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On the origin of SARS-CoV-2——The blind watchmaker argument

Science China(Life Sciences) 2021年第9期64卷 1560-1563页

作者： Chung-I Wu Haijun Wen Jian Lu Xiao-dong Su Alice CHughes Weiwei Zhai chen chen Hua chen Mingkun Li Shuhui Song Zhaohui Qian Qihui Wang Bingjie chen Zixiao Guo Yongsen Ruan Xuemei Lu fuwen Wei Li Jin Le Kang Yongbiao Xue Guoping Zhao Ya-Ping Zhang State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Landscape Ecology Group Center for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Biomedical Innovation Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Beijing Institute of Genomics Chinese Academy of Sciencesand China National Centre for BioinformationBeijing 100101China Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China MOE Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200433China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China

In the comparison with SARS-CoVof 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more *** the blind watchmaker argument,such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection.

关键词： argument origin adapted

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腹部外科手术患者营养风险和营养支持治疗情况调查

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中国中西医结合外科杂志 2024年第1期30卷 100-104页

作者：于福文王辰茜田书霞天津市中西医结合医院临床药学科天津300100 天津医科大学临床医学院药学系天津300276

目的:调查我院腹部外科手术患者营养风险现患率和营养支持治疗的现状。方法:采用回顾性定点连续抽样法,选取2021年10月-2022年10月我院收治的腹部外科手术患者,入院24 h内行营养风险筛查(NRS2002),分析患者营养风险发生情况、是否给予... 详细信息

目的:调查我院腹部外科手术患者营养风险现患率和营养支持治疗的现状。方法:采用回顾性定点连续抽样法,选取2021年10月-2022年10月我院收治的腹部外科手术患者,入院24 h内行营养风险筛查(NRS2002),分析患者营养风险发生情况、是否给予营养支持治疗以及营养支持治疗的方式等。结果:符合条件入组的腹部外科入院患者1401例,其中具有营养风险(NRS2002评分≥3分)的患者435例,无营养风险的患者(NRS2002评分<3分)966例,营养风险现患率为31.05%(435/1401)。营养不良指体质指数(BMI)<18.5 kg/m2或白蛋白<30 g/L的患者90例,本研究中营养不良现患率为6.42%(90/1401)。具有营养风险的435例患者中,293例(67.36%)于营养筛查后的7 d内给予营养支持治疗,142例(32.64%)7 d内未给予营养支持治疗。无营养风险的966例患者中,516例(53.42%)7 d内给予营养支持治疗,450例7 d内未给予营养支持治疗(46.58%)。具有营养风险并给予营养支持治疗的293例患者中,133例(45.39%)使用肠外营养(PN),44例(15.02%)使用肠内营养(EN),116例(39.59%)使用PN+EN。1401例患者中,手术患者615例,NRS2002评分≥3分的180例,营养风险现患率29.27%,非手术患者786例,NRS2002评分≥3分的255例,营养风险现患率32.44%,两组营养风险现患率无明显差异(P>0.05)。615例手术患者中,胆囊胆管手术420例,NRS2002评分≥3分111例,营养风险现患率26.35%,胰腺手术191例,NRS2002评分≥3分68例,营养风险现患率35.60%,胰腺手术组的营养风险现患率高于胆囊胆管手术,差异有统计学意义(P <0.05)。结论:腹部外科手术患者的营养支持治疗率不足,营养支持治疗方式以PN为主,胰腺手术患者营养风险现患率高于胆囊胆管手术患者。

关键词：腹部外科手术营养风险筛查 NRS2002 营养支持治疗

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超声造影在识别Ⅰ期子宫静脉内平滑肌瘤病中的诊断价值

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中国超声医学杂志 2024年第11期40卷 1293-1296页

作者：陈琦张超顾小宁石富文刘芳成珍珍杨敏刘冬梅首都医科大学附属北京世纪坛医院超声科首都医科大学附属北京朝阳医院超声科

目的分析Ⅰ期子宫静脉内平滑肌瘤病（IVL）的超声造影特征，探讨超声造影识别Ⅰ期IVL的应用价值。方法回顾性收集经手术病理证实为Ⅰ期IVL的16例患者的临床病历、常规超声与超声造影资料，总结Ⅰ期IVL的常规超声及超声造影特征。结果 ... 详细信息

目的分析Ⅰ期子宫静脉内平滑肌瘤病（IVL）的超声造影特征，探讨超声造影识别Ⅰ期IVL的应用价值。方法回顾性收集经手术病理证实为Ⅰ期IVL的16例患者的临床病历、常规超声与超声造影资料，总结Ⅰ期IVL的常规超声及超声造影特征。结果（1）常规超声和超声造影的诊断准确度分别为25%（4/16）、62.5%（10/16）,两者差异有统计学意义（χ2=4.571,P<0.05）。（2）常规超声诊断正确的4例均为宫旁病灶，1例表现为混合回声肿块，内见迂曲无回声；3例表现为静脉内低回声。（3）超声造影表现为增强早期肿块内部血管先显影，横切面显示多个斑点状增强区；达峰期不均匀低增强，并呈“蠕虫样”沿静脉延伸；增强晚期无明显的“血管环征”,静脉内IVL表现为低增强的病灶被周围持续高增强的静脉血流环绕的特点，呈“夹心饼干”征。结论超声造影在Ⅰ期IVL的诊断中具有重要意义，能够弥补常规超声的不足，提高诊断准确度。

关键词：子宫静脉内平滑肌瘤病超声超声造影

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一种新的电梯平衡系数测试方法及其测试仪器

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中国电梯 2024年第1期35卷 32-37页

作者：张学伦邓富文陈武孙邦文重庆品智建设工程质量检测有限公司重庆401120

在电梯运行过程中,轿厢与对重两侧的重量分配呈连续变化趋势,导致平衡系数处于动态变化状态;而且,电梯安装完毕后各运动部件的重量很难核实,从而导致在电梯安装调试和检验检测中较难准确测试电梯平衡系数。针对此难题,分析了电梯平衡系... 详细信息

在电梯运行过程中,轿厢与对重两侧的重量分配呈连续变化趋势,导致平衡系数处于动态变化状态;而且,电梯安装完毕后各运动部件的重量很难核实,从而导致在电梯安装调试和检验检测中较难准确测试电梯平衡系数。针对此难题,分析了电梯平衡系数的参数特性和传统测试方法存在的问题,提出了一种可以便捷、高效、准确测试平衡系数范围的方法,并设计了用于该测试方法的测试仪。最后分析了该测试方法及测试仪的特点,并通过实例验证了该测试方法的可行性。

关键词：电梯平衡系数测试方法测试仪

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应用于炮口冲击波的生物表面压力测试系统

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兵器装备工程学报 2022年第5期43卷 261-265页

作者：陈学文赖富文牛博怀高赫王文廉中北大学仪器科学与动态测试教育部重点试验室太原030051 中北大学电子测试技术国家重点试验室太原030051 中国人民解放军63853部队吉林白城137000

针对目前冲击波生物效应试验中不易直接获取生物体表面冲击波压力数据的问题,提出并设计了一种可穿戴式的多通道多重触发式的冲击波存储测试系统。该系统采用微型传感器进行多路循环采集同时结合多重触发技术以满足冲击波测试中试验动... 详细信息

针对目前冲击波生物效应试验中不易直接获取生物体表面冲击波压力数据的问题,提出并设计了一种可穿戴式的多通道多重触发式的冲击波存储测试系统。该系统采用微型传感器进行多路循环采集同时结合多重触发技术以满足冲击波测试中试验动物多部位压力信号采集的需求,对系统进行了小型化设计提高了仪器安装的简易性。在靶场进行了山羊损伤效应试验,测试系统成功获取了连续炮击时试验羊在冲击波作用下多个部位的多组压力曲线。试验结果证明测试系统稳定性、实用性良好,能为炮口冲击波生物效应试验提供准确、可靠的数据。

关键词：炮口冲击波生物效应存储测试多通道多重触发

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FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways

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MOLECULAR CELL 2023年第15期83卷 2810-+页

作者： Huang, Min Yao, fuwen Nie, Litong Wang, Chao Su, Dan Zhang, Huimin Li, Siting Tang, Mengfan Feng, Xu Yu, Bin chen, Zhen Wang, Shimin Yin, Ling Mou, Lisha Hart, Traver chen, Junjie Univ Texas MD Anderson Canc Ctr Dept Expt Radiat Oncol Houston TX 77030 USA Shenzhen Univ Shenzhen Peoples Hosp 2 Shenzhen Inst Translat Med Hlth Sci CtrDept Hepatopancreatobiliary SurgAffi Shenzhen Peoples R China Univ Texas MD Anderson Canc Ctr Dept Bioinformat & Computat Biol Houston TX 77030 USA

DNA damage-activated signaling pathways are critical for coordinating multiple cellular processes, which must be tightly regulated to maintain genome stability. To provide a comprehensive and unbiased perspective of DNA damage response (DDR) signaling pathways, we performed 30 fluorescence-activated cell sorting (FACS)-based genome-wide CRISPR screens in human cell lines with antibodies recognizing distinct endogenous DNA damage signaling proteins to identify critical regulators involved in DDR. We discovered that proteasome-mediated processing is an early and prerequisite event for cells to trigger camptothecinand etoposide-induced DDR signaling. Furthermore, we identified PRMT1 and PRMT5 as modulators that regulate ATM protein level. Moreover, we discovered that GNB1L is a key regulator of DDR signaling via its role as a co-chaperone specifically regulating PIKK proteins. Collectively, these screens offer a rich resource for further investigation of DDR, which may provide insight into strategies of targeting these DDR pathways to improve therapeutic outcomes.

关键词： FACS-based CRISPR screen DDR signaling antibody proteasome PRMT5 GNB1L

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培门冬酰胺酶治疗急性淋巴细胞白血病患儿高血糖发生情况及危险因素分析

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中国当代医药 2023年第5期30卷 99-102页

作者：陈庆法刘福稳梁昌达江西省儿童医院血液科江西南昌330000

目的分析培门冬酰胺酶治疗急性淋巴细胞白血病(ALL)患儿的高血糖发生情况及危险因素,为改善ALL患儿长期预后及临床治疗提供参考意义。方法回顾性分析江西省儿童医院2016年1月至2021年6月收治的728例ALL患儿的临床资料,研究对象均进行培... 详细信息

目的分析培门冬酰胺酶治疗急性淋巴细胞白血病(ALL)患儿的高血糖发生情况及危险因素,为改善ALL患儿长期预后及临床治疗提供参考意义。方法回顾性分析江西省儿童医院2016年1月至2021年6月收治的728例ALL患儿的临床资料,研究对象均进行培门冬酰胺酶治疗,所有研究对象诱导化疗期间至少每周复查1次血糖,根据诱导化疗后是否继发高血糖将其分为继发高血糖组(n=16)、非继发高血糖组(n=712)。采用单因素分析及多因素logistic回归分析筛选ALL患儿培门冬酰胺酶治疗过程中发生高血糖的独立危险因素。结果培门冬酰胺酶治疗ALL患儿时高血糖发生率为2.20%(16/728);单因素分析结果提示,不同免疫分型、白血病危险度分型、髓外侵犯情况以及初始乳酸脱氢酶(LDH)水平的ALL患儿诱导化疗期间的血糖水平比较,差异有统计学意义(P<0.05);多因素分析结果提示,中危型白血病(β=2.028,OR=7.599,95%CI:1.727~33.440)、合并骨髓侵犯(β=1.691,OR=5.425,95%CI:1.050~28.036)以及初始LDH水平≥高限2倍(β=1.496,OR=4.464,95%CI:1.446~13.777)均是影响ALL患儿继发高血糖的独立危险因素(P<0.05)。结论ALL患儿白血病免疫分型、白血病危险度分型为高危、合并髓外侵犯以及初始LDH水平≥高限2倍等均可独立导致ALL患儿诱导化疗后继发高血糖,医务人员需针对具备上述危险因素的患儿展开严密监测,并对已发生高血糖者及时采取降糖干预措施。

关键词：培门冬酰胺酶急性淋巴细胞白血病高血糖发生情况危险因素

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Towards Unified Alignment Between Agents, Humans, and Environment

arXiv

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arXiv 2024年

作者： Yang, Zonghan Liu, An Liu, Zijun Liu, Kaiming Xiong, Fangzhou Wang, Yile Yang, Zeyuan Hu, Qingyuan chen, Xinrui Zhang, Zhenhe Luo, fuwen Guo, Zhicheng Li, Peng Liu, Yang Department of Computer Science and Technology Tsinghua University Beijing China Tsinghua University Beijing China

The rapid progress of foundation models has led to the prosperity of autonomous agents, which leverage the universal capabilities of foundation models to conduct reasoning, decision-making, and environmental interaction. However, the efficacy of agents remains limited when operating in intricate, realistic environments. In this work, we introduce the principles of Unified Alignment for Agents (UA2), which advocate for the simultaneous alignment of agents with human intentions, environmental dynamics, and self-constraints such as the limitation of monetary budgets. From the perspective of UA2, we review the current agent research and highlight the neglected factors in existing agent benchmarks and method candidates. We also conduct proof-of-concept studies by introducing realistic features to WebShop (Yao et al., 2022a), including user profiles to demonstrate intentions, personalized reranking for complex environmental dynamics, and runtime cost statistics to reflect self-constraints. We then follow the principles of UA2 to propose an initial design of our agent and benchmark its performance with several candidate baselines in the retrofitted WebShop. The extensive experimental results further prove the importance of the principles of UA2. Our research sheds light on the next steps of autonomous agent research with improved general problem-solving abilities. © 2024, CC BY.

关键词： Autonomous agents

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Position: towards unified alignment between agents, humans, and environment 24

Position: towards unified alignment between agents, humans, ...

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Proceedings of the 41st International Conference on Machine Learning

作者： Zonghan Yang An Liu Zijun Liu Kaiming Liu Fangzhou Xiong Yile Wang Zeyuan Yang Qingyuan Hu Xinrui chen Zhenhe Zhang fuwen Luo Zhicheng Guo Peng Li Yang Liu Dept. of Comp. Sci. & Tech. Institute for AI Tsinghua University Beijing China Institute for AI Industry Research (AIR) Tsinghua University Beijing China Dept. of Comp. Sci. & Tech. Institute for AI Tsinghua University Beijing China and Institute for AI Industry Research (AIR) Tsinghua University Beijing China and Jiangsu Collaborative Innovation Center for Language Competence Jiangsu China

The rapid progress of foundation models has led to the prosperity of autonomous agents, which leverage the universal capabilities of foundation models to conduct reasoning, decision-making, and environmental interaction. However, the efficacy of agents remains limited when operating in intricate, realistic environments. In this work, we introduce the principles of Unified Alignment for Agents (UA2), which advocate for the simultaneous alignment of agents with human intentions, environmental dynamics, and self-constraints such as the limitation of monetary budgets. From the perspective of UA2, we review the current agent research and highlight the neglected factors in existing agent benchmarks and method candidates. We also conduct proof-of-concept studies by introducing realistic features to Web-Shop (Yao et al., 2022a), including user profiles to demonstrate intentions, personalized reranking for complex environmental dynamics, and runtime cost statistics to reflect self-constraints. We then follow the principles of UA2 to propose an initial design of our agent and benchmark its performance with several candidate baselines in the retrofitted WebShop. The extensive experimental results further prove the importance of the principles of UA2. Our research sheds light on the next steps of autonomous agent research with improved general problem-solving abilities.

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Tunable photoluminescence and temperature sensing properties of Ce³⁺, Eu²⁺ co-doped Ca2-xSrxMgSi2O7 phosphors

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JOURNAL OF LUMINESCENCE 2021年 240卷 118417-118417页

作者： Zhou, Liuyan Liu, fuwen Ye, Renguang Lei, Lei Guo, Weigang chen, Liang Deng, Degang Xu, Shiqing China Jiliang Univ Coll Mat & Chem Hangzhou 310018 Peoples R China China Jiliang Univ Inst Optoelect Mat & Devices Hangzhou 310018 Peoples R China Hangzhou Vocat & Tech Coll Hangzhou 310018 Peoples R China

A series of Ca2-xSrxMgSi2O7: Ce3+, Eu2+ (x = 0, 0.5, 1, 1.5, 2) phosphors were synthesized on the basis of high temperature solid-state reaction strategy. Its phase composition, optical spectral properties, fluorescence lifetime and temperature sensitivity were investigated in detail. Under excitation at 342 nm, the emission spectra of Ca2MgSi2O7: Ce3+, Eu2+ exhibit a purple emission band (Ce3+ ions) and a green emission band (Eu2+ ions). The emission band of Ce3+ overlaps with the excitation band of Eu2+, indicating that there may be energy transfer (ET) between the two ions. The decreasing fluorescence lifetime of Ce3+ with increasing Eu2+ concentration further proves the existent of ET process in Ca2MgSi2O7: Ce3+, Eu2+ phosphor. In addition, Ca2-xSrxMgSi2O7: Ce3+, Eu2+ solid solution was designed and synthesized by Sr2+ substituting Ca2+. As Sr2+ gradually replaced Ca2+, the blue-shift of Ce3+ and Eu(2+)emission band were caused by the change of crystal field. With the increase of temperature, the fluorescence intensity of Ce3+ and Eu2+ emission bands decreased slowly and rapidly, respectively. Hence, in the Ce3+/Eu2+ co-activated Ca2-xSrxMgSi2O7 phosphor, Ce3+ ions and Eu2+ ions can be used as fluorescence intensity ratio (FIR) signals. The maximum relative sensitivity can reach 2.43% K-1 (at 293 K) under 342 nm excitation. The above results indicate that Ca2-xSrxMgSi2O7: Ce3+, Eu2+ phosphors are potential candidates for optical thermometer materials.

关键词： Ca2-xSrxMgSi2O7: Ce3+ Eu2+ Optical thermometer Energy transfer Fluorescence intensity ratio

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