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Studies on Triterpenoid Glycosides from Rhizomes ofPanacis majoris and Their Antiplatelet Aggregation Activity

Chemical Research in Chinese Universities 2016年第6期32卷 943-946页

作者： li Min JIN Yongri WANG Xiaozhong WU Qian liU Ying li Peng li xuwen College of Chemistry Jilin University Changchun 130021 P. R. China

A new triterpenoid glycoside（l） and seven known triterpenoid glycosides, pseudoginsenoside RT2（2）,yesanchinoside R2（3）, vinaginsenoside R13（4）, vinaginsenoside R8（5）, notoginsenoside E（6）, 6＂＇-O-acetylginsenosideRe（7）, 6＂-O-acetylginsenoside Rbl（8）, were isolated from the rhizomes of Panaeis maforis. The new triterpenoidglycoside was elucidated as 3-O-[β-D-glucopyranosyl-（l→2）-fl-D-（6＇-O-ethyl）-glucuronopyranosyl]-oleanolicacid-28-O-β-D-glucopyranoside by extensive spectroscopic and phytochemical methods. Compounds 2-8 wereobtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate（ADP）-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibitedmoderate antiplatelet aggregation activity induced by arachidonic acid（AA）.

关键词： Panacis majoris Rhizome Triterpenoid glycoside Antiplatelet aggregation

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Recent advances in the synthesis of biodegradable polyesters by sustainable polymerization: lipase-catalyzed polymerization

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RSC ADVANCES 2020年第59期10卷 36230-36240页

作者： liu, Ying Song, lijie Feng, Na Jiang, Wei Jin, Yongri li, xuwen Jilin Univ Coll Chem 2699 Qianjin Rd Changchun 130012 Jilin Peoples R China Jilin Prov Acad Tradit Chinese Med Clin Hosp 1 Changchun 130021 Peoples R China Zhengzhou Univ Acad Med Sci Dept Mol Pathol Applicat Ctr Precis MedAffiliated Hosp 2 Zhengzhou 450052 Henan Peoples R China

Over the past three decades, enzymatic polymerization has dramatically developed and gradually broadened as a creative methodology in the construction of polymeric materials with tailor-made structures and properties. Compared with transition metal catalyst polymerizations, enzymatic polymerization is more attractive in the biomedicine field due to the metal-free residue, good biocompatibility, and few by-products. Meanwhile, enzymatic polymerization has far more activity towards macrolides. In this review, the synthesis of lipase-catalyzed polymer materials is systematically summarized, focusing on the synthesis of the complex and well-defined polymers. The enzymatic polyester synthesis was then discussed concerning the different reaction types, including ring-opening polymerization, polycondensation, a combination of ring-opening polymerization with polycondensation, and chemoenzymatic polymerization. Besides, exploration of novel biocatalysts and reaction media was also described, with particular emphasis on the enzymes obtainedviaimmobilization or protein engineering strategies, green solvents, and reactors. Finally, recent developments in catalytic kinetics and mechanistic studies through the use of spectroscopy, mathematics, and computer techniques have been introduced. Besides, we addressed the remaining central issues in enzymatic polymerization and discussed current studies aimed at providing answers.

关键词： Ring opening polymerization

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Green determination of aconitum alkaloids in Aconitum carmichaeli (Fuzi) by an ionic liquid aqueous two-phase system and recovery of the ionic liquid coupled with in situ liquid-liquid microextraction

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ANALYTICAL METHODS 2016年第35期8卷 6566-6572页

作者： Wang, Xiaozhong li, xuwen li, Lanjie li, Min Wu, Qian liu, Ying Yang, Jie Jin, Yongri Jilin Univ Coll Chem Changchun 130012 Peoples R China Ningxia Univ Sch Chem & Chem Engn Yinchuan 750021 Peoples R China

A green and effective extraction system based on the use of an ultrasound-assisted ionic liquid aqueous two-phase system (IL-ATPS) was developed for the determination of aconitum alkaloids in lateral roots of Aconitum carmichaeli Debx (Fuzi in Chinese). IL-ATPS parameters, including the type and amount of ionic liquid, amount of salts, and pH value, as well as extraction time, were investigated. Under the optimized conditions, the recoveries of the analytes varied from 80.37 to 107.18%. The detection limits and quantification limits for the analytes were achieved within the ranges of 0.048-0.082 mg g(-1) and 0.16-0.30 mg g(-1), respectively. After extraction, the recovery of ionic liquids without the use of organic solvents was also confirmed. The hydrophilic ionic liquids (1-hexyl-3-methylimidazolium bromide) were converted into hydrophobic ionic liquids (1-hexyl-3-methylimidazolium hexafluorophosphate) by a metathesis reaction, and in situ liquid-liquid microextraction was triggered simultaneously. Finally, 0.1 mol L-1 HCl aqueous solution (containing 5% Tween-20) was used as the back-extraction agent to recover the ionic liquids.

关键词： Ionic liquids Aconitum alkaloids 1-hexyl-3-methylimidazolium liquid Phase Microextraction Aconitum carmichaelii phase system mining system

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Anti-allergic Effects of Ginsenosides Extracted by High Temperature and High Pressure Method

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Chemical Research in Chinese Universities 2018年第3期34卷 382-388页

作者： liU Ying li xuwen ZHANG Hanqi WU Qian SHI Xiaolei JIN Yongri College of Chemistry Jilin University Changchun 130021 P. R. China College of Food Science and Engineering Jilin University Changchun 130062 P. R. China

Ginseng（Panax ginseng C. A. Mey.） is a traditional medicinal herb in Asia. Studies have shown that ginsenosides significantly affect immnnoregulation and rare ginsenosides have anti-allergic effects. In this research, a high temperature and high pressure method was utilized to increase the contents of rare ginsenosides in the ginseng extract（GE）. The anti-allergic effects of this extract were investigated in vivo. Water was used as the extraction solvent in extracting the rare ginsenosides via the high temperature and high pressure method. Extraction time and temperature were investigated in order to increase the contents of rare ginsenosides. Rare ginsenosides were qualitatively analyzed by HPLC-ESI-MS and quantitatively analyzed by HPLC-UV. Anti-allergic effects of the extracts were assessed using the ovalbumin（OVA）-induced allergic asthma model in vivo. An extraction temperature of 145 ℃ and extraction time of 2.0 h were chosen as the optimal conditions. Compared with traditional method, the contents of total rare ginsenosides extracted were considerably higher using the new method, that is, 14.74 times that extracted by the traditional method. In our in vivo experiments, treatment with high concentration GE may have anti-allergic erects in decreasing the total amount of IgE in serum and IL-4 in bronchoalveolar lavage fluid（BALF）, aud in improving the ratio of CD4^＋ to CD8^＋ T cells. The high temperature and high pressure method was an effective method to obtain GE containing more rare ginsenosides, which maybe become anti-allergic agents.

关键词： Food allergy High temperature and high pressure method Ovalbumin Rare ginsenoside

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Intra-articular injection of vancomycin after arthrotomy closure following gentamicin-impregnated bone cementation in primary total knee arthroplasty provides a high intra-articular concentration while avoiding systemic toxicity: a prospective study

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JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 2024年第1期19卷 1-9页

作者： li, xuwen Lai, Junhao Yang, Xue Xu, Hao Xiang, Shuai Qingdao Univ Affiliated Hosp Dept Traumatol Qingdao Shandong Peoples R China Qingdao Univ Affiliated Hosp Dept Joint Surg Qingdao 266000 Shandong Peoples R China Qingdao Univ Affiliated Hosp Operat Room Qingdao Shandong Peoples R China

BackgroundThis study aimed to elucidate the safety and intra-articular elution profiles of vancomycin and gentamicin bone cement in patients undergoing primary total knee arthroplasty (TKA), with a focus on serum safety thresholds and therapeutic *** patients who underwent unilateral primary TKA were prospectively enrolled. The implants were fixed using gentamicin-impregnated bone cement, and after arthrotomy closure, 1000 mg of vancomycin suspended in 25 mL of normal saline was directly injected into the joint. Peripheral venous blood and drain fluid samples were collected 2, 8, and 24 h postoperatively. The serum and intra-articular concentrations of vancomycin and gentamicin were analyzed using liquid chromatography-tandem mass spectrometry within 24 *** data reflecting renal and liver function were recorded preoperatively, and at 24 and 72 h postoperatively. A total of 100 patients were included. At 2, 8, and 24 h postoperatively, the serum vancomycin concentration was 7.0 +/- 2.0, 5.7 +/- 1.8, and 3.6 +/- 1.4 mu g/mL, respectively, while the intra-articular concentration was 468.5 (interquartile range [IQR] 286.0 to 774.8), 139.5 (IQR 52.0 to 295.3), and 34.4 (IQR 22.2 to 56.8) mu g/mL, respectively;33.2 (IQR 19.5 to 80.5) mg vancomycin was lost in drainage fluid at 24 h postoperatively. For gentamicin, the overall intra-articular concentration was 70.4 (IQR 35.4 to 109.2), 33.8 (IQR 17.8 to 73.9), and 21.1 (IQR 12.2 to 36.0) mu g/mL at 2, 8, and 24 h postoperatively, respectively, with an undetectable serum concentration. No cases of acute renal injury, liver injury, ototoxicity, or anaphylaxis were ***-articular injection of 1000 mg vancomycin after arthrotomy closure combined with gentamicin-impregnated bone cement provided a therapeutic intra-articular concentration while avoiding systemic toxicity over the initial 24 h after primary TKA. Therefore, intra-articular vancomycin administration may off

关键词： Vancomycin Gentamicin Total knee arthroplasty

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The research and implementation of interfacing based on PCI express

The research and implementation of interfacing based on PCI ...

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9th International Conference on Electronic Measurement and Instruments, ICEMI 2009

作者： Wu, Qiang Xu, Jiamou li, xuwen Jia, Kebin College of Electronic Information and Control Engineering Beijing University of Technology Pingleyuan 100 Chaoyang district 100124 China

ISBN: (纸本)9781424438624

PCI Express is rapidly establishing itself as the successor to PCI, which provides higher performance, increased flexibility, and scalability for next-generation systems. FPGA offers a flexible solution for PCI Express compared with ASIC. Using IP Core and designing a DMA module in FPGA, this paper implemented a high-performance PCI Express system. IP Core handles the protocols defined by PCI Express specification. DMA module accelerates the transmission between FPGA and PC memory, sufficiently exploiting PCI Express bus bandwidth. This article proposes and achieves a PCI Express system having DMA transfer ability and emphatically describes the design of the DMA engine in system-logic, in addition to the corresponding Windows WDM driver and GUI application. The result of performance test is presented finally. ©2009 IEEE.

关键词： Intellectual property core

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Hardware design of ADSP-BF548 based portable patient monitor

Hardware design of ADSP-BF548 based portable patient monitor

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2nd Annual Conference on Electrical and Control Engineering, ICECE 2011

作者： li, xuwen Wu, Qiang Wu, Shuicai College of Life Science and Bio-engineering Beijing University of Technology Beijing China College of Electronic Information and Control Engineering Beijing University of Technology Beijing China

ISBN: (纸本)9781424481637

This paper studies on hardware design of a novel patient monitor based on one ADSP-BF548 blackfin dsp. The NIBP, 12-lead ECG, SPO2 and body temperature functions are successfully implemented. A 6.4 inch TFT LCD with a touch screen is used as GUI output to display all monitor curves and parameters. Through the convergent capabilities of the blackfin dsp, the patient moitor can store data into NAND FLASH and SD card. The Ethernet, USB and WCDMA communication functions are also realized. Another advantage of this design is the powerful DSP computation performance which can guarantee more complex algorithms into one processor system. © 2011 IEEE.

关键词： Electrocardiography

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A POWER MANAGEMENT CIRCUIT COMPATIBLE with Ti SmartReflex and Xilinx Ultrascale+ MPSoC DUAL VOLTAGE MECHANISM 10

A POWER MANAGEMENT CIRCUIT COMPATIBLE with Ti SmartReflex an...

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10th International Conference on Computing and Pattern Recognition, ICCPR 2021

作者： li, Chenyun li, xuwen Tang, Changjiang Wu, Qiang Beijing University of Technology China

ISBN: (纸本)9781450390439

Since the semiconductor technology has entered the age of 90 nm, the static power consumption of the chip has increased rapidly. For edge computing devices, the waste of power can not be ignored. This paper uses the relationship between power consumption and power supply voltage of FPGA and DSP, analyzes the characteristics of the traditional scheme, and designs a hardware circuit according to the different mechanisms of reducing static power consumption of FPGA and DSP According to the design of FPGA and DSP core power supply voltage compatibility, the system realizes the requirement of FPGA and DSP for power supply voltage amplitude and realizes dynamic control of power supply voltage. After verification and comparison, FPGA and DSP can realize the adjustment of performance power consumption and stable operation under the power system. © 2021 ACM.

关键词： Field programmable gate arrays (FPGA)

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An optimized microwave-assisted extraction method for increasing yields of rare ginsenosides from Panax quinquefolius L.

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JOURNAL OF GINSENG RESEARCH 2016年第4期40卷 415-422页

作者： Yao, Hua li, xuwen liu, Ying Wu, Qian Jin, Yongri Jilin Univ China Japan Union Hosp Ctr Sci Res Changchun Jilin Peoples R China Jilin Univ Coll Chem 2519 Jiefang St Changchun 130012 Jilin Peoples R China

Background: Rare ginsenosides in Panax quinquefolius L. have strong bioactivities. The fact that it is hard to obtain large amounts of rare ginsenosides seriously restricts further research on these compounds. An easy, fast, and efficient method to obtain different kinds of rare ginsenosides simultaneously and to quantify each one precisely is urgently needed. Methods: Microwave-assisted extraction (MAE) was used to extract nine kinds of rare ginsenosides from P. quinquefolius L. In this article, rare ginsenosides [20(S)-Rhl, 20(R)-Rhl, Rg6, F4, Rk3, 20(S)-Rg3, 20(R)-Rg3, Rk1, and Rg5] were identified by high performance liquid chromatography (HPLC)-electrospray ionization-mass spectrometry. The quantity information of rare ginsenosides was analyzed by HPLC-UV at 203 nm. Results: The optimal conditions for MAE were using water as solvent with the material ratio of 1:40 (w/v) at a temperature of 145 degrees C, and extracting for 15 min under microwave power of 1,600 W. Seven kinds of rare ginsenosides 120(S)-Rh1, 20(R)-Rh1, Rg6, F4, Rk3, Rk1, and Rg5] had high extraction yields, but those of 20(S)-Rg3 and 20(R)-Rg3 were lower. Compared with the conventional method, the extraction yields of the nine rare ginsenosides were significantly increased. Conclusion: The results indicate that rare ginsenosides can be extracted effectively by MAE from P. quinquefolius L in a short time. Microwave radiation plays an important role in MAE. The probable generation process of rare ginsenosides is also discussed in the article. It will be meaningful for further investigation or application of rare ginsenosides. Copyright (C) 2016, The Korean Society of Ginseng, Published by Elsevier.

关键词： high performance liquid chromatography/mass spectrometry microwave-assisted extraction Panax quinquefolius L. rare ginsenosides

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Inhibitory activity of narirutin on RBL-2H3 cells degranulation

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IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 2021年第1期43卷 68-76页

作者： Niu, liyan Wei, Jihao li, xuwen Jin, Yongri Shi, Xiaolei Jilin Univ Coll Food Sci & Engn Changchun Peoples R China Jilin Univ Coll Chem Changchun Peoples R China

Context: It is an efficient strategy to apply inhibition of mast cell degranulation for evaluating anti-allergic effects of compounds. Previous works confirmed that narirutin had anti-allergic activity in OVA induced allergic asthma murine model. However, the mechanism is not clear. Objective: Here, inhibitory mechanism of narirutin on RBL-2H3 cells degranulation was investigated. Materials and methods: Cell viability was analyzed by CCK-8 kits, cell degranulation was analyzed by EliSA methods, morphology and ultrastructure of cells was observed by atomic force microscopy, intracellular Ca (2+) concentration was measured by fluorescence microscopre, mRNA expression were measured by PCR, and signaling pathways were measured by WB. Results: The results showed that narirutin have no direct effects on mRNA expression of Fc epsilon RI subunit. However, it inhibited Ca2+ influx by suppressing the phosphorylation of Syk, LAT and PLC gamma 1 signaling pathway transduction. Subsequently, the inhibition of Ca2+ influx directly leads to NF-kappa B signaling pathway transduction decreased. Narirutin can also suppress the phosphorylation of MAPK signaling pathways by decreasing the expression of P-p38, P-ERK and P-JNK, inhibit the synergistic effect for Ca2+ influx, and then reduce the release of IL-4, TNF-alpha, histamine and beta-HEX. Conclusion: Our study suggested that the inhibitory mechanism of narirutin on RBL-2H3 cells degranulation could be related to regulate MAPK, NF-kappa B and Tyrosine kinase signaling pathway.

关键词： Allergy narirutin degranulation mechanism

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