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27th International Conference on Computer Supported Cooperative Work in Design (CSCWD)

作者： Shang, xuwen Zhang, Jue jiang, Xingguo Luo, Hong Beijing Univ Posts & Telecommun Beijing Key Lab Intelligent Telecommun Software & Beijing Peoples R China Beihang Univ Dept Comp Sci & Engn Beijing Peoples R China

ISBN: (纸本)9798350349184;9798350349191

Nowadays, due to the increasingly complex and huge data flow, anomaly detection has become an important technology to ensure the high security and reliability of the systems. It helps identify unusual observations in the data, thereby protecting safety and reducing risk. However, in the field of multivariate temporal anomaly detection, there are still some difficulties in spatio-temporal correlation mining of variables, generalization ability in dealing with complex temporal sequences, and feature learning under different granularity. Therefore, we propose an unsupervised anomaly detection method for multivariate time series based on contrastive learning and Autoformer autoencoder. In order to fully explore the spatio-temporal correlation of time series data, this paper uses Graph Attention Network and Auto-Correlation to jointly learn spatio-temporal correlation, and obtain positive and negative pairs through time-domain and frequency-domain data augmentation. Finally, the Autoformer autoencoder is used for anomaly detection in a predictive manner. In the loss function section, a joint loss function is formed by introducing contrastive learning losses at the time step and time window granularity, combined with prediction loss, to improve the learning effect. This paper investigates the performance of the proposed method through experiments on the SMAP and MSL public datasets, and achieves better results than baseline methods.

关键词： anomaly detection multivariate time series contrastive learning autoformer spatio-temporal correlation

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Isothermal Stage Kinetics of Direct Coal Liquefaction for Shenhua Shendong Bituminous Coal

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ENERGY & FUELS 2015年第11期29卷 7526-7531页

作者： jiang, Hongbo Wang, Xiuhui Shan, Xiangen Li, Kejian Zhang, xuwen Cao, Xueping Weng, Huixin E China Univ Sci & Technol Res Inst Petr Proc Shanghai 200237 Peoples R China Natl Engn Lab Direct Coal Liquefact Shanghai 201108 Peoples R China

To study the direct coal liquefaction in the isothermal stage of Shenhua Shendong bituminous coal, the direct coal liquefaction with an iron-based catalyst was carried out in a 0.01 ton/day continuous tubular facility in the temperature range of 445-465 degrees C, with hydrogenated anthracene and wash oil as the solvent. An eight-lump kinetic model of the isothermal stage was proposed, and the kinetic parameters were estimated. The result showed that, in the isothermal stage, the oil was mainly obtained from pre-asphaltene and asphaltene (PAA) rather than from coal directly. The model was valid for the isothermal stage of direct coal liquefaction.

关键词： TEMPERATURE RANGE Mentoring Coal liquefaction absorbent oil kinetic model stream stage Kinetic parameters bituminous coal

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HPV vaccination strategy for 14-year-old females and economic returns for cervical cancer prevention in Wuxi City, China: a cost effectiveness analysis

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COST EFFECTIVENESS AND RESOURCE ALLOCATION 2024年第1期22卷 1页

作者： jiang, Jingfeng Zhao, Fanqi Hong, Xiang Wang, xuwen Nanjing Med Univ Wuxi Ctr Dis Control & Prevent Affiliated Wuxi Ctr Dis Control & Prevent Wuxi 214023 Peoples R China Southeast Univ Minist Educ Sch Publ Hlth Dept Epidemiol & Hlth StatKey Lab Environm Med & Nanjing Peoples R China

Background Since December 2021, Wuxi, China has offered a two-dose human papillomavirus (HPV) vaccination to 14-year-old females for free. This study evaluated the costs and benefits of this vaccination scheduled in the Expanded Program on Immunization in Wuxi from the perspective of the cities' demographic characteristics, economic development, and policy support. Methods The model-based economic evaluation used TreeAge Pro software to construct a decision tree-Markov model for the vaccination strategy in which 100,000 14-year-old females received two doses of bivalent HPV vaccine or no vaccination. Costs and effects of the strategy were assessed from a societal perspective through literature research and data obtained from the Wuxi Centre for Disease Control and Prevention. Univariate, multivariate, and probabilistic sensitivity analyses assessed the stability of the findings. Results The cost of the bivalent HPV vaccine in Wuxi is 711.3 CNY. The two-dose of bivalent HPV vaccine for 100,000 14-year-old females would cost an additional 658,016 CNY compared to no vaccination, but would result in 1,960 Quality Adjustment Years of Life (QALYs). Using the per capita gross domestic product of 187,415 CNY in 2021 in Wuxi as the willingness-to-pay threshold, the vaccination strategy costs 3,357.37 CNY per QALY gained, which is much lower than the threshold, suggesting that it is a very cost-effective strategy. In addition, the vaccine strategy reduced the incidence of cervical cancer by 300 cases and cervical cancer deaths by 181 cases, representing a benefit-cost ratio of 2.86 (> 1) when health output outcomes were measured in monetary terms. These results suggested that the vaccination strategy was advantageous. Sensitivity analyses showed that changes in the parameters did not affect the conclusions and that the findings were robust. Conclusions Compared to no vaccination, the delivery of two doses of bivalent HPV vaccine for 14-year-old females was a more highly cost-

关键词： Cost-effectiveness HPV Cervical cancer Vaccination

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Synthesis and bioactivity of thiazolidin-2-cyanamide derivatives against type III secretion system of Xanthomonas oryzae on rice

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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2018年第Jul.期149卷 89-97页

作者： Xiang, xuwen Tao, Hui jiang, Shan Zhang, Lian-Hui Cui, Zi-Ning South China Agr Univ State Key Lab Conservat & Utilizat Subtrop Agrobi Integrat Microbiol Res Ctr Guangdong Prov Key Lab Microbial Signals & Dis Co Guangzhou 510642 Guangdong Peoples R China Guizhou Univ Minist Educ Key Lab Green Pesticide & Agr Bioengn Guiyang 550025 Guizhou Peoples R China

Targeting virulence factors of bacterial without affecting their growth and survival, has been an initiative strategy for the development of novel anti-microbial agents. The type III secretion system (T3SS), one of essential and highly conserved virulence factors in most Gram-negative pathogenic bacteria, has been regarded as an effective target that developed new anti-microbial drugs. Xanthomonas oryzae pv. oryzae (Xoo) is one of the most Important bacterial pathogens on rice, which causes leaf blight disease. To discover potential anti-virulence agents against the pathogens, a new series of thiazolidin-2-cyanamide derivatives containing 5-phenyl-2-furan were designed and synthesized. Their structures were characterized by H-1 NMR, C-13 NMR, MS, and elemental analysis. All the title compounds inhibited the promoter activity of a harpin gene hpa1, significantly, that were further checked for the impact on bacterial growth and on the hypersensitive response (HR) caused by Xoo on non-host tobacco plants. The results indicated that treatment of Xoo with the title compounds II-2,II-3 and II-4 resulted in significantly attenuated HR without affecting bacterial growth or survival. Moreover, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis showed that the expression of the Xoo T3SS was suppressed by treatment with the three inhibitors. The mRNA levels of representative genes in the hrp (hypersensitive response and pathogenicity) cluster, as well as the regulatory genes hrpG and hrpX, were reduced. Finally, the in vivo test demonstrated that the compounds could reduce the disease symptoms of Xoo on the rice cultivar (Oryza sativa) IR24.

关键词： Xanthomonas oryzae pv. oryzae (Xoo) Type III secretion system (T3SS) Small molecule inhibitors Virulence factors Thiazolidin-2-cyanamide Synthesis

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Kinetics of naphthalene catalytic hydrogenation under high temperature and high pressure

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PETROLEUM SCIENCE AND TECHNOLOGY 2020年第3期38卷 266-270页

作者： Bie, Shiquan jiang, Hongbo Wang, Wei Shu, Geping Zhang, xuwen Wang, Hongxue Gao, Shansong East China Univ Sci & Technol Res Inst Petr Proc 130 Meilong Rd Shanghai Peoples R China East China Univ Sci & Technol Int Joint Res Ctr Green Energy Chem Engn Shanghai Peoples R China China Shenhua Coal Liquid & Chem Shanghai Res Ins Natl Engn Lab Direct Coal Liquefact Shanghai Peoples R China

The catalytic hydrogenation reaction of naphthalene was carried out on the Ni-Mo/Al2O3 catalyst by using a constant-temperature fixed-bed reactor with the temperature ranging from 315 degrees C to 400 degrees C and pressure ranging from 12 to 20 MPa. The model of naphthalene catalytic hydrogenation was proposed based on the Langmuir-Hinshelwood-Hougen-Watson competitive adsorption theory, and the model parameters were estimated. The results show that the hydrogenation reaction of naphthalene to tetralin is fast, and tetralin tends to form trans-decalin, while there is no direct conversion between trans-decalin and cis-decalin. The reaction activation energy of naphthalene to tetralin is the smallest.

关键词： Catalytic hydrogenation high temperature and high pressure kinetics naphthalene Ni-Mo Al2O3

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On-Orbit Geometric Calibration and Validation of Optical-1 HR 19

On-Orbit Geometric Calibration and Validation of Optical-1 H...

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19th National Symposium on Remote Sensing of China - Remote Sensing of the Environment

作者： jiang Yonghua Zhang Guo Huang Wenchao Qin xuwen Wuhan Univ Sch Remote Sensing & Informat Engn Wuhan 430079 Peoples R China Wuhan Univ State Key Lab Informat Engn Surveying Mapping & R Wuhan 430079 Peoples R China State Bur Surveying & Mapping Satellite Surveying & Mapping Applicat Ctr Beijing 100083 Peoples R China China Geol Survey Beijing 10037 Peoples R China

ISBN: (纸本)9781628418910

Owing to relatively simplistic domestic hardware technology and a lack of on-orbit geometric calibration, particularly interior calibration, the positioning accuracies of Optical-1 HR satellites can vary greatly depending on the presence of ground control points (GCPs). Without GCPs, accuracies are typically lower than 100 pixels, whereas when GCPs are plentiful, accuracy is higher than one pixel, demonstrating the potential for a large discrepancy between international optical satellites with the same image resolution. This study investigated a new method of geometric calibration for Optical-1 HR satellites. Experiments were conducted to demonstrate the positive effects on positioning accuracy achieved by the calibration method. After calibration by our method, a positioning accuracy of higher than one pixel was obtained with only a small number of GCPs, which is equivalent to the accuracy of advanced international optical satellites with the same image resolution.

关键词： Optical-1 HR geometric calibration offset matrix look angle image stitching

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Effect of hydrogenation of liquefied heavy oil on direct coal liquefaction

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FUEL 2017年 194卷 291-296页

作者： Shan Xiangen Shu Geping Li Kejian Zhang xuwen Wang Hongxue Cao Xueping jiang Hongbo Weng Huixin East China Univ Sci & Technol Res Inst Petr Proc Shanghai 200237 Peoples R China Natl Engn Lab Direct Coal Liquefact Shanghai 201108 Peoples R China

The effect of hydrotreatment of liquefied heavy oil on direct coal liquefaction (DCL) was studied by hydrogenating the liquefied heavy oil (initial boiling point greater than 320 degrees C) in a 30 ml continuous hydrogenation apparatus at operating conditions of pressure (P) 13-19 MPa, temperature (T) 360-400 degrees C, liquid space velocity (LHSV) 0.6-1.4 h(-1). After hydrogenation, the properties and hydrocarbon composition of liquefied heavy oil were regulated, leading to the enhancement of hydrogen donating ability and 5.6% increase in oil yield of DCL as compared with non-hydrogenated raw oil. Based on the results, a new method of preparing recycle solvent for direct coal liquefaction by mixing hydrogenated heavy oil and un-hydrogenated middle oil in a suitable proportion was proposed, which has been verified to be effective and efficient to increase oil yield. (C) 2017 Elsevier Ltd. All rights reserved.

关键词： Direct coal liquefaction Hydrogenation Liquefied product Hydrogenated oil Hydrogen-donating ability

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Identification of the Metabolites in Rat Urine after Oral Administration and Elucidation of the Metabolic Process of Naozhenning Granule Using LC-MS

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JOURNAL OF CHROMATOGRAPHIC SCIENCE 2020年第9期58卷 804-813页

作者： Li, Rongrong Liu, Yanzhi Liu, Haixia Wei, Chunhong Wang, jiang Qin, Xuemei Wang, xuwen Li, Zhenyu Shanxi Univ Modern Res Ctr Tradit Chinese Med Taiyuan 030006 Peoples R China Shanxi Zhendong Ante Biol Pharmaceut Co Ltd Jinzhong 030600 Peoples R China

Naozhenning (NZN) granule, a Chinese herbal formula, is widely used to treat craniocerebral trauma and promote functional recovery. In our previous study, the chemical components, as well as the serum metabolites in the male Sprague-Dawley rats of the NZN granule after oral administration were characterized. In this study, the urine metabolites in the male Sprague-Dawley rats were further investigated by ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-Orbitrap high-resolution accurate mass spectrometry. In order to identify the urine metabolites comprehensively, three sample preparation methods were used, including solid-phase extraction, protein precipitation method and solvent partition. Based on the accurate molecular weight and the fragmentation information from the MS spectra, a total of 76 urine metabolites were identified, which including 17 prototypes and 59 metabolites. The results showed that the detected urine metabolites were different for the different pretreatment methods, as some metabolites could only be detected in the particular pretreatment method. In addition, the metabolic processes of the components from NZN granule to the serum and urine were also elucidated and discussed. The results will provide useful information for further studying the relationship between the chemical components and pharmacological activity of NZN granule.

关键词： Metabolites

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Regulation of Mammalian Target of Rapamycin Complex 1 by Bcl-2 and Bcl-X_L Proteins

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JOURNAL OF BIOLOGICAL CHEMISTRY 2013年第40期288卷 28824-28830页

作者： Zou, Huafei Lai, Yumei Zhao, xuwen Yan, Gonghong Ma, Dongzhu Cardenes, Nayra Shiva, Sruti Liu, Yongjian Bai, Xiaochun jiang, Yong jiang, Yu Univ Pittsburgh Sch Med Dept Pharmacol & Chem Biol Pittsburgh PA 15261 USA Univ Pittsburgh Sch Med Vasc Med Inst Pittsburgh PA 15261 USA Southern Med Univ Dept Pathol Sch Basic Med Sci Guangzhou 510515 Guangdong Peoples R China Southern Med Univ Dept Cell Biol Sch Basic Med Sci Guangzhou 510515 Guangdong Peoples R China

Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell growth and metabolism. Its activity is controlled by various types of signals, including growth factors, nutrients, and stresses. In this study, we show that changes in expression levels of two antiapoptotic proteins, Bcl-2 and Bcl-X-L, also affect mTORC1 signaling activity. In cells overexpressing Bcl-X-L, mTORC1 activity is increased and becomes less sensitive to growth factor or nutrient conditions. In contrast, reduction in expression levels of the two antiapoptotic proteins inhibits mTORC1 signaling activity. Our results suggest that the effect of Bcl-2 and Bcl-X-L on mTORC1 is mediated by FKBP38, an inhibitor of mTORC1. The two proteins compete with mTORC1 for FKBP38 binding and hence alter mTORC1 activity. This study reveals a novel cross-talk between Bcl-2/X-L and mTORC1 signaling, which is likely to contribute to cancer development.

关键词： Bcl-2 Mitochondria mTOR Complex (mTORC) S6 Kinase Signaling Bcl-XL FKBP38 mTORC1

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Parameters Optimization Method for ADRC of Permanent Magnet Synchronous Motor Based on CMA-ES 43

Parameters Optimization Method for ADRC of Permanent Magnet ...

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43rd Chinese Control Conference (CCC)

作者： jiang, Tianjian Yang, Yang Li, Zhiyuan Yang, Tianqi Chen, xuwen Nanjing Univ Posts & Telecommun Coll Automat Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun Coll Aritif Intelligence Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun Coll Internet Things Nanjing 210023 Peoples R China

ISBN: (纸本)9798350366907;9789887581581

Active disturbance rejection control (ADRC) is widely used to control permanent magnet synchronous motors (PMSM). However, the settings of gain parameters in ADRC is often dependent on engineers' experience. Also, it is difficult to design the parameters accurately by hand to achieve satisfactory results. A method based on evolution strategy with covariance matrix adaptation (CMA-ES) for optimizing the gain parameters of ADRC is proposed. By setting up some optimization tasks and using the CMA-ES algorithm, reinforcement learning is performed on the parameters of ADRC. In view of the high population size and complexity of CMA-ES, we adopt a parallel computation method to speed up the optimization process. The method can effectively optimize the ADRC gain parameters to adapt to the specified application environment, and at the same time reduce the dependence of setting ADRC parameters on human experience as well as time consumption. Finally, we verify that this CMA-ES-based parameter optimization method can effectively improve the control performance of the motor by running simulations and comparing the motor speed changes before and after optimization.

关键词： Permanent-magnet Synchronous Motor Active Disturbance Rejection Control Field-oriented Control Swarm Optimization High Throughput Computing Modern Control

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