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中国卫生标准管理 2024年第10期15卷 7-10页

作者：刘福文张文军赵银珊甘肃省中医药学会办公室甘肃兰州730000 武威市中医医院公共卫生与应急管理科甘肃武威733000 甘肃中医药大学针灸推拿学院甘肃兰州730000

卫生管理是医院管理工作中的重要组成部分,基于信息技术推进医院卫生管理信息化建设,对提高医院卫生管理工作的效率和质量具有重要作用。文章以武威市中医医院为例,研究信息技术在医院卫生管理中的应用。文章阐述了医院卫生管理开展信... 详细信息

卫生管理是医院管理工作中的重要组成部分,基于信息技术推进医院卫生管理信息化建设,对提高医院卫生管理工作的效率和质量具有重要作用。文章以武威市中医医院为例,研究信息技术在医院卫生管理中的应用。文章阐述了医院卫生管理开展信息化建设的意义,分析了信息技术用于医院卫生管理中所存在的问题及原因,并就如何优化医院卫生管理中信息技术应用提出对策建议。通过具体案例证明,利用信息技术对医院公共卫生管理信息系统进行优化改进,可以提高信息采集的及时性、准确性与完整性,减少传染病的漏报、迟报与填报不完整,更好地保障医疗卫生安全。

关键词：医院卫生管理信息技术信息化建设问题对策

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Radiomics based on ¹⁸F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study

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CANCER MEDICINE 2020年第2期9卷 496-506页

作者： Ou, Xuejin zhang, Jing Wang, Jian Pang, fuwen Wang, Yongsheng Wei, Xiawei Ma, Xuelei Sichuan Univ West China Hosp Dept Biotherapy Chengdu Sichuan Peoples R China Sichuan Univ State Key Lab Biotherapy Chengdu Sichuan Peoples R China Sichuan Univ West China Hosp Dept Thorac Oncol Chengdu Sichuan Peoples R China Sichuan Univ West China Hosp State Key Lab Biotherapy & Canc Ctr Chengdu Sichuan Peoples R China Sichuan Univ West China Hosp Dept Neurosurg Chengdu Sichuan Peoples R China Nanjing Univ Sci & Technol Sch Comp Sci Nanjing Jiangsu Peoples R China Sichuan Univ West China Hosp Dept Nucl Med Chengdu Sichuan Peoples R China Sichuan Univ West China Hosp Natl Clin Res Ctr Geriatr Lab Aging Res & NanotoxicolState Key Lab Biother Chengdu Sichuan Peoples R China

Purpose Our study assessed the ability F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) radiomics to differentiate breast carcinoma from breast lymphoma using machine-learning approach. Methods Sixty-five breast nodules from 44 patients diagnosed as breast carcinoma or breast lymphoma were included. Standardized uptake value (SUV) and radiomic features from CT and PET images were extracted using local image features extraction software. Six discriminative models including PETa (based on clinical, SUV and radiomic features from PET images), PETb (SUV and radiomic features from PET images), PETc (radiomic features only from PET images), CTa (clinical and radiomic features from CT images), CTb (radiomic features only from CT images), and SUV model were generated using least absolute shrinkage and selection operator method and linear discriminant analysis. The areas under the receiver operating characteristic curve (AUCs), accuracy, sensitivity, and specificity were calculated to evaluate the discriminative ability of these models. Results PETa and CTa models showed the best ability to differentiation in training and validation group (AUCs of 0.867 and 0.806 for PETa model, AUCs of 0.891 and 0.759 for CTa model, respectively). Conclusion Models based on clinical, SUV, and radiomic features of F-18-FDG PET/CT images could accurately discriminate breast carcinoma from breast lymphoma.

关键词： breast lymphoma diagnosis linear discriminant analysis machine-learning radiomic

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轻量化无人机航拍目标检测算法

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电子测量技术 2022年第19期45卷 167-174页

作者：王恒涛张上陈想贾付文三峡大学湖北省建筑质量检测装备工程技术研究中心宜昌443002 三峡大学计算机与信息学院宜昌443002

针对无人机航拍背景复杂、检测目标小且密集。提出一种基于YOLOv5的轻量化无人机航拍目标检测算法SDS-YOLO。首先,SDS-YOLO算法重构轻量化网络结构,对特征提取网络和特征融合网络进行重构。调节检测层和感受野架构,建立深层语义与浅层... 详细信息

针对无人机航拍背景复杂、检测目标小且密集。提出一种基于YOLOv5的轻量化无人机航拍目标检测算法SDS-YOLO。首先,SDS-YOLO算法重构轻量化网络结构,对特征提取网络和特征融合网络进行重构。调节检测层和感受野架构,建立深层语义与浅层语义多尺度检测信息依赖关系,增加浅层网络特征层的权重,提高对微小目标的检测能力;其次,利用聚类算法对预选框进行调整,实现重构网络最优的预选框选择机制,加快模型收敛速度。最后,使用Varifocal loss训练SDS-YOLO使IACS回归,提高模型对密集物体的检测能力。结果表明,模型经过优化后,精度提高了7.64%;模型体积4.25 MB,相较于原模型大幅下降;模型计算量和推理速度均有提高。相较于当前主流算法,SDS-YOLO在各方面均取得了不错的改进,满足无人机航拍实时目标检测要求。

关键词：目标检测多尺度融合模型轻量化 YOLOv5 Varifocal loss

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大数据下公共卫生管理模式创新研究

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中国卫生标准管理 2024年第9期15卷 13-17页

作者：张文军刘福文赵银珊武威市中医医院公共卫生与应急管理科甘肃武威733000 甘肃省中医药学会办公室甘肃兰州730000 甘肃中医药大学针灸推拿学院甘肃兰州730000

大数据时代,利用大数据技术创新公共卫生管理模式,是顺应公共卫生管理改革要求的趋势。文章介绍了大数据下公共卫生管理的特点,包括了管理精准化、管理科学化、管理高效化等。阐述了大数据下公共卫生管理的创新转向,包括树立现代型公共... 详细信息

大数据时代,利用大数据技术创新公共卫生管理模式,是顺应公共卫生管理改革要求的趋势。文章介绍了大数据下公共卫生管理的特点,包括了管理精准化、管理科学化、管理高效化等。阐述了大数据下公共卫生管理的创新转向,包括树立现代型公共卫生管理理念,构建管理多元化主体,同时推进科学型管理与整体化格局建设,管理格局向整体化转向。提出基于大数据的公共卫生管理模式创新路径,强调要持续推进公共卫生管理的合作化、网络化、开放化与动态化建设,使公共卫生相关数据更加安全,协同管理更加便捷,提高管理效率,更好地保障民众安全。

关键词：大数据医院公共卫生管理模式创新转向路径

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Ecotoxicity assessment of sodium dimethyldithiocarbamate and its micro-sized metal chelates in Caenorhabditis elegans

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SCIENCE OF THE TOTAL ENVIRONMENT 2020年 720卷 137666-000页

作者： Wang, Yitian zhang, Han Wu, Xiangyu Xue, Cheng Hu, Yang Khan, Asim Liu, fuwen Cai, Lankun East China Univ Sci & Technol Sch Resources & Environm Engn State Environm Protect Key Lab Environm Risk Asse Shanghai 200237 Peoples R China

Sodium dimethyldithiocarbamate (SDDC) is a widely used heavy metal chelating agent in harmless treatment of wastewater and hazardous waste, but SDDC and its heavy metal chelates may leak into the environment and bring potential ecological risks. In this study, the model organism Caenorhabditis elegans was used to evaluate the toxic effect of SDDC and its heavy metal Cu, Pb chelates. Multiple endpoints were investigated by subacute exposure to SDDC (0.01-100 mg/L) and micro-sized Cu, Pb chelates of SDDC (1-100 mg/L). Our data indicated that the LC50 value of SDDC was 139.39 mg/L (95% Cl: 111.03, 174.75 mg/L). In addition, SDDC was found that concentration of 1 mg/L is a safe limit value for nematode C. elegans, and concentration above 1 mg/L caused adverse effects on the survival, growth, locomotion behaviors and reactive oxygen species (ROS) production of exposed nematodes. Furthermore, all tested SDDC-Cu and SDDC-Pb chelates had obviously lower toxic effect than untreated Cu, Pb metals. These two chelates also had a lower toxic effect than SDDC agent due to its more stable structure. Moreover, SDDC-Cu had a higher toxic effect than SDDC-Pb at the same concentration. Thus, our results suggest that SDDC as a kind of chelating agent applied in harmless treatment of heavy metals, the safe addition limit should not be exceeded. (C) 2020 Elsevier B.V. All rights reserved.

关键词： Sodium dimethyldithiocarbamate Heavy metal Chelating agent C. elegans Ecological risk

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Genomic evidence for low genetic diversity but purging of strong deleterious variants in snow leopards

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GENOME BIOLOGY 2025年第1期26卷 1-24页

作者： Yang, Lin Jin, Hong Yang, Qien Poyarkov, Andrey Korablev, Miroslav Rozhnov, Viatcheslav Shao, Junjie Fu, Qiaomei Hernandez-Blanco, Jose Antonio Zhan, Xiangjiang Yu, Li Alexandrov, Dmitry Dai, Qingyan Munkhtsog, Bariushaa Du, Xin Munkhtsog, Bayaraa Ma, Liqing Chen, Wanlin Malykh, Sergei Jin, Yipeng He, Shunfu zhang, Tongzuo Wu, Guosheng Shi, Yonghong Wei, fuwen Hu, Yibo Chinese Acad Sci Inst Zool CAS Key Lab Anim Ecol & Conservat Biol Beijing Peoples R China Jiangxi Agr Univ Coll Forestry Jiangxi Key Lab Conservat Biol Nanchang Jiangxi Peoples R China Southern Marine Sci & Engn Ctr Evolut & Conservat Biol Guangdong Lab Guangzhou Peoples R China Chinese Acad Sci Northwest Inst Plateau Biol Key Lab Adaptat & Evolut Plateau Biota Xining Qinghai Peoples R China Russian Acad Sci AN Severtsov Inst Ecol & Evolut Moscow Russia Univ Chinese Acad Sci Beijing Peoples R China Chinese Acad Sci Inst Vertebrate Paleontol & Paleoanthropol Key Lab Vertebrate Evolut & Human Origins Beijing Peoples R China Yunnan Univ State Key Lab Conservat & Utilizat Bioresource Kunming 650091 Yunnan Peoples R China Irbis Mongolia Ctr Ulaanbaatar Mongolia Mongolian Acad Sci Inst Biol Ulaanbaatar Mongolia Qinghai Univ Qinghai Acad Anim Sci & Vet Med Qinghai Prov Key Lab Pathogen Diag Anim Dis Xining 810016 Qinghai Peoples R China Qinghai Univ Green Techn Res Prevent & Control Xining Qinghai Peoples R China China Agr Univ Coll Vet Med Clin Dept Beijing Peoples R China Xining Wildlife Zoo Xining Qinghai Peoples R China Golmud Forestry & Grassland Stn Qinghai Prov Haixi 816000 Peoples R China

BackgroundLong-term persistence of species with low genetic diversity is the focus of widespread attention in conservation biology. The snow leopard, Panthera uncia, is a big cat from high-alpine regions of Asia. However, its subspecies taxonomy, evolutionary history, evolutionary potential, and survival strategy remain unclear, which greatly hampers their *** sequence a high-quality chromosome-level genome of the snow leopard and the genomes of 52 wild snow leopards. Population genomics reveal the existence of two large genetic lineages in global snow leopards, the northern and southern lineages, supported by the biogeography. The Last Glacial Maximum drove the divergence of two lineages. Microclimate differences and large rivers between the western and central Himalayas likely maintain the differentiation of two lineages. EPAS1 is positively selected in the southern lineage with almost fixed amino acid substitutions and shows an increased allele frequency with elevation. Compared to the southern lineage, the northern lineage exhibits a lower level of genomic diversity and higher levels of inbreeding and genetic load, consistent with its recent population decline. We find that snow leopards have extremely low genomic diversity and higher inbreeding than other Carnivora species;however, strong deleterious mutations have been effectively purged in snow leopards by historical population bottlenecks and inbreeding, which may be a vital genetic mechanism for their population survival and *** findings reveal the survival strategy of a species with low genetic diversity and highlight the importance of unveiling both genetic diversity and genetic burden for the conservation of threatened species.

关键词： Snow leopards Population genomics Genetic structure Genomic diversity Deleterious variants EPAS1

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Study on the Optimization of AC/DC Hybrid Micro-grid System Based on ILC Power Control

Study on the Optimization of AC/DC Hybrid Micro-grid System ...

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Chinese Automation Congress (CAC)

作者： Hu, Kai zhang, Danhong Su, Yixin Qi, Yue Su, fuwen Zeng, Qiyi Wuhan Univ Technol Sch Automat Wuhan Peoples R China China Ship Dev & Design Wuhan Peoples R China Wuhan Univ Technol Sch Comp Sci & Technol Wuhan Peoples R China

ISBN: (纸本)9781728176871

In order to improve the power quality of AC/DC hybrid micro-grid and the response characteristics when the load changes, an AC/DC micro-grid containing wind turbine, photovoltaic power generation unit, fuel cell and energy storage equipment is established, and the ILC power control strategy is used to optimize the system. The transient responses of micro-grid to load transformations under different control strategies are simulated and compared, which verify the superiority of ILC power control strategy and provide a simulation platform for the further study of the micro-grid.

关键词： AC/DC Micro-grid System Optimization ILC Power Control

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CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease

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METABOLISM-CLINICAL AND EXPERIMENTAL 2024年 150卷 155724-155724页

作者： Zuo, fuwen Wang, Youzhao Xu, Xinlei Ding, Ruihao Tang, Wei Sun, Yu Wang, Xiaojie zhang, Yan Wu, Jichao Xie, Yusheng Liu, Min Wang, Ziying Yi, Fan Shandong Univ Sch Basic Med Sci Dept Pharmacol Jinan 250012 Peoples R China Shandong Univ Sch Basic Med Sci Dept Pathogen Biol Jinan 250012 Peoples R China Chinese Minist Educ Natl Key Lab Innovat & Transformat Luobing Theory Key Lab Cardiovasc Remodeling & Funct Res Jinan 250012 Peoples R China Shandong Univ Qilu Hosp Chinese Minist Hlth Jinan 250012 Peoples R China

Background and aims: Podocyte injury is considered as the most important early event contributing to diabetic kidney disease (DKD). Recent findings provide new insights into the roles of lipids and lipid-modulating proteins as key determinants of podocyte function in health and kidney disease. CCDC92, a novel member of coiled-coil domain-containing protein family, was indicated relevant to lipid metabolism, coronary heart disease and type 2 diabetes. However, the expression pattern and role of CCDC92 in the kidney is not clear. This study was designed to elucidate the contribution of CCDC92 in the pathogenesis of DKD. Methods: Sections with a pathological diagnosis of different classes of DKD, including subjects with mild DKD (class II, n = 6), subjects with moderate DKD (class III, n = 6) or subjects with severe DKD (class IV, n = 6), and control samples (n = 12) were detected for the expression level of CCDC92 and lipid accumulation. Two types of diabetic mice model (db/db and HFD/STZ) in podocyte-specific Ccdc92 knockout background were generated to clarify the role of CCDC92 in podocyte lipotoxicity. Results: The level of CCDC92 was increased in renal biopsies sections from patients with DKD, which was correlated with eGFR and lipid accumulation in glomeruli. In animal studies, CCDC92 were also induced in the kidney from two independent diabetic models, especially in podocytes. Podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and ectopic lipid deposition under diabetic condition. Mechanically, CCDC92 promoted podocyte lipotoxicity, at least in part through ABCA1 signaling-mediated lipid homeostasis. Conclusion: Our studies demonstrates that CCDC92 acts as a novel regulator of lipid homeostasis to promote podocyte injury in DKD, suggesting that CCDC92 might be a potential biomarker of podocyte injury in DKD, and targeting CCDC92 may be an effective innovative therapeutic strategy for patients with DKD.

关键词： CCDC92 Podocytes Lipotoxicity Diabetic kidney disease

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Spatial patterns and conservation of genetic and phylogenetic diversity of wildlife in China

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SCIENCE ADVANCES 2021年第4期7卷 000-000页

作者： Hu, Yibo Fan, Huizhong Chen, Youhua Chang, Jiang Zhan, Xiangjiang Wu, Hua zhang, Baowei Wang, Meng zhang, Wenyan Yang, Lin Hou, Xian Shen, Xing Pan, Tao Wu, Wei Li, Jun Hu, Haihua Wei, fuwen Chinese Acad Sci Inst Zool CAS Key Lab Anim Ecol & Conservat Biol Beijing Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Chinese Acad Sci Ctr Excellence Anim Evolut & Genet Kunming Yunnan Peoples R China Chinese Acad Sci Chengdu Inst Biol Chengdu Peoples R China Chinese Res Inst Environm Sci State Key Lab Environm Criteria & Risk Assessment Beijing Peoples R China Cent China Normal Univ Sch Life Sci Inst Evolut & Ecol Wuhan Peoples R China Anhui Univ Sch Life Sci Hefei Peoples R China Chinese Acad Sci Inst Bot State Key Lab Systemat & Evolutionary Bot Beijing Peoples R China Southern Marine Sci & Engn Guangdong Lab Guangzho Guangzhou Guangdong Peoples R China

Genetic diversity and phylogenetic diversity reflect the evolutionary potential and history of species, respectively. However, the levels and spatial patterns of genetic and phylogenetic diversity of wildlife at the regional scale have largely remained unclear. Here, we performed meta-analyses of genetic diversity in Chinese terrestrial vertebrates based on three genetic markers and investigated their phylogenetic diversity based on a dated phylogenetic tree of 2461 species. We detected strong positive spatial correlations among mitochondrial DNA-based genetic diversity, phylogenetic diversity, and species richness. Moreover, the terrestrial vertebrates harbored higher genetic and phylogenetic diversity in South China and Southwest China than in other regions. Last, climatic factors (precipitation and temperature) had significant positive effects while altitude and human population density had significant negative impacts on levels of mitochondrial DNA-based genetic diversity in most cases. Our findings will help guide national-level genetic diversity conservation plans and a post-2020 biodiversity conservation framework.

关键词： Conservation

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基于多保真代理模型的塔机臂架结构优化

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机电工程 2024年第11期41卷 1967-1976页

作者：张建康刘富文郭冠辰张帅宋学官孙田李子陆大连理工大学机械工程学院辽宁大连116024 大连理工大学高性能精密制造全国重点实验室辽宁大连116024 抚顺永茂建筑机械有限公司辽宁抚顺113000

起重臂架是动臂式塔机的关键工作部件,负责提升运输建筑材料,其制造成本和工作耗能与自身重量成正比,需要对臂架的重量优化展开研究,因此提出了一种针对动臂式塔机臂架的高效优化设计方法。首先,基于有限元法,计算了不同臂架幅度下的极... 详细信息

起重臂架是动臂式塔机的关键工作部件,负责提升运输建筑材料,其制造成本和工作耗能与自身重量成正比,需要对臂架的重量优化展开研究,因此提出了一种针对动臂式塔机臂架的高效优化设计方法。首先,基于有限元法,计算了不同臂架幅度下的极限工况应力及变形,确定了最危险工况,并以此工况作为优化设计的基础工况;然后,选定了臂架上12个结构参数为设计变量,进行了参数化建模,利用拉丁超立方采样(LHS)选取了样本点,基于有限元仿真数据,构建了三种基于径向基函数(RBF)的代理模型并对其精度进行了评估;最后,基于精度高的多保真代理模型(MFS),以臂架重量最小为优化目标,构建了臂架优化问题的数学模型,使用遗传算法(GA)完成了优化设计。研究结果表明:优化后的臂架满足强度、刚度要求,整个臂架不会发生断裂和失稳,而且臂架重量减轻了25.03%;同时,多保真代理模型的预测结果和仿真结果误差小于3%,证明了多保真代理模型的准确性,进而证明了基于多保真代理模型的臂架优化方法的有效性。

关键词：动臂式塔式起重机臂架结构轻量化设计多保真代理模型遗传算法优化设计拉丁超立方采样径向基函数

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