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国际肿瘤学杂志 2018年第4期45卷 250-252页

作者：刘恒铫赵国丽王福文蔡海波张月英济南大学山东省医学科学院医学与生命科学学院 250200 山东省医学科学院药物研究所国家卫生和计划生育委员会生物技术药物重点实验室山东省罕少见病重点实验室山东省医学科学院基础医学研究所病理学与病理生理学研究室济宁市第一人民医院胸外科

Notch信号通路参与肺癌干细胞的异常分化和自我更新,深入研究Notch信号通路在肺癌干细胞调控中的作用,有望在肺癌的诊断及治疗中找到新的靶点.作用于Notch信号通路的抑制剂可能成为有效治疗肺癌的药物.肺癌干细胞被认为是肺癌复发的主... 详细信息

Notch信号通路参与肺癌干细胞的异常分化和自我更新,深入研究Notch信号通路在肺癌干细胞调控中的作用,有望在肺癌的诊断及治疗中找到新的靶点.作用于Notch信号通路的抑制剂可能成为有效治疗肺癌的药物.肺癌干细胞被认为是肺癌复发的主要因素,因此针对肺癌干细胞的靶向治疗可能比针对整个肿瘤的治疗更有效.

关键词：受体,Notch 肺肿瘤肿瘤干细胞抑制剂

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四川栗子坪国家级自然保护区鸟类资源与多样性分析

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四川动物 2018年第2期37卷 224-233页

作者：张勘徐雨李晓清唐博冉小东田佼刘富文四川栗子坪国家级自然保护区四川石棉625400 贵州师范大学生命科学学院贵阳550025 成都市雷雀生态环保科技有限公司成都610064

通过野外调查并结合有关文献,四川栗子坪国家级自然保护区有鸟类15目53科260种,其中,留鸟169种(65.0%),夏候鸟57种(21.9%),冬候鸟18种(6.9%),旅鸟16种(6.2%);东洋界物种161种(61.9%),古北界物种70种(26.9%),广布种29种(11.2%)。保护区... 详细信息

通过野外调查并结合有关文献,四川栗子坪国家级自然保护区有鸟类15目53科260种,其中,留鸟169种(65.0%),夏候鸟57种(21.9%),冬候鸟18种(6.9%),旅鸟16种(6.2%);东洋界物种161种(61.9%),古北界物种70种(26.9%),广布种29种(11.2%)。保护区分布有IUCN红色名录鸟类6种,其中濒危(EN)1种,易危(VU)2种,近危(NT)3种;国家Ⅰ级重点保护野生鸟类4种,国家Ⅱ级重点保护野生鸟类20种;中国特有鸟类14种。分析表明,秋季优势物种4种,春季5种。秋季的鸟类多样性低于春季,但无论秋季还是春季,中低海拔阔叶林的鸟类多样性最高,针叶林和针阔混交林次之,河谷灌丛最低。秋季和春季鸟类群落相似性指数以及不同生境之间鸟类物种相似性指数皆低于0.50,说明时间和空间上群落组成差异较大。在保护区鸟类保护与管理中,建议注重维持多样的生境类型,同时应当重视保护中低海拔阔叶林。

关键词：鸟类动物区系多样性季节生境保护

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Single-Junction Binary-Blend Nonfullerene Polymer Solar Cells with 12.1% Efficiency

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ADVANCED MATERIALS 2017年第18期29卷 1700144.1-1700144.1页

作者： Zhao, fuwen Dai, Shuixing Wu, Yang zhang, Qianqian Wang, Jiayu Jiang, Li Ling, Qidan Wei, Zhixiang Ma, Wei You, Wei Wang, Chunru Zhan, Xiaowei Peking Univ Minist Educ Key Lab Polymer Chem & Phys Dept Mat Sci & EngnColl Engn Beijing 100871 Peoples R China Chinese Acad Sci Inst Chem Beijing 100190 Peoples R China Fujian Normal Univ Coll Mat Sci & Engn Fujian Key Lab Polymer Mat Fuzhou 350007 Peoples R China Xi An Jiao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China Univ North Carolina Chapel Hill Dept Chem Chapel Hill NC 27599 USA Natl Ctr Nanosci & Technol Beijing 100190 Peoples R China

A new fluorinated nonfullerene acceptor, ITIC-Th1, has been designed and synthesized by introducing fluorine (F) atoms onto the end-capping group 1,1-dicyanomethylene-3-indanone (IC). On the one hand, incorporation of F would improve intramolecular interaction, enhance the push-pull effect between the donor unit indacenodithieno[3,2-b] thiophene and the acceptor unit IC due to electron-withdrawing effect of F, and finally adjust energy levels and reduce bandgap, which is beneficial to light harvesting and enhancing short-circuit current density (JSC). On the other hand, incorporation of F would improve intermolecular interactions through C. F center dot center dot center dot S, C. F center dot center dot center dot H, and C. F center dot center dot center dot pi noncovalent interactions and enhance electron mobility, which is beneficial to enhancing JSC and fill factor. Indeed, the results show that fluorinated ITIC-Th1 exhibits redshifted absorption, smaller optical bandgap, and higher electron mobility than the nonfluorinated ITIC-Th. Furthermore, nonfullerene organic solar cells (OSCs) based on fluorinated ITIC-Th1 electron acceptor and a wide-bandgap polymer donor FTAZ based on benzodithiophene and benzotriazole exhibit power conversion efficiency (PCE) as high as 12.1%, significantly higher than that of nonfluorinated ITIC-Th (8.88%). The PCE of 12.1% is the highest in fullerene and nonfullerene-based single-junction binary-blend OSCs. Moreover, the OSCs based on FTAZ: ITIC-Th1 show much better efficiency and better stability than the control devices based on FTAZ: PC71BM (PCE = 5.22%).

关键词： fluorination fused-ring electron acceptors nonfullerene polymer solar cells

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住培人员组织支持感与住培制度满意度相关研究

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中国医院 2018年第10期22卷 34-36页

作者：曾卫龙李兵张艳玲余中光黄福文徐学虎广西医科大学第四附属医院广西柳州市柳石路1号545005 中日友好医院北京市朝阳区樱花园东街100029 广州医科大学附属第三医院

目的:了解不同岗位住培人员组织支持感和住培制度满意度现况,比较不同特征人员的差异性,探讨组织支持感与住培制度满意度的关系。方法:对参加2017年住院医师规范化培训高峰论坛的住培人员进行问卷调查。结果:全科医师的组织支持感和对... 详细信息

目的:了解不同岗位住培人员组织支持感和住培制度满意度现况,比较不同特征人员的差异性,探讨组织支持感与住培制度满意度的关系。方法:对参加2017年住院医师规范化培训高峰论坛的住培人员进行问卷调查。结果:全科医师的组织支持感和对住培制度满意度最低,住培学员的组织支持感和对住培制度满意度也显著低于其他岗位。结论:组织支持感对住培制度满意度具有预测作用。建议给予年轻、低从业年限的住培人员更多关怀,提高住培各类人员的组织支持感,确保住培学员培训期间待遇水平及公平性,加快健全全科医学人才队伍培养、使用、激励机制,保障住培质量。

关键词：全科医学住院医师规范化培训住培制度满意度组织支持感

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基于X射线数字成像的预制剪力墙套筒灌浆连接质量检测技术研究

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建筑结构 2018年第7期48卷 57-61页

作者：李向民高润东许清风王卓琳张富文谢莹上海市建筑科学研究院上海市工程结构安全重点实验室上海200032 北京天助瑞邦影像设备有限公司北京100176

结合工程实际设计了预制剪力墙试件和预制夹心保温剪力墙试件,开展了基于X射线数字成像法（DR）的检测技术研究,并和X射线胶片成像法、X射线计算机成像法（CR）进行了对比。研究结果表明：DR检测技术用于预制剪力墙或预制夹心保温剪力... 详细信息

结合工程实际设计了预制剪力墙试件和预制夹心保温剪力墙试件,开展了基于X射线数字成像法（DR）的检测技术研究,并和X射线胶片成像法、X射线计算机成像法（CR）进行了对比。研究结果表明：DR检测技术用于预制剪力墙或预制夹心保温剪力墙中单排居中套筒或梅花形布置套筒的灌浆质量的检测是可行的,用于双排对称布置套筒的灌浆质量检测,必要时需要结合破损法进行判别;与胶片成像检测技术和CR检测技术相比,DR检测技术成像更为清晰,在预制剪力墙套筒灌浆连接质量的检测中应用前景十分广阔。

关键词：套筒灌浆连接质量 X射线数字成像法 X射线胶片成像法 X射线计算机成像法

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Seismic collapse simulation of spatial RC frame structures

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COMPUTERS & STRUCTURES 2013年第Apr.期119卷 140-154页

作者： Lu, Xilin Wang, Jingjing zhang, fuwen Tongji Univ State Key Lab Disaster Reduct Civil Engn Shanghai 200092 Peoples R China Shanghai Key Lab New Technol Res Engn Struct Shanghai 200032 Peoples R China Shanghai Res Inst Bldg Sci Grp Co Ltd Shanghai 200032 Peoples R China

A special DEM (distinct/discrete element method) model employing spring model designed for RC members is proposed to simulate seismic collapse of spatial RC frame structures. The failure criteria are developed. Methods to get the rotational displacement and the contact detection algorithm prove good accuracy and efficiency. Taking advantages of this model, a Visual C++6.0 based simulation program, 3DCollap1.0, is developed and then verified by simulating the shaking table test of a RC frame featuring strong-beam-weak-column from minor and moderate earthquakes to severe earthquake which results in structural collapse. The collapse process of a strong-column-weak-beam RC frame is also successfully simulated. (C) 2013 Elsevier Ltd. All rights reserved.

关键词： SMSM DEM Spatial frame structure Seismic collapse Simulation program Collapse pattern

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First near complete mitochondrial genome of large toothed toad,Oreolalax major(Anura: Megophryidae) from southwest China

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Mitochondrial DNA Part B 2017年第1期2卷 37-38页

作者： fuwen Liu Yusong Liu Yan Li Qingyong Ni Yongfang Yao Huailiang Xu Mingxian Yang Taifu Wang Jiacai Wang Dingqi Rao Mingwang zhang College of Animal Science and Technology Sichuan Agricultural University Chengdu Sichuan ChinaChengdu Leique Ecology-Environmental Protection Science and Technology Limited Company Chengdu Sichuan China College of Animal Science and Technology Sichuan Agricultural University Chengdu Sichuan China College of Life Science Sichuan Agricultural University Ya’an Sichuan China Sichuan Baodinggou Nature Reserve Maoxian Sichuan China Sichuan Wawushan Nature Reserve Hongya Sichuan China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China

In this study, the near complete mitogenome sequence (15,469 bp) ofOreolalax majorwas determined using polymerase chain reaction (PCR). It includes 13 protein-coding genes (PCGs), 2 ribosomal RNA (rRNA) genes and 19 transfer RNA (tRNA) genes (GenBank accession number KU310894). The features ofO. majorhave one more tRNA gene (tRNAMet) behind the original one beforeND2which is similar toLeptobrachium *** analyses were based on the concatenated sequences of the 13 protein-encoding genes ofO. majorand other related species.

关键词： Mitochondrial genome Oreolalax major phylogenetic analysis

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Determination of migration of hazardous elements from non-stick pan materials in five food simulants by ICP-MS

Determination of migration of hazardous elements from non-st...

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Chinese Materials Congress on Methods of Design and Characterization of Materials, Research and Development of Technological Processes, 2015

作者： Gao, Jianguo Zhao, fuwen Chunping, L.I. Sun, Zhuojun zhang, Shuai Gao, Jian zhang, Qianqian Song, Xiaoyun Qingdao Entry-Exit Inspection and Quarantine Bureau Qingdao266001 China College of Chemistry and Chemical Engineering Ocean University of China QingdaoShandong266003 China Inspection and Quarantine Comprehensive Technology Centre of Guizhou Entry-Exit Inspection and Quarantine Bureau Guizhou550004 China Qingdao Double Peach Specialty Chemicals Co.Ltd Qingdao266031 China Inspection and Quarantine Center of Shandong Exit and Entry Inspection and Quarantine Bureau 2 Zhongshan Road Qingdao266001 China University of California Berkeley B.A. 2700 Hearst Avenue Stern Hall BerkeleyCA94720 United States College of Chemistry and Chemical Engineering Shandong University of Science and Technology Qingdao266590 China

ISBN: (纸本)9783038357629

A method for the determination of seven hazardous elements in Non-stick Pan Materials in five food simulants by inductively coupled plasma mass spectrometry(ICP-MS) was established. Using this method, the experiments were carried out on the samples of imitated migratory elements (Cr, Mn, Ni, Cu, As, Pb, Cd) in food simulants of water, 4%(W/V)acetic acid solution, 10%(V/V)ethanol solution, 2g/L sodium chloride solution and olive oil. The sample preparation method of five food simulants was confirmed through experiment. Experiments by resolution, stability, sensitivity and other parameters were adjusted tuning instrument to determine the instrument to achieve the best working condition. The linear range of this methods was 0.1~50ng/ml. For all elements, the correlation coefficient of the calibration curves was above 0.9990 and the detection limits were within the range of 0.008~0.12ng/ml. Most of the recoveries at 1ng/ml concentration level was from 85.34%~112.3%, while the RSD was from 0.37%~4.1%. © 2016 Trans Tech Publications, Switzerland.

关键词： Inductively coupled plasma mass spectrometry

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$H_{\infty }$ Fault Detection for Networked Mechanical Spring-Mass Systems With Incomplete Information

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IEEE Transactions on Industrial Electronics 2016年第9期63卷 5622-5631页

作者： Huaicheng Yan Fengfeng Qian Hao zhang fuwen Yang Ge Guo Key Laboratory of Advanced Control and Optimization for Chemical Processes of the Ministry of Education and also with the School of Information Science and Engineering East China University of Science and Technology Shanghai China Department of Control Science and Engineering Tongji University Shanghai China School of Engineering Griffith University Gold Coast QLD Australia School of Information Science and Technology Dalian Maritime University Dalian China

This paper focuses on the H ∞ fault detection (FD) problem for spring-mass systems (SMSs) over networks with distributed state delays, random packet losses, sensor saturation as well as multiplicative noises via unreliable communication channels. The output measurements are affected by sensor saturation which is described by sector-nonlinearities. The multiplicative noises are described as a form of Gaussian white noises multiplied by the states. A series of stochastic variables are introduced to describe the randomly occurring distributed state delays. Random packet losses are also introduced in unreliable communications. The purpose of this paper is to design an FD filter such that: 1) The FD dynamic system is exponentially stable in the mean square. 2) The error between the fault signal and the residual signal is controlled to the minimum. 3) The optimal H ∞ filtering performance index is achieved. A sufficient condition for the FD filter design is derived in terms of the solution to a linear matrix inequality (LMI). When the LMI has a feasible solution, the explicit parameters of the desired FD filter can be obtained. Finally, a simulation experiment is illustrated to show the effectiveness and application of the designed method.

关键词： Fault detection Packet loss Vehicles Delays Robustness Suspensions

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Combining Energy Transfer and Optimized Morphology for Highly Efficient Ternary Polymer Solar Cells

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ADVANCED ENERGY MATERIALS 2017年第13期7卷 n/a-N.PAG页

作者： Zhao, fuwen Li, Yang Wang, Zaiyu Yang, Yang Wang, Zhen He, Guiying zhang, Jianqi Jiang, Li Wang, Taishan Wei, Zhixiang Ma, Wei Li, Bao Xia, Andong Li, Yongfang Wang, Chunru Chinese Acad Sci Inst Chem Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Xi An Jiao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China Natl Ctr Nanosci & Technol Beijing 100190 Peoples R China Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Peoples R China

Aimed at achieving ideal morphology, illuminating morphology-performance relationship, and further improving the power conversion efficiency (PCE) of ternary polymer solar cells (TSCs), a ternary system is designed based on PTB7-Th: PffBT4T-2OD:PC71BM in this work. The PffBT4T-2OD owns large absorption cross section, proper energy levels, and good crystallinity, which enhances exciton generation, charge dissociation and transport and suppresses charge recombination, thus remarkably increasing the short-circuit current density (J(sc)) and fill factor (FF). Finally, a notable PCE of 10.72% is obtained for the TSCs with 15% weight ratio of PffBT4T-2OD. As for the working mechanism, it confirmed the energy transfer from PffBT4T-2OD to PTB7-Th, which contributes to the improved exciton generation. And morphology characterization indicates that the devices with 15% PffBT4T-2OD possess both appropriate domain size (25 nm) and enhanced domain purity. Under this condition, it affords numerous D/A interface for exciton dissociation and good bicontinuous nanostructure for charge transport simultaneously. As a result, the device with 15% PffBT4T-2OD exhibits improved exciton generation, enhanced charge dissociation possibility, elevated hole mobility and inhibited charge recombination, leading to elevated Jsc (19.02 mA cm(-2)) and FF (72.62%) simultaneously. This work indicates that morphology optimization as well as energy transfer plays a significant role in improving TSC performance.

关键词： energy transfer optimized morphology ternary polymer solar cells

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