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Event-Triggered Asynchronous Guaranteed Cost Control for Markov Jump Discrete-Time Neural Networks With Distributed Delay and Channel Fading

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IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS 2018年第8期29卷 3588-3598页

作者： Yan, Huaicheng Zhang, Hao Yang, fuwen Zhan, Xisheng Peng, chen East China Univ Sci & Technol Minist Educ Key Lab Adv Control & Optimizat Chem Proc Shanghai 200237 Peoples R China Hubei Normal Univ Coll Mechatron & Control Engn Huangshi 435002 Peoples R China Griffith Univ Sch Engn Gold Coast Qld 4222 Australia Shanghai Univ Sch Mechatron Engn & Automat Shanghai 200072 Peoples R China

This paper is concerned with the guaranteed cost control problem for a class of Markov jump discrete-time neural networks (NNs) with event-triggered mechanism, asynchronous jumping, and fading channels. The Markov jump NNs are introduced to be close to reality, where the modes of the NNs and guaranteed cost controller are determined by two mutually independent Markov chains. The asynchronous phenomenon is considered, which increases the difficulty of designing required mode-dependent controller. The event-triggered mechanism is designed by comparing the relative measurement error with the last triggered state at the process of data transmission, which is used to eliminate dispensable transmission and reduce the networked energy consumption. In addition, the signal fading is considered for the effect of signal reflection and shadow in wireless networks, which is modeled by the novel Rice fading models. Some novel sufficient conditions are obtained to guarantee that the closed-loop system reaches a specified cost value under the designed jumping state feedback control law in terms of linear matrix inequalities. Finally, some simulation results are provided to illustrate the effectiveness of the proposed method.

关键词： Asynchronous control event-triggered mechanism fading channels guaranteed cost control Markov jump neural networks

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Pseudomyxoma peritonei induced by low-grade appendiceal mucinous neoplasm accompanied by rectal cancer: a case report and literature review

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BMC SURGERY 2019年第1期19卷 42-42页

作者： Ning, Shili Yang, Yanliang Wang, chen Luo, fuwen Dalian Med Univ Hosp 2 Dept Gen Surg Zhongshan Rd Dalian 116023 Liaoning Peoples R China

BackgroundPseudomyxoma peritonei (PMP) is a disease involving the peritoneum characterized by the production of large quantities of mucinous ascites. PMP has a low incidence, is difficult to diagnose, and has a guarded prognosis. PMP induced by low-grade appendiceal mucinous neoplasm is extremely rare, and PMP accompanied by rectal cancer is even *** presentationWe present a unique case of a 70-year-old male with PMP induced by low-grade appendiceal mucinous neoplasm accompanied by rectal cancer. The patient's clinical, surgical, and histologic data were reviewed. The patient had persistent distended abdominal pain without radiating lower back pain, abdominal distension for 1month, and no exhaustion or defecation for 4days. A transabdominal ultrasound-guided biopsy was performed on the first day. The patient received an emergency exploratory laparotomy because of increased abdominal pressure. We performed cytoreductive surgery, enterolysis, intestinal decompression, special tumour treatment and radical resection of rectal carcinoma. The postoperative course was uneventful. The postoperative histological diagnoses were PMP, low-grade appendiceal mucinous neoplasm and rectal medium differentiated adenocarcinoma. At the 1-year follow-up visit, no tumour recurrence was observed by computed tomography (CT). We also performed a literature *** should be aware that PMP can rarely be accompanied by rectal cancer, which represents an easily missed diagnosis and increases the difficulty of diagnosis and treatment. Additionally, there are some typical characteristics of PMP with respect to diagnosis and treatment.

关键词： Pseudomyxoma peritonei Appendiceal mucinous neoplasm Rectal cancer Diagnosis Treatment

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Correction to “Designing Superhydrophilic Hydrogels as Binder-Free Catalysts for Enhanced Oxygen Evolution Performance”

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Industrial & Engineering Chemistry Research 2023年第17期62卷 6806页

作者： Yong Yan chenyang Zhang Xin Deng Jin Zhang Yali Xue Jie Zhang Yingjian Luo fuwen Yang Gang Wang Ruilin Wang Jinwei chen

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Diet Evolution and Habitat Contraction of Giant Pandas via Stable Isotope Analysis

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CURRENT BIOLOGY 2019年第4期29卷 664-+页

作者： Han, Han Wei, Wei Hu, Yibo Nie, Yonggang Ji, Xueping Yan, Li Zhang, Zejun Shi, Xiaoxue Zhu, Lifeng Luo, Yunbing chen, Weicai Wei, fuwen Chinese Acad Sci Inst Zool Key Lab Anim Ecol & Conservat Biol Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China China West Normal Univ Minist Educ Key Lab Southwest China Wildlife Resources Conser Nanchong 637009 Peoples R China Chinese Acad Sci Ctr Excellence Anim Evolut & Genet Kunming 650223 Yunnan Peoples R China Yunnan Cultural Rel & Archaeol Inst Kunming 650118 Yunnan Peoples R China Baoshan Museum Baoshan 678000 Peoples R China Hubei Prov Inst Cultural Rel & Archaeol Wuhan 430077 Hubei Peoples R China Nat Hist Museum Guangxi Zhuang Autonomous Reg Nanning 530012 Peoples R China

The ancestral panda Ailurarctos lufengensis, excavated from the late Miocene, is thought to be carnivorous or omnivorous [1]. Today, giant pandas exclusively consume bamboo and have distinctive tooth, skull, and muscle characteristics adapted to a tough and fibrous bamboo diet during their long evolution [1, 2]. A special feature, the pseudo-thumb, has evolved to permit the precise and efficient grasping of bamboo [3, 4]. Unlike those of extant pandas, little is known about the diet and habitat preferences of extinct pandas. Prevailing studies suggest that the panda shifted to specialized bamboo feeding in the Pleistocene [5, 6];however, this remains questionable. Pandas now survive in a fraction of their historical habitat [7], but no specific information has been reported. Stable isotope analyses can be used to understand diet- and habitat-related changes in animals [8]. Isotopic signals in bone collagen reflect dietary compositions of ancient human diets [9, 10] and dietary changes between historical and modern animal populations [11, 12]. Here, we conduct stable isotope analyses of bone and tooth samples from ancient and modern pandas and from sympatric fauna. We show that pandas have had a diet dominated by C-3 resources over time and space and that trophic niches of ancient and modern pandas are distinctly different. The isotopic trophic and ecological niche widths of ancient pandas are approximately three times larger than those of modern pandas, suggesting that ancient pandas possibly had more complex diets and habitats than do their modern counterparts. Our findings provide insight into the dietary evolution and habitat contraction of pandas.

关键词： stable isotopes diet shift habitat contraction giant panda

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论羌塘盆地油气勘探前景

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地质论评 2020年第5期66卷 1091-1113页

作者：王剑付修根沈利军谭富文宋春彦陈文彬西南石油大学羌塘盆地研究院成都610500 油气藏地质与开发工程国家重点实验室(西南石油大学) 成都610500 西南石油大学地球科学与技术学院成都610500 中国地质调查局成都地质调查中心成都610081

羌塘盆地与中东油气区同属于特提斯构造域,是我国陆上新区面积最大的海相盆地。近20年来,我国油气地质工作者在条件极其艰苦的藏北高原开展了系统的油气地质调查和研究工作,完成了从含油气盆地分析到资源潜力评价、战略选区、靶区预测... 详细信息

羌塘盆地与中东油气区同属于特提斯构造域,是我国陆上新区面积最大的海相盆地。近20年来,我国油气地质工作者在条件极其艰苦的藏北高原开展了系统的油气地质调查和研究工作,完成了从含油气盆地分析到资源潜力评价、战略选区、靶区预测、井位论证及实施科探井的全过程,获得了一系列新发现和新认识,提出了羌塘盆地是我国最有希望取得突破的油气勘探新区。但是,对上述认识也还存在不同的看法,特别是对油气保存条件和盆地生烃潜力,还存在"好"与"不好"两种截然不同的观点。本文根据最近完成的羌塘盆地科探井工程(羌科-1井)及其配套的地质—地球物理工作所取得的最新资料,结合近20年来羌塘盆地油气地质调查所取得的成果,重点围绕烃源岩与保存条件这两个方面,对羌塘盆地油气地质特征进行论述,力求客观、准确评价羌塘盆地油气保存条件,同时分析、预测了盆地生烃潜力及油气远景,并提出下一步油气勘探建议,以期持续推进羌塘盆地未来油气勘探工作,早日实现盆地油气勘探重大突破。

关键词：羌塘盆地羌科-1井烃源岩保存条件油气资源潜力

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Insulation Characteristics of Fluoronitriles / CO₂ Gas Mixture under DC Electric Field

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IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION 2018年第4期25卷 1324-1331页

作者： Tu, Youping cheng, Yi Wang, Cong Ai, Xin Zhou, fuwen chen, Geng North China Elect Power Univ State Key Lab Alternate Elect Power Syst Renewabl Beijing 102206 Peoples R China

Environmentally friendly DC gas insulated transmission line (GIL) is currently one of the hot topics in advanced electric power equipment. Recently, fluoronitriles have been widely studied and considered to replace SF6 in GILs. In this paper, the breakdown voltage, insulator flashover voltage, and the partial discharge inception voltage of fluoronitriles / CO2 gas mixtures are reported in a DC electric field. The mole ratio of the mixed gases are 4 : 96 % and 8 : 92 %, and the gas pressure is in the range 304.7 to 717.83 kPa. Based on the results, the breakdown field strength of fluoronitriles / CO2 gas mixture shows a growth tendency with increasing gas pressure in a uniform electric field. At 717.83 kPa, the positive breakdown field strength is higher than the negative and reached a maximum. In a non-uniform electric field, the negative breakdown voltage of fluoronitriles / CO2 gas mixture increases with increasing gas pressure. In the contrast, the positive breakdown voltage decreases with the rise of gas pressure, which exhibits a significant polarity effect. The flashover voltage of fluoronitriles / CO2 gas mixture increases with increasing gas pressure. At the same gas pressure, the negative flashover voltage is slightly higher than the positive. The negative flashover voltage of fluoronitriles / CO2 gas mixture at 717.83 kPa is equal to 96.06 % of SF6 gas at 0.5 MPa abs. The negative partial discharge inception voltage (PDIV) of the fluoronitriles / CO2 gas mixture is greater than the positive, and both 4 : 96 % and 8 : 92 % gas mixtures showed higher PDIV than the SF6. Considering the insulation characteristics, the fluoronitriles / CO2 mixture has the potential to replace SF6 in DC gas insulated transmission lines.

关键词： gas-insulated transmission line mixture of fluoronitriles / CO2 DC breakdown voltage flashover voltage partial discharge inception voltage

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Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold

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JOURNAL OF MEDICINAL CHEMISTRY 2021年第19期64卷 14283-14298页

作者： Rong, Jian Mori, Wakana Xia, Xiaotian Schafroth, Michael A. Zhao, Chunyu Van, Richard S. Yamasaki, Tomoteru chen, Jiahui Xiao, Zhiwei Haider, Ahmed Ogasawara, Daisuke Hiraishi, Atsuto Shao, Tuo Zhang, Yiding chen, Zhen Pang, fuwen Hu, Kuan Xie, Lin Fujinaga, Masayuki Kumata, Katsushi Gou, Yuancheng Fang, Yang Gu, Shuyin Wei, Huiyi Bao, Liang Xu, Hao Collier, Thomas L. Shao, Yihan Carson, Richard E. Cravatt, Benjamin F. Wang, Lu Zhang, Ming-Rong Liang, Steven H. Massachusetts Gen Hosp Div Nucl Med & Mol Imaging Boston MA 02114 USA Harvard Med Sch Dept Radiol Boston MA 02114 USA Natl Inst Quantum & Radiol Sci & Technol Natl Inst Radiol Sci Dept Adv Nucl Med Sci Chiba 2638555 Japan Skaggs Inst Chem Biol La Jolla CA 92037 USA Scripps Res Inst Dept Chem Physiol La Jolla CA 92037 USA Univ Oklahoma Dept Chem & Biochem Norman OK 73019 USA Chemshuttle Inc Wuxi 214174 Jiangsu Peoples R China Jinan Univ Affiliated Hosp 1 Ctr Cyclotron & PET Radiopharmaceut Dept Nucl Med Guangzhou 510630 Peoples R China Jinan Univ Affiliated Hosp 1 PET CT MRI Ctr Guangzhou 510630 Peoples R China Yale Univ Sch Med Dept Radiol & Biomed Imaging New Haven CT 06520 USA

Monoacylglycerol lipase (MAGL) is a 33 kDa serine protease primarily responsible for hydrolyzing 2-arachidonoylglycerol into the proinflammatory eicosanoid precursor arachidonic acid in the central nervous system. Inhibition of MAGL constitutes an attractive therapeutic concept for treating psychiatric disorders and neurodegenerative diseases. Herein, we present the design and synthesis of multiple reversible MAGL inhibitor candidates based on a piperazinyl azetidine scaffold. Compounds 10 and 15 were identified as the best-performing reversible MAGL inhibitors by pharmacological evaluations, thus channeling their radiolabeling with fluorine-18 in high radiochemical yields and favorable molar activity. Furthermore, evaluation of [F-18]10 and [F-18]15 ([F-18]MAGL-2102) by autoradiography and positron emission tomography (PET) imaging in rodents and nonhuman primates demonstrated favorable brain uptakes, heterogeneous radioactivity distribution, good specific binding, and adequate brain kinetics, and [F-18]15 demonstrated a better performance. In conclusion, [F-18]15 was found to be a suitable PET radioligand for the visualization of MAGL, harboring potential for the successful translation into humans.

关键词： Peptides and proteins Ligands Central nervous system Rodent models Inhibitors

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血清SM4D水平与绝经后骨质疏松症患者骨密度和骨代谢指标的相关性研究

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中国骨质疏松杂志 2021年第3期27卷 392-395页

作者：吴林清陈运崇张国如王婧婧王继宏温树正潘富文三亚中心医院骨科海南三亚572000 三亚中心医院脊柱与关节科海南三亚572000 三亚中心医院检验科海南三亚572000 内蒙古医科大学第二附属医院手足外科内蒙古呼和浩特010000

目的探讨绝经后骨质疏松症(postmenopausal osteoporosis,POP)患者血清4D同型二聚体(SM4D)水平与骨密度(bone mineral density,BMD)和骨转换指标的关系。方法通过双能X线吸收测定法对257例POP患者和90例健康对照者进行BMD测量。通过酶... 详细信息

目的探讨绝经后骨质疏松症(postmenopausal osteoporosis,POP)患者血清4D同型二聚体(SM4D)水平与骨密度(bone mineral density,BMD)和骨转换指标的关系。方法通过双能X线吸收测定法对257例POP患者和90例健康对照者进行BMD测量。通过酶联免疫吸附测定法测定受试者血清SM4D、BAP、BGP和TRACP-5b水平。使用自动电化学发光系统测量I型血清交联N端肽(NTX)、25-羟基维生素D[25(OH)D]和骨钙素的N-mid片段水平(N-MID-OT)。结果与健康对照组相比,POP妇女的SM4D水平显著升高[(1.40±0.33)μg/L vs.(0.58±0.18)μg/L,P=0.006]。SM4D水平与血清TRACP-5b和NTX水平呈正相关,与腰椎和股骨颈BMD、血清BAP和BGP水平呈负相关。SM4D水平与年龄、体质量指数以及血清25(OH)D和N-MID-OT水平之间无相关性。腰椎和股骨颈骨密度(β=-0.354,P<0.001;β=-31.234,P<0.001)和血清BAP水平(β=0.127,P=0.019)是POP患者血清SM4D水平的独立预测因子。结论绝经后骨质疏松症女性SM4D与骨密度和骨转换指标密切相关。

关键词： SM4D 绝经后骨质疏松症骨密度骨转换

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A glassy carbon electrode modified with graphene quantum dots and silver nanoparticles for simultaneous determination of guanine and adenine

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MICROCHIMICA ACTA 2015年第1-2期182卷 315-322页

作者： Wang, Guoying Shi, Gaofeng chen, Xuefu Yao, Ruixing chen, fuwen Lanzhou Univ Technol Sch Petrochem Engn Lanzhou 730050 Peoples R China

A glassy carbon electrode (GCE) was modified with graphene quantum dots (GQDs) carrying silver nanoparticles. The modified GCE displays excellent performance in the electrochemical oxidation of guanine and adenine in showing lower anodic peak overpotentials (of 0.625 and 0.929 V, respectively) and increased anodic peak currents. The effective surface area of the modified GCE is about 21.5 times larger than that of the bare GCE. The electron transfer coefficient (alpha) and the electron transfer number (n) were calculated to be 2 and 0.60 for guanine, and 2 and 0.64 for adenine, respectively. Linear relationships between peak current and the concentrations were obtained in the range from 0.015 to 430 mu M (for guanine) and 0.015 to 390 mu M (for adenine). The detection limits are 10 nM and 12 nM (at a signal-to-noise ratio of 3), respectively. The modified GCE can well distinguish between guanine and adenine in mixed solutions, has fast response, a low detection limit, good reproducibility, and high stability.

关键词： Guanine Adenine Graphene quantum dots Silver nanoparticles Modified electrode

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Failure analysis and revamping methods for loading threaded joints of raiseboring machine

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IOP Conference Series: Earth and Environmental Science 2020年第5期546卷

作者： Guoye Jing fuwen Hu Yun chen Mine Construction Branch China Coal Research Institute Beijing 100013 China National Engineering Laboratory for Deep Shaft Construction Technology in Coal Mine Beijing School of Mechanical and Material Engineering North China University of Technology Beijing 100144 China Ningxia Tiandi Benniu Industrial Group Co. Ltd. Shizuishan 753001 China

The process of raise boring (or back reaming) has been successfully employed for vertical mine development. The technology has successfully evolved from early small borehole diameter less than 2m to large diameter greater than 8m without incident. However, in our developed raise boring machines, the threaded joints connecting reamers and drill rods suffered several fracture accidents during reaming in different geological and geotechnical conditions. Under this background, it is undoubtedly of great engineering value to explore the failure mechanisms and put forward systematic quality control and risk control measures. The fractured threaded joints were visually examined on-site, and then examined in the laboratory using fractographic and metallographic examination, mechanical testing and chemical composition analysis. Firstly, the end faces of threaded joints could not to be installed to fit the end faces of spindles due to over-specified tolerances or insufficient preload. Secondly, it was found that the manganese (Mn) contents in material samples are higher than the national standards values. Thirdly, the heat treatment of water-quenching of workpieces perhaps caused a certain degree of residual stresses. Clearly this systematic inspection suggested we should take overall improvements to eliminate the potential failure mechanisms. After check and measurement of product and process performance, the cause-and-effect relationships undoubtedly were complex and multifaceted. Therefore, the component was redesigned using revamping methods including material compositions upgrade, fitting tolerances control, optimization of heat treatment process. Moreover, a systems approach and the institution of quality management system including increasing the preload, adding anti-dropping device and executing a Plan-Do-Check-Act cycle were implemented. Through this investigation and recommendations, the device has been in operation for more than two years without any problems.

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