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Estimated Pulse Wave Velocity as a Novel Non-Invasive Biomarker for Metabolic Syndrome Among People Living with HIV

DIABETES METABOLIC SYNDROME AND OBESITY 2024年 17卷 1999-2010页

作者： Chen, Suling jiang, Yuanhui Lin, Xiaoli Chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun Peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

Purpose: This study aims to investigate the relationship between estimated pulse wave velocity (ePWV) and metabolic syndrome (MetS) in people living with HIV (PLWH), proposing a novel and convenient predictor for early detection of MetS in PLWH. Patients and Methods: A total of 485 PLWH were enrolled. These participants were categorized into two groups based on the estimated pulse wave velocity (ePWV) level. Demographic and clinical data were collected to investigate the correlation between ePWV and MetS. Results: The cohort of 485 PLWH was categorized into high-ePWV and low-ePWV groups based on ePWV cutoff value of 10 m/s. We observed significant differences in components of MetS including triglycerides (TG, P < 0.05), HDL cholesterol (HDL-C, P < 0.01), systolic blood pressure (SBP, P < 0.001), diastolic blood pressure (DBP, P < 0.05), and fasting plasma glucose (FPG, P < 0.001) between the two groups. Furthermore, we employed receiver operating characteristic (ROC) curves to demonstrate the effectiveness of ePWV as a predictive indicator for MetS in PLWH (AUC = 0.739, P < 0.001). According to the ROC curve, the optimal cut-off value of ePWV was 7.4 m/s, and its sensitivity and specificity in diagnosing MetS in PLWH were 79.03% and 64.07%, respectively. Although the 7.4 m/s cutoff increased the false positive rate compared to the traditional cutoff, it significantly reduced the rate of missed diagnoses, effectively identifying 79.03% of PLWH with MetS. Conclusion: ePWV is a non-invasive and convenient novel biomarker with predictive capabilities for MetS in PLWH.

关键词： HIV/AIDS highly active antiretroviral therapy metabolic syndrome estimated pulse wave velocity

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Review of catalytic pyrolysis of biomass for bio-oil

Review of catalytic pyrolysis of biomass for bio-oil

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International Conference on Materials for Renewable Energy and Environment

作者： Shi, Kaiqi Shao, Shuangxi Huang, Qiang Liang, xuwen Lan, jiang Ya, Li Key Laboratory of Biomass Green Transformation Ningbo University of Technology Ningbo China

ISBN: (纸本)9781612847504

Pyrolysis utilizes biomass to produce a liquid product bio-oil which is widely used as a potential energy source and a low-cost feedstock for chemical production. Considerable efforts have been made to convert biomass to bio-oil since the oil crisis in mid-1970s. This review focuses on the recent developments in catalysts used in pyrlysis of biomass for bio-oil production. In this review, 5 types of catalysts such as metal oxide, molecular sieve, mineral, transition metal and others, have been given. Molecular sieves, such as HZSM-5, ZSM-5, MCM-41, SBA-15, HUSY, REY and their modified catalysts are most widely used in biomass catalytic pyrolysis process. The effects of catalysts on bio-oil yields, quality, composition, stability etc. are also discussed. Although catalysts in pyrolysis of biomass produce markedly influences on bio-oil products, the variety of catalyst types and properties make generalizations difficult to define, in regard to trying to critically analyze the literature. © 2011 IEEE.

关键词： Biomass

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Analysis and Optimization of the Power Generation Right Transfer Mechanism 12

Analysis and Optimization of the Power Generation Right Tran...

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12th IEEE PES Asia-Pacific Power and Energy Engineering Conference, APPEEC 2020

作者： Fan, Jie jiang, Yu Wang, Yang Ding, Yu Liu, xuwen Yao, Yunting State Grid Jiangsu Electric Power Co. Ltd. Nanjing China Southeast University School of Electrical Engineering Nanjing China

ISBN: (纸本)9781728157481

With the further development of China's electricity reform, the consumption of renewable energy in a market-oriented way has become an important goal. The transfer of power generation rights has become the most important form used by Chinese provinces. This paper firstly analyzes the corresponding policy adopted in jiangsu province and the framework of power generation right transfer trading, and then models and simulates the power generation right transfer trading market by using system dynamics through Vensim software. Finally, the key factors influencing the development of renewable energy in the transfer market of power generation rights are analyzed and optimized. According to this, some Suggestions are put forward to improve the market construction policy. © 2020 IEEE.

关键词： System theory

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Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis

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ACS APPLIED MATERIALS & INTERFACES 2020年第52期12卷 57757-57767页

作者： Guo, Qin Chen, Qinjun Zhang, Yujie Zhou, Wenxi Li, xuwen Li, Chao Zhang, Yiwen Chen, Hongyi Liu, Peixin Chu, Yongchao Sun, Tao jiang, Chen Fudan Univ State Key Lab Med Neurobiol Key Lab Smart Drug Delivery Minist Educ Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China

As a rapid proliferating tissue, tumor cells have to optimize nutrient utilization to withstand harsh conditions. Several approaches have been explored to inhibit the growth and metastasis of tumor by disrupting the reprogrammed tumor metabolism. However, nutrient limitations within solid tumors may induce the metabolic flexibility of malignant cells to sustain growth and survival using one nutrient to fill metabolite pools normally supplied by the other. To overcome this predicament, a promising click-nucleic-acid-containing platform for codelivery of rapamycin, anti-PFKFB4 siRNA, and targeting ligand aptamer AS1411 was applied. PFKFB4 could act as a promising target for tumor therapy for being a molecular fulcrum that could couple glycolysis to autophagy by promoting aggressive metastatic tumors. The downregulation of PFKFB4 can help inhibit the SRC3/Akt/mTOR pathway, leading autophagy to the direction of promoting apoptosis of tumor cells, which is induced by the collapse of tumor cellular homeostasis, while low dosages of rapamycin could decrease surgery-induced immune dysfunction. Enhanced tumor autophagy, favorable in vivo antitumor efficacy, and effective systematic immune activation are observed after treatment, suggesting that autophagy and glycolysis can serve as an integrated target for tumor treatment.

关键词： tumor metabolism codelivery click nucleic acid immune activation tumor therapy

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Research on sound source localization based on sound sensor 4

Research on sound source localization based on sound sensor

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4rth International Conference on Applied Mathematics, Modelling, and Intelligent Computing, CAMMIC 2024

作者： Jin, Hailei Wang, xuwen Huang, Kun Xiong, Xiaomin Zhang, Minshu Li, jiang Xinyu Power Supply Branch of State Grid jiangxi Power Co. Ltd. Xinyu338000 China Shanghai University of Electric Power Shanghai200090 China

ISBN: (纸本)9781510681637

Nowadays, most of the 10 kV distribution network cable lines are laid underground in the form of direct burial or casing, and the cable is cut off by the construction machinery, resulting in the accident of line tripping. In the construction of urban construction, third-party external forces such as manual excavation, mechanical excavation and illegal invasion will cause serious damage to underground cables. Therefore, it is of great engineering application value to develop cable marking piles with sound source localization function and find the location of damage points in time. In order to improve the accuracy and effectiveness of positioning, but also to achieve rapid positioning of the source of damage, this paper is based on the sound sensor, using its flexibility, efficiency and timeliness, by controlling the number and location of the sound sensor, combined with the sound intensity to locate the sound source. At the same time, the sound sensor is connected with the number and position of the marking pile, and the traditional cable marking pile is improved to accurately locate the damage source in time. © 2024 SPIE.

关键词： Excavation

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Downregulation of Skp2 inhibits the growth and metastasis of gastric cancer cells in vitro and in vivo

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TUMOR BIOLOGY 2013年第1期34卷 181-192页

作者： Wei, Zheng jiang, Xian Liu, Fengjun Qiao, Haiquan Zhou, Baoguo Zhai, Bo Zhang, Lianfeng Zhang, xuwen Han, Likun jiang, Hongchi Krissansen, Geoffrey W. Sun, Xueying Harbin Med Univ Affiliated Hosp 1 Dept Gen Surg Hepatosplen Surg Ctr Harbin 150001 Peoples R China Shandong Univ Qilu Hosp Dept Gen Surg Jinan 250100 Peoples R China Univ Auckland Fac Med & Hlth Sci Dept Mol Med & Pathol Auckland 1005 New Zealand

S-phase kinase-associated protein-2 (Skp2) is overexpressed in human cancers and associated with poor prognosis. Skp2 acts as an oncogenic protein by enhancing cancer cell growth and tumor metastasis. The present study has demonstrated that small hairpin RNA (shRNA)-mediated downregulation of Skp2 markedly inhibits the viability, proliferation, colony formation, migration, invasion, and apoptosis of human gastric cancer MGC803 cells, which express a high level of Skp2. In contrast, Skp2 shRNA had only a slight effect on the above properties of BGC823 cells, which express a low level of Skp2. In accord, knockdown of Skp2 suppressed the ability of MGC803 cells to form tumors and to metastasize to the lungs of mice, and the growth of established tumors, by inhibiting cell proliferation and enhancing cell apoptosis. In contrast, overexpression of Skp2 promoted tumorigenesis of BGC823 cells in mice. Skp2 depletion induced cell cycle arrest in the G(1)/S phase by upregulating p27, p21, and p57 and downregulating cyclin E and cyclin-dependent kinase 2. Skp2 depletion also increased caspase-3 activity, impeded the ability of cells to form filopoidia and locomote, upregulated RECK (reversion-inducing cysteine-rich protein with kazal motifs), and downregulated matrix metalloproteinase (MMP)-2 and MMP-9 activity and expression. The results suggest that downregulating Skp2 warrants investigation as a promising strategy to treat gastric cancers that express high levels of Skp2.

关键词： S-phase kinase-associated protein-2 Gastric cancer Proliferation Cell cycle Metastasis p27

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Deep Reinforcement Learning Home Energy Management Based Local Energy Trading in a Blockchain Platform 9

Deep Reinforcement Learning Home Energy Management Based Loc...

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9th Asia Conference on Power and Electrical Engineering, ACPEE 2024

作者： jiang, Yu Feng, Yingchun Fan, Jie Gao, Bo Wang, Yang Liu, xuwen Jiangsu Electric Power Trading Center State Grid Jiangsu Electric Power Co. LTD Nanjing China

ISBN: (纸本)9798350309638

Decentralized peer-to-peer Local Energy Markets (LEMs) are gaining popularity as local power production from Renewable Energy Sources (RESs) increases. The study investigates a blockchain-driven LEM in which prosumers and consumers buy and sell energy independently of the involvement of a third party. The suggested scheme involves Home Energy Management (HEM) and demurrage mechanisms that enable both consumers and prosumers to reduce their power prices and improve their power usage. The end-user can likewise move the load to off-peak periods and benefit from lower energy costs from the LEM through the approach. In this solution, HEM and demurrage mechanisms are used to optimize power usage as well as energy costs. As well as providing adequate power for the LEM, it is economically beneficial for end users and the community. The proposed system in the study utilizes the Deep Deterministic Policy Gradient (DDPG) algorithm and demurrage mechanisms to optimize electricity usage and energy costs. Meanwhile, smart contract on the Ethereum blockchain regulate and safeguard the electricity trading process. © 2024 IEEE.

关键词： Blockchain

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Risk prevention of different forms of gestational diabetes mellitus based on energy metabolism prior to diagnosis

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TECHNOLOGY AND HEALTH CARE 2022年第1_suppl期30卷 S285-S292页

作者： Lu, Jiayu jiang, Hongqing Zhang, Song Yang, Yimin Hao, Dongmei Li, xuwen Chen, Aiqing Shao, Jing Liu, Xiaohong Yang, Lin Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing Peoples R China Haidian Maternal & Children Hlth Hosp Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China

BACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic disease that seriously endangers the health of mothers and children. It is important to monitor GDM in real-time before diagnosis and to prevent it effectively. OBJECTIVE: GDM was divided into the second trimester diagnosed diabetes mellitus (GDM_24) and the third trimester diagnosed diabetes mellitus (GDM_30). The risk prediction of two types of GDM was performed in normal pregnant women at 11-13 and 16-19 weeks of pregnancy, respectively. METHODS: By stages, the K-W test was used to analyze the differences between basic information and energy metabolism factors, and multiple logistic regression was used to analyze the risk of energy metabolism factors and to correct the confounders with significant differences. RESULTS: For the GDM_24 group, each additional unit of oxygen consumption (VO2), carbon dioxide production, and resting energy expenditure (REE) increased the risk by 2.4%, 3.5%, 0.4%, and 2.1%, 2.6%, and 0.3%, respectively, at 11-13 and 16-19 weeks of pregnancy. For the GDM_30 group, each additional unit of VO2 and REE was associated with an increased risk of 2.3% and 0.3%, respectively, at 16-19 weeks of pregnancy. CONCLUSION: The risk of GDM_30 only appeared in pregnant women during 16-19 weeks of pregnancy, which may indicate that GDM_24 and GDM_30 have different pathogenesis.

关键词： Diabetes mellitus in the second trimester diagnosis of diabetes mellitus in the third trimester energy metabolism

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Improved Eagle Perching Optimizer Based P2P Energy Trading for Smart Homes 9

Improved Eagle Perching Optimizer Based P2P Energy Trading f...

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9th Asia Conference on Power and Electrical Engineering, ACPEE 2024

作者： jiang, Yu Feng, Yingchun Fan, Jie Gao, Bo Wang, Yang Liu, xuwen State Grid Jiangsu Electric Power Co. LTD Jiangsu Electric Power Trading Center Nanjing China

ISBN: (纸本)9798350309638

The purpose of the study is to optimize power price in smart homes that connect to share energy. A Demand Side Management (DSM) system is used to coordinate P2P energy trading between smart homes using the improved eagle perching optimizer (IEPO). The IEPO algorithm produces optimum solutions for 99% of actual datasets, according to the outcomes. It is possible that consumer price distribution in the microgrid (MG) could be unequal as a result of P2P energy trading. The Pareto optimality principle addresses the issue of unequal price distribution, preventing households from being harmed by improving the costs of others. A final evaluation is performed on the effect of renewable energy and the penetration of storage within the MG. As the renewable energy and the penetration of storage increases, savings cannot necessarily be linear. As the saturation point approaches, they slowly begin to decline. © 2024 IEEE.

关键词： Demand side management

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NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STRAIN DISTRIBUTION OF VERTICALLY PLACED METAL HYDRIDE BASED HYDROGEN STORAGE CONTAINER 23

NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STR...

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23rd World Hydrogen Energy Conference: Bridging Continents by H2, WHEC 2022

作者： Cao, Shuaijie Yin, xuwen Yang, Fusheng jiang, Lijun Wu, Yuanfang Wu, Zhen Zhang, Zaoxiao Xi'an Jiaotong University School of Chemical Engineering and Technology Shaanxi Xi'an China Xinjiang University School of Mechanical Engineering Xinjiang Uygur Autonomous Regions Urumqi China Co. LTD Beijing China

ISBN: (纸本)9786250008430

Pulverization, settling and agglomeration, and the consequent densification may occur for metal hydride particles during the charge-discharge cycles, which will affect the wall strain of their container for hydrogen storage. In order to study the effects of different factors on the wall strain of metal hydride hydrogen storage vessel, a reaction-thermal-mechanical coupling model for LaNi5 alloy was modified with regard to some relevant parameters, by which sensitivity analysis was conducted. Finally, the strain distribution along the height of reactor filling Mg2Ni was predicted by the model and compared with experimental results reported in literature. © 2022 Proceedings of WHEC 2022 - 23rd World Hydrogen Energy Conference: Bridging Continents by H2. All rights reserved.

关键词： Hydrogen storage

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