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Cocrystals of axially N-embedded quasi-carbon nanohoops via modulating the electron affinity of guest acceptors

Science China Chemistry 2025年

作者： Li Zhang Shuhai Qiu Shunlong Hu Hanren Xu xuwen Sun Wei jiang Da-Hui Qu Zhaohui Wang Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materi-obiology and Dynamic Chemistry Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of Chemistry Tsinghua University

Organic donor-acceptor cocrystals of π-conjugated molecues have shown diverse applications in materials science. However,most cocrystals exist in neutral forms dominated by π-π interactions, while the ionic congeners and corresponding properties are rarely studied due to difficulties in harnessing the degree of charge transfer. Herein, we report cocrystals of axially N-embedded quasi-carbon nanohoops(DPP-D and DPP-T) with electron deficient guests. By modulating the electron affinity of the acceptor guests, the electronic structures of the complexes can be tuned from neutral to ionic states. Specifically, DPP-D interacts with TCNB molecules to form neutral superstructures via intermolecular π-π interactions, giving rise to a deep-red emission in the solid state. In contrast, an ionic complex showing near-infrared region absorptions and paramagnetic character on account of strong charge-transfer interactions is generated when DDQ molecules are involved. Their unique properties can be explained by different degrees of charge transfer and assembly modes, which have clearly been manifested by crystal structures and theoretical calculations. Our studies provide rare examples of π-conjugated macrocycle-based donor-acceptor cocrystals in both neutral and ionic forms, and give insight to the design of multicomponent carbon nanomaterials.

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种子微生物的研究进展

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中国农学通报 2014年第21期30卷 47-51页

作者：李贺勤江绪文青岛农业大学农学与植物保护学院/山东省旱作农业技术重点实验室山东青岛266109

种子微生物是寄附于种子内、外部或种子之间的各种微生物的统称,是影响种子活力的一个重要因素。为了更好地对种子微生物进行控制和利用,研究通过查阅文献资料,围绕种子微生物的主要类群和来源、普遍性和多样性、主要研究方法以及对种... 详细信息

种子微生物是寄附于种子内、外部或种子之间的各种微生物的统称,是影响种子活力的一个重要因素。为了更好地对种子微生物进行控制和利用,研究通过查阅文献资料,围绕种子微生物的主要类群和来源、普遍性和多样性、主要研究方法以及对种子活力影响四个方面归纳了其最新研究进展及当前存在的问题,并根据已有结果指出了该领域未来的研究方向。

关键词：种子微生物种子活力

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“种子加工原理与工艺”课程教学内容改革与实践

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科教文汇 2014年第25期 50-51页

作者：江绪文李贺勤青岛农业大学农学与植物保护学院山东青岛266109

围绕中国现代种业人才需求和青岛农业大学应用型人才培养特色名校建设目标,本研究从分析青岛农业大学"种子加工原理与工艺"课程建设现状及存在的问题入手,探索教学内容改革的基本原则及技术路线,并初步构建了多元化课程体系... 详细信息

围绕中国现代种业人才需求和青岛农业大学应用型人才培养特色名校建设目标,本研究从分析青岛农业大学"种子加工原理与工艺"课程建设现状及存在的问题入手,探索教学内容改革的基本原则及技术路线,并初步构建了多元化课程体系。目前实践效果良好,为今后中国应用型特色种业人才培养体系的深入改革创新、研究实践提供了参考。

关键词：种子加工工艺教学改革应用型

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A Methionine Allocation Nanoregulator for the Suppression of Cancer Stem Cells and Support to the Immune Cells by Epigenetic Regulation

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ADVANCED SCIENCE 2025年第15期12卷 e2415207页

作者： Su, Boyu Chen, Qinjun Li, xuwen Fang, Mingzhu Wang, Yu Song, Haolin You, Haoyu Zhou, Zheng Wu, Yuxing Zhao, Zhenhao Chen, Yun Fan, Hongrui Li, Chufeng jiang, Chen Sun, Tao Fudan Univ State Key Lab Med Neurobiol Sch Pharm Dept PharmaceutKey Lab Smart Drug DeliveryMinist Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Epigenetic dysregulation is prevalent in human cancers, affecting gene expression and metabolic patterns to meet the demands of malignant evolution and abnormal epigenetic processes, and resulting in a protumor immune microenvironment. Tumors require a steady supply of methionine for maintaining epigenetic flexibility, which is the only exogenous precursor of methyl donor S-adenosylmethionine for methylation, crucial for their resistance to therapies and survival in a nutrient-deficient microenvironment. Thus, tumor cells upregulate the Lat4 transporter to compete and deprive methionine in the microenvironment, sustaining their malignant phenotypes and also impairing immune cell functions. Addressing this methionine addiction is the key to overcoming drug resistance and improving immune response. Despite the challenge of lacking specific Lat4 inhibitors, an oxaliplatin prodrug crosslinked fluorinated polycation/anti-Lat4 small interfering RNA complex nanoregulator (AS-F-NP) has been designed and developed here. This nanoregulator restricted the greedy methionine uptake of tumor cells by knocking down Lat4, which in turn inhibited the malignant evolution of the tumor while restoring the viability and function of tumor-infiltrating immune cells.

关键词： cancer therapy epigenetic immune methionine oxaliplatin siRNA

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PEG引发对草坪草种子萌发及活力的影响

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种子 2006年第11期25卷 20-25,30页

作者：马卉徐秀红江绪文张文明安徽农业大学农学院合肥230036

采用PEG-6000引发处理8个样品草坪草种子(高羊茅4个:美洲虎3号(1)、美洲虎3号(2)、全体和爱瑞3号;多年生黑麦草1个:爱神特;早熟禾1个:公园;狗牙根2个:1个种子已脱壳,1个未脱壳,研究PEG引发对不同草坪草种子萌发及活力的影响。结果表明,... 详细信息

采用PEG-6000引发处理8个样品草坪草种子(高羊茅4个:美洲虎3号(1)、美洲虎3号(2)、全体和爱瑞3号;多年生黑麦草1个:爱神特;早熟禾1个:公园;狗牙根2个:1个种子已脱壳,1个未脱壳,研究PEG引发对不同草坪草种子萌发及活力的影响。结果表明,适宜的PEG引发处理可以显著提高草坪草种子的发芽率和活力,不同样品PEG处理的适宜浓度和时间不同:美洲虎3号(1)和(2)为20%,72 h;全体和爱瑞3号为15%,72 h;爱神特为25%,48 h;狗牙根未脱壳和已脱壳种子分别为20%,48 h和15%,24 h。

关键词： PEG引发草坪草种子活力

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种子包衣对玉米种子贮藏过程中种子活力的影响

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种子 2015年第12期34卷 76-80页

作者：姜海燕李贺勤张文健彭飞江绪文青岛农业大学山东青岛266109

采用2种不同的种衣剂对3个玉米品种种子包衣处理后进行室温贮藏,分别于贮藏3个月、6个月、9个月和12个月进行发芽试验、田间出苗试验和种子含水量测定,以未包衣种子为对照,探讨贮藏期包衣处理对玉米种子活力的影响。结果表明:贮藏后,包... 详细信息

采用2种不同的种衣剂对3个玉米品种种子包衣处理后进行室温贮藏,分别于贮藏3个月、6个月、9个月和12个月进行发芽试验、田间出苗试验和种子含水量测定,以未包衣种子为对照,探讨贮藏期包衣处理对玉米种子活力的影响。结果表明:贮藏后,包衣种子的发芽势、发芽率存在低于对照的趋势,田间出苗率存在先高后低的变化趋势,种子含水量均高于对照;贮藏6个月内,种子包衣可有效提高种子活力;2种种衣剂之间效果差异不显著,其中T 2效果更好。

关键词：玉米种子包衣种子活力贮藏

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CircFBLN2 regulates duck myoblast proliferation and differentiation through miR-22-5p and MEF2C interaction

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POULTRY SCIENCE 2025年第5期104卷 105063页

作者： Liu, Shuibing Wu, Jintao jiang, Hongxia Zhou, Ya'nan Huang, xuwen Wang, Yuxiang Xie, Zhanbin Liao, Zurong Ding, Zhenxvan Liu, Jing Hu, Xiaolong Mao, Huirong Liu, Sanfeng Chen, Biao Jiangxi Agr Univ Coll Anim Sci & Technol Nanchang 330045 Jiangxi Peoples R China South China Agr Univ Coll Anim Sci Guangzhou 510642 Guangdong Peoples R China Jiangxi Agr Univ Poultry Inst Nanchang 330045 Peoples R China

The growth and development of duck skeletal muscle significantly affect duck meat production, making it essential to understand the molecular mechanisms underlying these processes. Circular RNAs (circRNAs) and microRNAs (miRNAs) are identified in many species and play essential roles in the regulation of myogenic processes;however, research on circRNAs and miRNAs involved in the duck skeletal muscle development is limited. In prior whole-transcriptome RNA sequencing study, we identified differential expression of miR-22-5p and the novel circular RNA circFBLN2, which arises from the second exon of the FBLN2 gene, in duck primary myoblasts (DPMs). In this study, we confirmed the circular structure of circFBLN2 and explored its expression patterns and functional implications in myogenesis. To elucidate the function of circFBLN2 in the myogenic processes of duck, we conducted experiments involving both the silencing and overexpression of circFBLN2 in DPMs. Our findings indicated that circFBLN2 inhibits DPM proliferation while promoting their differentiation. Conversely, when miR-22-5p was silenced and overexpressed, it exhibited opposing effects by promoting the proliferation of DPMs and inhibiting their differentiation. These results suggest a complex dynamic interplay between circFBLN2 and miR-22-5p in the regulation of DPMs proliferation and differentiation. Additionally, our results revealed that both circFBLN2 and myocyte enhancer factor 2 C (MEF2C) act as sponges for miR-22-5p, as demonstrated by binding predictions and dual-luciferase reporter assays. These results offer novel perspectives on the regulatory pathways underlying the duck embryonic skeletal muscle development, underscoring the pivotal function of circFBLN2 in the regulation of miR-22-5p expression. This research deepens our comprehension of the molecular underpinnings of avian myogenesis, potentially paving the way for more effective approaches to bolster growth and development of livestock.

关键词： Duck skeletal muscle circFBLN2 miR-22-5p MEF2C

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1984—2015年太湖地区大气能见度变化遥感监测与评价

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中国环境监测 2017年第5期33卷 176-179页

作者：姜晟李旭文牛志春王甜甜茅晶晶江苏省环境监测中心江苏南京210036

研究收集整理了1984—2015年太湖区域342幅Landsat系列卫星遥感影像,利用ENVI软件FLAASH模块计算获取了区域大气能见度均值,通过太湖周边苏州、无锡、常州3市地面自动站能见度监测值加以验证,并在此基础上对1984—2015年该地区大气能见... 详细信息

研究收集整理了1984—2015年太湖区域342幅Landsat系列卫星遥感影像,利用ENVI软件FLAASH模块计算获取了区域大气能见度均值,通过太湖周边苏州、无锡、常州3市地面自动站能见度监测值加以验证,并在此基础上对1984—2015年该地区大气能见度遥感监测结果进行了分析与评价。研究结果表明:太湖地区在20世纪80年代能见度水平相对较好,20世纪90年代后逐渐下滑,总体呈下降趋势。2015年遥感反演能见度均值为14.80 km,与1984年的21.46 km相比下降了31.05%,下降速率约为0.21 km/a。

关键词：大气能见度遥感太湖

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Transcriptomic profiling of the high-vigour maize (Zea mays L.) hybrid variety response to cold and drought stresses during seed germination

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SCIENTIFIC REPORTS 2021年第1期11卷 1-16页

作者： Li, Heqin Yue, Haiwang Xie, Junliang Bu, Junzhou Li, Li Xin, Xueying Zhao, Yanming Zhang, Haiyan Yang, Li Wang, Jianhua jiang, xuwen Qingdao Agr Univ Coll Agron Maize Res Inst Qingdao 266109 Peoples R China Hebei Acad Agr & Forestry Sci Dryland Farming Inst Hengshui 053000 Peoples R China China Agr Univ Seed Sci & Technol Res Ctr Beijing 100193 Peoples R China Nat Resources & Planning Bur Hengshui City Taocheng Branch Hengshui 053000 Peoples R China

Abiotic stresses, including cold and drought, negatively affect maize (Zea mays L.) seed field emergence and later yield and quality. In order to reveal the molecular mechanism of maize seed resistance to abiotic stress at seed germination, the global transcriptome of high- vigour variety Zhongdi175 exposed to cold- and drought- stress was analyzed by RNA-seq. In the comparison between the control and different stressed sample, 12,299 differentially expressed genes (DEGs) were detected, of which 9605 and 7837 DEGs were identified under cold- and drought- stress, respectively. Functional annotation analysis suggested that stress response mediated by the pathways involving ribosome, phenylpropanoid biosynthesis and biosynthesis of secondary metabolites, among others. Of the obtained DEGs (12,299), 5,143 genes are common to cold- and drought- stress, at least 2248 TFs in 56 TF families were identified that are involved in cold and/or drought treatments during seed germination, including bHLH, NAC, MYB and WRKY families, which suggested that common mechanisms may be originated during maize seed germination in response to different abiotic stresses. This study will provide a better understanding of the molecular mechanism of response to abiotic stress during maize seed germination, and could be useful for cultivar improvement and breeding of high vigour maize cultivars.

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Modifiable factors affects cancer-specific survival: findings from a large population-based prospective cohort study

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JOURNAL OF TRANSLATIONAL MEDICINE 2025年第1期23卷 1-12页

作者： Chen, Xiong Zhu, Dongxi Li, Chenchen Lin, Yi Lv, Lin Ai, Feiling Chen, Zhijian Shen, Runnan Shen, xuwen You, Guochang jiang, Zhige Zhong, Wenlong Lin, Tianxin Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Urol Guangzhou Peoples R China Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet & Guangdong Hong Kong Joint Lab RNA Med Guangzhou Guangdong Peoples R China Guangdong Prov Clin Res Ctr Urol Dis Guangzhou Peoples R China Sun Yat Sen Univ Affiliated Hosp 6 Dept Med Oncol Guangzhou Peoples R China Sun Yat Sen Univ Sch Med Guangzhou Peoples R China Ludwig Maximilian Univ Munich Fac Med Munich Germany

BackgroundModifiable factors affect cancer's survival but literature did not differentiate prior to versus after cancer diagnosis. It is essential to provide references for the intervention prioritized at different *** this prospective cohort study, we analyzed national data from the UK Biobank, including 121,399 participants, to assess the association of modifiable factors with cancer-specific survival (CSS) in two independent cohorts: a pre-cancer cohort (n = 78,027) and a post-cancer cohort (n = 43,372). Additionally, a weighted standardized score was derived to evaluate the joint effects across different domains. Interactions between the six domains and age at diagnosis, sex, and cancer site were evaluated using likelihood ratio tests. Subgroup analyses were then performed for factors showing significant effect modification. Population-attributable fractions (PAF) of different domains on 5-year cancer-specific death were *** study comprehensively presented the differential patterns of modifiable factors' impact on CSS among pre-cancer and post-cancer cohorts, sexes and different cancer sites. In the pre-cancer cohort, CSS were predominantly attributable to smoking/alcohol consumption (PAF 92%) and daily activity (PAF 106%). Men exhibited a higher risk than women for dietary habits (HR:125 versus 118), daily activity (HR:150 versus 129) and living environment (HR:113 versus 103). The impact of modifiable factors, including daily activity, smoking/alcohol consumption, and physical measures, on CSS varied across different cancer sites. In the post-cancer cohort, 186% of 5-year cancer-specific deaths were attributable to unfavourable mental health. In subgroup analysis, the risk of CSS in the domain of smoking/alcohol consumption was higher in men than that in women (HR: 158 versus 134). The impact of modi

关键词： Cancer-specific survival Modifiable factor Population-attributable fractions

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