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Metabolic Nanoregulators Induce Ferroptosis and Change Metabolite Flow to Reverse Immunosuppressive Tumor Microenvironment

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ACS NANO 2024年第51期18卷 34996-35012页

作者： Wang, Yu Chen, Qinjun Luo, Yifan Qu, Yangqi Li, xuwen Song, Haolin Li, Chufeng Zhang, Yiwen Sun, Tao jiang, Chen Fudan Univ Key Lab Smart Drug Delivery State Key Lab Med Neurobiol Dept PharmaceutSch PharmInst Brain SciMinist Ed Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Aberrant energy and substance metabolic pathways of tumor cells critically support tumor cell proliferation by hijacking the resources from nonmalignant cells, thereby establishing a metabolite flow favorable to tumor progression. This metabolic adaptation of tumor cells further modulates the immune landscape, ultimately creating a tumor microenvironment characterized by drug resistance and immunosuppression. The synergistic regulation of energy and substance metabolic pathways might be a good antitumor therapeutic paradigm. However, due to the metabolic convergence, it is crucial to selectively modulate the aberrant metabolism of tumor cells without compromising the functionality of other cells. Small-molecule drugs have the ability to target a wide range of biomolecules for antitumor therapy, but their application is limited by undesirable toxicities. Constructing nanodrug delivery systems can improve their properties and allow for the inclusion of multiple drugs, thereby exerting synergistic antitumor effects. In this study, we developed a two-drug codelivery system using drugs-conjugated multibranched polymers to modulate tumor cell metabolism by exploiting synthetic lethal pathways for safe and effective antitumor therapy. By delivery of adapalene and erastin simultaneously through nanoparticles, the material and energy metabolism of tumor cells can be regulated. This nanoparticle construction achieves tumor tissue targeting and responsive drug release, alters metabolite flow within tumor cells, and effectively kills tumor cells. Additionally, the nanoparticles can reverse the tumor immunosuppressive microenvironment, starting from single-cell regulation to whole-lesion control.

关键词： metabolic nanoregulators metabolite flow ferroptosis immunosuppression multibranched polymers

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Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

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CANCER NANOTECHNOLOGY 2022年第1期13卷 1-18页

作者： Yao, Hua Mu, Xupeng Wei, Zhenhong Li, Xiuying Wu, Liya Jin, Yongri Li, xuwen Li, Jing jiang, Jinlan Jilin Univ Sci Res Ctr China Japan Union Hosp Changchun 130033 Peoples R China Jilin Univ Coll Chem Changchun 130021 Peoples R China

Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and facile synthesis methods combining with pharmacoactive natural components have been investigated to construct safe and multifunctional bioactive Au nanoparticles (NPs). Ginsenoside Rh-2 is protopanaxadiol type compound isolated from plants of genus Panax, with excellent anticancer effect and antioxidant activity. In this research, we prepared the novel Au nanoparticles using ginsenoside Rh-2 as both reducing and stabilizing agents. Results The synthesized Au@ginsenoside Rh-2 NPs were proved to exhibit desirable inhibitory effect on different cancer cell lines, which benefited from the inherent anticancer effect of the ginsenoside Rh-2. Investigations in vitro indicated that Au@ginsenoside Rh-2 NPs inhibited cell proliferation, cell migration and invasion, induced cell cycle arrest, enhanced the reactive oxygen species (ROS) generation, and regulated the protein expressions of caspase-3, 8, 9 to trigger cell apoptosis as well. Conclusions Because of the absence of toxic chemical surfactants, the eco-friendly synthesis method of Au NPs modified by natural phytochemicals avoided tedious separation and modification processes. On the other hand, Au@ginsenoside Rh-2 NPs also improved water solubility and bioavailability of the hydrophobic drug ginsenoside Rh-2. It broadened minds for preparation and application of traditional Chinese medicines (TCMs) modified metal nanoparticles and deserved further study.

关键词： Ginsenoside Rh-2 Au nanoparticles Drug-modified nanocomposite Facile synthesis Anticancer activity

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Determination of IgG by electron spin resonance spectroscopy using Fe₃O₄ nanoparticles as probe

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MICROCHEMICAL JOURNAL 2018年 141卷 444-450页

作者： Tian, Sizhu jiang, Jia Zang, Shuang Wang, Kun Yu, Yong Li, xuwen Zhang, Hanqi Yu, Aimin Zhang, Ziwei Jilin Univ Coll Chem Qianjin St 2699 Changchun 130012 Jilin Peoples R China Jilin Univ Coll Instrumentat & Elect Engn West Minzhu St 938 Changchun 130061 Jilin Peoples R China

A novel electron spin resonance (ESR) spectroscopy method for determination of rabbit IgG was presented. Anti rabbit IgG antibody was bound to Fe3O4 nanoparticles (FeNPs). The FeNPs were used as probe to give ESR signal. After the optimization of the assay, a molar ratio 500:1 of antibody to FeNPs was selected. The sepharose beads were used as solid phase and used to separate the analyte from the sample solution. Two typical immunoassay formats, sandwich and competitive formats, were applied to the determination of IgG. The analytical sensitivities obtained by sandwich and competitive formats were 0.13 mu g mL(-1) and 0.56 mu g mL(-1), respectively. The two formats were applied to the determination of the rabbit IgG in rabbit serum. The diluted sample was directly analyzed and other additional sample treatment was not required. The analytical results of the spiked samples indicated that the recoveries of the analytes were acceptable. Furthermore, the sample preparation time used in this method is shorter than most existing immunoassay methods.

关键词： Electron spin resonance Sandwich Competitive Fe3O4 nanoparticles Sepharose beads Rabbit serum

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Improved Eagle Perching Optimizer Based P2P Energy Trading for Smart Homes 9

Improved Eagle Perching Optimizer Based P2P Energy Trading f...

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9th Asia Conference on Power and Electrical Engineering, ACPEE 2024

作者： jiang, Yu Feng, Yingchun Fan, Jie Gao, Bo Wang, Yang Liu, xuwen State Grid Jiangsu Electric Power Co. LTD Jiangsu Electric Power Trading Center Nanjing China

ISBN: (纸本)9798350309638

The purpose of the study is to optimize power price in smart homes that connect to share energy. A Demand Side Management (DSM) system is used to coordinate P2P energy trading between smart homes using the improved eagle perching optimizer (IEPO). The IEPO algorithm produces optimum solutions for 99% of actual datasets, according to the outcomes. It is possible that consumer price distribution in the microgrid (MG) could be unequal as a result of P2P energy trading. The Pareto optimality principle addresses the issue of unequal price distribution, preventing households from being harmed by improving the costs of others. A final evaluation is performed on the effect of renewable energy and the penetration of storage within the MG. As the renewable energy and the penetration of storage increases, savings cannot necessarily be linear. As the saturation point approaches, they slowly begin to decline. © 2024 IEEE.

关键词： Demand side management

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Histopathological analysis and the immune related gene expression profiles of mandarin fish (Siniperca chuatsi) infected with Aeromonas hydrophila

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FISH & SHELLFISH IMMUNOLOGY 2018年 83卷 410-415页

作者： Chen, Nan jiang, Jingjing Gao, Xiaojian Li, Xixi Zhang, Yue Liu, Xiaodan Yang, Hui Bing, xuwen Zhang, Xiaojun Yangzhou Univ Coll Anim Sci & Technol Yangzhou 225009 Jiangsu Peoples R China Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Key Lab Freshwater Fisheries & Germplasm Utilizat Minist Agr Wuxi 214081 Peoples R China

Hemorrhagic septicemia of mandarin fish (Siniperca chuatsi) was mainly caused by Aeromonas hydrophila which was an opportunistic pathogen. In recent years, the disease has caused tremendous economic loss with high morbidity and mass mortality in the mandarin fish breeding industry. Histopathological analysis and the immune related gene expression profiles of mandarin fish (S. chuatsi) infected with A. hydrophila were investigated in this study. Transmission electron microscopy (TEM) images showed that the cells of A. hydrophila densely covered with a mass of fimbriae. Histopathological analysis revealed that inflammation, vacuolization and extensive necrosis existed in the gill, liver, spleen and head kidney of the diseased fish. Quantitative real-time PCR was performed to measure mRNA expression levels for six immune related genes in mandarin fish after A. hydrophila infection. The transcriptional analysis of these immune related genes demonstrated that the expression levels of major histocompatibility complex class II (MHC II), T cell receptor alpha (TCR alpha), tumor necrosis factor alpha (TNF alpha), CC chemokine 3, interleukin 8 (IL-8) and Hepcidin were strongly up-regulated in spleen and head kidney of mandarin fish post-infection. These results will contribute to further study on the pathogenesis and host defensive system in A. hydrophila infection.

关键词： Mandarin fish Aeromonas hydrophila Histopathology Immune related genes

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Development and validation of a predictive model for metabolic syndrome in a large cohort of people living with HIV

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VIROLOGY JOURNAL 2024年第1期21卷 1-12页

作者： Chen, Suling Xu, Yuyuan jiang, Yuanhui Chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun Peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Minist Educ Key Lab Infect Dis Res South China Guangzhou Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

BackgroundThe global prevalence of metabolic syndrome (MetS) in people living with HIV (PLWH) is on the rise in the post era of antiretroviral therapy (ART). Nevertheless, there are no validated predictive models available for assessing the risk of MetS in this specific *** study included PLWH who participated in annual follow-ups at Southern Medical University Nanfang Hospital from September 2022 to November 2023. Participants enrolled in this study were divided into the training set and validation set based on the follow-up duration. We employed both multivariate logistic regression and lasso regression to develop three distinct prediction models. Subsequently, the optimal model was determined through comprehensive analyses, including receiver operating characteristic (ROC) curve analysis, calibration curve, and decision curve analysis (DCA). Ultimately, we generated a nomogram for the optimal model and analyzed the correlation between the model score and the components of *** total of 1017 participants were included in this study, with 814 in the training set and 203 in the validation set. The ultimate prediction model of MetS risk in PLWH incorporated five factors: age, CD8 + T cell counts, controlled attenuation parameter (CAP), gamma-glutamyl transferase (gamma-GT) and lactate dehydrogenase (LDH). The area under the ROC curve (AUC) of the model in the training set and validation set was 0.849 and 0.834, respectively. Furthermore, we revealed a significant correlation between the model score and the MetS components. Additionally, the model score revealed significant group differences in MetS and related metabolic *** study established a potential model for predicting MetS in PLWH.

关键词： HIV/AIDS Metabolic syndrome Clinical prediction model Nomogram Clinical endocrinology

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NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STRAIN DISTRIBUTION OF VERTICALLY PLACED METAL HYDRIDE BASED HYDROGEN STORAGE CONTAINER 23

NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STR...

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23rd World Hydrogen Energy Conference: Bridging Continents by H2, WHEC 2022

作者： Cao, Shuaijie Yin, xuwen Yang, Fusheng jiang, Lijun Wu, Yuanfang Wu, Zhen Zhang, Zaoxiao Xi'an Jiaotong University School of Chemical Engineering and Technology Shaanxi Xi'an China Xinjiang University School of Mechanical Engineering Xinjiang Uygur Autonomous Regions Urumqi China Co. LTD Beijing China

ISBN: (纸本)9786250008430

Pulverization, settling and agglomeration, and the consequent densification may occur for metal hydride particles during the charge-discharge cycles, which will affect the wall strain of their container for hydrogen storage. In order to study the effects of different factors on the wall strain of metal hydride hydrogen storage vessel, a reaction-thermal-mechanical coupling model for LaNi5 alloy was modified with regard to some relevant parameters, by which sensitivity analysis was conducted. Finally, the strain distribution along the height of reactor filling Mg2Ni was predicted by the model and compared with experimental results reported in literature. © 2022 Proceedings of WHEC 2022 - 23rd World Hydrogen Energy Conference: Bridging Continents by H2. All rights reserved.

关键词： Hydrogen storage

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Estimated Pulse Wave Velocity as a Novel Non-Invasive Biomarker for Metabolic Syndrome Among People Living with HIV

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DIABETES METABOLIC SYNDROME AND OBESITY 2024年 17卷 1999-2010页

作者： Chen, Suling jiang, Yuanhui Lin, Xiaoli Chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun Peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

Purpose: This study aims to investigate the relationship between estimated pulse wave velocity (ePWV) and metabolic syndrome (MetS) in people living with HIV (PLWH), proposing a novel and convenient predictor for early detection of MetS in PLWH. Patients and Methods: A total of 485 PLWH were enrolled. These participants were categorized into two groups based on the estimated pulse wave velocity (ePWV) level. Demographic and clinical data were collected to investigate the correlation between ePWV and MetS. Results: The cohort of 485 PLWH was categorized into high-ePWV and low-ePWV groups based on ePWV cutoff value of 10 m/s. We observed significant differences in components of MetS including triglycerides (TG, P < 0.05), HDL cholesterol (HDL-C, P < 0.01), systolic blood pressure (SBP, P < 0.001), diastolic blood pressure (DBP, P < 0.05), and fasting plasma glucose (FPG, P < 0.001) between the two groups. Furthermore, we employed receiver operating characteristic (ROC) curves to demonstrate the effectiveness of ePWV as a predictive indicator for MetS in PLWH (AUC = 0.739, P < 0.001). According to the ROC curve, the optimal cut-off value of ePWV was 7.4 m/s, and its sensitivity and specificity in diagnosing MetS in PLWH were 79.03% and 64.07%, respectively. Although the 7.4 m/s cutoff increased the false positive rate compared to the traditional cutoff, it significantly reduced the rate of missed diagnoses, effectively identifying 79.03% of PLWH with MetS. Conclusion: ePWV is a non-invasive and convenient novel biomarker with predictive capabilities for MetS in PLWH.

关键词： HIV/AIDS highly active antiretroviral therapy metabolic syndrome estimated pulse wave velocity

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Research progress of 3D printing technology in functional food, powering the future of food

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TRENDS IN FOOD SCIENCE & TECHNOLOGY 2024年 149卷

作者： Wu, Rina jiang, Jinhui An, Feiyu Ma, xuwen Wu, Junrui Shenyang Agr Univ Coll Food Sci Shenyang 110866 Peoples R China Engn Res Ctr Food Fermentat Technol Shenyang 110161 Liaoning Peoples R China Key Lab Microbial Fermentat Technol Innovat Shenyang 110866 Peoples R China

Background: 3D printing (3DP) technology is an innovative additive manufacturing technique. 3DP technology has witnessed significant adoption across the food industry. The recent upsurge in living standards and the growing emphasis on healthcare have spurred the evolution of functional foods, marking a significant trend in the culinary landscape. Scope and approach: This paper undertakes a comprehensive review of existing literature on 3DP food to elucidate the advancements in functional food applications within the realm of 3D printing. The objective is to delve into the progress, mechanisms, challenges, and unresolved issues surrounding the integration of functional food in 3DP technology. Key findings and conclusions: The burgeoning popularity of functional foods signals a transformative shift in the food industry. We summarized the utilization of functional proteins, lipids, carbohydrates, small molecule substances (minerals and vitamins), and probiotics in 3DP foods. The relevant mechanism is also explained. It is widely used in the elderly, children and swallowing patients by its personalized customization and soft texture. However, persistent challenges such as heat loss of functional substances necessitate further resolution. The future trajectory of 3DP food points towards commercialization, necessitating stringent considerations for food quality, safety, and optimization of 3D printing processes to safeguard human health. The advent of 4D and 5D food printing technologies presents promising avenues for advancement, underscoring the need to unravel the intricacies of food printing processes to adapt to evolving market demands and realize the potential of 6D and 7D food printing realms.

关键词： Food 3D printing Nutrition Functional substance Probiotics

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Improvement of the mechanical properties of single-walled carbon nanotube networks by carbon plasma coatings

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CARBON 2013年 53卷 50-61页

作者： Kaskela, Antti Koskinen, Jari jiang, Hua Tian, Ying Liu, xuwen Susi, Toma Kaukonen, Markus Nasibulin, Albert G. Kauppinen, Esko I. Aalto Univ Dept Appl Phys NanoMat Grp Espoo 00076 Finland Aalto Univ Ctr New Mat Espoo 00076 Finland Aalto Univ Dept Mat Sci & Engn Espoo 00076 Finland

Carbon vacuum arc was used to deposit 5-25 nm thick carbon coatings on single-walled carbon nanotube (SWCNT) networks. The SWCNT bundles thus embedded in conformal coatings maintained their optical transparency and electrical conductivity. Sheet resistances of the networks were measured during the vacuum arc deposition, revealing initially a 100-fold increase, followed by significant recovery after exposing the samples to an ambient atmosphere. Nanoindentation measurements revealed improved elasticity of the network after applying the carbon coating. Pristine SWCNT networks were easily deformed permanently, but a 20 nm carbon coating strengthened the nanostructure, resulting in a fully elastic recovery from a 20 mu N load applied with a Berkovich tip. In nano-wear tests on selected areas, the coated SWCNT maintained its networking integrity after two passes raster scan at loads up to 25 mu N. On the other hand, the pristine networks were badly damaged under a 10 mu N scan load and completely displaced under 25 mu N. Raman and electron energy loss spectroscopies indicated the carbon coating on bundles to be mainly sp(2) bonded. Finite element modeling suggests that the low content of sp(3) bonds may be due to heating by the intense ion flux during the plasma pulse. (C) 2012 Elsevier Ltd. All rights reserved.

关键词： SURFACE coatings MATERIALS -- Mechanical properties PLASMA (Ionized gases) VACUUM arcs CONFORMAL coatings ELECTRIC conductivity

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