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Adaptable graphitic C6N6-based copper single-atom catalyst for intelligent biosensing

NATURE COMMUNICATIONS 2023年第1期14卷 1-11页

作者： Hong, Qing Yang, Hong Fang, Yanfeng Li, Wang Zhu, Caixia Wang, Zhuang Liang, Sicheng Cao, xuwen Zhou, Zhixin Shen, Yanfei liu, Songqin Zhang, Yuanjian Southeast Univ Sch Chem & Chem Engn Jiangsu Engn Lab Smart Carbon Rich Mat & Device Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Peoples R China Southeast Univ Med Sch Nanjing 210009 Peoples R China

Self-adaptability is highly envisioned for artificial devices such as robots with chemical noses. For this goal, seeking catalysts with multiple and modulable reaction pathways is promising but generally hampered by inconsistent reaction conditions and negative internal interferences. Herein, we report an adaptable graphitic C6N6-based copper single-atom catalyst. It drives the basic oxidation of peroxidase substrates by a bound copper-oxo pathway, and undertakes a second gain reaction triggered by light via a free hydroxyl radical pathway. Such multiformity of reactive oxygen-related intermediates for the same oxidation reaction makes the reaction conditions capable to be the same. Moreover, the unique topological structure of CuSAC6N6 along with the specialized donor-pi-acceptor linker promotes intramolecular charge separation and migration, thus inhibiting negative interferences of the above two reaction pathways. As a result, a sound basic activity and a superb gain of up to 3.6 times under household lights are observed, superior to that of the controls, including peroxidase-like catalysts, photocatalysts, or their mixtures. CuSAC6N6 is further applied to a glucose biosensor, which can intelligently switch sensitivity and linear detection range in vitro. Catalysts with multiple and modulable reaction pathways are promising but generally hampered by inconsistent reaction conditions and negative internal interferences. Herein, the authors report an adaptable graphitic C6N6-based copper singleatom catalyst

关键词： Bioanalytical chemistry Biocatalysis Materials for energy and catalysis

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Comparison of whole-body 18F-FDG PET/CT and PET/MRI for distant metastases in patients with malignant tumors: a meta-analysis

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BMC CANCER 2023年第1期23卷 37-37页

作者： Zhang, Cici Liang, Zhishan liu, Wei Zeng, xuwen Mo, Yuzhen Guangzhou Red Cross Hosp Dept Radiol Guangzhou Peoples R China Peoples Hosp Guangxi Zhuang Autonomous Reg Dept Cardiol Nanning Peoples R China Guangzhou Red Cross Hosp Dept Breast Guangzhou Peoples R China 396 TongFu Rd HaiZhu Dist Guangzhou Guangdong Peoples R China

Background As a first-line imaging modality, whole-body fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) and 18F-FDG PET/magnetic resonance imaging (MRI) had been widely applied in clinical practice. However, 18F-FDG PET/MRI may be superior to PET/CT for the diagnosis of distant metastases in patients with advanced-stage. Therefore, it is timely and important to systematically determine the diagnostic accuracy of 18F-FDG PET/MRI compared with that of 18F-FDG PET/CT for the diagnosis of distant *** This study aimed to compare the diagnostic accuracy of 18F-FDG PET/CT and PET/MRI for the diagnosis of distant metastases in patients with malignant tumors. Relevant studies using both 18F-FDG PET/CT and PET/MRI for assessment of distant metastases in patients with malignant tumors were searched in PubMed, Embase, The Cochrane Library, and Scopus from January 2010 to November 2023. Two reviewers independently selected studies according to the inclusion and exclusion criteria. A reviewer extracted relevant data and assessed the quality of the eligible studies. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and area under the summary receiver operating characteristic curve (AUC) for 18F-FDG PET/CT and PET/MRI were analyzed. Subgroup analysis was *** Across 14 studies (1042 patients), 18F-FDG PET/MRI had a higher sensitivity (0.87 versus 0.81), AUC value (0.98 versus 0.95), and similar specificity (0.97 versus 0.97), than PET/CT for detecting distant metastases. In 3 studies of breast cancer (182 patients), 18F-FDG PET/MRI had a higher sensitivity (0.95 versus 0.87) and specificity (0.96 versus 0.94) than PET/CT. In 5 studies of lung cancer (429 patients), 18F-FDG PET/CT had a higher sensitivity (0.87 versus 0.84) and a lower specificity (0.95 versus 0.96) to PET/*** 18F-FDG PET/MRI and PET/CT both performed well as detectors of distant meta

关键词： Tumor Distant metastases Positron emission tomography magnetic resonance imaging computed tomography

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No ureteral catheter mini percutaneous nephrolithotomy (NUC-mPCNL) achieves enhanced recovery after surgery (ERAS)

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SCIENTIFIC REPORTS 2024年第1期14卷 1-7页

作者： Li, xuwen Tan, Zhongyu Yu, Yue Zhou, Xiaochen Xi, Haibo liu, Wei Nanchang Univ Affiliated Hosp 1 Dept Urol Jiangxi Prov Key Lab Urinary Syst DisJiangxi Med Nanchang Jiangxi Peoples R China

Conventional mini percutaneous nephrolithotomy (mPCNL) typically necessitates the pre-operative placement of ureteral catheters. With the development of enhanced recovery after surgery (ERAS), we introduce a novel approach: no ureteral catheter mini percutaneous nephrolithotomy (NUC-mPCNL). To evaluate the efficacy and safety of this innovative procedure compared to mPCNL, we compared the total operative time, stone clearance rate (SCR), stone-free rate (SFR), and complications among patients undergoing either modality from January to September 2021. Our findings revealed a statistically significant reduction in the mean total operative time for the NUC-mPCNL group (42.6 +/- 2.4 vs. 60.2 +/- 3.4 min, p < 0.001). The SCR, SFR and CSFR were comparable between two groups (98.5% vs. 97.8%, 84.3% vs. 76.0%, 64.7% vs. 60.0%, p = 0.337, 0.295, 0.625). WBC rise, hemoglobin drop and neutrophil percentage rise were similar in both groups. The overall complication rate in the NUC-mPCNL group was lower;however, the difference was not statistically significant (Clavien I, II and III;11 vs. 13, 1 vs. 2 and 1 vs. 1). Consequently, we conclude that NUC-mPCNL effectively shortens the operative time and holds potential for expedited postoperative recovery.

关键词： Renal stones Enhanced recovery after surgery Mini percutaneous nephrolithotomy Ureteral catheter Efficacy

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Submarine Continental Slopes Stability Prediction of Natural Gas HydratesBased on Machine Learning

Submarine Continental Slopes Stability Prediction of Natural...

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Offshore Technology Conference, OTC 2025

作者： Chen, Yu He, Yufa Wang, Yixuan Zhou, Yunjian Fu, Qiang Qin, xuwen liu, Dingyuan Tian, Zheng Zhang, Kexin CNOOC Research Institute Ltd State Key Laboratory of Offshore Natural Gas Hydrates Beijing China Huairou Laboratory Beijing China China Aero Geophysical Survey and Remote Sensing Center for Natural Resources Beijing China

ISBN: (纸本)9781959025610

In the process of extracting naturally-occurring oceanic gas hydrates, the dissociation of hydrates can causea reduction in soil strength. This reduction has the potential to trigger slope failure and submarine landslides,which present a catastrophic threat to offshore facilities and hydrate production. This research aims to create a robust and accurate machine-learning model that can efficiently predict stability of submarine continental slopes where gas hydrates are widespread. By collecting and analyzing 144 relevant cases, a comprehensive dataset was constructed, incorporating slope basic data, overlying and underlying layer data, and geological parameters of the hydrate layer. After conducting a correlation coefficient analysis between the characteristic parameters of the dataset and the output, the key characteristic parameters were determined. To model the dataset and assess its performance, four machine learning techniques were employed: Random Forest(RF), XGBoost, K-Nearest Neighbors (KNN), and Support Vector Machine (SVM). Formation physical parameters, geotechnical parameters, and NGH parameters were taken as input parameters, and the stability of NGH slopes was taken as prediction indicator. Evaluation metrics such as the ROC and confusion matrix were employed to comprehensively evaluate these models’ classification ability. Among these algorithms,the RF algorithm achieves the best prediction accuracy and AUC value, demonstrating its potential in submarine continental slopes stability prediction of natural gas hydrates. Additionally, sensitive analysis using Gini impurity calculations revealed that hydrate decomposition degree is the most significant factor affecting slope stability, followed by the burial depth and thickness of the hydrate layer. The slope angle,cohesion, and internal friction angle also have significant impacts. This study provides a new perspective for predicting submarine continental slopes stability with NGH and offers a scientific

关键词： Landslides

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Influence of hydrostatic pressure on the corrosion and discharging behavior of Al-Zn-In-Mg-Ti alloy

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JOURNAL OF ALLOYS AND COMPOUNDS 2023年 936卷

作者： Hu, Shengbo Yuan, xuwen liu, Li liu, Rui Li, Fengguang liu, Jianyong Guo, Rui Yang, Wei Wang, Fuhui Hubei Univ Automot Technol Sch Mat Sci & Engn Shiyan 442002 Peoples R China Northeastern Univ Shenyang Natl Lab Mat Sci 3-11 Wenhua Rd Shenyang 110819 Peoples R China

The corrosion and discharging behavior of Al-Zn-In-Mg-Ti alloy were studied at a series pressures ranged from 0.1 MPa to 13.0 MPa using weigh loss experiments, electrochemical techniques, and imaging mea-surements et al. Results reveal that the self-corrosion and self-discharging process of Al-Zn-In-Mg-Ti alloy live through the same three stages, which are all accelerated by hydrostatic pressure. The discharging performance of Al-Zn-In-Mg-Ti drops with increasing pressure, which is caused by the acceleration of cathodic process and severer intergranular corrosion. The corresponding cathodic protection design based on Al-Zn-In-Mg-Ti sacrificial anode with the changing pressure has been set up, which follows exponential function.(c) 2022 Elsevier B.V. All rights reserved.

关键词： Sacrificial anode Hydrostatic pressure Intergranular corrosion EIS

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Carrier-Carrier Repulsion Limits the Conductivity of N-Doped Organic Semiconductors

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ADVANCED MATERIALS 2024年第44期36卷 e2404397页

作者： Yang, xuwen Ye, Gang liu, Jian Chiechi, Ryan C. Koster, L. Jan Anton Univ Groningen Zernike Inst Adv Mat Nijenborgh 3 NL-9747 AG Groningen Netherlands Hubei Univ Sch Mat Sci & Engn Key Lab Green Preparat & Applicat Funct Mat Hubei Key Lab Polymer Mat Youyi Rd 368 Wuhan 430062 Peoples R China Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Polymer Phys & Chem Changchun 130022 Jilin Peoples R China North Carolina State Univ Dept Chem Raleigh NC 27695 USA

Molecular doping is a key strategy to enhance the electrical conductivity of organic semiconductors. Typically, the electrical conductivity shows a maximum value upon increased doping, after which the conductivity decreases. This decrease in conductivity is commonly attributed to unfavorable changes in the morphology. However, in recent simulation work, has shown, that the conductivity-at high doping-is instead limited by electron-electron repulsion rather than by morphology, at least for some material combinations. Based on the simulations, this limitation is expected to show up in the dependence of the Seebeck coefficient versus carrier density: the Seebeck coefficient will follow Heike's formula if carrier-carrier repulsion limits the conductivity. Here, the electrical conductivity and Seebeck coefficient are measured as a function of doping for a series of n-type organic semiconductors. Additionally, the resulting carrier density is measured using metal-insulator-semiconductor diodes, which link dopant loading and the number of charge carriers. At high carrier densities, the Seebeck coefficient indeed follows Heike's formula, confirming that the conductivity is limited by carrier-carrier repulsion rather than by morphological effects. This study shows that current models of hopping transport in organic semiconductors may be incomplete. As a result, this study offers novel insights in the design of organic semiconductors. The combined dependence of the electrical conductivity and Seebeck coefficient on the carrier density shows that the electrical conductivity at high doping is limited by the repulsion of electrons by other electrons. The carrier density nx corresponding to the maximum electrical conductivity coincides with the carrier density at which the Seebeck coefficient collapses onto Heike's law. image

关键词： doping electrical conductivity hopping transport organic semiconductors

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Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4914-4933页

作者： Chao Huang Yang Jin Panpan Fu Kongying Hu Mengxue Wang Wenjing Zai Ting Hua Xinluo Song Jianyu Ye Yiqing Zhang Gan Luo Haiyu Wang Jiangxia liu Jieliang Chen xuwen Li Zhenghong Yuan Key Laboratory of Medical Molecular Virology(MOE/NHC) Research Unit of Cure of Chronic Hepatitis B Virus Infection(CAMS)Shanghai Frontiers Science Center of Pathogenic Microbes and InfectionSchool of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China Shanghai Institute of Infectious Disease and Biosecurity Shanghai 200032China Guixi Hospital of Chinese Medicine Guixi 335400China

Due to the limitations of current anti-HBV therapies, the HBV core (HBc or HBcAg) protein assembly modulators (CpAMs) are believed to be potential anti-HBV agents. Therefore, discovering safe and efficient CpAMs is of great value. In this study, we established a HiBiT-based high-throughput screening system targeting HBc and screened novel CpAMs from an in-house marine chemicals library. A novel lead compound 8a, a derivative of the marine natural product naamidine J, has been successfully screened for potential anti-HBV activity. Bioactivity-driven synthesis was then conducted, and the structure‒activity relationship was analyzed, resulting in the discovery of the most effective compound 11a (IC50 = 0.24 μmol/L). Furthermore, 11a was found to significantly inhibit HBV replication in multiple cell models and exhibit a synergistic effect with tenofovir disoproxil fumarate (TDF) and IFNa2 in vitro for anti-HBV activity. Treatment with 11a in a hydrodynamic-injection mouse model demonstrated significant anti-HBV activity without apparent hepatotoxicity. These findings suggest that the naamidine J derivative 11a could be used as the HBV core protein assembly modulator to develop safe and effective anti-HBV therapies.

关键词： Anti-HBV HBV coreprotein Coreproteinassembly modulators Marine natural products HiBiT

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Multi-Target Feeding-Behavior Recognition Method for Cows Based on Improved RefineMask

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SENSORS 2024年第10期24卷 2975页

作者： Li, xuwen Gao, Ronghua Li, Qifeng Wang, Rong liu, Shanghao Huang, Weiwei Yang, liuyiyi Zhuo, Zhenyuan Tianjin Agr Univ Coll Comp & Informat Engn Tianjin 300384 Peoples R China Beijing Acad Agr & Forestry Sci Res Ctr Informat Technol Beijing 100097 Peoples R China Northwest A&F Univ Coll Informat Engn Xianyang 712100 Peoples R China Beijing Univ Agr Coll Intelligent Sci & Engn Beijing 100096 Peoples R China

Within the current process of large-scale dairy-cattle breeding, to address the problems of low recognition-accuracy and significant recognition-error associated with existing visual methods, we propose a method for recognizing the feeding behavior of dairy cows, one based on an improved RefineMask instance-segmentation model, and using high-quality detection and segmentation results to realize the recognition of the feeding behavior of dairy cows. Firstly, the input features are better extracted by incorporating the convolutional block attention module into the residual module of the feature extraction network. Secondly, an efficient channel attention module is incorporated into the neck design to achieve efficient integration of feature extraction while avoiding the surge of parameter volume computation. Subsequently, the GIoU loss function is used to increase the area of the prediction frame to optimize the convergence speed of the loss function, thus improving the regression accuracy. Finally, the logic of using mask information to recognize foraging behavior was designed, and the accurate recognition of foraging behavior was achieved according to the segmentation results of the model. We constructed, trained, and tested a cow dataset consisting of 1000 images from 50 different individual cows at peak feeding times. The method's effectiveness, robustness, and accuracy were verified by comparing it with example segmentation algorithms such as MSRCNN, Point_Rend, Cascade_Mask, and ConvNet_V2. The experimental results show that the accuracy of the improved RefineMask algorithm in recognizing the bounding box and accurately determining the segmentation mask is 98.3%, which is higher than that of the benchmark model by 0.7 percentage points;for this, the model parameter count size was 49.96 M, which meets the practical needs of local deployment. In addition, the technologies under study performed well in a variety of scenarios and adapted to various light environment

关键词： RefineMask instance segmentation feeding behavior behavioral recognition

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Elucidating Orbital Delocalization Effects on Boosting Electrochemiluminescence Efficiency of Carbon Nitrides

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ADVANCED OPTICAL MATERIALS 2022年第18期10卷

作者： Fang, Yanfeng Hou, Yuhua Yang, Hong Chen, Ran Li, Wang Ma, Jin Han, Dan Cao, xuwen liu, Songqin Shen, Yanfei Zhang, Yuanjian Southeast Univ Jiangsu Engn Lab Smart Carbon Rich Mat & Device Jiangsu Prov Hitech Key Lab Biomed Res State Key Lab BioelectSch Chem & Chem Engn Nanjing 211189 Peoples R China Southeast Univ Med Sch Nanjing 211189 Peoples R China

Highly efficient inter-conversion of different types of energy is the core of science and technology. Among them, electrochemiluminescence (ECL), an emission of light excited by electrochemical reactions, has drawn attention as a powerful tool across diverse fields in addressing global energy, environment, and health challenges. Nonetheless, the ECL efficiency (phi(ECL)) of most luminophores in aqueous solutions is low, significantly hampering their broad applications. Along this line, developing ECL luminophores with high phi(ECL) and understanding the associated intrinsic factors is highly envisioned. Herein, taking carbon nitride (CN) with rigid 2D backbones as an emerging model luminophore, it is reported that the orbital delocalization is a unified and quantifiable factor for its phi(ECL). Behind the complicated transformation of molecular structures of cyano-terminal groups and triazine/heptazine basal frameworks, the orbital delocalization of CN is found to be generally improved at an elevated condensation temperature. Such intrinsic evolution in electronic structure favored the electron injection in excitation and follow-up photon emission in ECL for CN. As a result, the cathodic phi(ECL) of CN is remarkably improved to a new milestone of 24-fold greater than the previous record.

关键词： carbon nitrides electrochemiluminescence energy conversion efficiency orbital delocalization photoelectrochemistry

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环境中微塑料的微生物降解机制与生物强化

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地学前缘 2025年第3期32卷 248-262页

作者：丁佳妍刘翔宇陈旭文汤磊高彦征南京农业大学土壤有机污染控制与修复研究所江苏南京210095

作为一类新污染物,环境中微塑料威胁生态安全和人类健康。微生物降解技术因其经济高效、环境友好的特质而备受关注。近些年来,生物膜、酶工程、基因调控等技术在微塑料微生物降解研究中取得重要进展。生物膜降解微塑料的过程通常包括改... 详细信息

作为一类新污染物,环境中微塑料威胁生态安全和人类健康。微生物降解技术因其经济高效、环境友好的特质而备受关注。近些年来,生物膜、酶工程、基因调控等技术在微塑料微生物降解研究中取得重要进展。生物膜降解微塑料的过程通常包括改变表面特性、浸出添加剂、酶或自由基攻击、渗透分解等阶段。细胞外酶可裂解微塑料的大分子结构,细胞内酶则可改变底物结构并处理代谢产物,两者协同作用构建高效酶系统已成为当前研究的重点之一。基于基因工程技术,以往已培育了多种工程菌株,通过生物信息学挖掘功能基因、解析代谢途径,并结合宏基因组修饰技术,显著提升了微塑料的降解效率。本文综述了微生物降解微塑料的最新研究进展,剖析了微塑料降解功能微生物的物种多样性、降解代谢途径及其机制等。已有研究表明,细菌、真菌和微藻等多种微生物皆具备降解微塑料的能力,其中复合菌群的协同作用尤为显著。细菌主要通过分泌水解酶和氧化酶,切断大分子链或改变塑料化学结构来降解微塑料;真菌则依靠分泌细胞内、外酶及生物表面活性剂,将微塑料分解为单体,菌丝还能增强作用效果;微藻可借助光合作用,分泌毒素、酶以及胞外聚合物促进降解。微塑料的降解通常经历生物劣化、碎片化、同化及矿化四个阶段,不同微生物对聚乙烯、聚苯乙烯等各类微塑料降解效率及机制存在差异。本综述为深入探究微塑料微生物降解原理、进一步发展微生物降解微塑料的方法和技术提供了依据。

关键词：微塑料微生物降解代谢途径降解机制

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