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Identification of genetic loci associated with rough dwarf disease resistance in maize by integrating GWAS and linkage mapping

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PLANT SCIENCE 2022年 315卷 111100-111100页

作者： Zhao, Meiai Liu, Shuangshuang Pei, Yuhe jiang, xuwen Jaqueth, Jennifer S. Li, Bailin Han, Jing Jeffers, Daniel Wang, Jiabo Song, Xiyun Qingdao Agr Univ Coll Life Sci Key Lab Plant Biotechnol Univ Shandong Prov Qingdao 266109 Peoples R China Qingdao Agr Univ Coll Agron Key Lab Qingdao Major Crop Germplasm Resource Inn Qingdao 266109 Peoples R China Corteva Agrisci 7300 NW 62nd Ave Johnston IA 50131 USA Shandong Denghai Pioneer Jinan 254000 Shandong Peoples R China Yunnan Acad Agr Sci Yunnan Off Kunming 650205 Yunnan Peoples R China Southwest Minzu Univ Minist Educ Key Lab Qinghai Tibetan Plateau Anim Genet Resour Chengdu 160041 Sichuan Peoples R China

Maize rough dwarf disease (MRDD) is a viral disease that causes substantial yield loss, especially in China's summer planted maize area. Discovery of resistance genes would help in developing high-yielding resistant maize hybrids. Genome-wide association studies (GWASs) have advanced quickly and are now a powerful tool for dissecting complex genetic architectures. In this study, the disease severity index (DSI) of 292 maize inbred lines and an F6 linkage population were investigated across multiple environments for two years. Using the genotypes obtained from the Maize SNP 50K chip, a GWAS was performed with four analytical models. The results showed that 22 SNPs distributed on chromosomes 1, 3, 4, 6, 7 and 8 were significantly associated with resistance to MRDD (P<0.0001). The SNPs on chromosomes 3, 6 and 8 were consistent with the quantitative trait locus (QTL) regions from linkage mapping in an RIL population. Candidate genes identified by GWAS included an LRR receptor-like serine/threonine-protein kinase (GRMZM2G141288), and a DRE-binding protein (GRMZM2G006745). In addition, we performed an allele variation analysis of the SNP loci selected by GWAS and linkage mapping and found that the main alleles of the two SNP loci PZE_101170408 and PZE_106082685 on chromosome 1 differed in terms of disease-resistant materials and disease-susceptible materials. The identified SNPs and genes provide useful information for MRDD-related gene cloning and insights on the underlying disease resistance mechanisms, and they can be used in marker-assisted breeding to develop MRDD-resistant maize.

关键词： Maize MRDD GWAS Linkage mapping Candidate genes

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Transcriptomic profiling of the high-vigour maize (Zea mays L.) hybrid variety response to cold and drought stresses during seed germination

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SCIENTIFIC REPORTS 2021年第1期11卷 1-16页

作者： Li, Heqin Yue, Haiwang Xie, Junliang Bu, Junzhou Li, Li Xin, Xueying Zhao, Yanming Zhang, Haiyan Yang, Li Wang, Jianhua jiang, xuwen Qingdao Agr Univ Coll Agron Maize Res Inst Qingdao 266109 Peoples R China Hebei Acad Agr & Forestry Sci Dryland Farming Inst Hengshui 053000 Peoples R China China Agr Univ Seed Sci & Technol Res Ctr Beijing 100193 Peoples R China Nat Resources & Planning Bur Hengshui City Taocheng Branch Hengshui 053000 Peoples R China

Abiotic stresses, including cold and drought, negatively affect maize (Zea mays L.) seed field emergence and later yield and quality. In order to reveal the molecular mechanism of maize seed resistance to abiotic stress at seed germination, the global transcriptome of high- vigour variety Zhongdi175 exposed to cold- and drought- stress was analyzed by RNA-seq. In the comparison between the control and different stressed sample, 12,299 differentially expressed genes (DEGs) were detected, of which 9605 and 7837 DEGs were identified under cold- and drought- stress, respectively. Functional annotation analysis suggested that stress response mediated by the pathways involving ribosome, phenylpropanoid biosynthesis and biosynthesis of secondary metabolites, among others. Of the obtained DEGs (12,299), 5,143 genes are common to cold- and drought- stress, at least 2248 TFs in 56 TF families were identified that are involved in cold and/or drought treatments during seed germination, including bHLH, NAC, MYB and WRKY families, which suggested that common mechanisms may be originated during maize seed germination in response to different abiotic stresses. This study will provide a better understanding of the molecular mechanism of response to abiotic stress during maize seed germination, and could be useful for cultivar improvement and breeding of high vigour maize cultivars.

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The synthesis of an iron tailings-based geopolymer with synergistic electromagnetic wave consumption property

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ENVIRONMENTAL RESEARCH 2025年 268卷 120744页

作者： Wang, Tianyu Ning, xuwen Yang, Lang Rao, Feng jiang, Kaixi Fuzhou Univ Sch Mat Sci & Engn Fuzhou 350108 Fujian Peoples R China Fuzhou Univ Zijin Sch Geol & Min Fuzhou 350108 Fujian Peoples R China Fuzhou Univ Fujian Key Lab Green Extract & High Value Utilizat Fuzhou 350108 Fujian Peoples R China

In this study, combination of wave absorption materials with different loss mechanisms are added into iron ore tailings-blast furnace slag (IOT-BFS) based geopolymers. The employed materials are hollow glass microsphere (HGM), carbon nanotubes (CNT) and carbonyl iron powder (CIP). Microstructures of the geopolymers are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and concrete porous structure analyzer. Conductivity and electromagnetic absorption property of the geopolymers are measured by a conductivity tester and a vector network analyzer (VNA). As increasing the content of wave absorption materials, compressive strength of the geopolymer decreased from 60.5 to 33.8 MPa. Compared with geopolymers containing HGM and CNT, wave absorption band below -5 dB of the geopolymers with HGM and CIP was wider, particularly at frequencies below 7 GHz, due to the synergism of space and magnetic loss. Its absorption bandwidth with the reflection loss less than -5 dB reaches 15.6 GHz. This study gives a clue for preparation of geopolymers with satisfactory electromagnetic wave absorption properties in the utilization as construction materials.

关键词： Geopolymers Electromagnetic wave absorption Iron ore tailings Microstructure

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First-Principles Study of SnS for Small Gas-Sensing Applications

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JOURNAL OF ELECTRONIC MATERIALS 2024年第2期53卷 622-630页

作者： Hung, Chiahsiang jiang, Yuncai Lei, Shuangying Gao, Ran Tao, xuwen Southeast Univ Key Lab Microelectromechan Syst Minist Educ Nanjing 210096 Peoples R China

Two-dimensional SnS holds significant potential in gas-sensing because of its numerous excellent characteristics. Based on first-principles density functional theory (DFT), the adsorption properties of small gas molecules such as NO2, SO2, and NO on SnS have been thoroughly investigated. The results indicate that SnS can effectively adsorb NO2, SO2, and NO gases, attributed to their higher adsorption energies. Differing from the case of SO2 adsorption, SnS undergoes a transition from a non-magnetic state to a magnetic state upon the adsorption of NO2 and NO gases. To investigate the sensing characteristics of these three adsorption systems, the adsorption densities and I-V curves were calculated using a thermodynamic statistical model and the nonequilibrium Green's function method, respectively. These findings demonstrate that NO2 adsorption not only exhibits the highest adsorption densities but also generates the maximum current at the same voltage. These results highlight the potential of SnS for serving as a selective and reversible NO2 gas sensor.

关键词： First-principles SnS gas adsorption sensor

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Preliminary studies on the molecular mechanism of intramuscular fat deposition in the longest dorsal muscle of sheep

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BMC GENOMICS 2024年第1期25卷 592页

作者： Shao, xuwen Lu, Xintan Sun, Xinming jiang, Huaizhi Chen, Yang Jilin Agr Univ Coll Anim Sci & Technol Changchun 130118 Peoples R China Minist Agr & Rural Affairs Key Lab Livestock & Poultry Resources Sheep & Goat Changchun Peoples R China

Background Intramuscular fat content is an important index reflecting the quality of mutton, which directly affects the flavor and tenderness of mutton. Livestock and poultry intramuscular fat content is influenced by genetics, nutritional level, and environmental factors. Key regulatory factors play a crucial role in intramuscular fat deposition. However, there is a limited amount of research on the identification and function of key genes involved in intramuscular fat content deposition specifically in sheep. Results Histological differences in the longest dorsal muscle of the small-tailed frigid sheep increased in diameter and decreased in several muscle fibers with increasing monthly age;The intramuscular fat content of the longest dorsal muscle of the small-tailed cold sheep varied with age, with a minimum of 1 month of age, a maximum of 6 months of age, and a minimum of 12 months of age. Transcriptomic sequencing and bioinformatics analysis revealed a large number of differential genes in the longest dorsal muscles of little-tailed billy goats of different months of age, which were enriched in multiple GO entries and KEGG pathways. Among them, the pathway associated with intramuscular fat was the AMPK signaling pathway, and the related genes were PPARGC1A and ADIPOQ;Immunohistochemical studies showed that PPARGC1A and ADIPOQ proteins were expressed in connective tissues, cell membranes, and, to a lesser extent, the cytoplasm of the longest dorsal muscle of the little-tailed frigid sheep;Real-time PCR and Western Blot validation showed that PPARGC1A and ADIPOQ were both expressed in the longest dorsal muscle of the little-tailed frigid sheep at different ages, and there were age differences in the amount of expression. The ADIPOQ gene was negatively correlated with the intramuscular fat content of the longest dorsal muscle, and the PPARGC1A gene was positively correlated with the intramuscular fat content of the longest dorsal muscle;As inferred from the above

关键词： Small-tailed frigid sheep Longest dorsal muscle Intramuscular fat Growth and development Transcriptomics

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The role of apparent diffusion coefficient in the grading of adult isocitrate dehydrogenase-mutant astrocytomas: relationship with the Ki-67 proliferation index

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ACTA RADIOLOGICA 2024年第5期65卷 489-498页

作者： She, Yingxia Liu, Xianwang jiang, Jian Wang, xuwen Niu, Qian Zhou, Junlin Lanzhou Univ Second Hosp Radiol Dept Lanzhou Peoples R China Lanzhou Univ Second Hosp Key Lab Med Imaging Gansu Prov Lanzhou Peoples R China Lanzhou Univ Second Hosp Gansu Int Sci & Technol Cooperat Base Med Imaging Lanzhou Peoples R China Lanzhou Univ Second Hosp Pathol Dept Lanzhou Peoples R China Lanzhou Univ Second Hosp Dept Radiol Cuiyingmen 82 Lanzhou 730030 Peoples R China

Background: The grading of adult isocitrate dehydrogenase (IDH)-mutant astrocytomas is a crucial prognostic factor. Purpose: To investigate the value of conventional magnetic resonance imaging (MRI) features and apparent diffusion coefficient (ADC) in the grading of adult IDH-mutant astrocytomas, and to analyze the correlation between ADC and the Ki-67 proliferation index. Material and Methods: The clinical and MRI data of 82 patients with adult IDH-mutant astrocytoma who underwent surgical resection and molecular genetic testing with IDH and 1p/19q were retrospectively analyzed. The conventional MRI features, ADC(min), ADC(mean), and nADC of the tumors were compared using the Kruskal-Wallis single factor ANOVA and chi-square tests. Receiver operating characteristic (ROC) curves were drawn to evaluate conventional MRI and ADC accuracy in differentiating tumor grades. Pearson correlation analysis was performed to determine the correlation between ADC and the Ki-67 proliferation index. Results: The difference in enhancement, ADC(min), ADC(mean), and nADC among WHO grade 2, 3, and 4 tumors was statistically significant (all P <0.05). ADC(min) showed the preferable diagnostic accuracy for grading WHO grade 2 and 3 tumors (AUC=0.724, sensitivity=63.4%, specificity=80%, positive predictive value (PPV)=62.0%;negative predictive value (NPV)=82.5%), and distinguishing grade 3 from grade 4 tumors (AUC=0.764, sensitivity=70%, specificity=76.2%, PPV=75.0%, NPV=71.4%). Enhancement + ADC model showed an optimal predictive accuracy (grade 2 vs. 3: AUC = 0.759;grade 3 vs. 4: AUC = 0.799). The Ki-67 proliferation index was negatively correlated with ADC(min), ADC(mean), and nADC (all P <0.05), and positively correlated with tumor grade. Conclusion: Conventional MRI features and ADC are valuable to predict pathological grading of adult IDH-mutant astrocytomas.

关键词： Apparent diffusion coefficient astrocytomas isocitrate dehydrogenase-mutant Ki-67 proliferation index

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Anomaly Detection for Multivariate Time Series Based on Contrastive Learning and Autoformer 27

Anomaly Detection for Multivariate Time Series Based on Cont...

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27th International Conference on Computer Supported Cooperative Work in Design (CSCWD)

作者： Shang, xuwen Zhang, Jue jiang, Xingguo Luo, Hong Beijing Univ Posts & Telecommun Beijing Key Lab Intelligent Telecommun Software & Beijing Peoples R China Beihang Univ Dept Comp Sci & Engn Beijing Peoples R China

ISBN: (纸本)9798350349184;9798350349191

Nowadays, due to the increasingly complex and huge data flow, anomaly detection has become an important technology to ensure the high security and reliability of the systems. It helps identify unusual observations in the data, thereby protecting safety and reducing risk. However, in the field of multivariate temporal anomaly detection, there are still some difficulties in spatio-temporal correlation mining of variables, generalization ability in dealing with complex temporal sequences, and feature learning under different granularity. Therefore, we propose an unsupervised anomaly detection method for multivariate time series based on contrastive learning and Autoformer autoencoder. In order to fully explore the spatio-temporal correlation of time series data, this paper uses Graph Attention Network and Auto-Correlation to jointly learn spatio-temporal correlation, and obtain positive and negative pairs through time-domain and frequency-domain data augmentation. Finally, the Autoformer autoencoder is used for anomaly detection in a predictive manner. In the loss function section, a joint loss function is formed by introducing contrastive learning losses at the time step and time window granularity, combined with prediction loss, to improve the learning effect. This paper investigates the performance of the proposed method through experiments on the SMAP and MSL public datasets, and achieves better results than baseline methods.

关键词： anomaly detection multivariate time series contrastive learning autoformer spatio-temporal correlation

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Binding characteristics of Pb and Zn to low-temperature feces-based biochar-derived DOM revealed by EEM-PARAFAC combined with general and moving-window two-dimensional correlation analyses

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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2023年第10期30卷 27525-27538页

作者： He, Changjun He, xuwen Yuan, Run Li, Na jiang, Jinyuan Chinese Res Inst Environm Sci Res Ctr Environm Pollut Control Technol Beijing 100012 Peoples R China China Univ Min & Technol Beijing Sch Chem & Environm Engn Beijing 100083 Peoples R China

Pyrolysis carbonization of human feces has shown potential for converting feces biomass into a soil amendment. However, little is known about the interactions of DOM derived from feces-based biochar produced at low-temperature with heavy metals (HMs). In this study, the binding properties of Pb(II) and Zn(II) with DOM derived from feces-based biochar produced at low pyrolysis temperatures were investigated using EEM-PARAFAC combined with general, and moving-window two-dimensional correlation analyses (2D-COS). The results revealed that DOM from biochar produced at 280 degrees C exhibited a higher Pb(II) and Zn(II) affinity and more binding sites than DOM produced at 380 degrees C. The fulvic-like and humic-like components exhibited obvious fluorescence quenching after the heavy metal addition, and the complexes formed with Pb(II) and Zn(II) were more stable. C-H groups exhibited the fastest response to Pb(II) and Zn(II) binding in the FB280 DOM, while the COO- groups of carboxylic acids in the FB380 DOM exhibited the fastest response to Pb(II) and Zn(II). Moreover, the mutation concentration range of components and functional groups in DOM, as analyzed by MW2D-COS, was greater for Zn(II) than for Pb(II). These results provide a more detailed molecular-level understanding of the interaction mechanisms between heavy metals and feces-based biochar-derived DOM and the effect of HM concentration on DOM binding. Further, these results will help to provide a reasonable reference for feces management and feces-based biochar in controlling soil HMs.

关键词： Human feces Biochar Dissolved organic matter Heavy metals binding Moving-window analysis

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HPV vaccination strategy for 14-year-old females and economic returns for cervical cancer prevention in Wuxi City, China: a cost effectiveness analysis

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COST EFFECTIVENESS AND RESOURCE ALLOCATION 2024年第1期22卷 1页

作者： jiang, Jingfeng Zhao, Fanqi Hong, Xiang Wang, xuwen Nanjing Med Univ Wuxi Ctr Dis Control & Prevent Affiliated Wuxi Ctr Dis Control & Prevent Wuxi 214023 Peoples R China Southeast Univ Minist Educ Sch Publ Hlth Dept Epidemiol & Hlth StatKey Lab Environm Med & Nanjing Peoples R China

Background Since December 2021, Wuxi, China has offered a two-dose human papillomavirus (HPV) vaccination to 14-year-old females for free. This study evaluated the costs and benefits of this vaccination scheduled in the Expanded Program on Immunization in Wuxi from the perspective of the cities' demographic characteristics, economic development, and policy support. Methods The model-based economic evaluation used TreeAge Pro software to construct a decision tree-Markov model for the vaccination strategy in which 100,000 14-year-old females received two doses of bivalent HPV vaccine or no vaccination. Costs and effects of the strategy were assessed from a societal perspective through literature research and data obtained from the Wuxi Centre for Disease Control and Prevention. Univariate, multivariate, and probabilistic sensitivity analyses assessed the stability of the findings. Results The cost of the bivalent HPV vaccine in Wuxi is 711.3 CNY. The two-dose of bivalent HPV vaccine for 100,000 14-year-old females would cost an additional 658,016 CNY compared to no vaccination, but would result in 1,960 Quality Adjustment Years of Life (QALYs). Using the per capita gross domestic product of 187,415 CNY in 2021 in Wuxi as the willingness-to-pay threshold, the vaccination strategy costs 3,357.37 CNY per QALY gained, which is much lower than the threshold, suggesting that it is a very cost-effective strategy. In addition, the vaccine strategy reduced the incidence of cervical cancer by 300 cases and cervical cancer deaths by 181 cases, representing a benefit-cost ratio of 2.86 (> 1) when health output outcomes were measured in monetary terms. These results suggested that the vaccination strategy was advantageous. Sensitivity analyses showed that changes in the parameters did not affect the conclusions and that the findings were robust. Conclusions Compared to no vaccination, the delivery of two doses of bivalent HPV vaccine for 14-year-old females was a more highly cost-

关键词： Cost-effectiveness HPV Cervical cancer Vaccination

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Numerical and experimental investigation of the effect of cold extrusion process on residual stress and fatigue life of internal thread of high-strength steel

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INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY 2023年第9-10期127卷 4713-4726页

作者： Wan, Nian He, Qiang Jing, xuwen jiang, Yonggang Zhou, Honggen Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212000 Peoples R China Cssc Huangpu Wenchong Shipbuilding Co Ltd Guangdong Prov Key Lab Adv Welding Technol Ships Guangzhou 510715 Peoples R China

In order to improve the fatigue performance of the internal thread of the connecting rod for marine diesel engine, the internal thread cold extrusion technology is introduced into the bolt hole position. Based on the three-dimensional finite element model, the residual stress distribution around the cold extrusion internal thread of 42CrMo4 high-strength steel plate hole structure under different edge distance ratios is analyzed in detail. The multiaxial fatigue life prediction model of thread is established based on the stress-strain method;the accuracy and feasibility of the prediction model are further verified by fatigue experiments. The thread surfaces are examined by utilizing the scanning electron microscope and coordinate with the X-ray diffraction method to measure the residual stress of thread. The relationship between the residual stress distribution, surface structure, and fatigue life of the extrusion thread is revealed. The research shows that the improved fatigue prediction model gives a satisfactory accuracy in predicting the fatigue life. Both the tangential residual stress fields around the extrusion thread and the surface structure have a certain influence on its fatigue life, especially when the edge distance ratio is less than 2. The tangential residual compressive stress of the cold extrusion internal thread decreases with the edge distance ratio being smaller, while the depth of the stress zone increases firstly and then decreases. Higher load will greatly reduce the fatigue life and dispersion of the thread;the fatigue life increases linearly with the increase of the edge distance ratio under lower stress level.

关键词： Cold extrusion thread Edge distance ratio Finite element simulation Fatigue life High-strength steel

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