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Kinetics of naphthalene catalytic hydrogenation under high temperature and high pressure

PETROLEUM SCIENCE AND TECHNOLOGY 2020年第3期38卷 266-270页

作者： Bie, Shiquan jiang, Hongbo Wang, Wei Shu, Geping Zhang, xuwen Wang, Hongxue Gao, Shansong East China Univ Sci & Technol Res Inst Petr Proc 130 Meilong Rd Shanghai Peoples R China East China Univ Sci & Technol Int Joint Res Ctr Green Energy Chem Engn Shanghai Peoples R China China Shenhua Coal Liquid & Chem Shanghai Res Ins Natl Engn Lab Direct Coal Liquefact Shanghai Peoples R China

The catalytic hydrogenation reaction of naphthalene was carried out on the Ni-Mo/Al2O3 catalyst by using a constant-temperature fixed-bed reactor with the temperature ranging from 315 degrees C to 400 degrees C and pressure ranging from 12 to 20 MPa. The model of naphthalene catalytic hydrogenation was proposed based on the Langmuir-Hinshelwood-Hougen-Watson competitive adsorption theory, and the model parameters were estimated. The results show that the hydrogenation reaction of naphthalene to tetralin is fast, and tetralin tends to form trans-decalin, while there is no direct conversion between trans-decalin and cis-decalin. The reaction activation energy of naphthalene to tetralin is the smallest.

关键词： Catalytic hydrogenation high temperature and high pressure kinetics naphthalene Ni-Mo Al2O3

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Marketization and Energy Poverty: Empirical Evidence from China

SSRN

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SSRN 2022年

作者： Shi, Xinjie Zeng, Pei Qiu, Tongwei jiang, Qiang Cui, Liu Gao, xuwen Peking University China

Along with economic growth, improving the quality of life of its citizens is a focal issue for the Chinese government. Energy poverty—a topic closely related to people’s quality of life—has received global attention. This article focuses on the relationship between marketization and energy poverty, estimating the intrinsic relationship between marketization and energy poverty by constructing panel data using the instrumental variable method. The study reveals a significant upward trend in marketization in China in recent years, with a concomitant decrease in energy poverty. The results confirm that marketization improves the quantity of energy supply and alleviates energy poverty, and that the quality of energy supply is also an effective way for marketization to impact energy poverty. However, this mechanism is mainly reflected in the fact that marketization increases the accumulation of human capital and promotes the use of clean energy, but not in the improvement of energy supply efficiency by marketization. Additionally, marketization-led increase in people’s income alleviates energy poverty. This study adds to the existing literature and provides important policy insights for market-based development and energy poverty reduction. © 2022, The Authors. All rights reserved.

关键词： Economic analysis

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Gestational diabetes mellitus prediction model: A risk factors analysis of pregnant women with gestational diabetes mellitus but have normal oral glucose tolerance test results in the second trimester of pregnancy

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S57-S63页

作者： Lu, Jiayu Zhang, Song jiang, Hongqing Yang, Lin Hao, Dongmei Yang, Yimin Li, xuwen Chen, Aiqing Shao, Jing Liu, Xiaohong Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing 100124 Peoples R China Haidian Maternal & Children Hlth Hosp Beijing 100080 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Oral glucose tolerance test (OGTT) is a standard for the diagnosis of gestational diabetes mellitus (GDM). However, clinically, some cases with normal results were diagnosed as GDM in the third trimester. OBJECTIVE: To establish a risk model based on energy metabolism, epidemiology, and biochemistry that could predict the GDM pregnant women with normal OGTT results in the second trimester. METHODS: Qualitative and quantitative data were analyzed to find out the risk factors, and the binary logistic backward LR regression was used to establish the prediction model of each factor and comprehensive factor, respectively. RESULTS: The risk factors including the rest energy expenditure per kilogram of body weight, oxygen consumption per kilogram of body weight, if more than the weight gain criteria of the Institute of Medicine, the increase of body mass index between the second trimester and pre-pregnancy, and fasting blood glucose. By comparison, the comprehensive model had the best prediction performance, indicating that 85% of high-risk individuals were correctly classified. CONCLUSION: Energy metabolism, epidemiology, and biochemistry had better recognition ability for the GDM pregnant women with normal OGTT results in the second trimester. The addition of metabolic factors in the second trimester also improved the overall prediction performance.

关键词： Prediction model gestational diabetes mellitus rest energy metabolism

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Transcytosis Mediated Deep Tumor Penetration for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer

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ADVANCED FUNCTIONAL MATERIALS 2023年第28期33卷

作者： Chen, Hongyi Song, Haolin Luo, Yifan Li, Chufeng Wang, Yu Liu, Jie Luo, Feifei Fan, Hongrui Li, xuwen Sun, Tao jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryState Key Lab Med Neur Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fudan Univ Huashan Hosp Dept Digest Dis Shanghai 200040 Peoples R China

The hyperproliferative tumor stroma of pancreatic ductal adenocarcinoma (PDAC) severely limits drug permeation and constructs an immunosuppressive microenvironment, causing resistance to chemotherapy and immunotherapy. Traditional nanomedicine mainly focuses on manipulating nanoparticles' particle size or electrical characteristics to penetrate deep PDAC through the paracellular pathway, but the transcellular pathway is often ignored. Therefore, a versatile drug-polymer conjugate PODEA-Gem-HMI is prepared and assembled into nanoparticles for the codelivery of chemotherapy drug gemcitabine and focal adhesion kinase (FAK) inhibitor defactinib. While sensing the mild acidity in the tumor microenvironment, the nanoparticle will disintegrate and release defactinib to modulate the tumor stroma. The PODEA block of the conjugate can bind with cell membranes reversibly and trigger adsorption-mediated transcytosis (AMT) for promoted tumor penetration and cellular uptake. The internalized conjugates will release gemcitabine responding to the overexpressed glutathione (GSH) for enhanced chemotherapy, and PHMI can condensate the STING monomers for prolonged spontaneous immune stimulation.

关键词： sting activation stroma modulation transcytosis tumor penetration

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Identification of the Metabolites in Rat Urine after Oral Administration and Elucidation of the Metabolic Process of Naozhenning Granule Using LC-MS

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JOURNAL OF CHROMATOGRAPHIC SCIENCE 2020年第9期58卷 804-813页

作者： Li, Rongrong Liu, Yanzhi Liu, Haixia Wei, Chunhong Wang, jiang Qin, Xuemei Wang, xuwen Li, Zhenyu Shanxi Univ Modern Res Ctr Tradit Chinese Med Taiyuan 030006 Peoples R China Shanxi Zhendong Ante Biol Pharmaceut Co Ltd Jinzhong 030600 Peoples R China

Naozhenning (NZN) granule, a Chinese herbal formula, is widely used to treat craniocerebral trauma and promote functional recovery. In our previous study, the chemical components, as well as the serum metabolites in the male Sprague-Dawley rats of the NZN granule after oral administration were characterized. In this study, the urine metabolites in the male Sprague-Dawley rats were further investigated by ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-Orbitrap high-resolution accurate mass spectrometry. In order to identify the urine metabolites comprehensively, three sample preparation methods were used, including solid-phase extraction, protein precipitation method and solvent partition. Based on the accurate molecular weight and the fragmentation information from the MS spectra, a total of 76 urine metabolites were identified, which including 17 prototypes and 59 metabolites. The results showed that the detected urine metabolites were different for the different pretreatment methods, as some metabolites could only be detected in the particular pretreatment method. In addition, the metabolic processes of the components from NZN granule to the serum and urine were also elucidated and discussed. The results will provide useful information for further studying the relationship between the chemical components and pharmacological activity of NZN granule.

关键词： Metabolites

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微生物燃料电池工作原理及产电性能提升策略

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环境工程技术学报 2024年第2期14卷 699-709页

作者：蒋进元张月何绪文谭伟宋浩洋石冬妮赵洪兵中国环境科学研究院环境污染控制工程技术研究中心中国矿业大学(北京)化学与环境工程学院四川省广元生态环境监测中心站

微生物燃料电池(MFC)是一种解决其他能源在环境方面不足的新技术,目前低能量输出是MFC实际应用的关键瓶颈。基于MFC工作原理,提出微生物活性差、电子迁移阻力、质子传输阻力及阴极还原反应缓慢是MFC能量输出的限制因素,并从以下5个方面... 详细信息

微生物燃料电池(MFC)是一种解决其他能源在环境方面不足的新技术,目前低能量输出是MFC实际应用的关键瓶颈。基于MFC工作原理,提出微生物活性差、电子迁移阻力、质子传输阻力及阴极还原反应缓慢是MFC能量输出的限制因素,并从以下5个方面综述了提升MFC产电性能策略:调节pH和选择最佳盐度,加强微生物代谢活性;改性阳极材料,降低电子迁移阻力;增强电解液电导率、优化隔膜材料及缩短电极间距减小质子传输阻力;制备高效阴极催化剂和选择优异电子受体加快阴极还原反应速率;改进MFC反应器构型,提高整体产电性能。未来,可在合成新型阴极催化剂、降低膜污染、优化微生物生长环境、制备优异的电极材料和改进MFC反应器配置5个方面开展重点研究。

关键词：微生物燃料电池(MFC) 产电性能输出功率微生物活性策略

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福建近海漂移物漂移轨迹分析及模拟

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厦门大学学报（自然科学版） 2023年第3期62卷 435-443页

作者：曾银东郭民权方许闻江毓武郑祥靖中国海洋大学海洋与大气学院山东青岛266100 福建省海洋预报台福建福州350003 厦门大学海洋与地球学院福建厦门361102

浮子漂移实验能够捕捉海域表面海流的特征,为提高海上漂移物漂移轨迹预测模式的预测精度提供改进依据.通过在福建近海的浮子漂移实验,选取兴化湾、厦门湾与湾外近岸海域浮子的运动轨迹,对研究海域的表面流进行分析,并在业务化三维海洋... 详细信息

浮子漂移实验能够捕捉海域表面海流的特征,为提高海上漂移物漂移轨迹预测模式的预测精度提供改进依据.通过在福建近海的浮子漂移实验,选取兴化湾、厦门湾与湾外近岸海域浮子的运动轨迹,对研究海域的表面流进行分析,并在业务化三维海洋动力模型基础上,结合拉格朗日粒子追踪法,建立了福建近海海上目标物漂移轨迹预测模式,利用浮子漂移实验对漂移模式在福建近海的适用性进行了验证.研究结果表明:湾内浮子运动主要受潮流作用,呈现往复运动的趋势;湾外浮子运动主要由外海环流驱动,有沿等深线迁移趋势,并受到潮过程作用局部形成回流.而本研究构建的福建近海海上目标物漂移轨迹预测模式的模拟结果与浮子漂移结果基本一致,并且相对于湾内的轨迹预测,湾外的模拟有更高的可信度.同时浮子漂移实验还表明FES潮流模型在台湾海峡有较高的准确度,而湾内欠佳.

关键词：福建近海浮子漂移实验拉格朗日粒子追踪法漂移轨迹预测

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《齐民要术》所载传统种业技术分析

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中国科技史杂志 2017年第4期38卷 411-419页

作者：江绪文王宝卿青岛农业大学农学院青岛农业大学齐民书院

《齐民要术》是中国现存最早、保存最完整的古代农学巨著,也是世界农学史上最早、最有价值的专著之一,它的内容包含了大量的种业文化知识和技术经验。本文以其为标本,结合现代种业科技理论,较为全面地归纳、梳理了书中所载的传统种业知... 详细信息

《齐民要术》是中国现存最早、保存最完整的古代农学巨著,也是世界农学史上最早、最有价值的专著之一,它的内容包含了大量的种业文化知识和技术经验。本文以其为标本,结合现代种业科技理论,较为全面地归纳、梳理了书中所载的传统种业知识。借鉴先人种业技术经验,依托现代先进科技,对促进现代种业快速发展具有重要意义。

关键词：齐民要术种业技术种子质量

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Reconciling the Cooperative-Competitive Patterns among Tumor and Immune Cells for Triple-Negative Breast Cancer Treatment Using Multimodule Nanocomplexes

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ADVANCED MATERIALS 2024年第26期36卷 2312219-2312219页

作者： Li, xuwen Guo, Qin Chen, Qinjun Chu, Yongchao Zhang, Yiwen Chen, Hongyi Zhao, Zhenhao Wang, Yu Luo, Yifan Li, Chufeng You, Haoyu Song, Haolin Su, Boyu Jalili, Kiyumars Sun, Tao jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryMinist EducState Key Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Sahand Univ Technol Fac Polymer Engn POB 51317-11111 Tabriz Iran Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Targeting the competitive-cooperative relationships among tumor cells and various immune cells can efficiently reverse the immune-dysfunction microenvironment to boost the immunotherapies for the triple-negative breast cancer treatment. Hence, a bacterial outer membrane vesicle-based nanocomplex is designed for specifically targeting malignant cells and immune cells to reconcile the relationships based on metabolic-immune crosstalk. By uniquely utilizing the property of charge-reversal polymers to realize function separation, the nanocomplexes could synergistically regulate tumor cells and immune cells. This approach could reshape the immunosuppressive competition-cooperation pattern into one that is immune-responsive, showcasing significant potential for inducing tumor remission in TNBC models. A multimodule nanocomplex dual targeting tumor-associated macrophages (TAMs) and tumor cells is devised to reconcile cooperative-competitive patterns among multiple cells through metabolic-immune regulation. The reversion of metabolic disequilibrium-immunosuppression tumor microenvironment is observed in TNBC models after treatment, contributing to the tumor remission. image

关键词： bacterial outer membrane CD24 l-arginine metabolic regulation T cell activation tumor-associated macrophages repolarization

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The spectral characteristics of biochar-derived dissolved organic matter at different pyrolysis temperatures

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JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING 2021年第5期9卷

作者： He, Changjun He, xuwen Li, Jiajia Luo, Yong Li, Junchao Pei, Ying jiang, Jinyuan Chinese Res Inst Environm Sci Res Ctr Environm Pollut Control Technol 8 An Wai Da Yang Fang Beijing 100012 Peoples R China China Univ Min & Technol Beijing Sch Chem & Environm Engn Beijing 100083 Peoples R China

Comprehensive assessment of the dissolved organic matter (DOM) released from biochar is essential because it affects the migration and transformation of pollutants. The pyrolysis temperature and feedstock are the main factors affecting the amount and structure of DOM released from biochar. In this study, biochar-derived DOM was produced from three feedstocks at five temperatures (200-600 degrees C), and the effects of the pyrolysis temperature and feedstock on its components were investigated using UV-vis, Synchronous fluorescence, excitation emission matrix-parallel factor (EEM-PARAFAC) analysis and Fourier transform infrared-two-dimensional-correlation spectroscopy (FTIR-2D-COS). It was found that the biochar-derived DOM contents of the fruit peel and dewatered sludge biochar gradually decreased with increasing pyrolysis temperature;however, the DOM content of fresh human manure biochar increased at 600 degrees C, and a higher DOM content was obtained at low temperatures. The SUVA 254 and SUVA 260 shown that most of the aromatic substances in the DOM existed in the hydrophobic fraction. Moreover, the DOM mainly contained humic acid-like substances and protein-like substances. As the pyrolysis temperature increased, the protein-like and humic acid substances exhibited opposite trends, with higher protein-like contents at high temperatures. In addition, based on the FTIR-2D-COS analysis, the variations in the functional groups of the DOM depended on the pyrolysis temperature and the type of feedstock. This study highlights the importance of combining multiple optical techniques to evaluate biochar-derived DOM and provides valuable information for biochar applications.

关键词： Human Manure-Biochar Dissolved Organic Matter (DOM) FTIR-2D-COS Protein-like Humic acid-like

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