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Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

MOLECULAR CELL 2022年第7期82卷 1297-+页

作者： zhang, Chuanchao Zhou, Bo Gu, Feng Liu, Hongmei Wu, Honglin Yao, fuwen Zheng, Hui Fu, Hui Chong, Wei Cai, Shurui Huang, Min Ma, Xiaolu Guo, Zhifang Li, Tingting Deng, Wenyuan Zheng, Meiwen Ji, Qiao Zhao, Yongliang Ma, Yongjie Wang, Qi-En Tang, Tie-Shan Guo, Caixia Chinese Acad Sci CAS Key Lab Genom & Precis Med Beijing Inst Genom Univ Chinese Acad SciChina Natl Ctr Bioinformat Beijing 100101 Peoples R China Tianjin Med Univ Canc Inst & Hosp Dept Breast Canc Pathol & Res Lab Tianjin 300060 Peoples R China Chinese Acad Sci State Key Lab Membrane Biol Inst Zool Univ Chinese Acad Sci Beijing 100101 Peoples R China Ohio State Univ Dept Radiat Oncol Ctr Comprehens Canc Columbus OH 43016 USA Chinese Acad Sci Inst Stem Cell & Regenerat Beijing 100101 Peoples R China Beijing Inst Stem Cell & Regenerat Med Beijing 100101 Peoples R China

Synthetic lethality through combinatorial targeting DNA damage response (DDR) pathways provides exciting anticancer therapeutic benefit. Currently, the long noncoding RNAs (lncRNAs) have been implicated in tumor drug resistance;however, their potential significance in DDR is still largely unknown. Here, we report that a human lncRNA, CTD-2256P15.2, encodes a micropeptide, named PAR-amplifying and CtIP-maintaining micropeptide (PACMP), with a dual function to maintain CtIP abundance and promote poly(ADP-ribosyl)ation. PACMP not only prevents CtIP from ubiquitination through inhibiting the CtIP-KLHL15 association but also directly binds DNA damage-induced poly(ADP-ribose) chains to enhance PARP1-dependent poly(ADP-ribosyl)ation. Targeting PACMP alone inhibits tumor growth by causing a synthetic lethal interaction between CtIP and PARP inhibitions and confers sensitivity to PARP/ATR/CDK4/6 inhibitors, ionizing radiation, epirubicin, and camptothecin. Our findings reveal that a lncRNA-derived micropeptide regulates cancer progression and drug resistance by modulating DDR, whose inhibition could be employed to augment the existing anticancer therapeutic strategies.

关键词： CtIP DNA damage response DNA double-strand break repair PARP inhibitor drug resistance long noncoding RNA micropeptide poly(ADP-ribosyl)ation synthetic lethal

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100km Optical Chirp Chain BOTDA with Spatial Resolution of 4m

100km Optical Chirp Chain BOTDA with Spatial Resolution of 4...

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Asia Communications and Photonics Conference (ACP) / International Conference on Information Photonics and Optical Communications (IPOC)

作者： Wu, Guangzhe Li, Bozhong Wang, Ying Li, Can Deng, Li Xia, Xiaomeng Lu, He Jin, Wei Wang, Qian Bai, fuwen Ma, Chao Zhou, Xinyan Lei, Hanlin Hu, Chao Huang, Liwei zhang, Liyan Shui, Biao Zhou, Hongyan Wu, Jun State Grid Informat & Telecommun Branch Beijing 100761 Peoples R China Yangtze Opt Fibre & Cable Joint Stock Ltd Co Stata Key Lab Opt Fibre & Cable Mfg Technol Wuhan 430073 Peoples R China Hubei Opt Valley Lab Wuhan 430071 Peoples R China

We proposed OCC-BOTDA using pattern recognition algorithm and differential pulse-width pair technique, which can improve the spatial resolution and sensing range effectively. A spatial resolution of 4m is achieved wit... 详细信息

ISBN: (纸本)9781665481557

关键词： Fiber optics sensors Distributed optical fiber sensing Non-linear optics Stimulated Brillouin scattering Fibers

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慢性萎缩性胃炎中医证型与Hp感染及胃黏膜癌前病理变化的相关性研究

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中国中医药现代远程教育 2018年第23期16卷 59-60,80页

作者：杨静茹淑瑛张福文李柏北京中医药大学东直门医院东区脾胃病科北京101121

目的探讨慢性萎缩性胃炎的中医证型分布与幽门螺旋杆菌(Hp)感染及胃黏膜癌前病理变化之间的关系。方法统计170例慢性萎缩性胃炎患者的中医证型分布、Hp感染情况及胃黏膜病理表现,分析证型分布与Hp感染、腺体萎缩程度、肠上皮化生、异型... 详细信息

目的探讨慢性萎缩性胃炎的中医证型分布与幽门螺旋杆菌(Hp)感染及胃黏膜癌前病理变化之间的关系。方法统计170例慢性萎缩性胃炎患者的中医证型分布、Hp感染情况及胃黏膜病理表现,分析证型分布与Hp感染、腺体萎缩程度、肠上皮化生、异型增生之间的相关性。结果不同证型间HP感染阳性率差异有统计学意义(P<0.05),各证型Hp感染阳性率从高到低为:脾胃湿热证>肝胃不和证>胃阴不足证>脾胃虚弱证>胃络瘀血证;各证型间腺体萎缩程度差异有统计学意义(P<0.05),肝胃不和证轻度萎缩所占比例最高,胃络瘀血证的重度萎缩所占比例高于其他证型;各个证型间存在肠化生、异型增生的差异无统计学意义(P>0.05)。结论慢性萎缩性胃炎中医证型与Hp感染、胃黏膜萎缩程度存在一定的相关性。

关键词：慢性萎缩性胃炎证型分布幽门螺旋杆菌癌前病理变化痞满

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Ultra-low loss and large effective area G.654.E fiber in non-relay ultra-long haul optical transmission

Ultra-low loss and large effective area G.654.E fiber in non...

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2022 Applied Optics and Photonics China: Optical Information and Networks, AOPC 2022

作者： Wu, Guangzhe Li, Bozhong Liu, Jun Wei, Yong Qu, Yanwen Wang, Ruichun Deng, Li Wang, Ying zhang, Xiaowei Yuan, Lijuan Liu, Ying Zhou, Xinyan Fan, Hongjun Lu, He Bai, fuwen Wang, Qian Jin, Wei Ma, Chao Zhu, Jihong Zhou, Hongyan Hu, Chao Wu, Jun State Grid Information & Telecommunication Branch Beijing100761 China Information and Telecommunication Company State Grid Hebei Electric Power Company Shijiazhuang050000 China Southwest Electric Power Design Institute Co. Ltd. China Energy Engineering Group Chengdu610056 China State Key Laboratory of Optical Fibre and Cable Manufacture Technology Yangtze Optical Fibre and Cable Joint Stock Limited Company Wuhan430073 China Jiangsu Tongguang Optical Fiber Cable Limited Company Haimen226100 China

ISBN: (纸本)9781510662384

In this paper, the properties of ultra-low loss and large effective area G.654.E fiber were studied, including the optical properties and cabling performance. Based on the tests of the transmission performances of different optical fibers in non-relay ultra-long haul optical transmission system, practical suggestions for optical fiber selection of electric communication construction were proposed. G.654.E fiber was utilized in practical engineering, verifying the theoretical research and identifying optimal direction and methods. 467 km non-relay ultra-long haul optical transmission was realized, creating a new record in electric communication network. © 2023 SPIE.

关键词： Optical fibers

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Interface properties and bias temperature instability with ternary H-Cl-N mixed plasma post-oxidation annealing in 4H-SiC MOS capacitors

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APPLIED SURFACE SCIENCE 2019年 488卷 293-302页

作者： Yang, Chao zhang, Fanglong Yin, Zhipeng Su, Yan Qin, fuwen Wang, Dejun Dalian Univ Technol Fac Elect Informat & Elect Engn Sch Control Sci & Engn Liaoning Integrated Circuit Technol Key Lab Dalian 116024 Peoples R China Dalian Univ Technol Minist Educ State Key Lab Mat Modificat Laser Ion & Electron Dalian 116024 Peoples R China

Interface properties and bias temperature instability (BTI) are the two critical issues that severely restricted the performance and reliability of SiC metal-oxide-semiconductor (MOS) devices. In this work, we simultaneously improved interface properties and BTI in 4H-SiC MOS capacitors by modifying SiC/SiO2 interface via ternary H-Cl-N mixed plasma post-oxidation annealing (POA). Results showed that H-Cl-N mixed plasma POA improved the oxide insulating properties, reduced density of interface traps, and improved the BTI both at low temperature and high temperature. The modification of interface was achieved by enriching H, Cl, and N elements at and near the interface, which not only led to a smoother interface, but also could bond with interfacial traps. The synergistic effects of H, Cl, and N in reducing traps at and near the interface were due to the conversion of the trap levels to or outside the lower half of the SiC bandgap, thereby suppressing electron trapping. Density Functional Theory calculations further indicated that the Cl and N could passivate mobile ions and Si-Si bonds. N passivation and combined N and H passivation were stable and effective in passivating Si-Si bonds and reducing oxygen vacancies.

关键词： 4H-SiC MOS capacitor Interface properties Bias temperature instability Electron cyclotron resonance Post-oxidation annealing

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灌浆缺陷对钢筋套筒灌浆连接接头强度影响的试验研究

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建筑结构 2018年第7期48卷 52-56页

作者：李向民高润东许清风王卓琳张富文上海市建筑科学研究院上海市工程结构安全重点实验室

钢筋套筒灌浆连接是装配整体式混凝土结构的核心,对结构整体性能至关重要。针对适应14,20,25mm三种直径的钢筋套筒灌浆连接接头GTZQ4-14,GTZQ4-20,GTZQ4-25,通过在套筒内下段钢筋锚固段底部设置灌浆缺陷,研究了不同大小的缺陷对接头对... 详细信息

钢筋套筒灌浆连接是装配整体式混凝土结构的核心,对结构整体性能至关重要。针对适应14,20,25mm三种直径的钢筋套筒灌浆连接接头GTZQ4-14,GTZQ4-20,GTZQ4-25,通过在套筒内下段钢筋锚固段底部设置灌浆缺陷,研究了不同大小的缺陷对接头对中单向拉伸强度的影响。研究结果表明,对于常用型号灌浆套筒,当套筒端头灌浆缺陷长度不超过套筒内一侧钢筋锚固长度（8d）的30%时,其接头的对中单向拉伸强度仍能符合要求。研究结果可为套筒灌浆质量检测评估和后续整治提供依据。

关键词：钢筋套筒灌浆连接灌浆缺陷强度破坏形态

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社会主义核心价值观:实现以人民为中心思想的价值支撑

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河南理工大学学报（社会科学版） 2017年第2期18卷 1-5页

作者：张富文河南理工大学马克思主义学院河南焦作454000

社会主义核心价值观既是实现以人民为中心思想的精神动力,也是在宏观、中观、微观辩证统一的基础上,为以人民为中心思想的实现提供价值支撑。从宏观上看,国家层面的价值追求有利于提供切实的政治、文化、社会条件及相关价值导向,为以人... 详细信息

社会主义核心价值观既是实现以人民为中心思想的精神动力,也是在宏观、中观、微观辩证统一的基础上,为以人民为中心思想的实现提供价值支撑。从宏观上看,国家层面的价值追求有利于提供切实的政治、文化、社会条件及相关价值导向,为以人民为中心思想的实现提供价值原则;从中观上看,社会集体层面的价值要求有利于恢复社会成员的道德自省、自觉,培育良好的道德文化氛围,为以人民为中心思想的实现提供价值准则;从微观上看,个人层面的价值原则有利于提升人的道德境界,追求美好的道德风尚,为以人民为中心思想的实现提供价值标准。

关键词：社会主义核心价值观以人民为中心精神动力价值支撑

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FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways

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MOLECULAR CELL 2023年第15期83卷 2810-+页

作者： Huang, Min Yao, fuwen Nie, Litong Wang, Chao Su, Dan zhang, Huimin Li, Siting Tang, Mengfan Feng, Xu Yu, Bin Chen, Zhen Wang, Shimin Yin, Ling Mou, Lisha Hart, Traver Chen, Junjie Univ Texas MD Anderson Canc Ctr Dept Expt Radiat Oncol Houston TX 77030 USA Shenzhen Univ Shenzhen Peoples Hosp 2 Shenzhen Inst Translat Med Hlth Sci CtrDept Hepatopancreatobiliary SurgAffi Shenzhen Peoples R China Univ Texas MD Anderson Canc Ctr Dept Bioinformat & Computat Biol Houston TX 77030 USA

DNA damage-activated signaling pathways are critical for coordinating multiple cellular processes, which must be tightly regulated to maintain genome stability. To provide a comprehensive and unbiased perspective of DNA damage response (DDR) signaling pathways, we performed 30 fluorescence-activated cell sorting (FACS)-based genome-wide CRISPR screens in human cell lines with antibodies recognizing distinct endogenous DNA damage signaling proteins to identify critical regulators involved in DDR. We discovered that proteasome-mediated processing is an early and prerequisite event for cells to trigger camptothecinand etoposide-induced DDR signaling. Furthermore, we identified PRMT1 and PRMT5 as modulators that regulate ATM protein level. Moreover, we discovered that GNB1L is a key regulator of DDR signaling via its role as a co-chaperone specifically regulating PIKK proteins. Collectively, these screens offer a rich resource for further investigation of DDR, which may provide insight into strategies of targeting these DDR pathways to improve therapeutic outcomes.

关键词： FACS-based CRISPR screen DDR signaling antibody proteasome PRMT5 GNB1L

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Emerging Approaches in Enhancing the Efficiency and Stability in Non-Fullerene Organic Solar Cells

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ADVANCED ENERGY MATERIALS 2020年第47期10卷 2002746-2002746页

作者： Zhao, fuwen zhang, Huotian zhang, Rui Yuan, Jun He, Dan Zou, Yingping Gao, Feng Cent South Univ State Key Lab Powder Met Changsha 410083 Hunan Peoples R China Linkoping Univ Dept Phys Chem & Biol IFM SE-58183 Linkoping Sweden

The past three years have witnessed rapid growth in the field of organic solar cells (OSCs) based on non-fullerene acceptors (NFAs), with intensive efforts being devoted to material development, device engineering, and understanding of device physics. The power conversion efficiency of single-junction OSCs has now reached high values of over 18%. The boost in efficiency results from a combination of promising features in NFA OSCs, including efficient charge generation, good charge transport, and small voltage losses. In addition to efficiency, stability, which is another critical parameter for the commercialization of NFA OSCs, has also been investigated. This review summarizes recent advances in the field, highlights approaches for enhancing the efficiency and stability of NFA OSCs, and discusses possible strategies for further advances of NFA OSCs.

关键词： device stability narrow‐ gap non‐ fullerene acceptors voltage losses

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Optical Chirp Chain BOTDA with 150 km sensing range based on Brillouin loss scheme 20

Optical Chirp Chain BOTDA with 150 km sensing range based on...

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20th International Conference on Optical Communications and Networks, ICOCN 2022

作者： Wu, Guangzhe Li, Bozhong Wang, Ying Li, Can Zhou, Hongyan Hu, Chao Zhou, Xinyan Lei, Hanlin Deng, Li Xia, Xiaomeng Huang, Liwei Lu, He Jin, Wei Wang, Qian Bai, fuwen Ma, Chao zhang, Liyan Shui, Biao Wu, Jun State Grid Information and Telecommunication Branch Beijing100761 China Stata Key Laboratory of Optical Fibre and Cable Manufacture Technology Yangtze Optical Fibre and Cable Joint Stock Limited Company Wuhan430073 China

ISBN: (数字)9781665458986

ISBN: (纸本)9781665458986

Long range distributed optical fiber sensing is urgently needed in many areas, such as pipeline safety, road and bridge monitoring, and so on. Optical chirp chain Brillouin optical time-domain analysis is considered successfully scheme of fast distributed optical fiber sensing, and here, we proposed a fast-monitoring sensing scheme with ultra-long sensing range, which is based on optical chirp chain and Brillouin loss spectrum, and a final parameter of 3.2-s measurement time, 6-m spatial resolution and 150-km sensing range have been achieved over a single-mode fiber. © 2022 IEEE.

关键词： Single mode fibers

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