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28th International Ocean and Polar Engineering Conference, ISOPE 2018

作者： Wang, Alan M. Jin, Xiaojian Liu, Yiyong Tao, fuwen He, chen He, Min Offshore Tianjin Oil Engineering China Co. Ltd. China Shenzhen Division ChinaNational Offshore Oil Corporation Shenzhen Guangdong China

ISBN: (纸本)9781880653876

This paper presents the floatover hardware systems and the operation procedures of this innovative low-deck floatover technology, as well as its successful application in the floatover operations for a drilling and production (DPP) platform in South China Sea. Great lessons were learned from the first failure attempt. A combination of conventional low-deck floatover scheme and strand-jack lifting technology is adopted to rectify previous serious defects. Various field measurements, including a barge motion monitoring system, an environmental monitoring system, a visual monitoring system, and a strain gauge stress monitoring system, etc., have been employed to ensure the success of this challenging floatover installation. The advantages and disadvantages of this unique floatover method are also addressed here. Copyright © 2018 by the International Society of Offshore and Polar Engineers (ISOPE)

关键词： Strain gages

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Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer

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NATURE COMMUNICATIONS 2021年第1期12卷 6858-6858页

作者： Yin, Yuan Fan, Huizhong Zhou, Botong Hu, Yibo Fan, Guangyi Wang, Jinhuan Zhou, Fan Nie, Wenhui Zhang, chenzhou Liu, Lin Zhong, Zhenyu Zhu, Wenbo Liu, Guichun Lin, Zeshan Liu, Chang Zhou, Jiong Huang, Guangping Li, Zihe Yu, Jianping Zhang, Yaolei Yang, Yue Zhuo, Bingzhao Zhang, Baowei Chang, Jiang Qian, Haiyuan Peng, Yingmei chen, Xianqing chen, Lei Li, Zhipeng Zhou, Qi Wang, Wen Wei, fuwen Northwestern Polytech Univ Sch Ecol & Environm Xian 710072 Peoples R China Chinese Acad Sci Inst Zool CAS Key Lab Anim Ecol & Conservat Biol Beijing 100101 Peoples R China Southern Marine Sci & Engn Guangdong Lab Guangzho Ctr Evolut & Conservat Biol Guangzhou 511458 Guangdong Peoples R China Chinese Acad Sci Ctr Excellence Anim Evolut & Genet Kunming 650223 Yunnan Peoples R China BGI Shenzhen BGI Qingdao Qingdao 266555 Peoples R China BGI Shenzhen Shenzhen 518083 Peoples R China BGI Shenzhen China Natl GeneBank Shenzhen 518120 Peoples R China Chinese Acad Sci Kunming Inst Zool State Key Lab Genet Resources & Evolut Kunming Cell Bank Kunming 650223 Yunnan Peoples R China Frasergen Bioinformat Co Ltd Wuhan 430074 Hubei Peoples R China Beijing Milu Ecol Res Ctr Beijing 100076 Peoples R China Qianjiangyuan Natl Pk Kaihua 324300 Peoples R China Tech Univ Denmark Dept Biotechnol & Biomed DK-2800 Lyngby Denmark Anhui Univ Sch Life Sci Hefei 230039 Peoples R China Chinese Res Inst Environm Sci State Key Lab Environm Criteria & Risk Assessment Beijing 100012 Peoples R China Jilin Agr Univ Colleague Anim Sci & Technol Changchun 130118 Peoples R China Chinese Acad Agr Sci Inst Special Anim & Plant Sci Changchun Peoples R China Zhejiang Univ Life Sci Inst MOE Lab Biosyst Homeostasis & Protect Hangzhou 310058 Peoples R China Zhejiang Univ Life Sci Inst Zhejiang Prov Key Lab Canc Mol Cell Biol Hangzhou 310058 Peoples R China Univ Vienna Dept Neurosci & Dev Biol A-1090 Vienna Austria Zhejiang Univ Affiliated Hosp 2 Ctr Reprod Med Sch Med Hangzhou 310052 Peoples R China

Muntjac deer have experienced drastic karyotype changes during their speciation, making it an ideal model for studying mechanisms and functional consequences of mammalian chromosome evolution. Here we generated chromosome-level genomes for Hydropotes inermis (2n = 70), Muntiacus reevesi (2n = 46), female and male M. crinifrons (2n = 8/9) and a contig-level genome for M. gongshanensis (2n = 8/9). These high-quality genomes combined with Hi-C data allowed us to reveal the evolution of 3D chromatin architectures during mammalian chromosome evolution. We find that the chromosome fusion events of muntjac species did not alter the A/B compartment structure and topologically associated domains near the fusion sites, but new chromatin interactions were gradually established across the fusion sites. The recently borne neo-Y chromosome of M. crinifrons, which underwent male-specific inversions, has dramatically restructured chromatin compartments, recapitulating the early evolution of canonical mammalian Y chromosomes. We also reveal that a complex structure containing unique centromeric satellite, truncated telomeric and palindrome repeats might have mediated muntjacs' recurrent chromosome fusions. These results provide insights into the recurrent chromosome tandem fusion in muntjacs, early evolution of mammalian sex chromosomes, and reveal how chromosome rearrangements can reshape the 3D chromatin regulatory conformations during species evolution. Muntjac deer underwent rapid species radiation and dramatic chromosome fusions within a short period of time. Here the authors reveal that repeat sequences likely mediated illegitimate recombination to result in chromosome fusions and that 3D chromatin architecture around fusion sites have no significant change, while significant interactions across fusion sites were gradually established after speciation.

关键词： Genome evolution Evolutionary genetics Epigenomics Comparative genomics

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Ag@Sn Core-Shell Powder Preform with a High Re-Melting Temperature for High-Temperature Power Devices Packaging

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ADVANCED ENGINEERING MATERIALS 2018年第1期20卷

作者： Yu, fuwen Wang, Bin Guo, Qiang Ma, Xin Li, Mingyu chen, Hongtao Harbin Inst Technol Shenzhen Grad Sch Mat Sci & Engn Dept Shenzhen 518055 Peoples R China Hoerson Elect Technol Co Ltd Shenzhen 518126 Peoples R China

In this paper, the authors propose a highly conductive die attach material based on Ag@Sn powder for power devices operating at high temperatures or in other harsh environments. The preform can be reflowed at 250 degrees C (18 degrees C above the T-m of Sn, 232 degrees C), but the resulting bondline can sustain high temperatures up to 400 degrees C with a high shear strength due to the high re-melting temperature of the formed Ag3Sn (T-m = 480 degrees C) after the complete consumption of the outer Sn layers. In addition, the formed bondline exhibits excellent electrical and thermal conductivities due to the embedded Ag particles in the interconnections. The interconnections also exhibit excellent reliability under thermal shock cycling from 55 to 200 degrees C because of the increased bondline thickness and inherent ductility of the Ag particles embedded in the Ag3Sn.

关键词： die attach high re-melting temperature Ag@Sn power devices

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国产超低损耗光纤长期运行测试与工程实践

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电力信息与通信技术 2020年第12期18卷 71-75页

作者：李伟华白夫文朱京邓黎周庆伟陈佟国家电网有限公司信息通信分公司北京100761 北京中电飞华通信股份有限公司北京100070

目前,特高压工程广泛使用的超低损耗光纤主要依赖于进口,文章通过在1000 kV特高压交流工程中首次应用国产G.652D超低损耗(Ultra Low Loss,ULL)光纤,成功使用此ULL光纤开通了10 Gbit/s试验电路,开通2 M及155 M测试业务并安全稳定运行,实... 详细信息

目前,特高压工程广泛使用的超低损耗光纤主要依赖于进口,文章通过在1000 kV特高压交流工程中首次应用国产G.652D超低损耗(Ultra Low Loss,ULL)光纤,成功使用此ULL光纤开通了10 Gbit/s试验电路,开通2 M及155 M测试业务并安全稳定运行,实践验证了使用国产ULL光纤的OPGW光缆在特高压线路运行的可行性,并通过半年以上长期运行监测,光纤衰耗未发生劣化,为该类型光纤推广应用奠定了基础。

关键词：国产超低损耗光纤运行测试特高压

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Recent selection and introgression facilitated high-altitude adaptation in cattle

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Science Bulletin 2024年第21期69卷 3415-3424页

作者： Yang Lyu fuwen Wang Haijian cheng Jing Han Ruihua Dang Xiaoting Xia Hui Wang Jincheng Zhong Johannes A.Lenstra Hucai Zhang Jianlin Han David E.MacHugh Ivica Medugorac Maulik Upadhyay Alexander SLeonard He Ding Xiaorui Yang Ming-Shan Wang Suolang Quji Basang Zhuzha Pubu Quzhen Silang Wangmu Nima Cangjue Da Wa Weidong Ma Jianyong Liu Jicai Zhang Bizhi Huang Xingshan Qi Fuqiang Li Yongzhen Huang Yun Ma Yu Wang Yuanpeng Gao Wenfa Lu Chuzhao Lei Ningbo chen Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Key Laboratory of Animal Production Product Qualityand SecurityMinistry of EducationCollege of Animal Science and TechnologyJilin Agricultural UniversityChangchun 130118China Institute of Animal Science and Veterinary Medicine Shandong Academy of Agricultural SciencesShandong Key Lab of Animal Disease Control and BreedingJinan 250000China College of Veterinary Medicine Northwest A&F UniversityYangling 712100China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Sichuan Province and Ministry of EducationSouthwest Minzu UniversityChengdu 610000China Faculty of Veterinary Medicine Utrecht UniversityUtrecht 3584 CMThe Netherlands Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650500China Southwest United Graduate School Kunming 650500China Yazhouwan National Laboratory Sanya 572024China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agriculture Sciences(CAAS)Beijing 100000China Animal Genomics Laboratory UCD School of Agriculture and Food ScienceUniversity College DublinDublin D04 V1W8Ireland UCD Conway Institute of Biomolecular and Biomedical Research University College DublinDublin D04 V1W8Ireland Population Genomics Group Department of Veterinary SciencesLMU MunichMartinsried 82152Germany Animal Genomics ETH ZurichUniversitaetstrasse 2Zurich 8006Switzerland State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Animal Husbandry and Veterinary Science Xizang Autonomous Region Academy of Agricultural and Animal Husbandry SciencesLhasa 850000China Shigatse City Kan

During the past 3000 years,cattle on the Qinghai-Xizang Plateau have developed adaptive phenotypes under the selective pressure of hypoxia,ultraviolet(UV)radiation,and extreme *** genetic mechanism underlying this rapid adaptation is not yet well ***,we present whole-genome resequencing data for 258 cattle from 32 cattle breeds/populations,including 89 Tibetan cattle representing eight populations distributed at altitudes ranging from 3400 m to 4300 *** genomic analysis revealed that Tibetan cattle exhibited a continuous phylogeographic cline from the East Asian taurine to the South Asian indicine *** found that recently selected genes in Tibetan cattle were related to body size(HMGA2 and NCAPG)and energy expenditure(DUOXA2).We identiﬁed signals of sympatric introgression from yak into Tibetan cattle at different altitudes,covering 0.64%–3.26%of their genomes,which included introgressed genes responsible for hypoxia response(EGLN1),cold adaptation(LRP11),DNA damage repair(LATS1),and UV radiation resistance(GNPAT).We observed that introgressed yak alleles were associated with noncoding variants,including those in present *** Tibetan cattle,three yak introgressed SNPs in the EGLN1 promoter region reduced the expression of EGLN1,suggesting that these genomic variants enhance hypoxia *** together,our results indicated complex adaptation processes in Tibetan cattle,where recently selected genes and introgressed yak alleles jointly facilitated rapid adaptation to high-altitude environments.

关键词： Tibetan cattle Introgression High-altitude adaptation Noncoding variant Cis-regulation

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楚雄州林下中药材白芨和滇黄精丰产栽培试验研究

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林业调查规划 2020年第2期45卷 119-123页

作者：高文学施庭有周庆宏段福文陈晓祥楚雄彝族自治州林业和草原科学研究所云南楚雄675005

为加快楚雄州生物医药大健康产业的发展步伐,于2016年2月—2017年9月,选择楚雄州具有代表类性的郁闭度0.5~0.7的云南松林下,开展白芨和滇黄精丰产栽培试验,对栽培密度、腐殖土量、底肥量、追肥量等四因素设三个不同水平进行正交试验。... 详细信息

为加快楚雄州生物医药大健康产业的发展步伐,于2016年2月—2017年9月,选择楚雄州具有代表类性的郁闭度0.5~0.7的云南松林下,开展白芨和滇黄精丰产栽培试验,对栽培密度、腐殖土量、底肥量、追肥量等四因素设三个不同水平进行正交试验。结果表明,栽培密度对二者保存率有极显著影响,但白芨适合密植,以15 cm×20 cm株行距为佳;滇黄精不宜密植,以25 cm×40 cm株行距为佳。腐植土对二者块茎生长量有显著影响,底肥及追肥对二者生长无明显影响。

关键词：白芨滇黄精林下中药材丰产栽培措施楚雄州

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Sliding Mode Estimation-based Control for Stochastic Time Delays in Networked Micorgrid 36

Sliding Mode Estimation-based Control for Stochastic Time De...

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第36届中国控制会议

作者： Xuping Zhou Huaicheng Yan chen Peng fuwen Yang Key Laboratory of Advanced Control and Optimization for Chemical Process of Ministry of Education East China University of Science and Technology School of Mechatronic Engineering and Automation Shanghai University School of Engineering Griffith University

ISBN: (纸本)9781538629185

This paper proposes a sliding mode estimation-based control to solve the stochastic time delay problem in networked microgrid,because stochastic delay has a great impact on the stability and performance of large power grids（LPG）.To analyze the delay effects,the microgrid system model is derived according to the characteristics of the inverter in grid-connected *** on the microgrid system model,the stochastic delay estimation with learning parameter and delayed states are *** control signal designed by sliding mode control（SMC） and the learning parameter of delay estimation are adaptively changed in the sliding mode estimation-based control *** reaching law（ERL） is proposed to solve the chattering issues of *** 3.3 KW microgrid parameters are added into simulation to verify the effectiveness and performance of the proposed control strategy.

关键词： Networked Microgrid Sliding Mode Control（SMC） Stochastic Delay Estimation

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Invasive micropapillary carcinoma of the breast has a better long-term survival than invasive ductal carcinoma of the breast in spite of its aggressive clinical presentations: a comparison based on large population database and case-control analysis

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CANCER MEDICINE 2017年第12期6卷 2775-2786页

作者： chen, Hongliang Wu, Kejin Wang, Maoli Wang, fuwen Zhang, Mingdi Zhang, Peng Fudan Univ Dept Breast Surg Obstet & Gynecol Hosp Shanghai 200011 Peoples R China

There are controversies in the comparison of overall survival between invasive micropapillary carcinoma of the breast (IMPC) and invasive ductal carcinoma (IDC). The objective of this study was to compare the long-term survival outcome between non-metastatic IMPC and IDC. The Surveillance, Epidemiology, and End Results database was searched to identify women with non-metastatic IMPC and IDC diagnosed between 2001 and 2013. Comparisons of patient and tumor characteristics were performed using Pearson's chi-square. The propensity score matching method was applied with each IMPC matched to one IDC. Breast cancer-specific survival (BCSS) and overall survival (OS) were estimated using the Kaplan-Meier product limit method and compared across groups using the log-rank statistic. Multivariate analysis was performed through Cox models. IMPC was presented with aggressive clinical presentations such as larger tumor, more positive lymph nodes, and more advanced stage compared with IDC. A higher rate of estrogen receptor (ER)/progesterone receptor (PR) positivity was also observed in IMPC. With a median follow-up of 64months, IMPC had a better BCSS (P=0.031) and OS (P=0.012) compared with IDC. In a case-control analysis IMPC was still an independent favorable prognostic factor for BCSS (HR=0.410, P<0.001, 95% CI: 0.293-0.572) and OS (HR=0.497, P<0.001, 95% CI: 0.387-0.637). In subgroup analysis, IMPC always showed a better survival outcome compared with IDC except in AJCC stage I and histologic grade I disease. IMPC has a better long-term survival outcome compared with IDC in spite of its highly aggressive clinical presentation.

关键词： Breast cancer-specific survival case-control analysis invasive ductal carcinoma invasive micropapillary carcinoma of the breast overall survival

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A standard mastectomy should not be the only recommended breast surgical treatment for non-metastatic inflammatory breast cancer: A large population-based study in the Surveillance, Epidemiology, and End Results database 18

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BREAST 2017年 35卷 48-54页

作者： chen, Hongliang Wu, Kejin Wang, Maoli Wang, fuwen Zhang, Mingdi Zhang, Peng Fudan Univ Dept Breast Surg Obstet & Gynecol Hosp 419 Fangxie Rd Shanghai 200011 Peoples R China

Background: Standard mastectomy has long been the recommended breast surgical treatment for non-metastatic inflammatory breast cancer (IBC). The objective of this population-based study was to evaluate the significance of various breast surgical treatments for this highly aggressive subtype. Methods: The Surveillance, Epidemiology, and End Results program registry was searched to identify women with non-metastatic IBC receiving standard treatment including breast surgery, radiation therapy and chemotherapy diagnosed between 1998 and 2013. Comparisons of the proportions of various breast surgery procedures over the years were performed using Pearson's chi-square test. Breast cancer-specific survival (BCSS) and overall survival (OS) were estimated using the Kaplan-Meier product limit method and compared across groups using the log-rank statistic. Cox models were then fitted to compare the association between various breast surgical procedures and BCSS or OS after adjusting for patient and tumor characteristics. Results: A total of 3374 cases were identified. Over the years, the proportion of contralateral prophylactic mastectomy (CPM), breast reconstruction and both were increasing. The proportion of implant-based reconstruction was also increasing with no difference in survival compared with other types of reconstruction. There was no statistically significant difference in BCSS or OS among various breast surgery treatments, such as breast conserving surgery, CPM, breast reconstruction and standard unilateral mastectomy. Conclusions: Breast surgery is of great significance to the clinical outcome of IBC. Standard mastectomy should not be the only recommended breast surgical treatment. (C) 2017 Elsevier Ltd. All rights reserved.

关键词： Inflammatory breast cancer Mastectomy Breast conserving surgery Contralateral prophylactic mastectomy Breast reconstruction Breast cancer-specific survival Overall survival

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体素内不相干运动扩散加权成像对正常腰椎间盘扫描的可重复性研究

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实用放射学杂志 2019年第6期35卷 970-973页

作者：王媛周晟王闻奇陈晓飞董馥闻祁艳梅甘肃中医药大学甘肃兰州730000 甘肃省中医院放射科甘肃兰州730050

目的探讨体素内不相干运动扩散加权成像(IVIMGDWI)对正常腰椎间盘扫描的可重复性.方法经知情同意纳入 50例健康志愿者,男 30 例,女20 例,年龄2 1~30 岁,平均(2 5.20±2.04)岁.利用3.0T MR,先行腰椎矢状位T1 WI序列,矢状位、轴位T2... 详细信息

目的探讨体素内不相干运动扩散加权成像(IVIMGDWI)对正常腰椎间盘扫描的可重复性.方法经知情同意纳入 50例健康志愿者,男 30 例,女20 例,年龄2 1~30 岁,平均(2 5.20±2.04)岁.利用3.0T MR,先行腰椎矢状位T1 WI序列,矢状位、轴位T2 WI序列和矢状位 IVIMGDWI序列扫描 1 次,间隔4 h再行第 2 次矢状位 IVIMGDWI序列扫描.IVIMGDWI序列采用 10 个 b 值(0、10、20、40、60、80、100、200、400、600 s/mm2 ).参照 Pfirrmann分级标准对椎间盘进行分级.由 2 名医师在后处理工作站测得IVIMGDWI扫描每个椎间盘的快速 ADC(ADCfast )、慢速 ADC(ADCslow )、灌注分数(f)值.采用配对t 检验分析 2 次扫描 ADCfast 、ADCslow 、f值是否有差异,采用组内相关系数(ICC)分析 2 次采集的 ADCfast 、ADCslow 、f值的一致性(P＜0.05)和不同观察者对椎间盘ADCfast 、ADCslow 、f值测量的一致性(P＜0.05),从而评价 IVIMGDWI技术测量正常腰椎间盘的可重复性.结果 50 例健康志愿者的椎间盘中,符合标准(Pfirrmann分级为Ⅰ、Ⅱ级)的椎间盘共纳入230个.2次扫描的ADCslow值差异有统计学意义(t＝2.460,P＜0.05),ADCfast 、f值差异无统计学意义(t＝－0.418、1.273,P＞0.05);2次扫描的ADCfast 、ADCslow 、f值的差异有统计学意义,一致性一般(ICC＝0.478、0.306、0.316,P＜0.05).不同观察者对椎间盘 ADCfast 、ADCslow 、f 值的测量的一致性好(ICC＝0.929、0.909、0.91 1 ,P＜0.05 ).结论IVIMGDWI技术对正常腰椎间盘扫描在不同观察者间测量一致性好.IVIMGDWI技术对正常腰椎间盘 2 次扫描一致性一般,由于ADCslow表现的是组织的水分子扩散情况,这可能是因为 2 次扫描时间有间隔,所以腰椎间盘内的微环境发生了变化,而导致ADCslow值的差异.关于扫描时间不同可能会导致 IVIMGDWI数据的变化问题,笔者将会进一步研究.

关键词：体素内不相干运动扩散加权成像腰椎间盘退变腰椎间盘磁共振成像 Pfirrmann分级

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