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Efficient Moiré pattern removal with lightweight multi-scale feature extraction

JOURNAL OF ELECTRONIC IMAGING 2024年第2期33卷 023050-023050页

作者： li, xuwen Gan, Min Su, JianNan Chen, GuangYong Fuzhou Univ Coll Comp & Data Sci Fuzhou Peoples R China

In recent years, convolutional neural networks have excelled in image Moir & eacute;pattern removal, yet their high memory consumption poses challenges for resource-constrained devices. To address this, we propose the lightweight multi-scale network (LMSNet). Designing lightweight multi-scale feature extraction blocks and efficient adaptive channel fusion modules, we extend the receptive field of feature extraction and introduce lightweight convolutional decomposition. LMSNet achieves a balance between parameter numbers and reconstruction performance. Extensive experiments demonstrate that our LMSNet, with 0.77 million parameters, achieves Moir & eacute;pattern removal performance comparable to full high definition demoir & eacute;ing network (FHDe(2)Net) with 13.57 million parameters.

关键词： image demoir & eacute ing lightweight network information multi-distillation image restoration multi-scale feature extraction and fusion

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Solid-state electrochemiluminescence sensor based on TiO2@CdSe and Ru (bpy)32+@Ag NPs for ultrasensitive detection of malathion

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FOOD CHEMISTRY 2025年 470卷 142726页

作者： li, Huiling Tian, li Yang, Shuning li, Chao li, Ruidan Song, Yujia Guo, Yanjia li, xuwen Changchun Normal Univ Coll chem Changchun 130032 Peoples R China Jilin Univ Coll Chem Changchun 130012 Peoples R China

To sensitively monitor trace-level of malathion (MAT) in vegetable samples, an ultrasensitive solid-state electrochemiluminescence (ECL) sensor was proposed based on TiO2@CdSe and Ru(bpy)32+@Ag NPs. In this system, the introduction of Ag NPs enhanced the initial ECL signal of Ru(bpy)32+- tripropylamine (TPrA). When TiO2@CdSe was introduced into the system, the ECL signal was further enhanced, which may be due to the synergistic effect of the two complexes. Based on the fact that the addition of MAT causes ECL strength to decrease, a ECL sensor for the ultrasensitive trace detection of MAT has been successfully established. Under the optimized conditions, a wide liner detection range of MAT concentrations from 4.0 x 10- 14 to 4.0 x 10- 9 mol L- 1 and a low detection limit (S/N = 3) of 1.3 x 10-14 mol L- 1 were obtained. The ECL sensor has been applied to the detection of vegetable samples and satisfactory results were obtained.

关键词： Malathion Ru(bpy)32+ CdSe Electrochemiluminescence

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Yonarolide A, an unprecedented furanobutenolide-containing norcembranoid derivative formed by photoinduced intramolecular[2+2] cycloaddition

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Chinese Chemical Letters 2023年第2期34卷 420-424页

作者： Yeqing Du ligong Yao xuwen li Yuewei Guo School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery Shandong Laboratory Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Eight polycyclic furanobutenolide-containing norcembrane diterpenoids featuring C19 frameworks(1–8)were rapidly recognized and isolated from the Hainan soft coral Sinularia sp. by the HSQC-based small molecule accurate recognition technology. Yonarolide A(1a), featuring an unprecedented 5/6/4/4/7 pentacyclic ring skeleton, was surprisingly obtained as a transformed product by leaving compound 1 under indoor natural light, and was further proved to be a [2 + 2] cycloaddition product of 1 by photochemical reaction. The absolute stereochemistry of 1a and the three known norcembrane diterpenoids 1, 4, and7 were determined by using X-ray diffraction(XRD) analyses. Further, with the aid of XRD analysis, the structure of scabrolide B(2), which was previously reported of possessing 5/6/7 tricyclic skeleton, was firmly revised as 2a with the rare inelegane skeleton featured by the highly oxygenated 5/7/6 tricyclic carbocycle.

关键词： Soft coral Sinularia Norcembranoid Photocycloaddition SMART method

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Solid-state electrochemiluminescence sensor based on g-C3N4@ZIF-8 for ultrasensitive and specific detection of sulfapyridine

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MICROCHEMICAL JOURNAL 2025年 211卷

作者： li, Chao Lu, Juan Guo, Yanjia Wang, Jing Song, Yujia li, Ruidan Tian, li li, xuwen Changchun Normal Univ Coll chem Changchun 130032 Peoples R China Jilin Univ Coll Chem Changchun 130022 Peoples R China Technol Innovat Lab Res & Dev Econ Plants & Edible Changchun 130032 Peoples R China

In this study, a solid-state electrochemiluminescence (ECL) sensor was developed for ultrasensitive and specific detection of sulfapyridine (SPY) using graphitic carbon nitride (g-C3N4) as a luminescent reagent. The sensor was fabricated by sequentially coating composite material g-C3N4@ZIF-8 and Nafion onto the electrode surface. The g-C3N4, synthesized through high-temperature pyrolysis of melamine, generated a sensitive ECL signal in K2S2O8 solution. And g-C3N4 served as a carrier for ZIF-8, with the latter acting as a co-reaction promoter within the g-C3N4-K2S2O8 system, leading to a significant enhancement of the ECL signal. Additionally, molecularly imprinted polymers (MIPs) with SPY were introduced to further enhance the performance of the sensor by specifically recognizing SPY. Under optimal conditions, the prepared ECL sensor showed sensitive measurement of SPY in the linear range of 5.0 x 10(-13) similar to 5.0 x 10(-8) mol/L, with a detection limit (LOD) of 1.67 x 10(-13) (S/N = 3). The developed MIP-ECL sensor demonstrated good stability, high sensitivity, and reliable reproducibility, thus making it suitable for detecting SPY in real samples.

关键词： Electrochemiluminescence ZIF-8 Molecularly imprinted polymers Sulfapyridine g-C3N4

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Intra-articular injection of vancomycin after arthrotomy closure following gentamicin-impregnated bone cementation in primary total knee arthroplasty provides a high intra-articular concentration while avoiding systemic toxicity: a prospective study

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JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 2024年第1期19卷 1-9页

作者： li, xuwen Lai, Junhao Yang, Xue Xu, Hao Xiang, Shuai Qingdao Univ Affiliated Hosp Dept Traumatol Qingdao Shandong Peoples R China Qingdao Univ Affiliated Hosp Dept Joint Surg Qingdao 266000 Shandong Peoples R China Qingdao Univ Affiliated Hosp Operat Room Qingdao Shandong Peoples R China

BackgroundThis study aimed to elucidate the safety and intra-articular elution profiles of vancomycin and gentamicin bone cement in patients undergoing primary total knee arthroplasty (TKA), with a focus on serum safety thresholds and therapeutic *** patients who underwent unilateral primary TKA were prospectively enrolled. The implants were fixed using gentamicin-impregnated bone cement, and after arthrotomy closure, 1000 mg of vancomycin suspended in 25 mL of normal saline was directly injected into the joint. Peripheral venous blood and drain fluid samples were collected 2, 8, and 24 h postoperatively. The serum and intra-articular concentrations of vancomycin and gentamicin were analyzed using liquid chromatography-tandem mass spectrometry within 24 *** data reflecting renal and liver function were recorded preoperatively, and at 24 and 72 h postoperatively. A total of 100 patients were included. At 2, 8, and 24 h postoperatively, the serum vancomycin concentration was 7.0 +/- 2.0, 5.7 +/- 1.8, and 3.6 +/- 1.4 mu g/mL, respectively, while the intra-articular concentration was 468.5 (interquartile range [IQR] 286.0 to 774.8), 139.5 (IQR 52.0 to 295.3), and 34.4 (IQR 22.2 to 56.8) mu g/mL, respectively;33.2 (IQR 19.5 to 80.5) mg vancomycin was lost in drainage fluid at 24 h postoperatively. For gentamicin, the overall intra-articular concentration was 70.4 (IQR 35.4 to 109.2), 33.8 (IQR 17.8 to 73.9), and 21.1 (IQR 12.2 to 36.0) mu g/mL at 2, 8, and 24 h postoperatively, respectively, with an undetectable serum concentration. No cases of acute renal injury, liver injury, ototoxicity, or anaphylaxis were ***-articular injection of 1000 mg vancomycin after arthrotomy closure combined with gentamicin-impregnated bone cement provided a therapeutic intra-articular concentration while avoiding systemic toxicity over the initial 24 h after primary TKA. Therefore, intra-articular vancomycin administration may off

关键词： Vancomycin Gentamicin Total knee arthroplasty

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The biologically and ecologically important natural products from the Chinese sea hare Bursatella leachii:structures,stereochemistry and beyond

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Chinese Journal of Natural Medicines 2024年第11期22卷 1030-1039页

作者： ZHANG Xinyuan SU Mingzhi ZHU Mingxin CHEN Sha GAO Zhen GUO Yuewei li xuwen School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

A novel amide alkaloid,bursatamide A(1),featuring an unprecedented propyl-hexahydronaphthalene carbon frame-work,was isolated from the infrequently studied sea hare Bursatella leachi,alongside a new 3-phenoxypropanenitrile alkaloid,bursatellin B(2),and twelve known *** structures of 1 and 2 were elucidated through comprehensive spectroscopic data analyses,while their relative and absolute configurations(ACs)were established through total synthesis and a series of quantum chem-ical calculations,including calculated electronic circular dichroism(ECD)spectra,optical rotatory dispersion(ORD)methods,and DP4^(+) probability *** A(1)demonstrated inhibitory effects against the human pathogenic bacteria listeria monocyt-ogenes and Vibrio ***-bursatellin B(21),a diastereoisomer of 2,exhibited notable antibacterial activity against the fish pathogenic bacterium Streptococcus parauberis FP KSP28,with an MIC90 value of 0.0472 μg·mL^(-1).

关键词： Bursatella leachii Marine natural product Alkaloid Sea hare Antibacterial activity

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Manganese-based virus-mimicking nanomedicine with triple immunomodulatory functions inhibits breast cancer brain metastasis

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BIOMATERIALS 2025年 320卷 123262-123262页

作者： Zhao, Zhenhao Zhou, Jingyi li, xuwen Zhang, Tongyu Tian, Zonghua Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Minist EducKey Lab Smart Drug DeliveryState Key Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Hindered by the challenges of blood-brain barrier (BBB) hindrance, tumor heterogeneity and immunosuppressive microenvironment, patients with breast cancer brain metastasis have yet to benefit from current clinical treatments, experiencing instead a decline in quality of life due to radiochemotherapy. While virus-mimicking nanosystems (VMN) mimicking viral infection processes show promise in treating peripheral tumors, the inability to modulate the immunosuppressive microenvironment limits the efficacy against brain metastasis. Accordingly, a VMN-based triple immunomodulatory strategy is initially proposed, aiming to activate innate and adaptive immune responses and reverse the immunosuppressive microenvironment. Here, manganese-based virus-mimicking nanomedicine (Vir-HD@HM) with intratumoral drug enrichment is engineered. Vir-HD@HM can induce the immune response through the activation of cGAS-STING by mimicking the in vivo infection process of herpesviruses. Meanwhile, DNAzyme mimicking the genome can rescue the epigenetic silencing of PTEN with the assistance of Mn2+, thus ameliorating the immunosuppressive metastatic microenvironment and achieving synergistic sensitizing therapeutic efficacy. In vivo experiments substantiate the efficacy of VirHD@HM in recruiting NK cells and CD8+ T cells to metastatic foci, inhibiting Treg cells infiltration, and prolonging murine survival without adjunctive radiochemotherapy. This study demonstrates that Vir-HD@HM with triple immunomodulation offers an encouraging therapeutic option for patients with brain metastasis.

关键词： Breast cancer brain metastasis Virus-mimicking nanosystem Immune activation Immunosuppressive microenvironment regulation PTEN cGAS-STING

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A Review of Visual Estimation Research on live Pig Weight

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SENSORS 2024年第21期24卷 7093页

作者： Wang, Zhaoyang li, Qifeng Yu, Qinyang Qian, Wentai Gao, Ronghua Wang, Rong Wu, Tonghui li, xuwen China Agr Univ Coll Informat & Elect Engn Beijing 100083 Peoples R China Beijing Acad Agr & Forestry Sci Res Ctr Informat Technol Beijing 100097 Peoples R China Huazhong Agr Univ Coll Informat Wuhan 430070 Peoples R China Shanxi Agr Univ Coll Agr Engn Jinzhong 030801 Peoples R China Tianjin Agr Univ Coll Comp & Informat Engn Tianjin 300384 Peoples R China

The weight of live pigs is directly related to their health, nutrition management, disease prevention and control, and the overall economic benefits to livestock enterprises. Direct weighing can induce stress responses in pigs, leading to decreased productivity. Therefore, modern livestock industries are increasingly turning to non-contact techniques for estimating pig weight, such as automated monitoring systems based on computer vision. These technologies provide continuous, real-time weight-monitoring data without disrupting the pigs' normal activities or causing stress, thereby enhancing breeding efficiency and management levels. Two methods of pig weight estimation based on image and point cloud data are comprehensively analyzed in this paper. We first analyze the advantages and disadvantages of the two methods and then discuss the main problems and challenges in the field of pig weight estimation technology. Finally, we predict the key research areas and development directions in the future.

关键词： weight estimation non-contact computer vision image analysis point cloud stereoscopic vision

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Study on the influence of methanol on the precursor of soot and particulate matter of diesel engine fueled with F-T diesel

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ENERGY SOURCES PART A-RECOVERY UTIliZATION AND ENVIRONMENTAL EFFECTS 2025年第1期47卷 11891-11910页

作者： li, Ruina liu, Qingcheng Yang, Dahai Zhu, Jialong li, xuwen Yue, Hua Meng, Yang Jiangsu Univ Sch Automot & Traff Engn 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China Zhejiang Constant Power Machinery Co Ltd CST Res Inst Shaoxing Zhejiang Peoples R China

Methanol is a high-quality alternative fuel for diesel engines and mainly used for methanol intake injection (MII) and methanol mixing direct injection (MMDI) modes. The methanol injection mode influences the formation of soot precursors and particulate matter (PM). This paper carried out a methanol/F-T diesel engine bench test at 2400 r/min, 100% load with two methanol injection modes. And the effects of methanol injection mode on the soot precursor were investigated by establishing an in-cylinder working process simulation. Research has shown that when the methanol blending ratio is 30%, the smoke emissions of MMDI and MII were reduced by 25.3% and 30.2% compared to F-T diesel. Moreover, the MII mode was more conducive to improving the agglomeration degree of particulate matter. MII mode formed a uniform methanol mixture earlier than MMDI mode at the same crankshaft angle in the cylinder. Benzene (A1) is the first ring of aromatic hydrocarbons and the most important precursor of soot. When the methanol blending ratio was 30%, compared with MMDI, the peak concentration of A1 was reduced by 17.2% and appeared earlier by 14.3% in MII mode. C3H3 was the main intermediate product of aromatic hydrocarbons formation. Compared with the MMDI mode, the peak concentration of C3H3 in the MII mode was reduced by 51.6%, effectively suppressing the generation of benzene.

关键词： Diesel engine F-T diesel methanol methanol injection method PM soot

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Efficient combination of ionic-liquid-based ultrasound-assisted extraction, complex chromatography, and molecular docking for screening of acetylcholinesterase inhibitors from Ganoderma atrum

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JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION 2023年第2期17卷 1228-1240页

作者： Hou, Wanchao liu, Chunming li, Sainan Niu, Huazhou liu, Zhen Zhang, Yuchi Jin, Yongri li, xuwen Jilin Univ Coll Chem Changchun 130021 Jilin Peoples R China Changchun Normal Univ Cent Lab Changchun 130032 Peoples R China

Compounds extracted from Ganoderma atrum (G. atrum) is significantly beneficial to human health, have been incorporated in numerous remedies owing to their brain and kidney health benefits and antiinflammatory and diuretic properties. G. atrum a pilot of homology of medicine and food, has an important development value of functional food and health food. In this study, to develop a new ionic-liquid-based ultrasound-assisted extraction method and bio-affinity ultrafiltration coupled with LC and MS. Moreover, molecular docking was used to evaluate the activity of the AChE inhibitors, which were subsequently isolated and purified using consecutive counter-current chromatography (CCC) and semi-preparative high-performance liquid chromatography (HPLC). Lastly, the active compounds were identified using MS and nuclear magnetic resonance. Four AChE inhibitors, viz. ergosterol, ergosta-7,22-dien-3-one, ergosta-7-en-3 beta-ol, and ergosta-4,6,8(14),22-tetraen-3-one with purities of 92.23%, 90.19%, 90.52% and 96.72%, respectively, were obtained from G. atrum using consecutive CCC (ethyl acetate/methanol/water, 4.0:1.0:7.0, v/v/v) coupled with semi-preparative HPLC (4% A (0-30 min), 4-100% A (30-40 min)). Our results suggested that G. atrum extracts can be used in the potential prevention and treatment of neurodegenerative diseases. It will help to elucidate the mechanisms of action of various medicinal plants at the molecular level and provide more opportunities to discover and develop new potential therapeutic remedies from health care food resources.

关键词： Ganoderma atrum Ionic-liquid Acetylcholinesterase Inhibitor molecular Docking chromatography

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