Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising t...
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Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.
The effect of hydrotreatment of liquefied heavy oil on direct coal liquefaction (DCL) was studied by hydrogenating the liquefied heavy oil (initial boiling point greater than 320 degrees C) in a 30 ml continuous hydro...
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The effect of hydrotreatment of liquefied heavy oil on direct coal liquefaction (DCL) was studied by hydrogenating the liquefied heavy oil (initial boiling point greater than 320 degrees C) in a 30 ml continuous hydrogenation apparatus at operating conditions of pressure (P) 13-19 MPa, temperature (T) 360-400 degrees C, liquid space velocity (LHSV) 0.6-1.4 h(-1). After hydrogenation, the properties and hydrocarbon composition of liquefied heavy oil were regulated, leading to the enhancement of hydrogen donating ability and 5.6% increase in oil yield of DCL as compared with non-hydrogenated raw oil. Based on the results, a new method of preparing recycle solvent for direct coal liquefaction by mixing hydrogenated heavy oil and un-hydrogenated middle oil in a suitable proportion was proposed, which has been verified to be effective and efficient to increase oil yield. (C) 2017 Elsevier Ltd. All rights reserved.
Arterial pulse waveform analysis has been widely used to reflect physiological changes in the cardiovascular system. This study aimed to comprehensively investigate the changes of waveform characteristics of both phot...
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Arterial pulse waveform analysis has been widely used to reflect physiological changes in the cardiovascular system. This study aimed to comprehensively investigate the changes of waveform characteristics of both photoplethysmographic (PPG) and radial pulses with gestational age during normal pregnancy. PPG and radial pulses were simultaneously recorded from 130 healthy pregnant women at seven gestational time points. After normalizing the arterial pulse waveforms, the abscissa of notch point, the total pulse area and the reflection index were extracted and compared between different measurement points and between the PPG and radial pulses using post-hoc multiple comparisons with Bonferrioni correction. The results showed that the effect of gestational age on all the three waveform characteristics was significant (all p < 0.001) after adjusting for maternal age, heart rate and blood pressures. All the three waveform characteristics demonstrated similar changing trends with gestational age, and they were all significantly different between the measurements from gestational week 12-15 and the others (all p < 0.05, except for the PPG total pulse area between the first and second measurement points). In conclusion, this study has comprehensively quantified similar changes of both PPG and radial pulse waveform characteristics with gestational age.
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