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2022 International Conference on Wireless Communications, Electrical Engineering and Automation, WCEEA 2022

作者： Xu, Zhi Gao, Xingqu Song, Zhongquan Tian, xuwen jiang, Xiaohan Harbin Far Eastinstitute of Technology Harbin China Northeast Forestry University Engineering Consulting and Design Institute Harbin China

ISBN: (数字)9781665459525

ISBN: (纸本)9781665459525

In the traditional project cost management, due to the influence of many factors, its calculation accuracy is not high enough, which brings great difficulties to the construction project cost management. Using BIM technology to build a cost management model can provide very intuitive analysis results for cost managers, thus providing strong technical support for cost management of construction projects. This paper analyzes the application of BIM technology in construction cost management. © 2022 IEEE.

关键词： Cost engineering

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Synthesis and biological evaluation of 1,3,4-thiadiazole derivatives as type III secretion system inhibitors against Xanthomonas oryzae

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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2019年 160卷 87-94页

作者： Tao, Hui Tian, Hao jiang, Shan Xiang, xuwen Lin, Yinuo Ahmed, Wasim Tang, Riyuan Cui, Zi-Ning South China Agr Univ Guangdong Prov Key Lab Microbial Signals & Dis Co Integrat Microbiol Res Ctr State Key Lab Conservat & Utilizat Subtrop Agrobi Guangzhou 510642 Guangdong Peoples R China South China Agr Univ Coll Mat & Energy Dept Appl Chem Guangzhou 510642 Guangdong Peoples R China

Xanthomonas oryzae pv. oryzae (Xoo) infection directly leads to a severe disease known as leaf blight, which is a major cause of yield loss of rice. Use of traditional bactericides has resulted in severe resistance in pathogenic bacteria. A new approach screening compounds that target the virulence factors rather than killing bacterial pathogens is imperative. In gram-negative bacteria, the type III secretion system (T3SS) is a conserved and significant virulence factor considered as a target for drug development. Therefore, we designed and synthesized a new series of 5-phenyl-2-furan carboxylic acid derivatives stitched with 2-mercapto-1,3,4-thiadiazole. Bioassays revealed that the title candidates attenuated the hypersensitive response through suppressing the promoter activity of a harpin gene hpa1 without affecting bacterial growth. Quantitative real time polymerase chain reaction (qRT-PCR) analysis demonstrated reduced the expression of several genes associated with T3SS, when title compounds were applied. Additionally, hrp gene cluster members, including hrpG and hrpX, had reduced mRNA levels. In vivo greenhouse tests showed that candidate compounds could alleviate the effects of Xoo infection in rice (Oryza sativa) and possess better protective activity against rice bacterial leaf blight than bismerthiazol and thiodiazole copper. All tested compounds were safe to rice. This work suggests there are new safe options for Xoo control in rice from these 1,3,4-thiadiazole derivatives.

关键词： 2-mercapto-1,3,4-thiadiazole Inhibitors Type III secretion system (T3SS) Anti-virulence factors Xanthomonas oryzae pv. oryzae (Xoo)

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Metabolic Nanoregulators Induce Ferroptosis and Change Metabolite Flow to Reverse Immunosuppressive Tumor Microenvironment

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ACS NANO 2024年第51期18卷 34996-35012页

作者： Wang, Yu Chen, Qinjun Luo, Yifan Qu, Yangqi Li, xuwen Song, Haolin Li, Chufeng Zhang, Yiwen Sun, Tao jiang, Chen Fudan Univ Key Lab Smart Drug Delivery State Key Lab Med Neurobiol Dept PharmaceutSch PharmInst Brain SciMinist Ed Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Aberrant energy and substance metabolic pathways of tumor cells critically support tumor cell proliferation by hijacking the resources from nonmalignant cells, thereby establishing a metabolite flow favorable to tumor progression. This metabolic adaptation of tumor cells further modulates the immune landscape, ultimately creating a tumor microenvironment characterized by drug resistance and immunosuppression. The synergistic regulation of energy and substance metabolic pathways might be a good antitumor therapeutic paradigm. However, due to the metabolic convergence, it is crucial to selectively modulate the aberrant metabolism of tumor cells without compromising the functionality of other cells. Small-molecule drugs have the ability to target a wide range of biomolecules for antitumor therapy, but their application is limited by undesirable toxicities. Constructing nanodrug delivery systems can improve their properties and allow for the inclusion of multiple drugs, thereby exerting synergistic antitumor effects. In this study, we developed a two-drug codelivery system using drugs-conjugated multibranched polymers to modulate tumor cell metabolism by exploiting synthetic lethal pathways for safe and effective antitumor therapy. By delivery of adapalene and erastin simultaneously through nanoparticles, the material and energy metabolism of tumor cells can be regulated. This nanoparticle construction achieves tumor tissue targeting and responsive drug release, alters metabolite flow within tumor cells, and effectively kills tumor cells. Additionally, the nanoparticles can reverse the tumor immunosuppressive microenvironment, starting from single-cell regulation to whole-lesion control.

关键词： metabolic nanoregulators metabolite flow ferroptosis immunosuppression multibranched polymers

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Paecilomyces variotii extracts (ZNC) enhance plant immunity and promote plant growth

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PLANT AND SOIL 2019年第1-2期441卷 383-397页

作者： Lu, Chongchong Liu, Haifeng jiang, Depeng Wang, Lulu jiang, Yanke Tang, Shuya Hou, xuwen Han, Xinyi Liu, Zhiguang Zhang, Min Chu, Zhaohui Ding, Xinhua Shandong Agr Univ State Key Lab Crop Biol Shandong Prov Key Lab Biol Vegetable Dis & Insect Tai An 271018 Shandong Peoples R China Shandong Pengbo Biotechnol Co LTD Tai An 271018 Shandong Peoples R China Shandong Agr Univ Natl Engn Lab Efficient Utilizat Soil & Fertilize Coll Recourses & Environm Tai An 271018 Shandong Peoples R China

Background and aims The crude extract of the endophyte Paecilomyces variotii known as ZhiNengCong (ZNC) has function of promoting plant growth and enhancing disease resistance and is widely used in China. Our study aims to evaluate the molecular mechanisms of plant growth promotion and disease protection. Methods We generated transcriptome profiles from ZNC-treated seedlings using RNA sequencing. The function of salicylic acid (SA) in ZNC-mediated immunity was examined using SA biosynthesis and signaling pathway mutants. The concentrations of nitrogen (N) and phosphorus (P) in seedlings under ZNC treatment were measured. The effect of ZNC on the level of the hormone auxin in roots was tested using transgenic plants containing DR5::GFP. Results ZNC exhibited ultrahigh activity in promoting plant growth and enhancing disease resistance, even at concentrations as low as 1-10 ng/ml. ZNC induced ROS accumulation, callose deposition, and expression of PR genes. SA biosynthesis and signaling pathways were required for the ZNC-mediated defense response. Moreover, in improving plant growth, ZNC increased the level of auxin in root tips and regulated the absorption of N and P. Conclusion According to these results, ZNC is a highly effective plant elicitor that promotes plant growth by inducing auxin accumulation at the root tip at low concentrations and enhances plant disease resistance by activating the SA signaling pathway at high concentrations.

关键词： Plant elicitors Plant growth promotion Plant endophyte Disease resistance Auxin Salicylic acid

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Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

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CANCER NANOTECHNOLOGY 2022年第1期13卷 1-18页

作者： Yao, Hua Mu, Xupeng Wei, Zhenhong Li, Xiuying Wu, Liya Jin, Yongri Li, xuwen Li, Jing jiang, Jinlan Jilin Univ Sci Res Ctr China Japan Union Hosp Changchun 130033 Peoples R China Jilin Univ Coll Chem Changchun 130021 Peoples R China

Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and facile synthesis methods combining with pharmacoactive natural components have been investigated to construct safe and multifunctional bioactive Au nanoparticles (NPs). Ginsenoside Rh-2 is protopanaxadiol type compound isolated from plants of genus Panax, with excellent anticancer effect and antioxidant activity. In this research, we prepared the novel Au nanoparticles using ginsenoside Rh-2 as both reducing and stabilizing agents. Results The synthesized Au@ginsenoside Rh-2 NPs were proved to exhibit desirable inhibitory effect on different cancer cell lines, which benefited from the inherent anticancer effect of the ginsenoside Rh-2. Investigations in vitro indicated that Au@ginsenoside Rh-2 NPs inhibited cell proliferation, cell migration and invasion, induced cell cycle arrest, enhanced the reactive oxygen species (ROS) generation, and regulated the protein expressions of caspase-3, 8, 9 to trigger cell apoptosis as well. Conclusions Because of the absence of toxic chemical surfactants, the eco-friendly synthesis method of Au NPs modified by natural phytochemicals avoided tedious separation and modification processes. On the other hand, Au@ginsenoside Rh-2 NPs also improved water solubility and bioavailability of the hydrophobic drug ginsenoside Rh-2. It broadened minds for preparation and application of traditional Chinese medicines (TCMs) modified metal nanoparticles and deserved further study.

关键词： Ginsenoside Rh-2 Au nanoparticles Drug-modified nanocomposite Facile synthesis Anticancer activity

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Determination of IgG by electron spin resonance spectroscopy using Fe₃O₄ nanoparticles as probe

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MICROCHEMICAL JOURNAL 2018年 141卷 444-450页

作者： Tian, Sizhu jiang, Jia Zang, Shuang Wang, Kun Yu, Yong Li, xuwen Zhang, Hanqi Yu, Aimin Zhang, Ziwei Jilin Univ Coll Chem Qianjin St 2699 Changchun 130012 Jilin Peoples R China Jilin Univ Coll Instrumentat & Elect Engn West Minzhu St 938 Changchun 130061 Jilin Peoples R China

A novel electron spin resonance (ESR) spectroscopy method for determination of rabbit IgG was presented. Anti rabbit IgG antibody was bound to Fe3O4 nanoparticles (FeNPs). The FeNPs were used as probe to give ESR signal. After the optimization of the assay, a molar ratio 500:1 of antibody to FeNPs was selected. The sepharose beads were used as solid phase and used to separate the analyte from the sample solution. Two typical immunoassay formats, sandwich and competitive formats, were applied to the determination of IgG. The analytical sensitivities obtained by sandwich and competitive formats were 0.13 mu g mL(-1) and 0.56 mu g mL(-1), respectively. The two formats were applied to the determination of the rabbit IgG in rabbit serum. The diluted sample was directly analyzed and other additional sample treatment was not required. The analytical results of the spiked samples indicated that the recoveries of the analytes were acceptable. Furthermore, the sample preparation time used in this method is shorter than most existing immunoassay methods.

关键词： Electron spin resonance Sandwich Competitive Fe3O4 nanoparticles Sepharose beads Rabbit serum

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Histopathological analysis and the immune related gene expression profiles of mandarin fish (Siniperca chuatsi) infected with Aeromonas hydrophila

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FISH & SHELLFISH IMMUNOLOGY 2018年 83卷 410-415页

作者： Chen, Nan jiang, Jingjing Gao, Xiaojian Li, Xixi Zhang, Yue Liu, Xiaodan Yang, Hui Bing, xuwen Zhang, Xiaojun Yangzhou Univ Coll Anim Sci & Technol Yangzhou 225009 Jiangsu Peoples R China Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Key Lab Freshwater Fisheries & Germplasm Utilizat Minist Agr Wuxi 214081 Peoples R China

Hemorrhagic septicemia of mandarin fish (Siniperca chuatsi) was mainly caused by Aeromonas hydrophila which was an opportunistic pathogen. In recent years, the disease has caused tremendous economic loss with high morbidity and mass mortality in the mandarin fish breeding industry. Histopathological analysis and the immune related gene expression profiles of mandarin fish (S. chuatsi) infected with A. hydrophila were investigated in this study. Transmission electron microscopy (TEM) images showed that the cells of A. hydrophila densely covered with a mass of fimbriae. Histopathological analysis revealed that inflammation, vacuolization and extensive necrosis existed in the gill, liver, spleen and head kidney of the diseased fish. Quantitative real-time PCR was performed to measure mRNA expression levels for six immune related genes in mandarin fish after A. hydrophila infection. The transcriptional analysis of these immune related genes demonstrated that the expression levels of major histocompatibility complex class II (MHC II), T cell receptor alpha (TCR alpha), tumor necrosis factor alpha (TNF alpha), CC chemokine 3, interleukin 8 (IL-8) and Hepcidin were strongly up-regulated in spleen and head kidney of mandarin fish post-infection. These results will contribute to further study on the pathogenesis and host defensive system in A. hydrophila infection.

关键词： Mandarin fish Aeromonas hydrophila Histopathology Immune related genes

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Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead

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ADVANCED MATERIALS 2024年第11期36卷 2309582-2309582页

作者： Li, xuwen Sun, Tao jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Minist EducKey Lab Smart Drug Delivery Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Cancer metabolism plays multifaceted roles in the initiation and progression of tumors, and interventions in metabolism are considered fundamental approaches for cancer control. Within the vast metabolic networks of tumors, there exist numerous potential therapeutic targets, intricately interconnected with each other and with signaling networks related to immunity, metastasis, drug resistance, and more. Based on the characteristics of the tumor microenvironment, constructing drug delivery systems for multi-level modulation of the tumor microenvironment is proven as an effective strategy for achieving multidimensional control of cancer. Consequently, this article summarizes several features of tumor metabolism to provide insights into recent advancements in intelligent drug delivery systems for achieving multi-level regulation of the metabolic microenvironment in cancer, with the aim of offering a novel paradigm for cancer treatment. Latest advancements in intelligent drug delivery systems (DDS) exhibit distinctive advantages, including precise sensing, programmability, feedback control, and intrinsic activity. These attributes render them conducive to facilitating multi-dimensional therapeutic approaches grounded in metabolic ***

关键词： intelligent delivery systems metabolism regulation nanomedicine tumor metabolism

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Development and validation of a predictive model for metabolic syndrome in a large cohort of people living with HIV

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VIROLOGY JOURNAL 2024年第1期21卷 1-12页

作者： Chen, Suling Xu, Yuyuan jiang, Yuanhui Chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun Peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Minist Educ Key Lab Infect Dis Res South China Guangzhou Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

BackgroundThe global prevalence of metabolic syndrome (MetS) in people living with HIV (PLWH) is on the rise in the post era of antiretroviral therapy (ART). Nevertheless, there are no validated predictive models available for assessing the risk of MetS in this specific *** study included PLWH who participated in annual follow-ups at Southern Medical University Nanfang Hospital from September 2022 to November 2023. Participants enrolled in this study were divided into the training set and validation set based on the follow-up duration. We employed both multivariate logistic regression and lasso regression to develop three distinct prediction models. Subsequently, the optimal model was determined through comprehensive analyses, including receiver operating characteristic (ROC) curve analysis, calibration curve, and decision curve analysis (DCA). Ultimately, we generated a nomogram for the optimal model and analyzed the correlation between the model score and the components of *** total of 1017 participants were included in this study, with 814 in the training set and 203 in the validation set. The ultimate prediction model of MetS risk in PLWH incorporated five factors: age, CD8 + T cell counts, controlled attenuation parameter (CAP), gamma-glutamyl transferase (gamma-GT) and lactate dehydrogenase (LDH). The area under the ROC curve (AUC) of the model in the training set and validation set was 0.849 and 0.834, respectively. Furthermore, we revealed a significant correlation between the model score and the MetS components. Additionally, the model score revealed significant group differences in MetS and related metabolic *** study established a potential model for predicting MetS in PLWH.

关键词： HIV/AIDS Metabolic syndrome Clinical prediction model Nomogram Clinical endocrinology

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Improvement of the mechanical properties of single-walled carbon nanotube networks by carbon plasma coatings

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CARBON 2013年 53卷 50-61页

作者： Kaskela, Antti Koskinen, Jari jiang, Hua Tian, Ying Liu, xuwen Susi, Toma Kaukonen, Markus Nasibulin, Albert G. Kauppinen, Esko I. Aalto Univ Dept Appl Phys NanoMat Grp Espoo 00076 Finland Aalto Univ Ctr New Mat Espoo 00076 Finland Aalto Univ Dept Mat Sci & Engn Espoo 00076 Finland

Carbon vacuum arc was used to deposit 5-25 nm thick carbon coatings on single-walled carbon nanotube (SWCNT) networks. The SWCNT bundles thus embedded in conformal coatings maintained their optical transparency and electrical conductivity. Sheet resistances of the networks were measured during the vacuum arc deposition, revealing initially a 100-fold increase, followed by significant recovery after exposing the samples to an ambient atmosphere. Nanoindentation measurements revealed improved elasticity of the network after applying the carbon coating. Pristine SWCNT networks were easily deformed permanently, but a 20 nm carbon coating strengthened the nanostructure, resulting in a fully elastic recovery from a 20 mu N load applied with a Berkovich tip. In nano-wear tests on selected areas, the coated SWCNT maintained its networking integrity after two passes raster scan at loads up to 25 mu N. On the other hand, the pristine networks were badly damaged under a 10 mu N scan load and completely displaced under 25 mu N. Raman and electron energy loss spectroscopies indicated the carbon coating on bundles to be mainly sp(2) bonded. Finite element modeling suggests that the low content of sp(3) bonds may be due to heating by the intense ion flux during the plasma pulse. (C) 2012 Elsevier Ltd. All rights reserved.

关键词： SURFACE coatings MATERIALS -- Mechanical properties PLASMA (Ionized gases) VACUUM arcs CONFORMAL coatings ELECTRIC conductivity

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