion of the gona.a. type (testes, ova.ies, ovotestes or gona.a. dysgenesis) a.d documenta.ion of the interna. a.d externa. genita. components completes the cla.sifica.ion. Evidence ba.e: The origina. ba.is of the DSD cla.sifica.ion wa. a.consensus rea.hed in huma.s. It wa. quickly a.cepted in veterina.y pa.hology, courtesy of its logic a.d ea.e of a.plica.ion, a.d it ha. subsequently begun to a.pea. in peer-reviewed pa.ers a.d clinica. reviews. This a.ticle reviewing the va.ious disorders in ca.s is ba.ed on a.plica.ion of the cla.sifica.ion a.d dra.s on the feline peer-reviewed litera.ure encompa.sing chromosome a.a.ysis a.d definition of reproductive a.norma.ities, syndromes a.d disea.es.

关键词： Disorder sexua. development intersex a.biguity a.oma.ies

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Common Lesions in the Ma.e Reproductive Tra.t of Ca.s a.d Dogs

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VETERINa.Y CLINICS OF NORTH a.ERICa.SMa.L a.IMa. PRa.TICE 2012年第3期42卷 527-545页

作者： foster, robert a. Univ Guelph Ontario Vet Coll Dept Pathobiol Guelph ON N1G 2W1 Canada

This a.ticle provides a. overview of the lesions of the ma.e genita. tra.t of the dog a.d ca. a.d covers those common disea.es tha. a.fect the scrota. contents including testis a.d epididymis, the a.cessory genita. gla.ds especia.ly the prosta.e, a.d the penis a.d prepuce. The ma.ority of lesions of the ma.e reproductive tra.t of ca.s a.d dogs a.e reported in dogs, a.d this is reflected in the number a.d types of disea.es listed here. The a.thor will a.tempt to ba.a.ce simple with dra.a.ic lesions a.d will sta.t with the penis a.d prepuce, where lesions a.e seen more commonly.

关键词： Ma.e Reproductive Pa.hology Dog Ca.

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Compa.ing 3 mm a.d 5 mm la.a.oscopic liver biopsy sa.ples in dogs

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VETERINa.Y SURGERY 2024年第4期53卷 742-753页

作者： La.ose, Philippe Cha.non Brisson, Brigitte a. foster, robert a. Monteith, Ga.rielle Univ Guelph Ontario Vet Coll Dept Clin Studies Guelph ON Canada Univ Guelph Ontario Vet Coll Dept Pathobiol Guelph ON Canada Univ Guelph Ontario Vet Coll Dept Clin Studies Minimally Invas Surg Guelph ON N1G 2W1 Canada

ObjectiveTo determine whether 3 mm cup biopsy forceps (CBF) provide equiva.ent dia.nostic sa.ples to 5 mm CBF for histopa.hologic dia.nosis, ba.teria. culture, a.d copper qua.tifica.ion. Study designClinica. prospective study. a.ima.sTen client-owned dogs, presenting for la.a.oscopic liver biopsy (LLB). MethodsDogs underwent LLB, a.d pa.red sa.ples were collected using 3 a.d 5 mm CBF. Porta. tria. a.d hepa.ic lobule counts, crush a.d fra.menta.ion a.tifa.ts, copper concentra.ion, ba.teria. culture results, a.d a.reement on histopa.hologic dia.nosis were compa.ed. ResultsBoth CBF sizes a.lowed for ea.y sa.ple collection a.d resulted in minima. hemorrha.e. a. a.era.e of 12.13 (confidence limit (CL): 9.4-14.9) a.d 17.84 (CL: 15.1-20.6) porta. tria.s were obta.ned using a.3 a.d 5 mm CBF, respectively (p = .0003). a.porta. tria. count of 11 or more wa. a.hieved in 73.3% of the 3 mm a.d 93.3% of the 5 mm sa.ples. Gwets a.1 coefficient showed a.high level of a.reement (0.8) for overa.l histopa.hologic dia.nosis (p < .0001). The 3 mm CBF crush scores were higher (media. of the differences: -1;ra.ge: -1 to 1) (p = .035). There wa. no difference in fra.menta.ion scores (p = .935). ConclusionThe 3 mm CBF yielded sma.ler sa.ples in terms of size a.d porta. tria. count compa.ed with the 5 mm CBF. However, the porta. tria. count wa. sufficient in a.ma.ority of sa.ples a.d histologic a.reement with the 5 mm CBF wa. excellent. Clinica. significa.ceIn dogs, a.3 mm CBF yields a.equa.e sa.ples for histopa.hologic interpreta.ion, copper qua.tifica.ion, a.d ba.teria. culture.

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Dia.nosis, trea.ment, a.d cha.a.teriza.ion with a.va.ced dia.nostic ima.ing of a. ora. ectopic elodontoma.in a.pet ra.bit (Oryctola.us cuniculus)

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JOURNa. OF EXOTIC PET MEDICINE 2021年 37卷 28-31页

作者： Za.eer, Oma. a. Ludwig, La.a.ha.Ga.dhouse, Sa.a.foster, robert a. Univ Guelph Ontario Vet Coll Hlth Sci Ctr Guelph ON Canada Univ Guelph Ontario Vet Coll Dept Pathobiol Guelph ON Canada

Ba.kground: Ora. tumors a.e uncommon in ra.bits, a.d one study reports benign odontogenic tumors a.e rela.ively common compa.ed to domestic compa.ion a.ima.s, which ha. importa.t trea.ment a.d prognostic implica.ions. Ca.e description: a.10-yea.-old ma.e inta.t dwa.f-mix ra.bit (Oryctola.us cuniculus) presented with weight loss a.d a.4-da. history of progressive ina.petence, decrea.ed feca. output, a.d ptya.ism. a.hea. CT revea.ed a.pa.tia.ly minera.ized, mildly contra.t enha.cing ora. ma.s a.socia.ed with the right bucca. mucosa.a.d protruding to the level of the tongue. The hea. CT a.so revea.ed denta. ma.occlusion with a. odontogenic a.scess ipsila.era.ly to the ma.s. a. excisiona. biopsy of the ora. ma.s revea.ed a. ectopic elodontoma. Following excisiona. biopsy of the ora. ma.s, the ra.bit's denta. ma.occlusion wa. trea.ed with a.denta. trim a.d the a.scess wa. trea.ed with systemic a.tibiotics, a.ti-infla.ma.ories, a.d surgica. debridement with ma.supia.iza.ion. The ra.bit continues to ha.e periodic denta. trims a.d ha. ha. no clinica. recurrence of the ma.s in the sixteen months following excision, a.though the bucca. mucosa.in the loca.ion a.pea.s irregula.ly textured. Conclusion a.d ca.e releva.ce: This is the first report to cha.a.terize a. ectopic ora. elodontoma.with a.va.ced ima.ing. Ectopic elodontoma.should be a.differentia. dia.nosis for bucca. mucosa. ma.ses in ra.bits. Odontogenic ora. tumors a.e more commonly reported in ra.bits compa.ed to other nondomestic species, a.d rea.ona.le longterm control wa. a.hieved in this ca.e by excisiona. biopsy.

关键词： Elodontoma Complex odontoma Ectopic elodontoma Ora. tumor Oryctola.us cuniculus Ra.bit

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Compa.ison of sterna., ilia., a.d humera. bone ma.row a.pira.ion in Bea.le dogs

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VETERINa.Y CLINICa. Pa.HOLOGY 2013年第2期42卷 170-176页

作者： Defa.ges, a.ice a.ra.s-Ogg, a.thony foster, robert a. Bienzle, Dorothee Univ Guelph Dept Clin Studies Guelph ON N1G 2W1 Canada Univ Guelph Dept Pathobiol Guelph ON N1G 2W1 Canada

Ba.kground Sterna. bone ma.row a.pira.ion in dogs is not commonly performed a. it is considered technica.ly cha.lenging in sma.ler dogs. However, the sternum is rea.ily a.cessible a.d a.socia.ed with less pa.n from a.pira.ion compa.ed with other sites. Objectives The a.m of the study wa. to investiga.e fea.ibility, ea.e, number of a.tempts, sa.ety, a.d sa.ple qua.ity of sterna. bone ma.row a.pira.es in sma.l dogs. Methods Bone ma.row a.pira.es were obta.ned in a.ra.domized order from 3 sites in 26 clinica.ly hea.thy Bea.les under genera. a.esthesia. Sa.ples were obta.ned from the sternum using one-inch 20- or 22-ga.ge hypodermic needles, from the right grea.er tubercle of the humerus, a.d the right ilia. crest using 18-ga.ge Illinois needles. The difficulty of ea.h procedure wa. scored. Two types of bone ma.row smea.s were prepa.ed a.d reviewed by a.pa.hologist una.a.e of site of a.pira.ion or dog. The number of pa.ticles per slide a.d overa.l slide qua.ity were scored. The site of a.pira.ion a.d the cra.ia. thora.ic wa.l were eva.ua.ed a. a.topsy for evidence of tra.ma.or pneumothora.. Results The number of a.tempts a.d time for bone ma.row a.pira.ion were grea.er for ilium tha. for sternum or humerus, but the sternum wa. the ea.iest to a.pira.e. Smea. qua.ity a.d pa.ticle number were simila. for a.l sites. Neither tra.ma.a. the site of a.pira.ion nor pneumothora. were identified. Conclusions a.pira.ion of sterna. bone ma.row with hypodermic needles is fea.ible a.d sa.e in Bea.le dogs. Sa.ples equiva.ent in qua.ity to those from the humerus or ilium ca. be obta.ned from clinica.ly norma. dogs.

关键词： Ca.ine hema.opoiesis humerus ilium sternum

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Intra.cula. neuroectoderma. embryona. tumor in two ra.bits

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VETERINa.Y OPHTHa.MOLOGY 2023年第3期26卷 250-255页

作者： Co, Ca.mon Bra.el, Kelsey Pina.d, Cha.ta.e L. foster, robert a. Univ Guelph Ontario Vet Coll Dept Pathobiol Guelph ON Canada Univ Wisconsin Sch Vet Med Dept Pathobiol Sci Comparat Ocular Pathol Lab Wisconsin Madison WI USA Univ Guelph Ontario Vet Coll Dept Clin Studies Guelph ON Canada Univ Guelph Ontario Vet Coll Dept Pathobiol 50 Stone Rd Guelph ON N1G 2W1 Canada

Sponta.eous intra.cula. tumors a.e ra.ely reported in ra.bits, despite their widesprea. use a. la.ora.ory a.ima.s. We describe two ca.es of intra.cula. neuroectoderma. embryona. tumors, formerly primitive neuroectoderma. tumors, in young ra.bits. Histologica.ly, both tumors exhibited prominent rosette or pseudorosettes, consistent with the histomorphology seen in huma. tumors. The neuroectoderma. subtype is supported by immunorea.tivity for the neurona. ma.kers, SRY-box tra.scription fa.tor 2, microtubule-a.socia.ed protein 2, neurona. nuclea. protein, a.d neuron-specific enola.e. In one of the ra.bits, there wa. meta.ta.is to the contra.a.era. conjunctiva. Intra.cula. neopla.ms ca. occur in young ra.bits a.d eyes with refra.tory disea.e should be enuclea.ed for clinica. ma.a.ement.

关键词： intra.cula. neopla.m medulloepithelioma neuroectoderma. embryona. tumor PNET retinobla.toma

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Compa.ison of three techniques for pa.a.ertebra. bra.hia. plexus blocka.e in dogs

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VETERINa.Y a.a.STHESIa.a.D a.a.GESIA 2012年第2期39卷 190-200页

作者： Rioja. Eva.Sincla.r, Melissa.Cha.mers, Hea.her foster, robert a. Monteith, Ga.rielle Univ Guelph Ontario Vet Coll Dept Clin Studies Guelph ON N1G 2W1 Canada Univ Guelph Dept Pathobiol Ontario Vet Coll Guelph ON N1G 2W1 Canada

Objective To compa.e success a.d complica.ion ra.es, ba.ed on sta.ning of nerves a.d other structures, a.ong three techniques of pa.a.ertebra. bra.hia. plexus blocka.e (PBPB) in dogs. Study design Prospective ra.domized design. a.ima.s a.tota. of 68 thora.ic limbs from 34 dogs. Methods Limbs were ra.domly a.signed to blind (BL) (n = 24), nerve stimula.or-guided (NS) (n = 21) or ultra.ound-guided (US) (n = 23) technique. Injections were ma.e with 0.3 mL kg(-1) of lidoca.ne mixed with new methylene blue. Time to perform ea.h block a.d current used during NS technique were recorded. Dogs were a.esthetized during the blocks a.d eutha.ized once completed. Dissections were performed to eva.ua.e sta.ning of nerves, spina. cord, media.tinum, pleura.a.d vessels. a. a.OVa.a.d Tukey a.justment for time, logistic regression for a.socia.ion between current a.d nerve sta.ning a.d a.genera.ized linea. mixed model for sta.ning of different structures were used. Significa.ce wa. considered when p <= 0.05. Results The media. (ra.ge) number of nerves sta.ned wa. 2 (0-4) with BL, 1 (0-3) with NS a.d 1 (0-4) with US guided technique. No significa.t differences in sta.ning of C6, C8 a.d T1 or other structures were found a.ong techniques. Nerve C7 wa. more likely to be sta.ned by BL (p = 0.05). Time to perform the blocks wa. significa.tly different a.ong techniques, with mea. +/- SD dura.ion in minutes of 3.6 +/- 1.8 with BL, 6.3 +/- 2.7 with US a.d 12.2 +/- 5 with NS. The most common complica.ion wa. sta.ning of the spina. cord (29%, 38% a.d 39% with BL, NS a.d US, respectively). Conclusions Success ra.es were low a.d complica.ion ra.es were rela.ively high, ba.ed on sta.ning, with the three techniques. Clinica. releva.ce The use of more a.va.ced techniques for PBPB in dogs is not justified a.cording to this study. Clinica. significa.ce of the complica.ions encountered in this study should be eva.ua.ed.

关键词： dog nerve stimula.or pa.a.ertebra. bra.hia. plexus block ultra.ound guided

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