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Optimal operational controls for power grid

OPTIMAL CONTROL APPLICATIONS & METHODS 2022年第3期43卷 591-592页

作者： wang, Hong Yang, fuwen Oak Ridge Natl Lab POB 2009 Oak Ridge TN 37831 USA Griffith Univ Sch Engn & Built Environm Brisbane Qld Australia

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Geographic distributions shape the functional traits in a large mammalian family

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ECOLOGY AND EVOLUTION 2021年第19期11卷 13175-13185页

作者： Ma, Yingjie wang, Meng Wei, fuwen Nie, Yonggang Inst Zool Chinese Acad Sci Key Lab Anim Ecol & Conservat Biol Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Ctr Excellence Anim Evolut & Genet Chinese Acad Sci Kunming Yunnan Peoples R China

Traits of organisms are shaped by their living environments and also determined in part by their phylogenetic relationships. For example, phylogenetic relationships often affect the geographic distributions of animals and cause variation in their living environments, which usually play key roles in the life history and determine the functional traits of species. As an ancient family of mammals, bears widely distribute and have evolved some specific strategies for survival and reproduction during their long-term evolutionary histories. Many studies on the ecology of bears have been conducted in recent decades, but few have focused on the relationships between their geographic distributions and ecological adaptations. Here, using bears as a model system, we collected and reanalyzed data from the available literatures to explore how geographic distributions and phylogenetic relationships shape the functional traits of animals. We found a positive relationship between phylogenetic relatedness and geographic distributions, with bears distributed in adjacent areas applying more similar strategies to survive and reproduce: (a) Bears living at high latitudes consumed a higher proportion of vertebrates, which may provide more fat for adaptation to low temperatures, and (b) their reproduction rhythms follow fluctuations in seasonal forage availability and quality, in which bears reach mating status from March to May and give birth in approximately November or later.

关键词： ecological adaptation functional traits geographic distribution phylogeny reproduction Ursidae

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Digital Noah's Ark:last chance to save the endangered species

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Science China(Life Sciences) 2022年第11期65卷 2325-2327页

作者： fuwen Wei Guangping Huang Dengfeng Guan Huizhong Fan Wenliang Zhou Depeng wang Yibo Hu Center for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)Guangzhou 511458China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China GrandOmics Biosciences Beijing 102200China

Global biodiversity is undergoing dramatic loss,mostly due to anthropogenic actions and climate *** 2.3seed plants died out each year in the past 2.5 centuries(Humphreys et al.,2019).Current species extinction rates a... 详细信息

关键词： extinction likely mostly

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Integrins in the Regulation of Mesenchymal Stem Cell Differentiation by Mechanical Signals

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STEM CELL REVIEWS AND REPORTS 2022年第1期18卷 126-141页

作者： wang, Lei Zheng, fuwen Song, Ruixue Zhuang, Lequan Yang, Ming Suo, Jian Li, Lisha Jilin Univ Jilin Univ Hosp 1 Dept Gastrointestinal Surg Changchun 130021 Peoples R China Jilin Univ Norman Bethune Coll Med Changchun 130021 Peoples R China Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun 130021 Peoples R China Jilin Univ Coll Basic Med Sci Key Lab Pathobiol Minist Educ Changchun 130021 Peoples R China

Mesenchymal stem cells (MSCs) can sense and convert mechanical stimuli signals into a chemical response. Integrins are involved in the mechanotransduction from inside to outside and from outside to inside, and ultimately affect the fate of MSCs responding to different mechanical signals. Different integrins participate in different signaling pathways to regulate MSCs multi-differentiation. In this review, we summarize the latest advances in the effects of mechanical signals on the differentiation of MSCs, the importance of integrins in mechanotransduction, the relationship between integrin heterodimers and different mechanical signals, and the interaction among mechanical signals. We put forward our views on the prospect and challenges of developing mechanical biology in tissue engineering and regenerative medicine.

关键词： Integrin Mesenchymal stem cells (MSCs) Differentiation Mechanical signals Signaling pathways

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考虑操纵稳定性的适时四驱扭矩分配策略

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汽车零部件 2020年第5期 8-12页

作者：王敷玟凌新新张家彬陈强广州汽车集团股份有限公司汽车工程研究院广东广州511434

以某款全新开发的电控适时四驱SUV为研究对象,为同时发挥四轮驱动(4WD)与直接横摆力矩控制(DYC)的优势,建立适应于动力性及操纵稳定性的汽车动力学系统模型,提出基于轮胎最小滑移率同时保持横摆角速度跟随的适时四驱智能扭矩分配策略,采... 详细信息

以某款全新开发的电控适时四驱SUV为研究对象,为同时发挥四轮驱动(4WD)与直接横摆力矩控制(DYC)的优势,建立适应于动力性及操纵稳定性的汽车动力学系统模型,提出基于轮胎最小滑移率同时保持横摆角速度跟随的适时四驱智能扭矩分配策略,采用PID算法计算出保持车辆最小滑移率及横摆角速度跟随所需的四驱控制器控制电流并加以控制。然后将该算法移植到单片机中进行低附试验,全油门加速工况、蛇形工况及定圆加速工况试验结果表明:制定的智能扭矩分配策略在迅速抑制车轮打滑的同时能有效提升车辆在低附路面的操纵稳定性,进一步提高了车辆的主动安全性,具有较强的工程实用性。

关键词：适时四驱动力学模型智能扭矩分配策略操纵稳定性

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Compacting Molecular Stacking and Inhibiting Self-Aggregation in Fullerene Transporting Layer for Efficient and Stable Perovskite Solar Cells

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2025年第22期64卷 e202502950页

作者： He, Dan Zhang, Jiahao Gong, Xue-Yuan Ruan, Xinying Ma, Xin-Bo Yao, Chaoyi Shen, Xingxing Li, Ming-Hua Zhang, Jianqi Hu, Jin-Song wang, Chunru Zhao, fuwen Cent South Univ Coll Chem & Chem Engn State Key Lab Powder Met Changsha 410083 Peoples R China Beijing Univ Chem Technol Coll Chem Engn Beijing 100029 Peoples R China Chinese Acad Sci Inst Chem Beijing Natl Lab Mol Sci CAS Key Lab Mol Nanostruct & Nanotechnol Beijing 100190 Peoples R China Hebei Normal Univ Sci & Technol Coll Chem Engn Qinhuangdao 066004 Peoples R China Natl Ctr Nanosci & Technol CAS Ctr Excellence Nanosci CAS Key Lab Nanosyst & Hierarch Fabricat Beijing 100190 Peoples R China

The underdevelopment of electron transport layer (ETL) materials remains a critical bottleneck limiting the overall photovoltaic performance of inverted perovskite solar cells (PSCs). Fullerene derivatives, such as PCBM, are widely employed ETL materials in PSCs due to their excellent electron affinity and energy level alignment with the perovskite layer. However, PCBM suffers from high energy disorder, self-aggregation predilection, and insufficient defect passivation ability, leading to significant charge carrier recombination and accumulation at interfaces. Herein, a phosphate-substituted fullerene derivative, FuPE, is developed to enhance the performance of PCBM-based ETLs for PSCs. Incorporating FuPE efficiently compacts molecular stacking, enforces crystallinity and intermolecular interaction, suppresses self-aggregation, and improves interfacial compatibility of the FuPE:PCBM blend. Such endows the FuPE:PCBM blend film with enhanced electron mobility (0.183 cm2 V-1 s-1), lower trap density, more uniform film morphology, and superior defect-passivation ability, compared to the PCBM pristine one. Consequently, PSCs employing FuPE:PCBM as the ETL achieve reduced trap-assisted recombination, enhanced charge carrier extraction, and thus a remarkable power conversion efficiency exceeding 26% alongside improved operational stability. This work highlights an effective strategy for optimizing fullerene-based ETLs, advancing the development of highly efficient and durable PSCs.

关键词： Charge carrier transport Electron transport layer Fullerene materials Interfacial passivation Perovskite solar cells

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Phase transformation behaviours and mechanical properties of Ti6Al4V-0.55Fe alloy during continuous cooling

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MATERIALS SCIENCE AND TECHNOLOGY 2022年第17期38卷 1543-1553页

作者： Li, Xin Zhu, Qisong Liu, Sinong wang, Changliang Li, Feng Chen, fuwen Feng, Liang wang, Hui Cheng, Jialin Chang, Hui Nanjing Tech Univ Coll Mat Sci & Engn Nanjing 210009 Peoples R China Nanjing Tech Univ Tech Inst Adv Mat Nanjing 210009 Peoples R China Univ Sci & Technol Beijing State Key Lab Adv Met & Mat Beijing Peoples R China Nanjing Inst Technol Sch Mat Sci & Engn Nanjing Peoples R China

The phase transformation and mechanical properties of Ti6Al4V-0.55Fe alloy were investigated during the continuous cooling process. The curves of alpha phase precipitation exhibit a typical S-shaped pattern, which indicated that beta ->alpha phase transformation is a nucleation-growth-controlled process. The average activation energy is 231 kJ mol(-1) calculated by Kissinger-Akahira-Sunose method. The Avrami exponent during beta ->alpha transformation significantly changes with the increasing transformed volume fraction. It is found that the thickness of alpha phase lamellar decreased, while the strength and hardness increased with the increasing cooling rate. Moreover, the fracture morphology of the samples gradually changes from ductile fracture to brittle fracture under the cooling rate from 1 to 15 K min(-1), which illuminates that the plasticity of the alloy will decrease.

关键词： Ti6Al4V-0 55Fe phase transformation transformation kinetics microstructure evolution mechanical property

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A contrastive analysis of Sb distribution in Sn-Bi-Sb solder by WDS and EDS

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MATERIALS LETTERS 2024年 371卷

作者： Li, Fusheng wang, Zhigang Liu, Xixue Xu, Lei Zhang, fuwen He, Huijun Beijing COMPO Adv Technol Co Ltd Beijing 101407 Peoples R China GRIPM Adv Mat Co Ltd Beijing 101407 Peoples R China

This work provides a contrastive analysis of Sb distribution in Sn-57Bi-1Sb solder by WDS mapping, EDS count map and EDS net map. The mapping analysis on the same region shows that the WDS mapping provides the more accurate data on the distribution of Sb compared with EDS analysis, including the concentration gradient of dissolved Sb and the fine SnSb particles with size less than 1 mu m. WDS equipped with the enhanced spectral resolution is a critical technique to separate the complex overlap spectrum, which was recommended for the Sb detection in Sb-doped solders.

关键词： X-ray techniques Electron microscopy Electronic materials Segregation

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Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease

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Translational Neurodegeneration 2024年第1期13卷 759-779页

作者： Dongfang Jiang Hongmei Liu Tingting Li Song Zhao Keyan Yang fuwen Yao Bo Zhou Haiping Feng Sijia wang Jiaqi Shen Jinglan Tang Yu-Xin Zhang Yun wang Caixia Guo Tie-Shan Tang Key Laboratory of Organ Regeneration and Reconstruction State Key Laboratory of Membrane BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute of Genomics Chinese Academy of Sciences/China National Center for BioinformationBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100101China Department of Psychology UC San DiegoLa JollaCA 92093USA

Background Adult neurogenesis occurs in the subventricular zone(SVZ)and the subgranular zone of the dentate gyrus in the *** neuronal stem cells in these two neurogenic niches respond differently to various physiological and pathological ***,we have found that the decrement of carboxypeptidase E(CPE)with aging impairs the maturation of brain-derived neurotrophic factor(BDNF)and neurogenesis in the ***,it remains unknown whether these events occur in the hippocampus,and what the role of CPE is in the adult hippocampal neurogenesis in the context of Alzheimer’s disease(AD).Methods In vivo screening was performed to search for miRNA mimics capable of upregulating CPE expression and promoting neurogenesis in both neurogenic *** these,two agomirs were further assessed for their effects on hippocampal neurogenesis in the context of *** also explored whether these two agomirs could ameliorate behavioral symptoms and AD pathology in mice,using direct intracerebroventricular injection or by non-invasive intranasal *** Restoration of CPE expression in the hippocampus improved BDNF maturation and boosted adult hippocampal *** screening the miRNA mimics targeting the 5’UTR region of Cpe gene,we developed two agomirs that were capable of upregulating CPE *** two agomirs significantly rescued adult neurogenesis and cognition,showing multiple beneficial effects against the AD-associated pathologies in APP/PS1 *** note,noninvasive approach via intranasal delivery of these agomirs improved the behavioral and neurocognitive functions of APP/PS1 *** CPE may regulate adult hippocampal neurogenesis via the CPE-BDNF-TrkB signaling *** study supports the prospect of developing miRNA agomirs targeting CPE as biopharmaceuticals to counteract aging-and disease-related neurological decline in human brains.

关键词： Carboxypeptidase E Adult hippocampal neurogenesis Agomir BDNF Alzheimer’s disease Memory deficit Intranasal instillation

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Adaptive evolution of traits for parasitism and pathogen transmission potential in bat flies

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NATIONAL SCIENCE REVIEW 2025年第3期12卷 nwae245页

作者： Huang, Guangping Liu, Xing Huang, Xin Gao, Chuang wang, Zhilin Li, Junxia Wei, Xiaocui Yu, Wen-Hua Wu, Yi Liu, Ying Feng, Jiang Li, Yang Wei, fuwen Chinese Acad Sci Inst Zool Key Lab Anim Ecol & Conservat Biol Beijing 100101 Peoples R China Jiangxi Agr Univ Coll Forestry Jiangxi Prov Key Lab Conservat Biol Nanchang 330045 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Guangzhou Univ Sch Life Sci Key Lab Conservat & Applicat Biodivers South China Guangzhou 510006 Peoples R China Northeast Normal Univ Jilin Prov Key Lab Anim Resource Conservat & Utili Changchun 130024 Peoples R China

Deciphering the mechanisms underlying the transmission and spillover of zoonoses from reservoir hosts is essential in preventing future global pandemics. Bat flies-obligate blood-feeding ectoparasites of bats-are known carriers of diverse viruses. Here, we conducted a de novo assembly of a chromosome-level genome for the bat fly species Phthiridium sp. Comparative genomic analysis unveiled genes associated with specialized traits, such as the loss of eyes and wings, as well as elongated legs, which have adapted to parasitism on the dense fur of bats. Utilizing small RNA sequencing, we identified a spectrum of known and previously unclassified viruses in bat flies. Notably, experimental evidence indicated that bat flies can also feed on mammalian hosts other than bats, suggesting the potential for the spillover of bat-borne viruses. Furthermore, we demonstrated the role of the bat fly's RNA interference pathway in influencing the diversity and evolution of viruses. In summary, this study not only presents a new genome catalog to unveil the evolutionary mechanisms underpinning bat fly parasitism, but also provides a novel research system that can be used to investigate the mechanisms of cross-species transmission of bat-borne viruses and the co-evolution of bats and viruses.

关键词： bat fly bat host-pathogen interactions ectoparasites adaptive evolution virus-host dynamics antiviral RNA interference

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