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Development and validation of a predictive model for metabolic syndrome in a large cohort of people living with HIV

VIROLOGY JOURNAL 2024年第1期21卷 1-12页

作者： Chen, Suling Xu, Yuyuan jiang, Yuanhui Chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun Peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Minist Educ Key Lab Infect Dis Res South China Guangzhou Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

BackgroundThe global prevalence of metabolic syndrome (MetS) in people living with HIV (PLWH) is on the rise in the post era of antiretroviral therapy (ART). Nevertheless, there are no validated predictive models available for assessing the risk of MetS in this specific *** study included PLWH who participated in annual follow-ups at Southern Medical University Nanfang Hospital from September 2022 to November 2023. Participants enrolled in this study were divided into the training set and validation set based on the follow-up duration. We employed both multivariate logistic regression and lasso regression to develop three distinct prediction models. Subsequently, the optimal model was determined through comprehensive analyses, including receiver operating characteristic (ROC) curve analysis, calibration curve, and decision curve analysis (DCA). Ultimately, we generated a nomogram for the optimal model and analyzed the correlation between the model score and the components of *** total of 1017 participants were included in this study, with 814 in the training set and 203 in the validation set. The ultimate prediction model of MetS risk in PLWH incorporated five factors: age, CD8 + T cell counts, controlled attenuation parameter (CAP), gamma-glutamyl transferase (gamma-GT) and lactate dehydrogenase (LDH). The area under the ROC curve (AUC) of the model in the training set and validation set was 0.849 and 0.834, respectively. Furthermore, we revealed a significant correlation between the model score and the MetS components. Additionally, the model score revealed significant group differences in MetS and related metabolic *** study established a potential model for predicting MetS in PLWH.

关键词： HIV/AIDS Metabolic syndrome Clinical prediction model Nomogram Clinical endocrinology

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The catalytic thermal decomposition of ammonium perchlorate on CuMxOy (M = Fe, Ni, Co and Zn) catalysts and their applications in solid propellant

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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 2023年第13期148卷 6013-6026页

作者： Hu, Yinghui Wang, xuwen Hao, Jingwei jiang, Shouhang Zhang, Jian Yang, Yulin Lin, Kaifeng Zheng, Jian Shuai, Yong Harbin Inst Technol Sch Chem & Chem Engn MIIT Key Lab Crit Mat Technol New Energy Convers & Harbin 150001 Peoples R China Harbin Inst Technol Sch Energy Sci & Engn Harbin 150001 Peoples R China China Aerosp Sci & Technol Corp 16 Fucheng Rd Beijing 100048 Peoples R China

The excellent thermal decomposition efficiency of ammonium perchlorate (AP) is of great importance for obtaining propellant with fast specific impulse. In this study, four CuMxOy catalysts, including M = Fe, Ni, Co, and Zn, were synthesized and then used for catalyzing AP decomposition and hydroxyl-terminated polybutadiene (HTPB)-based solid propellant combustion. The existed synergistic effect in CuMxOy catalysts improved the catalytic activity and the most active CuZnO catalyst decreased the AP high-temperature decomposition temperature (HTD) from 412.5 to 289.4 ?. Kinetic studies indicated that CuMxOy catalysts inhibited the conversion of N2O to a fully oxidized product and decreased the activation energy (E-a) in HTD to concentrate AP decomposition to significantly decrease the heat loss, thereby increasing their decomposition efficiency. When applying the CuMxOy catalysts in the HTPB (hydroxyl-terminated polybutadiene)-based solid propellant, a faster burning rate and stronger optical emission spectrum were obtained. The CuMxOy catalyst is a potential additive for the preparation of outstanding combustion solid propellants.

关键词： Bimetal oxide catalyst Ammonium perchlorate Thermal decomposition Catalytic mechanism Burning rate

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Estimated Pulse Wave Velocity as a Novel Non-Invasive Biomarker for Metabolic Syndrome Among People Living with HIV

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DIABETES METABOLIC SYNDROME AND OBESITY 2024年 17卷 1999-2010页

作者： Chen, Suling jiang, Yuanhui Lin, Xiaoli Chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun Peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

Purpose: This study aims to investigate the relationship between estimated pulse wave velocity (ePWV) and metabolic syndrome (MetS) in people living with HIV (PLWH), proposing a novel and convenient predictor for early detection of MetS in PLWH. Patients and Methods: A total of 485 PLWH were enrolled. These participants were categorized into two groups based on the estimated pulse wave velocity (ePWV) level. Demographic and clinical data were collected to investigate the correlation between ePWV and MetS. Results: The cohort of 485 PLWH was categorized into high-ePWV and low-ePWV groups based on ePWV cutoff value of 10 m/s. We observed significant differences in components of MetS including triglycerides (TG, P < 0.05), HDL cholesterol (HDL-C, P < 0.01), systolic blood pressure (SBP, P < 0.001), diastolic blood pressure (DBP, P < 0.05), and fasting plasma glucose (FPG, P < 0.001) between the two groups. Furthermore, we employed receiver operating characteristic (ROC) curves to demonstrate the effectiveness of ePWV as a predictive indicator for MetS in PLWH (AUC = 0.739, P < 0.001). According to the ROC curve, the optimal cut-off value of ePWV was 7.4 m/s, and its sensitivity and specificity in diagnosing MetS in PLWH were 79.03% and 64.07%, respectively. Although the 7.4 m/s cutoff increased the false positive rate compared to the traditional cutoff, it significantly reduced the rate of missed diagnoses, effectively identifying 79.03% of PLWH with MetS. Conclusion: ePWV is a non-invasive and convenient novel biomarker with predictive capabilities for MetS in PLWH.

关键词： HIV/AIDS highly active antiretroviral therapy metabolic syndrome estimated pulse wave velocity

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Research progress of 3D printing technology in functional food, powering the future of food

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TRENDS IN FOOD SCIENCE & TECHNOLOGY 2024年 149卷

作者： Wu, Rina jiang, Jinhui An, Feiyu Ma, xuwen Wu, Junrui Shenyang Agr Univ Coll Food Sci Shenyang 110866 Peoples R China Engn Res Ctr Food Fermentat Technol Shenyang 110161 Liaoning Peoples R China Key Lab Microbial Fermentat Technol Innovat Shenyang 110866 Peoples R China

Background: 3D printing (3DP) technology is an innovative additive manufacturing technique. 3DP technology has witnessed significant adoption across the food industry. The recent upsurge in living standards and the growing emphasis on healthcare have spurred the evolution of functional foods, marking a significant trend in the culinary landscape. Scope and approach: This paper undertakes a comprehensive review of existing literature on 3DP food to elucidate the advancements in functional food applications within the realm of 3D printing. The objective is to delve into the progress, mechanisms, challenges, and unresolved issues surrounding the integration of functional food in 3DP technology. Key findings and conclusions: The burgeoning popularity of functional foods signals a transformative shift in the food industry. We summarized the utilization of functional proteins, lipids, carbohydrates, small molecule substances (minerals and vitamins), and probiotics in 3DP foods. The relevant mechanism is also explained. It is widely used in the elderly, children and swallowing patients by its personalized customization and soft texture. However, persistent challenges such as heat loss of functional substances necessitate further resolution. The future trajectory of 3DP food points towards commercialization, necessitating stringent considerations for food quality, safety, and optimization of 3D printing processes to safeguard human health. The advent of 4D and 5D food printing technologies presents promising avenues for advancement, underscoring the need to unravel the intricacies of food printing processes to adapt to evolving market demands and realize the potential of 6D and 7D food printing realms.

关键词： Food 3D printing Nutrition Functional substance Probiotics

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Power Market Regulation: Review and Prospect 5

Power Market Regulation: Review and Prospect

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5th IEEE International Electrical and Energy Conference, CIEEC 2022

作者： Gao, Bo Liu, xuwen jiang, Yu Tian, Ming State Grid Jiangsu Electric Power Co. Ltd Nanjing210024 China Jiangsu Power Trading Center Co. Ltd Nanjing210008 China

ISBN: (数字)9781665411042

ISBN: (纸本)9781665411042

A scientific and feasible power regulatory system can effectively prevent potential risks and promote its harmonious development of the power market. With the advancement of China's power spot market construction, the regulatory mechanism of the power market has again attracted the attention of the related designers. Since the power spot markets in North America, Australia, Europe, and other countries and regions have been maturely developed, they have accumulated rich practical experiences in handling with energy structure transformation, opening up power market competition, and improving the power regulatory system. Firstly, it introduces the electricity regulatory systems of various countries and elaborates the history of their electricity regulatory reforms;secondly, it analyzes the functions of electricity regulatory agencies in various countries in depth;then, it well compares and analyzes the regulatory agency evaluation mechanisms of the electricity markets in Australia, Europe and the United States;finally, based on the current situation of China's power market construction, we provide suggestions on the energy and power law and regulation system in the power market, improving the functions of regulatory agencies, strengthening regulatory informationization, and improving evaluation mechanisms. © 2022 IEEE.

关键词： Competition

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Numerical and experimental investigation of the residual stress distribution of internal thread cold extrusion and tap wear

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STRAIN 2024年第1期60卷 e12459-e12459页

作者： Wan, Nian He, Qiang Jing, xuwen jiang, Yonggang Zhou, Honggen Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Peoples R China Cssc Huangpu Wenchong Ship Bldg Co Ltd Guangzhou Peoples R China Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212000 Peoples R China

In order to improve the thread-forming quality of diesel engine piston connecting rod, the internal thread cold extrusion process was adopted for the through-hole structure of 42CrMo4 high-strength steel. The influence of different structural parameters of the tap on the residual stress distribution of the cold extrusion internal threads and self-wear were discussed with the help of three-dimensional elastic-plastic finite element model. The wear of tap was observed by an electron microscope, coordinated with the residual stress distribution of thread was measured by X-ray diffraction to explore the relationship between residual stress distribution of the cold extrusion internal thread, tool wear and tap structure. The optimal combination of tap structure parameters of residual stress and tool wear was obtained through grey relation method. The residual compressive stress and the depth of stress layer near the thread surface increased and the wear condition of the extrusion tap was improved when the tap with optimised structural parameters was used for processing, while maintaining the original thread connection strength. The results show that the internal thread with better-forming quality can be obtained by using the optimised extrusion tap, while the service life of the tap was prolonged.

关键词： cold extrusion internal thread high-strength steel residual stress structural parameter tool wear

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Cocrystals of axially N-embedded quasi-carbon nanohoops via modulating the electron affinity of guest acceptors

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Science China Chemistry 2025年

作者： Li Zhang Shuhai Qiu Shunlong Hu Hanren Xu xuwen Sun Wei jiang Da-Hui Qu Zhaohui Wang Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materi-obiology and Dynamic Chemistry Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of Chemistry Tsinghua University

Organic donor-acceptor cocrystals of π-conjugated molecues have shown diverse applications in materials science. However,most cocrystals exist in neutral forms dominated by π-π interactions, while the ionic congeners and corresponding properties are rarely studied due to difficulties in harnessing the degree of charge transfer. Herein, we report cocrystals of axially N-embedded quasi-carbon nanohoops(DPP-D and DPP-T) with electron deficient guests. By modulating the electron affinity of the acceptor guests, the electronic structures of the complexes can be tuned from neutral to ionic states. Specifically, DPP-D interacts with TCNB molecules to form neutral superstructures via intermolecular π-π interactions, giving rise to a deep-red emission in the solid state. In contrast, an ionic complex showing near-infrared region absorptions and paramagnetic character on account of strong charge-transfer interactions is generated when DDQ molecules are involved. Their unique properties can be explained by different degrees of charge transfer and assembly modes, which have clearly been manifested by crystal structures and theoretical calculations. Our studies provide rare examples of π-conjugated macrocycle-based donor-acceptor cocrystals in both neutral and ionic forms, and give insight to the design of multicomponent carbon nanomaterials.

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基于校院教育合作种子科学专业应用型特色人才培养模式的构建——以青岛农业大学为例

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种子 2020年第2期39卷 149-151,155页

作者：江绪文李贺勤宋希云王元英戴培刚孟鹤王建华青岛农业大学山东青岛266109 中国农业科学研究院烟草研究所山东青岛266109 中国农业大学北京100094

我国种业要做大做强,人才培养是关键。校院教育合作是产学研结合的一种重要形式,对提高高等农业院校种业人才培养质量具有重要意义。本文借鉴青岛农业大学烟草专业校院教育合作成功经验,结合种子科学专业应用型特色人才培养目标,从人才... 详细信息

我国种业要做大做强,人才培养是关键。校院教育合作是产学研结合的一种重要形式,对提高高等农业院校种业人才培养质量具有重要意义。本文借鉴青岛农业大学烟草专业校院教育合作成功经验,结合种子科学专业应用型特色人才培养目标,从人才培养方案修订和优化、师资队伍建设、课程教材体系改革、人才培养实践基地建设、教育合作配套制度措施制定等方面构建校院教育合作种子科学专业人才培养新模式,并为培植好人才成长的沃土提出了一些建设性策略。

关键词：校院教育合作种子科学专业实践创新应用型特色人才培养模式

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应用型特色人才培养模式下研究生Seminar课程教学改革与实践——以青岛农业大学作物学研究生Seminar为例

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科教导刊 2020年第8期 49-50页

作者：李贺勤江绪文王月福罗小勇青岛农业大学山东青岛266109

本文以青岛农业大学为例,回顾了作物学研究生Seminar课程发展历程,并围绕新时代作物学研究生培养目标,从教学目标、教学内容、教学方法和手段、教学考核、课程教学团队建设等方面对该课程进行了探索,以期促进作物学研究生培养质量的有... 详细信息

本文以青岛农业大学为例,回顾了作物学研究生Seminar课程发展历程,并围绕新时代作物学研究生培养目标,从教学目标、教学内容、教学方法和手段、教学考核、课程教学团队建设等方面对该课程进行了探索,以期促进作物学研究生培养质量的有效提升,同时为应用型特色高层次人才培养课程改革提供参考。

关键词：应用型特色人才研究生Seminar 作物学教学改革

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Anomaly Detection for Multivariate Time Series Based on Contrastive Learning and Autoformer

Anomaly Detection for Multivariate Time Series Based on Cont...

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International Conference on Computer Supported Cooperative Work in Design

作者： xuwen Shang Jue Zhang Xingguo jiang Hong Luo Beijing Key Laboratory of Intelligent Telecommunication Software and Multimedia Beijing University of Posts and Telecommunications Beijing China Department of Computer Science and Engineering Beihang University Beijing China

ISBN: (数字)9798350349184

ISBN: (纸本)9798350349191

Nowadays, due to the increasingly complex and huge data flow, anomaly detection has become an important technology to ensure the high security and reliability of the systems. It helps identify unusual observations in the data, thereby protecting safety and reducing risk. However, in the field of multivariate temporal anomaly detection, there are still some difficulties in spatio-temporal correlation mining of variables, generalization ability in dealing with complex temporal sequences, and feature learning under different granularity. Therefore, we propose an unsupervised anomaly detection method for multivariate time series based on contrastive learning and Autoformer autoencoder. In order to fully explore the spatio-temporal correlation of time series data, this paper uses Graph Attention Network and Auto-Correlation to jointly learn spatio-temporal correlation, and obtain positive and negative pairs through time-domain and frequency-domain data augmentation. Finally, the Autoformer autoencoder is used for anomaly detection in a predictive manner. In the loss function section, a joint loss function is formed by introducing contrastive learning losses at the time step and time window granularity, combined with prediction loss, to improve the learning effect. This paper investigates the performance of the proposed method through experiments on the SMAP and MSL public datasets, and achieves better results than baseline methods.

关键词： Correlation Computational modeling Time series analysis Contrastive learning Computer architecture Stability analysis Safety

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