检索结果-内蒙古大学图书馆

Physiological and cellular mechanisms of ischemic preconditioning microRNAs-mediated in underlying of ischemia/reperfusion injury in different organs

引用

MOLECULAR AND CELLULAR BIOCHEMISTRY 2025年第2期480卷 855-868页

作者： gheitasi, izadpanah Akbari, Ghaidafeh Savari, Feryal Yasuj Univ Med Sci Fac Med Dept Physiol Yasuj Iran Shoushtar Fac Med Sci Dept Med Basic Sci Shoushtar Iran

Ischemia-reperfusion (I/R) injury, as a pathological phenomenon, takes place when blood supply to an organ is disrupted and then aggravated during restoration of blood flow. Ischemic preconditioning (IPC) is a potent method for attenuating subsequent events of IR damage in numerous organs. IPC protocol is determined by a brief and sequential time periods of I/R before the main ischemia. MicroRNAs are endogenous non-coding RNAs that regulate post-transcriptionally target mRNA translation via degrading it and/or suppressing protein synthesis. This review introduces the physiological and cellular mechanisms of ischemic preconditioning microRNAs-mediated after I/R insult in different organs such as the liver, kidney, heart, brain, and intestine. Data of this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, Web of Science, and Scientific Information Database from 2000 to 2023. Based on these literature studies, IPC/IR intervention can affect cellular mechanisms including oxidative stress, apoptosis, angiogenesis, and inflammation through up-regulation or down-regulation of multiple microRNAs and their target genes.

关键词： Ischemia/reperfusion injury Ischemic preconditioning MicroRNAs

来源：评论

学校读者我要写书评

暂无评论

Combination Therapy with Losartan and ?-Tocopherol in Acute Ureteral Obstruction-Induced Renal Excretory Dysfunction and Acidification Defect

引用

2016年

作者： izadpanah gheitasi

Combination Therapy with Losartan and ?-Tocopherol in Acute Ureteral Obstruction-Induced Renal Excretory Dysfunction and Acidification Defect. by gheitasi, izadpanah; Moosavi, Seyed Mostafa; published by

关键词： ?-tocopherol acidification acute combination defect.

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to "Fluvoxamine ameliorates oxidative stress and inflammation induced by bile-duct ligation in male rats" [Heliyon Volume 8, Issue 12, December 2022, Article e12344]

引用

Heliyon 2025年第4期11卷 e42722页

作者： Zahra Barmoudeh Hossein Sadeghi izadpanah gheitasi Bahman Khalvati Navid Omidifar Mahdokht Azizi Zahra Moslemi Jafar Nikbakht Amir Hossein Doustimotlagh Student Research Committee Yasuj University of Medical Sciences Yasuj Iran. Medicinal Plants Research Center Yasuj University of Medical Sciences Yasuj Iran. Biotechnology Research Center Department of Pathology School of Medicine Shiraz University of Medical Sciences Shiraz Iran.

[This corrects the article DOI: 10.1016/***.2022.e12344.].

关键词：

来源：评论

学校读者我要写书评

暂无评论

Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion-Induced Kidney Injury in Male Rats

引用

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020年第1期2020卷

作者： gheitasi, izadpanah Azizi, Arsalan Omidifar, Navid Doustimotlagh, Amir Hossein Yasuj Univ Med Sci Med Plants Res Ctr Yasuj Iran Shiraz Univ Med Sci Sch Med Dept Pathol Biotechnol Res Ctr Shiraz Iran

Background. The most important cause of acute renal failure in normal kidneys is ischemia-reperfusion (I/R) injury. The aim of the current study was to investigate the protective effects of Origanum majorana (OM) methanolic extract, carvacrol, and vitamin E on I/R-induced kidney injury in male rats. Material and Method. Thirty Wistar male rats were randomly allocated into 5 groups;sham, I/R, I/R + OM (300 mg/kg), I/R + carvacrol (75 mg/kg), and I/R + vitamin E (100 mg/kg). Renal function markers, oxidant-antioxidant parameters, and histopathological examination were evaluated. Results. It was exhibited that the urea, creatinine, protein carbonyl, glomerular filtration rate, total thiol, ferric reducing antioxidant power, and histopathological changes markedly reversed in the treatment groups with OM or carvacrol in comparison to the I/R merely group. Conclusion. We conclude that OM extract or its ingredient, carvacrol, exerts renoprotective impacts in I/R-induced kidney injury possibly by scavenging free radicals and increasing antioxidant power.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats

引用

JOURNAL OF TOXICOLOGY 2021年第1期2021卷 6646963页

作者： Moslemi, Zahra gheitasi, izadpanah Doustimotlagh, Amir Hossein Yasuj Univ Med Sci Student Res Comm Yasuj Iran Yasuj Univ Med Sci Med Plants Res Ctr Yasuj Iran Yasuj Univ Med Sci Dept Clin Biochem Fac Med Yasuj Iran

Background. Renal ischemia-reperfusion (I/R) has a pivotal role in the progression of acute renal failure. Reactive oxygen species are considered the major constituents involved in the biochemical and pathophysiological changes that were shown during kidney I/R. The purpose of this study was to examine the renoprotective effects of Stachys pilifera ethanolic extract on oxidant-antioxidant status in renal I/R-injuries in male rats. Material and methods. Twenty-one male Wistar rats were arbitrarily distributed into 3 groups: sham control (SC), I/R, and I/R + Stachys pilifera ethanolic extract (500 mg/kg). The artery and vein of the right kidney were completely blocked, and the right kidney was completely removed in all groups. Then, the left kidney artery was blocked with suture thread for 30 minutes in only I/R and I/R + SP extract groups. Kidney function indices, oxidative stress markers, and hematoxylin and eosin staining were investigated in the plasma and kidney tissues. Results. It was shown that the urine Na and K, fractional excretion of Na and K, and protein carbonyl content markedly increased in the merely I/R group as compared to SC rats, while the administration of SP extract markedly reduced these indices (P<0.05). Also, glomerular filtration rate and total thiol meaningfully reduced in the I/R rats in contrast to the SC group, while the treatment with SP extract markedly augmented these indices (P<0.05). However, in agreement with renal function tests, SP extract had no significant effects on histopathological examinations. Conclusion. It seems that SP extract employs renoprotective effects on renal damage induced by I/R, possibly by improving of oxidant-antioxidant status in favor of the antioxidant system.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders in Underlying of Diabetes: A Review

引用

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 2022年第0期2022卷 2002768页

作者： gheitasi, izadpanah Savari, Feryal Akbari, Ghaidafeh Mohammadi, Jamshid Fallahzadeh, Ali Reza Sadeghi, Hossein Yasuj Univ Med Sci Med Plants Res Ctr Yasuj Iran Shoushtar Fac Med Sci Dept Basic Sci Shoushtar Iran Yasuj Univ Med Sci Cellular & Mol Res Ctr Yasuj Iran

Diabetes mellitus (DM) is one of the most important metabolic disorders associated with chronic hyperglycemia and occurs when the body cannot manage insulin secretion, insulin action, or both. Autoimmune destruction of pancreatic beta cells and insulin resistance are the major pathophysiological factors of types 1 and 2 of DM, respectively. Prolonged hyperglycemia leads to multiple organs dysfunctions, including nephropathy, neuropathy, cardiomyopathy, gastropathy, and micro- and macrovascular disorders. The basis of the metabolic abnormalities in carbohydrate, fat, and protein in diabetes is insufficient action of insulin on various target tissues. Medicinal plants are rich sources of bioactive chemical compounds with therapeutic effects. The beneficial effects of leaves, fruits, and flowers extracts of Crataegus oxyacantha, commonly called hawthorn, belonging to the Rosaceae family, are widely used as hawthorn-derived medicines. Data in this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, Web of Science, and Scientific Information Database from 2000 to 2021. Based on this review, hawthorn extracts appear both therapeutic and protective effects against diabetic-related complications in various organs through molecular mechanisms, such as decreasing triglyceride, cholesterol, very low density lipoprotein and increasing the antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity, decreasing malondialdehyde level, and attenuating tumor necrosis factor alpha, interleukin 6 and sirtuin 1/AMP-activated protein kinase (AMPK)/nuclear factor kappa B (NF-kappa B) pathway and increasing the phosphorylation of glucose transporter 4, insulin receptor substrate 1, AKT and phosphoinositide 3-kinases, and attenuating blood sugar and regulation of insulin secretion, insulin resistance, and improvement of histopathological changes in pancreatic beta cells. Collec

关键词：

来源：评论

学校读者我要写书评

暂无评论

Renoprotective effects of zinc sulfate against transient liver ischemia/reperfusion injury in rats

引用

HELIYON 2023年第5期9卷 e15505页

作者： gheitasi, izadpanah Doustimotlagh, Amir Hossein Kokhdan, Esmaeel Panahi Akbari, Ghaidafeh Barmak, Mehrzad Jafari Yasuj Univ Med Sci Med Plants Res Ctr Yasuj Iran Yasuj Univ Med Sci Cellular & Mol Res Ctr Yasuj Iran Yasuj Univ Med Sci Med Physiol Yasuj Iran

Objectives: Liver ischemia/reperfusion damage frequently occurs in setting of hepatic resection and liver transplantation. It leads to disturbance in remote organs such as heart, lung and kidneys. This study explored the consequences of hepatic ischemia/reperfusion on the oxidative stress parameters, biochemical factors, and histopathological alterations in the kidney's rats, as well as evaluated the role of zinc sulfate on above-mentioned parameters. Materials and methods: Twenty-eight male Wistar rats were accidently assigned into four groups (n = 7). They were Sham, ischemia/reperfusion, zinc sulfate pretreatment, and zinc sulfate pretreatment + ischemia/reperfusion groups. Sham group: obtained normal saline (2 ml/day, seven consecutive days), intraperitoneally, zinc sulfate pretreatment group: obtained zinc sulfate (5 mg/kg, seven consecutive days, intraperitoneally). Ischemia/reperfusion group: obtained normal saline as mentioned previous, then rats experienced the partial ischemia (%70) for 45 min followed by 60 min reperfusion. Zinc sulfate pretreatment group: obtained zinc sulfate as mentioned previous, then rats experience the partial ischemia/reperfusion as presented earlier. At the end of investigation, blood was withdrawn, liver and renal tissues were removed. Then, biochemical and oxidative stress parameters, and histological changes were evaluated in the mentioned tissues. Results: The findings of this experiment indicated that zinc sulfate markedly reduced the serum levels of liver and kidney function tests in relative to ischemia/reperfusion group. Also, antiox-idant enzymes activity, ferric reducing antioxidant power, and nitric oxide significantly increased, while malondialdehyde level declined in the renal tissue of zinc sulfate + ischemia/ reperfusion group compared to ischemia/reperfusion rats. Furthermore, zinc sulfate alleviated the liver and kidneys histopathological alterations following ischemia/reperfusion. Conclusion: Zinc sulfate amelior

关键词： Liver Ischemia reperfusion Kidney Zinc sulfate Rat

来源：评论

学校读者我要写书评

暂无评论

Liposome Extract of Stachys pilifera Benth Effectively Improved Liver Damage due to Bile Duct Ligation Rats

引用

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2021年第1期2021卷 8141563页

作者： Moslemi, Zahra Bardania, Hassan gheitasi, izadpanah Barmoudeh, Zahra Omidifar, Navid Parvin, Hamidreza Khalvati, Bahman Fouani, Mohamad Hassan Alipour, Mohsen Doustimotlagh, Amir Hossein Yasuj Univ Med Sci Student Res Comm Yasuj Iran Yasuj Univ Med Sci Med Plants Res Ctr Yasuj Iran Yasuj Univ Med Sci Cellular & Mol Res Ctr Yasuj Iran Yasuj Univ Med Sci Imamsajad Hosp Clin Res Dev Unit Yasuj Iran Shiraz Univ Med Sci Biotechnol Res Ctr Sch Med Dept Pathol Shiraz Iran Shiraz Univ Med Sci Pharmaceut Sci Res Ctr Sch Pharm Shiraz Iran Tarbiat Modares Univ Fac Biol Sci Dept Nanobiotechnol Tehran Iran Jahrom Univ Med Sci Sch Med Dept Adv Med Sci & Technol Jahrom Iran

Herbal medicines harbor essential therapeutic agents for the treatment of cholestasis. In this study, we have assessed the anticholestatic potential of Stachys pilifera Benth's (SPB's) hydroalcoholic extract encapsulated into liposomes using bile duct ligation- (BDL-) induced hepatic cholestasis in rats. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde (MDA), total thiol (T-SH) content, protein carbonyl (PCO), total bilirubin (TBIL), albumin (ALB), and nitric oxide (NO) metabolite levels were measured in either liver tissue or plasma to assess liver damage. Moreover, expression of proinflammatory cytokines (IL-1 beta and TNF-alpha) and liver fibrosis markers (TGF-beta and SM-alpha) which are driving forces of many liver disorders was also determined. The activity of AST, ALT, and ALP was significantly enhanced in the BDL group in comparison to the control group;however, treatment with liposomal (SPB) hydroalcoholic extract significantly reduced AST and ALT's activity. Increases in MDA, TBIL, and NO levels and T-SH content due to BDL were restored to control levels by liposomal (SPB) hydroalcoholic extract treatment. Similarly, hepatic and plasma oxidative marker MDA levels, significantly enhanced by BDL, were significantly decreased by liposomal (SPB) hydroalcoholic extract treatment. Moreover, histopathological findings further demonstrated a significant decrease in hepatic damage in the liposomal (SPB) hydroalcoholic extract-treated BDL group. In addition, liposomal (SPB) hydroalcoholic extract treatment decreased the liver expression of inflammatory cytokines (IL-1 beta, TNF-alpha) and liver fibrosis markers (TGF-beta and SM-alpha). Since liposomal (SPB) hydroalcoholic extract treatment alleviated the BDL-induced injury of the liver and improved the hepatic structure and function more efficiently in comparison to free SPB hydroalcoholic extract, probable liposomal (SPB) hydroalcoholic extract exhibits r

关键词： Rats

来源：评论

学校读者我要写书评

暂无评论

Fluvoxamine ameliorates oxidative stress and inflammation induced by bile-duct ligation in male rats

引用

HELIYON 2022年第12期8卷 e12344页

作者： Barmoudeh, Zahra Sadeghi, Hossein gheitasi, izadpanah Khalvati, Bahman Omidifar, Navid Azizi, Mahdokht Moslemi, Zahra Nikbakht, Jafar Doustimotlagh, Amir Hossein Yasuj Univ Med Sci Student Res Comm Yasuj Iran Yasuj Univ Med Sci Med Plants Res Ctr Yasuj Iran Shiraz Univ Med Sci Sch Med Dept Pathol Biotechnol Res Ctr Shiraz Iran

Introduction: Cholestasis is a disorder that the bile ducts were narrowed and bile acids are not released simply. Bile acids-induced liver damage is exacerbated by inflammation and oxidative stress. The goal of the current study was to investigate the protective impacts of fluvoxamine (Flu) on oxidant-antioxidant balance and inflammatory cytokines in the bile duct ligated (BDL) rats. Methods: Thirty-two male rats were arbitrarily allocated in 4 groups;sham-control (SC), SC+ 150 mg/kg Flu (SCF), bile duct ligation (BDL), and BDL+ 150 mg/kg Flu (BDLF). The rats received distilled water and Flu orally for one week. Biochemical analysis, hematoxylin and eosin staining, as well as oxidant/antioxidant status were evaluated. Also, the mRNA expression of TGF-beta 1, IL-1, TNF-alpha, and alpha-SMA were determined. Results: The findings indicated serum values of ALT, total bilirubin, and ALP slightly declined in the BDL + Flu group in contrast to BDL rats. The plasma protein carbonyl and inflammatory markers were markedly increased in the BDL group in contrast with SC group (P <= 0.05). Treatment with Flu in BDL rats markedly reduced the values of hepatic nitric oxide metabolite and malondialdehyde, plasma protein carbonyl, as well as TNF-alpha mRNA level (P <= 0.05). Histological parameters were improved in the BDL + Flu group in comparison to BDL merely rats. Conclusion: It seems that Flu declined oxidative stress probably by inhibiting lipid peroxidation, protein oxidation, and nitric oxide formation. Also, it reduced inflammation by decreasing TNF-alpha mRNA expression.

关键词： Oxidative stress Cholestasis Fluvoxamine Antioxidant Inflammation

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：