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Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy

MEDICAL HYPOTHESES 2025年 194卷 111548-111548页

作者： huang, qi Guangxi Med Univ Affiliated Hosp 1 Neurol Dept Nanning Guangxi Peoples R China

Acquired epilepsy is a widespread neurological disorder marked by recurrent seizures that typically appear after an initial brain injury (IBI) and a subsequent latent period (LP). The processes underlying epileptogenesis remain debated. There are limitations in the traditional view that solely attributes epileptogenesis to the IBI, as the effects of this injury do not persist through the LP. Recent studies indicate that electrographic seizures (ESs), which occur without visible clinical symptoms, are common among individuals with epilepsy. This finding prompts a reassessment of the relationship between ESs and epileptogenesis. We propose that ESs act as a persistent form of electrical injury that operates throughout the LP, potentially contributing to the development of an epileptic network. Testing of the hypothesis will be conducted using longitudinal intracranial EEG monitoring in a primate model, with computational neuroscience techniques employed to decode EEG pattern and provide insights into this dynamic system.

关键词： Acquired Epilepsy Electrographic Seizures Electrical Injury Latent Period Epileptic Network Epileptogenesis

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Investigating the p-Ω interactions and correlation functions

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 112-123页

作者： Ye Yan qi huang Youchang Yang Hongxia huang Jialun Ping Department of Physics Nanjing Normal UniversityNanjing210023China School of Science Guizhou University of Engineering ScienceBijie551700China

Motivated by experimental measurements,we investigate the p-Ωcorrelation functions and interactions on the basis of a quark *** solving the inverse scattering problem with channel coupling,we renormalize the coupling to other channels into an effective single-channel p-Ω*** effects of Coulomb interaction and spin-averaging are also *** to our results,the depletion of the p-Ωcorrelation functions,which is attributed to the J^(P)=2^(+)bound state not observed in the ALICE Collaboration's measurements(Nature 588,232(2020)),can be explained by the contribution of the attractive J^(P)=1^(+)component in *** far,we have provided a consistent description of the p-Ωsystem from the perspective of the quark model,including the energy spectrum,scattering phase shifts,and correlation *** existence of the p-Ωbound state has been supported by all three ***,a sign of the p-Ωcorrelation function's subtle sub-unity part can be seen in experimental measurements,which warrants more precise verification in the future.

关键词： correlation function p-Ωdibaryon quark delocalization color screening model

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Policy attention in China's low-carbon policy: central-local comparisons and risk awareness

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CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY 2025年 1-21页

作者： huang, qi Zhou, Lei Wei, Jiuchang Univ Sci & Technol China Sch Management 96 JinZhai Rd Hefei 230026 Anhui Peoples R China Univ Sci & Technol China Sch Publ Affairs 96 Jinzhai Rd Hefei 230026 Anhui Peoples R China

China is advancing its carbon neutral strategy by establishing a comprehensive low-carbon policy system. A topic analysis of policies can provide valuable insights into the specific measures taken by the country to achieve low-carbon goals and the government's main focus. This study examined 1971 Chinese low-carbon policy documents, totaling 6.8 million words and used mixed text-mining approaches to conduct policy analysis. We have found that China advances its low-carbon strategy through a coercive policy diffusion approach under the "1 + N" policy system, which outlines five guiding principles and ten key actions. Using topic modeling, this study identifies eight key areas of focus in China's low-carbon policies. Findings indicate that policy attention to low-carbon issues evolves alongside changing national strategic priorities, with a significant shift from conceptual promotion to practical implementation. In terms of the central-local relationship, the central government has established the regional phased action, ensuring that key policies are implemented in a top-down, coordinated manner. However, we also observed differences in policy focus: central policies prioritize institutional design and emissions regulation, while local governments focus more on the implementation and urban development. Additionally, we observed varying levels of risk awareness across different policy areas. The topics of carbon neutrality and new energy, responsible units, and city development are notably risk-related, with significant differences in risk focus between central and local governments in these areas. These findings underscore the evolving nature of China's low-carbon strategy and the differing priorities between central and local levels in policy execution and risk management.

关键词： Policy attention Low-carbon Carbon neutrality Risk awareness Text analysis China

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Simulation study of spray control strategy of small displacement low-pressure direct injection system

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COMBUSTION THEORY AND MODELLING 2025年第2期29卷 277-304页

作者： huang, qi Chen, Jianxin qiao, Jiajun Chongqing Univ Sci & Technol Dept Mech & Power Engn Chongqing Peoples R China

Small displacement low-pressure direct injection power systems, characterised by low weight and high-power density, are widely used in small-scale aviation power. However, these systems easily lead to issues such as fuel scouring of the cylinder wall, and the lubricant film damage, which can result in piston ring fracture stress and cylinder wall scoring. Therefore, this study presents an in-depth investigation of the spray characteristics of injectors within these power systems. A synergistic approach combining experimental methods and numerical simulation is employed to study the in-cylinder fuel-air mixture formation process and reduce the mass of fuel film formed during spray formation. A visual spray test platform has been established to assess the dynamic response characteristics of four-hole and ten-hole injectors, and the flow characteristics of the injectors are determined experimentally. Using prototype test bench data, the spray simulation computational model was calibrated, culminating in the development of a computational fluid dynamics simulation computational model was developed to dissect the in-cylinder flow and fuel-air mixture processes. The study optimises fuel injection control strategy by exploring the impact of different spray cone angles and injection durations on in-cylinder fuel-air mixture. The results show that excessively wide spray cone angle results in wall wetting, while a narrow angle causes slow fuel evaporation and uneven fuel-air mixture. Extending the injection duration ensures thorough fuel atomisation, which promotes a more uniform in-cylinder mixture. However, an excessively prolonged injection duration reduces the fuel evaporation rate and decreases the uniformity of the fuel-air mixture. The optimised strategies reduce the maximum fuel film mass by 13% (four-hole) and 49% (ten-hole). The findings of this study can be used as a reference for optimising spray control strategies in small displacement to low-pressure direct inje

关键词： small displacement powertrain spray characteristics mixture formation numerical simulation

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Some aspects of skew generalized Zbaganu constant in Banach spaces

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JOURNAL OF FIXED POINT THEORY AND APPLICATIONS 2025年第2期27卷 1-16页

作者： Wang, Yuxin Liu, qi Li, qian huang, qi Anqing Normal Univ Sch Math & Phys Anqing 246133 Peoples R China

In this paper, we shall introduce a skew generalized Zbaganu constant C-Z((p))(sigma,upsilon,X). First, we give the upper and lower bounds of this constant for any Banach spaces, as well as the exact values of the constant for some specific Banach spaces. The relationships between this constant and a few other constants are then shown, including the J(X), C-NJ(X), and C-NJ(p)(sigma,upsilon,X) constants. Furthermore, a characterization of uniformly non-square is provided, indicating that X possesses the fixed point property. A sufficient condition that implies normal structure is also established by the C-Z((p))(sigma,upsilon,X) constant. Finally, based on the C-Z((p))(sigma,upsilon,X) constant, another new constant (C) over tilde ((p))(Z)(sigma,upsilon,X)\ is also introduced, its range of values for any Banach spaces and the exact values for some specific Banach space are studied.

关键词： Banach spaces Geometric constants Uniformly non-square Normal structure

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Certificateless and Revocable Bilateral Access Control for Privacy-Preserving Edge-Cloud Computing

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IEEE INTERNET OF THINGS JOURNAL 2025年第8期12卷 10333-10348页

作者： huang, qi-An Si, Yain-Whar Univ Macau Dept Comp & Informat Sci Macau Peoples R China

With the rapid advancement of intelligent devices and cloud services, a novel edge-cloud computing paradigm is emerging, finding widespread adoption in numerous advanced applications. Despite its considerable convenience and benefits, edge-cloud computing raises security and privacy concerns. Although many cryptographic solutions have been proposed for the Internet of Things and cloud services, ensuring diverse access control in an untrusted edge-cloud environment and realizing flexible revocation and efficient outsourcing remain challenging. In this article, we propose a certificateless attribute-based matchmaking encryption scheme (CRO-ABME) that supports fine-grained bilateral access control, attribute and identity revocation, and cryptographic workload outsourcing. Leveraging CRO-ABME, we design an edge-cloud data sharing system that ensures secure data uploading with privacy protection between end-users, such that only authorized matchers can access the data in edge-cloud computing. Furthermore, rigorous security proofs for CRO-ABME are provided, and experimental analyses demonstrate the efficiency and flexibility of our proposed scheme.

关键词： Cloud computing Encryption Access control Internet of Things Security Outsourcing Servers Privacy Data privacy Protection Bilateral access control edge-cloud computing privacy-preserving revocation

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Mechanism investigation on the solid-solid phase transition of CL-20 induced by water vapor

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PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2025年第6期27卷 3253-3262页

作者： Guo, Ya Cai, Xuetong Jiao, Fangbao Guo, Zhicheng huang, qi Zhang, qi China Acad Engn Phys Inst Chem Mat Mianyang 621900 Peoples R China Southwest Univ Sci & Technol Sch Mat Sci & Engn State Key Lab Environm Friendly Energy Mat Mianyang 621010 Peoples R China

Energetic materials often possess different polymorphs that exhibit distinguishable performances. As a typical energetic material, hexanitrohexaazaisowurtzitane (CL-20 or HNIW) is one of the most powerful explosives nowadays. Phase transition of CL-20 induced by ubiquitous water vapor leading to an increase in sensitivity and a decrease in energy level is a key bottleneck that limits the widespread application of CL-20-based explosives. Herein, the solid-solid phase transition behavior of CL-20 induced by water vapor and the related mechanism have been investigated. The results show that CL-20 undergoes an irreversible epsilon to alpha phase transition at an initial temperature of 104 degrees C in the presence of water vapor, much lower than that induced by thermal stimulation alone. According to XRD results and phase transition kinetics analysis, a four-parameter model is established to describe the phase transition process as a function of time. Theoretical calculations further support the promoting effect of water molecules on the phase transition. Based on experimental and theoretical results, a possible mechanism of steam-induced solid-solid phase transition of CL-20 is proposed. This work will provide a theoretical basis for the reliable design of CL-20-based energetic materials and also for the study on polymorphic transition inhibition of organic crystals to obtain the preferred phase.

关键词： Explosives

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Exploring a 3D printed cataract capsulorhexis training system using machine vision and virtual reality technologies

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INTERNATIONAL OPHTHALMOLOGY 2025年第1期45卷 1-11页

作者： huang, qi Yu, Lanhui Gu, Xuejun Nanchang Univ Affiliated Eye Hosp Jiangxi Med CollJiangxi Prov Key Lab Vitreoretina Jiangxi Clin Res Ctr ophthalm DisJiangxi Prov Key Nanchang 330006 Jiangxi Peoples R China

Background The study focuses on developing a cataract capsulorhexis training system incorporating 3D printing and machine vision technologies. This system aims to improve surgical skills and proficiency in cataract surgery among medical students and interns. The initiative utilizes an eye model that closely simulates the capsulorhexis phase of real cataract surgeries, thereby providing a realistic training environment. Method A comparative study was conducted involving two cohorts of junior ophthalmologists, each comprising 18 participants. Group A, serving as the control group, did not receive any specific training. In contrast, Group B underwent a structured training regimen over a period of 2 months, with a total training duration of 21 days. Participants in Group B performed 20 capsulorhexis procedures daily, adhering to a prescribed training schedule to ensure the cumulative training time reached 21 days. Subsequently, both groups' capsulorhexis performance was assessed and scored using a virtual reality training system and an animal eye practice system. This dual-assessment approach provided a quantitative measure of the training model's efficacy. Results Training with 3D-printed models significantly improves cataract surgery accuracy and consistency. In evaluations using Eyesi and animal eyes, the group B (trained with 3D-printed models) showed lower IOL decentration (0.140 +/- 0.020 mm vs 0.198 +/- 0.032 mm;P < 0.001) and higher capsulorhexis circularity (0.974 +/- 0.022 vs 0.937 +/- 0.041;P = 0.001) compared to the group A. Similar trends were observed in animal eye evaluations. However, no significant differences were found in capsulorhexis diameter control between groups. Thus, 3D-printed models enhance surgical precision but have limited impact on capsulorhexis diameter. Conclusions Group B, trained with 3D-printed models, demonstrated superior surgical precision and capsulorhexis regularity compared to Group A. Specifically, Group B showed significantly

关键词： Cataract surgery Capsulorhexis 3D printing Machine vision Surgical skills training

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Hierarchical Deep Potential with Structure Constraints for Efficient Coarse-Grained Modeling

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JOURNAL OF CHEMICAL INFORMATION AND MODELING 2025年第7期65卷 3203-3214页

作者： huang, qi Li, Yedi Zhu, Lei Yu, Wenjie Chinese Acad Sci Shanghai Inst Microsyst & Informat Technol Natl Key Lab Mat Integrated Circuits Shanghai 200050 Peoples R China Univ Chinese Acad Sci Coll Mat Sci & Optoelect Technol Beijing 100049 Peoples R China

Coarse-grained molecular dynamics is a powerful approach for simulating large-scale systems by reducing the number of degrees of freedom. Nonetheless, the development of accurate coarse-grained force fields remains challenging, particularly for complex systems, such as polymers. In this study, we introduce a novel framework, hierarchical deep potential with structure constraints (HDP-SC), designed to construct coarse-grained force fields for polymer materials. Our methodology integrates a prior energy term obtained through direct Boltzmann inversion with a deep neural network potential, which is trained using hierarchical bead environment descriptors. This framework facilitates the reproduction of structural distributions and the potential of mean force, thus enhancing the accuracy and efficiency of the coarse-grained model. We validate our approach using polystyrene systems, demonstrating that the HDP-SC model not only successfully reproduces the structural properties of these systems but also remains applicable at larger scales. Our findings underscore the promise of machine learning-based techniques in advancing the development of coarse-grained force fields for polymer materials.

关键词： Coarse-grained modeling

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Research on the protective effect of Rhizoma of Anemarrhena asphodeloides on TMT induced AD mice model based on network pharmacology combined with in vitro and in vivo experimental validation

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JOURNAL OF PHARMACOLOGICAL SCIENCES 2025年第2期157卷 75-87页

作者： huang, qi Zhang, Yingli huang, Li Guo, Zhijun Wu, Deling Anhui Univ Chinese Med Dept Pharm Hefei 230012 Peoples R China Anhui Prov Key Lab Tradit Chinese Med Decoct Piece Hefei 236000 Peoples R China Bozhou Vocat & Tech Coll Bozhou 236000 Peoples R China China Resources Sanjiu Modern Chinese Med Pharmace Huizhou 516000 Peoples R China

Background: Alzheimer's disease (AD) is a neurodegenerative disease, and neuroprotection is an important approach to improving AD outcomes. Rhizoma of Anemarrhena asphodeloides (RAA) is a commonly used Traditional Chinese Medicine (TCM) with demonstrated neuroprotective effects, but its anti-AD mechanism requires further exploration. Aim of the study: To elucidate the neuroprotective mechanism of RAA on TMT-induced AD mice. Materials and methods: The AD mice model was established via intraperitoneal injection of TMT. The effect of RAA on ameliorating learning and memory was assessed using the Morris Water Maze (MWM) and Y-maze tests. Haematoxylin-Eosin (HE), Nissl, and TUNEL staining were used to observe the neuroprotective effect of RAA. The components in serum containing RAA (RAA-S) were detected using UPLC-Q-Orbitrap MS. Potential targets were predicted through network pharmacology and molecular docking. Serum levels of reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPx) were measured with ELISA kits. The HT22 hippocampal neuronal cell line injured by L-glutamate (L-Glu) was used to further elucidate the mechanism of RAA. ROS levels in HT22 cells were detected with the 2 '-7 ' dichlorodihydrofluorescein diacetate (DCFH-DA) fluorescent probe and flow cytometry. Apoptosis in HT22 cells was measured by flow cytometry. The proteins MAP2, GAP-43, Nrf2, Keap1, HO-1, Bax, and Bcl-2 were detected by Western blotting. Immunofluorescence staining was employed to observe Nrf2 nuclear translocation. Results: RAA significantly increased the residence time of mice in the W zone and enhanced the correct alternation rate in TMT-treated mice. RAA preserved the integrity and orderly arrangement of nerve cells. A total of 12 components were detected in RAA-S. AKT1, PPARG, CASP3, STAT3, HSP90AA1, and NFE2L2 (Nrf2) were involved in the RAA-S target pathway network. Molecular docking revealed that Nrf2 e

关键词： RAA AD Network pharmacology Experimental validation

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