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Quantitative evaluation of O2 activation half-reaction for Fe-N-C in oxidase-like activity enhancement

CATALYSIS SCIENCE & TECHNOLOGY 2021年第22期11卷 7255-7259页

作者： Chen, Xinghua Zhu, Caixia Xu, Yuan Wang, Kaiyuan Cao, xuwen Shen, Yanfei liu, Songqin Zhang, Yuanjian Southeast Univ Sch Chem & Chem Engn Jiangsu Engn Lab Smart Carbon Rich Mat & Device Jiangsu Prov Hitech Key Lab Biomed ResState Key Nanjing 211189 Peoples R China Southeast Univ Med Sch Nanjing 210009 Peoples R China

The oxidase-like activity of high-performance Fe-N-C was enhanced by up to 55% by using a secondary N-containing precursor in pyrolysis. Moreover, the exploration of the O-2 activation half-reaction using electrochemical methods was disclosed to be a practically facile approach to quantitatively evaluate the factors associated with the activity.

关键词： Iron compounds

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RMComBat: A Batch Effect Correction Algorithm for Repeated Measurement Sequencing Data to Prevent Overcorrection

RMComBat: A Batch Effect Correction Algorithm for Repeated M...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Yuqian liu Zhaoxing Wei Jiayin Wang Xiaoyan Zhu Ruoyu liu xuwen Wang Shenjie Wang Xin Lai School of Computer Science and Technology Xi’an Jiaotong University Xi’an China Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Xi’an Jiaotong University Xi’an China

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

Batch effects, caused by non-biological variations such as differences in laboratory conditions, reagent lots, or personnel, are a substantial source of noise in gene expression data. Accurately correcting these effects is crucial for valid biological inferences. However, the majority of existing batch effect correction algorithms are prone to overcorrection, where biologically meaningful signals are mistakenly identified as noise, especially in repeated measurement studies where time is confounded with batch. The failure to accurately distinguish between batch-related and biologically relevant variation leads to a loss of critical biological information. This paper presents RMComBat, an enhancement of the widely-used ComBat framework, which addresses this limitation by replacing the general linear model with a linear mixed-effects model. RMComBat incorporates subject-specific random intercepts to correct for sample correlation and enhance the preservation of biological signals. We tested RMComBat and several popular algorithms on simulated and real repeated measurement gene expression datasets, evaluating their performance through visual inspections and quantitative metrics. Results indicate that although most algorithms can reduce batch effects, they often do so at the cost of removing true biological signals. RMComBat demonstrates superior performance in preventing overcorrection, providing a more balanced and biologically informative correction in repeated measurement studies, so making it a valuable tool for improving the accuracy of gene expression analyses.

关键词： Visualization Sequential analysis Biological system modeling Noise Biomedical measurement Inspection Time measurement Gene expression Personnel Noise measurement

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Identifying key elements for evidence-base medicine using pretrained model and graph convolution network

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Procedia Computer Science 2023年 221卷 557-564页

作者： Fengchun Yang Xiaowei Xu Meng Wu xuwen Wang liu Shen Qing Qian Jiao Li Institute of Medical Information Chinese Academy of Medical Sciences/Peking Union Medical College Beijing 100020 China Key Laboratory of Medical Information Intelligent Technology Chinese Academy of Medical Sciences Beijing 100020 China

Objective: Evidence-based medicine (EBM) provides a framework to support clinicians' decision-making processes using the best evidence currently available in the field. The key elements of clinical research can be defined by a framework called PICO, which identifies the sentences in a medical literature text that belong to the four key elements reported in clinical trials: Participants/Problem (P), Intervention (I), Comparison (C) and Outcome (O). This study aims to establish an effective detection method for key elements of evidence-based medical research. Methods: Based on the text features of key elements framework, we propose a deep learning model BERTGCN which combined large-scale pretraining model and graph convolution network (GCN) for detecting key elements of evidence-based medicine. In this model, the sentences which are initialized with pre-trained BERT representations and the words in the EBM evidence were recognized as the sentence nodes and word of the graph which were used to train GCN model. At the same time, the sentences were used to fine tune the pretraining model. Results: We tested our proposed approach over PubMed-PICO dataset is a data set containing tens of thousands of EBM key elements extracted from PubMed. The F1-score of P/I/O in the model we proposed reached 91.3%, 85.8% and 90.0% respectively. Experimental results show that our model outperforms the current optimal model. Conclusions: BERTGCN is able to leverage the advantages of both worlds: large-scale pretraining and transudative learning to improve the efficiency of detecting evidence-based medical evidence from research publications.

关键词： evidence-based medicine natural language process graph convolution network evidence identification

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推进剂微射流冷却对高温非平衡气动热的影响机理

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空气动力学学报 2025年第4期43卷 20-29,I0001页

作者：邢旭雯杨肖峰刘磊杜雁霞空天飞行空气动力科学与技术全国重点实验室绵阳621000 中国空气动力研究与发展中心绵阳621000

飞行器在高速飞行时,可利用自身携带的推进剂通过微孔射流实现冷却,达到主动热防护效果。但在高温非平衡流条件下,可压缩外流与微射流交汇、射流排挤/掺混/反应多过程交织,微射流冷却主导性机制和影响因素复杂。本文建立了微射流黏性壁... 详细信息

飞行器在高速飞行时,可利用自身携带的推进剂通过微孔射流实现冷却,达到主动热防护效果。但在高温非平衡流条件下,可压缩外流与微射流交汇、射流排挤/掺混/反应多过程交织,微射流冷却主导性机制和影响因素复杂。本文建立了微射流黏性壁面边界模型,开展了微射流作用下高温非平衡流场数值模拟,探讨了射流孔径、速度和孔间距对冷却效果的影响规律,发现高温非平衡流条件下推进剂微射流冷却由边界层排挤、多相催化弱化两个基本过程主导:(1)低温微射流喷出对边界层产生排挤作用,改变边界层剖面形态,降低紧邻壁面处的温度法向梯度,从而降低壁面法向导热,实现冷却;(2)低温氧分子工质微射流排挤近壁氧原子,弱化氧催化效应,导致催化热降低。参数化研究结果表明:质量流量不变,增大射流孔大小,降热率与冷却范围均下降;射流孔面积不变,增大微射流速度,降热率与冷却范围增大;质量流量不变,减小孔间距,展向平均降热率峰值减小,但孔下游冷却范围增大,呈现较均匀的冷却效果。以上研究可对未来微射流冷却主动热防护的设计与优化提供重要的理论支撑和技术参考。

关键词：微射流冷却非平衡流动气动热壁面催化数值模拟

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An Enhanced Multiple Correction Method with Limited Independent Effective SNPs

An Enhanced Multiple Correction Method with Limited Independ...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Xin Lai Xiaohai Yang Jiayin Wang Xiaoyan Zhu Yuqian liu Ruoyu liu xuwen Wang Shenjie Wang School of Computer Science and Technology Xi’an Jiaotong University Xi’an China

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

In genome-wide association studies (GWAS) and candidate gene studies (CGS), appropriate multiple testing correction methods can effectively address linkage disequilibrium (LD) blocks and are crucial for controlling the family-wise error rate (FWER) while ensuring the reliability of results. In our recent research, we observed that when the number of independent effective Single Nucleotide Polymorphisms (SNPs) is relatively small, existing multiple testing correction methods struggle to effectively control the FWER at 0.05 and lack robustness. This study proposes an enhanced method that builds upon the Moskvina and Schmidt approach by incorporating additional SNP correlation information, allowing for precise control of the FWER at 0.05 with limited independent effective SNPs. We also leverage Monte Carlo integration on a GPU to accelerate the computation of significance thresholds. Our method was evaluated through both simulation studies and real genotype datasets, demonstrating superior performance and robustness compared to existing methods.

关键词： Couplings Monte Carlo methods Correlation Error analysis Graphics processing units Genomics Robustness Bioinformatics Genotypes

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内嵌叠氮化铜碳纳米管复合含能材料的制备与表征

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爆破器材 2019年第5期48卷 19-23页

作者：石城宽许湘宁董成刘旭文胡艳陈秉文南京理工大学化工学院

叠氮化铜是一种绿色环保的高能含能材料,其极高的静电感度限制了它在MEMS火工品微型装药中的应用。碳纳米管优异的导电性可以有效地降低叠氮化铜的静电感度,而且取向一致、高机械强度的碳纳米管可以有效地提高叠氮化铜的安全性和爆轰输... 详细信息

叠氮化铜是一种绿色环保的高能含能材料,其极高的静电感度限制了它在MEMS火工品微型装药中的应用。碳纳米管优异的导电性可以有效地降低叠氮化铜的静电感度,而且取向一致、高机械强度的碳纳米管可以有效地提高叠氮化铜的安全性和爆轰输出能量。本文中,设计并制备了基于硅基底及多孔氧化铝模板的内嵌叠氮化铜碳纳米管复合含能材料,探究了合适的制备条件,并对样品进行了表征分析。结果表明:在氧化电压45V、沉积电流密度0.1mA/cm^2条件下制备的复合材料,经72h叠氮化反应后得到的内嵌叠氮化铜碳纳米管复合含能材料在静电感度仪测试范围(≤25kV)内均未发火,有望作为一种新型含能装药应用于MEMS器件中。

关键词：叠氮化铜碳纳米管复合含能材料

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Mesoporous Palladium-Boron-Sulfur Alloy Nanospheres for Efficient Hydrogen Evolution

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INORGANIC CHEMISTRY 2021年第7期60卷 4380-4384页

作者： Guo, xuwen Chen, Zhichao Huang, Yanping Lv, Hao Wang, Yaru Sun, Lizhi Song, Kai liu, Ben Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab New Power Batteries Nanjing 210023 Peoples R China Shenzhen RELX Technol Co Ltd Shenzhen 518108 Peoples R China Sichuan Univ Coll Chem Chengdu 610064 Peoples R China Changchun Normal Univ Sch Life Sci Changchun 130032 Peoples R China Sichuan Univ Sch Chem Engn Ctr Engn Expt Teaching Chengdu 610065 Peoples R China

Ternary noble metal-metalloid-nonmetal PdBS alloy mesoporous nanospheres (MSs) with three-dimensional central-radial pore channels were prepared for an electrocatalytic hydrogen evolution reaction. The synthesis was performed via precise control in the reduction and nucleation growth of ternary PdBS alloy MSs along confined cylinder mesophases assembled by amphiphilic dioctadecyldimethylammonium chloride. The resultant PdBS alloy MSs disclosed a remarkably improved electrocatalytic performance due to their structural and compositional synergies. This finding extended our knowledge on the rational design and targeted synthesis of novel noble metal-metalloid-nonmetal alloys with desired structures and morphologies for catalysis and other applications.

关键词： Palladium Alloys Genetics Evolution reactions Transmission electron microscopy

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Multi-Objective Policy Monitoring Method for Epidemic Control

Multi-Objective Policy Monitoring Method for Epidemic Contro...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Xin Lai Rundong Fan Ruoyu liu Jiayin Wang Xiaoyan Zhu Yuqian liu xuwen Wang Shenjie Wang School of Computer Science and Technology Xi’an Jiaotong University Xi’an China

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

In the face of emerging infectious diseases such as COVID-19, timely government intervention is crucial, as swift policy actions can effectively prevent greater losses. However, policymakers often need to balance multiple conflicting objectives. The lack of high-quality data and suitable analytical tools poses significant challenges for policy evaluation, especially in multi-objective decision-making, where accurately assessing the impact of interventions becomes even more difficult. To address this issue, this paper proposes a real-time data-driven policy monitoring method for dynamically tracking the effects of policy interventions. We introduce a new non-parametric one-sided test control chart, leveraging the interpretability and ease of implementation of control charts to monitor risk levels across various policies. Experimental results demonstrate the effectiveness of this method in policy monitoring.

关键词： COVID-19 Epidemics Infectious diseases Government Process control Control charts Stability analysis Real-time systems Biomedical monitoring Monitoring

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番茄红素通过SIRT1/NF-κB轴抑制肾癌786-O细胞增殖且促进其凋亡

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中国肿瘤生物治疗杂志 2023年第9期30卷 789-796页

作者：刘伟杨树芹赵序雯滕州市中心人民医院病理科山东滕州277500

目的:探讨番茄红素通过沉默信息调节因子1(SIRT1)/核因子-κB(NF-κB)轴对肾癌786-O细胞增殖、凋亡的影响。方法:常规培养人正常肾细胞HK-2和人肾癌细胞786-O,实验分为对照组(0.1%DMSO)、顺铂组(40μg/mL)、番茄红素低质量浓度(2.5μg/... 详细信息

目的:探讨番茄红素通过沉默信息调节因子1(SIRT1)/核因子-κB(NF-κB)轴对肾癌786-O细胞增殖、凋亡的影响。方法:常规培养人正常肾细胞HK-2和人肾癌细胞786-O,实验分为对照组(0.1%DMSO)、顺铂组(40μg/mL)、番茄红素低质量浓度(2.5μg/mL)组、番茄红素高质量浓度(5μg/mL)组、番茄红素(5μg/mL)+EX527(SIRT1抑制剂)(3μmol/L)组。CCK-8法、克隆形成实验检测各组HK-2、786-O细胞的增殖能力,流式细胞术检测各组786-O细胞的凋亡,RH123、DCFH-DA染色分别检测各组786-O细胞的线粒体膜电位(MMP)、活性氧(ROS)水平,WB法检测各组786-O细胞中凋亡相关蛋白BAX、Bcl-2、C-casp3和SIRT1/NF-κB轴相关蛋白SIRT1、p-NF-κB蛋白的表达。786-O细胞移植瘤实验检测番茄红素低(5 mg/kg)、高质量浓度(20 mg/Kg)、顺铂(2 mg/kg)、番茄红素(20 mg/kg)+EX527(10 mg/kg)对移植瘤生长的影响,TUNEL法检测各组移植瘤组织中的细胞凋亡。结果:番茄红素呈剂量依赖性地抑制786-O细胞的增殖活性,番茄红素、顺铂均明显抑制786-O细胞的克隆形成能力且促进其凋亡,细胞中MMP损伤率升高而ROS水平降低,凋亡相关蛋白BAX、C-casp3表达均显著升高(均P<0.05)而Bcl-2表达下调(P<0.05),SIRT1表达显著升高(P<0.05)而p-NF-κB的表达显著降低(P<0.05),上述作用均可被EX527逆转;番茄红素、顺铂抑制786-O细胞移植瘤的生长且促进其细胞凋亡,其作用也能被EX527逆转。结论:番茄红素通过上调SIRT1、抑制NF-κB通路的激活进而抑制786-O细胞增殖且诱导其凋亡。

关键词：肾癌 786-O细胞番茄红素沉默信息调节因子1 核因子-κB 增殖凋亡

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Delays in routine childhood vaccinations and their relationship with parental vaccine hesitancy: a cross-sectional study in Wuxi, China

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EXPERT REVIEW OF VACCINES 2022年第1期21卷 135-143页

作者： Wang, Qiang Xiu, Shixin Yang, liuqing Han, Ying Huang, Jinxin Cui, Tingting Shi, Naiyang liu, Minqi Wang, xuwen Lu, Bing Jin, Hui Lin, Leesa Southeast Univ Sch Publ Hlth Dept Epidemiol & Hlth Stat 87 Dingjiaqiao Nanjing 210009 Peoples R China Southeast Univ Sch Publ Hlth Key Lab Environm Med Engn Minist Educ Nanjing Peoples R China Wuxi Ctr Dis Control & Prevent Dept Immunizat Planning Wuxi Jiangsu Peoples R China London Sch Hyg & Trop Med Dept Infect Dis Epidemiol London England Hong Kong Sci Pk Lab Data Discovery Hlth D24H Hong Kong Peoples R China

Objectives This study aimed to examine childhood vaccination delay, explore the association between vaccination delay and parental vaccine hesitancy, and assess childhood vaccination delays during the coronavirus disease (COVID)-19 pandemic in China. Methods This cross-sectional survey was conducted in Wuxi City. Participants were recruited from local vaccination clinics. Questionnaires were used to collect information about socio-demographics, vaccine hesitancy, and immunization clinic evaluations. Vaccination records were obtained from the Jiangsu Information Management System of Vaccination Cases. Results Overall, 2728 participants were included. The coverage for seven category A vaccines (Expanded Program on Immunization (EPI)) was more than 95% at 24 months. The proportion of children vaccinated in a timely manner was the highest for the first dose of the hepatitis B vaccine (91.6%) and the lowest for the Bacillus-Calmette-Guerin vaccine (44.6%). More than 50% of the planned vaccinations were delayed in February and March 2020. The Vaccine Hesitancy Scale scores were not associated with vaccination delay (P = 0.842). Children's vaccination delays were negatively associated with parents who reported convenient access to clinics and satisfaction with immunization services (P = 0.020, P = 0.045). Conclusions EPI is highly successful in China. Despite vaccination delays due to the COVID-19 pandemic, coverage was recovered after lockdown restrictions were eased.

关键词： Childhood vaccination delay timeliness vaccine hesitancy COVID-19 pandemic

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