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Fetal growth prediction: Establishing fetal growth prediction curves in the second trimester

TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S345-S350页

作者： Wang, Yan Bao, Xinyu Zhang, Song Yang, Lin liu, Guoli Yang, Yimin Li, xuwen Hao, Dongmei Chen, Aiqing liu, Xiaohong Shao, Jing Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Monitoring fetal weight during pregnancy has a guiding role in prenatal care. OBJECTIVE: To establish a personalized fetal growth curve for effectively monitoring fetal growth during pregnancy. METHODS: (1) This study retrospectively analyzed the birth weight database of 2,474 singleton newborns delivered normally at term. The personalized fetal growth curve model was formed by combining the estimating birth weight of newborns with the proportional weight formula. (2) Multiple linear stepwise regression method was used to estimate the birth weight of newborns. RESULTS: (1) Delivery gestational age, weight at first visit, maternal height, pre-pregnancy body mass index, fetal sex, parity had significant effects on birth weight. Based on these parameters, the formula for calculating term optimal weight was obtained (R-2 = 22.8%, P < 0.001). (2) The personalized fetal growth curve was obtained according to the epidemiological factors input model of each pregnant woman. CONCLUSIONS: A model of personalized fetal growth curve can be established, and be used to evaluate fetal growth and development through estimated fetal weight monitoring.

关键词： Fetal weight growth charts personal health services

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Assessing the prognostic impact of prostatic urethra involvement and developing a nomogram for T1 stage bladder cancer

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BMC UROLOGY 2023年第1期23卷 182-182页

作者： Wan, Hao Zhan, Xiangpeng Li, xuwen Chen, Tao Deng, Xinxi liu, Yang Deng, Jun Fu, Bin Li, Yu Nanchang Univ Dept Urol Affiliated Hosp 1 Nanchang Jiangxi Peoples R China Nanchang Univ Dept Cardiol Affiliated Hosp 2 Nanchang Jiangxi Peoples R China Jiu Jiang NO1 Peoples Hosp Dept Urol Jiujiang Jiangxi Peoples R China

Purpose To investigate prognostic values of prostatic urethra involvement (PUI) and construct a prognostic model that estimates the probability of cancer-specific survival for T1 bladder cancer patients. Method and materials We investigated the national Surveillance, Epidemiology, and End Results (SEER) database (2004-2015) to get patients diagnosed with T1 bladder cancer. An external validation cohort was obtained from the First Affiliated Hospital of Nanchang University. The Kaplan-Meier method with the log-rank test was applied to assess cancer-specific survival (CSS) and overall survival (OS). Moreover, the propensity score matching (PSM) and multivariable Cox proportional hazard model were performed. All patients were randomly divided into the development cohort and validation group at the ratio of 7:3. The performance of the model was internally validated by calibration curves and the concordance index (C-index). Results The PUI group had a lower survival rate of both CSS and overall survival OS before and after PSM when compared to non-involved patients (All P < 0.05). Multivariate analysis revealed a poor prognosis in the PUI group for cancer-specific mortality (CSM) and all-cause mortality (ACM) analyses before and after PSM (All P < 0.05). Seven variables, including age, surgery, radiotherapy, tumour size, PUI, and marital status, were incorporated in the final nomogram. The C-index in the development cohort was 0.715 (0.711-0.719), while it was 0.672 (0.667-0.677) in the validation group. Calibration plots for 3- and 5-year cancer-specific survival showed good concordance in the development and validation cohorts. Conclusions PUI was an independent risk factor of ACM and CSM in T1 bladder cancer patients. In addition, a highly discriminative and precise nomogram that predicted the individualized probability of cancer-specific survival for patients with T1 bladder cancer was constructed.

关键词： Prognosis T1 bladder cancer Prostatic urethra involved SEER Nomogram

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基于CiteSpace的黑茶研究现状可视化分析

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食品工业科技 2024年第8期45卷 397-406页

作者：张旭雯刘岁赵锦琦杨亚葛炳钢王坤波傅冬和湖南农业大学茶学教育部重点实验室湖南长沙410128 国家植物功能成分利用工程技术研究中心湖南长沙410128 湖南省植物功能成分利用协同创新中心湖南长沙410128 农业农村部园艺作物基因资源评价利用重点实验室湖南长沙410128

黑茶是最受欢迎的茶类之一,为梳理黑茶研究进程,本文利用CiteSpace可视化分析软件,基于中国知网(China national knowledge infrastructure,CNKI)数据库和Web of Science(WOS)数据库核心集合,筛选出的3436篇中文文献和617篇英文文献,对... 详细信息

黑茶是最受欢迎的茶类之一,为梳理黑茶研究进程,本文利用CiteSpace可视化分析软件,基于中国知网(China national knowledge infrastructure,CNKI)数据库和Web of Science(WOS)数据库核心集合,筛选出的3436篇中文文献和617篇英文文献,对作者、关键词、研究机构、国家以及发表期刊等信息进行可视化分析。结果表明,黑茶文献数量呈上升趋势,中文研究早于英文研究,正处于高速发展阶段;《福建茶叶》和《Journal of Agricultural and Food Chemistry》分别是发表黑茶文献最多的中英文期刊;黑茶研究形成了多个研究团体,学者代表有刘仲华、吕才有、周红杰等;研究机构主要为各大农业院校和茶叶研究所,其中,研究成果较深入的机构是云南农业大学、湖南农业大学和安徽农业大学;黑茶研究领域中,我国是影响力最大的国家,其次为美国和日本;中文研究侧重于黑茶品质形成机理、微生物、香气成分等方面,英文研究更关注黑茶的药理研究。黑茶对糖尿病、动脉粥样硬化等代谢疾病的干预功效研究仍是未来国内外研究的热点。

关键词：黑茶 CiteSpace 文献计量学科学知识图谱

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Single-Atom Fe-Anchored Nano-Diamond With Enhanced Dual-Enzyme Mimicking Performance for H2O2 and Glutathione Detection

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2022年 9卷 790849页

作者： liu, Ying Yan, Jianghong Huang, Yu Sun, Zhiheng Zhang, Huijing Fu, Lihaoyuan Li, xuwen Jin, Yongri Jilin Univ Coll Chem Changchun Peoples R China First Clin Hosp Jilin Prov Acad Tradit Chinese Med Changchun Peoples R China

Glutathione (GSH) is an important antioxidant and free radical scavenger that converts harmful toxins into harmless substances and excretes them out of the body. In the present study, we successfully prepared single-atom iron oxide-nanoparticle (Fe-NP)-modified nanodiamonds (NDs) named Fe-NDs via a one-pot in situ reduction method. This nanozyme functionally mimics two major enzymes, namely, peroxidase and oxidase. Accordingly, a colorimetric sensing platform was designed to detect hydrogen peroxide (H2O2) and GSH. Owing to their peroxidase-like activity, Fe-NDs can oxidize colorless 3,3 ',5,5 '-tetramethylbenzidine (TMB) into blue with sufficient linearity at H2O2 concentrations of 1-60 mu M and with a detection limit of 0.3 mu M. Furthermore, using different concentrations of GSH, oxidized TMB can be reduced to TMB, and the color change from blue to nearly colorless can be observed by the naked eye (linear range, 1-25 mu M;detection limit, 0.072 mu M). The established colorimetric method based on oxidase-like activity can be successfully used to detect reduced GSH in tablets and injections with good selectivity and high sensitivity. The results of this study exhibited reliable consistency with the detection results obtained using high-performance liquid chromatography (HPLC). Therefore, the Fe-NDs colorimetric sensor designed in this study offers adequate accuracy and sensitivity.

关键词： nanodiamond single-atom Fe peroxidase-like and oxidase-like activity colorimetric sensor glutathione

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Probing the surface forces between air bubbles and bitumen via direct force Measurements: Effects of aqueous chemistry

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FUEL 2024年第PartC期357卷

作者： Yang, Diling Qiao, Chenyu Mao, Xiaohui Wang, Jingyi Xie, Lei Chen, Jingsi Peng, xuwen Peng, Qiongyao Wang, Tao liu, Qi Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada

The surface interactions of air bubbles and other components (e.g., particles, oil droplets) significantly influence the operation efficiency of a variety of engineering processes such as oily water treatment, bitumen extraction and flotation. Herein, the surface interactions of air bubbles with two types of Athabasca bitumen samples in aqueous solutions of varying pH, salinity, type of cations and in the presence of surfactants have been systematically characterized using a bubble probe atomic force microscope (AFM) technique. AFM imaging has revealed that exposure to high concentrations of NaCl and CaCl2 solutions or alkaline environments causes roughening of the bitumen surfaces. The results of surface force measurements demonstrate that the interaction and attachment behaviors between bubbles and bitumen are significantly affected by ionic strength, solution pH, and the presence of surfactants. The experimental force measurement results could be accurately described by a theoretical model that incorporates Reynolds lubrication theory and augmented Young-Laplace equation, with the inclusion of disjoining pressure. In low-salinity conditions, the bubble-bitumen interaction is dominated by electric double layer (EDL) repulsion, which prevents surface attachment. This effect is more pronounced at elevated pH conditions. In high-salinity solutions, however, the EDL interactions are significantly reduced, and the hydrophobic interaction becomes the dominant factor, overcoming the van der Waals repulsion and leading to the attachment of bubbles to bitumen surfaces. Raising aqueous pH weakens the bubble-bitumen hydrophobic interaction, whereas the introduction of calcium ions strengthens this interaction, resulting in enhanced surface attachment. Interestingly, even in high-salinity conditions, the presence of a small number of surfactants can inhibit bubble-bitumen contact, mainly caused by reduced hydrophobic attraction and increased steric repulsion. This work provid

关键词： bitumen oil sands bitumen flotation bubbles surface interactions

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Gradient tumor microenvironment-promoted penetrating micelles for hypoxia relief and immunosuppression reversion in pancreatic cancer treatment

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ACTA BIOMATERIALIA 2023年第1期167卷 387-400页

作者： Luo, Yifan Li, Chao Zhang, Yiwen liu, Peixin Chen, Hongyi Zhao, Zhenhao Wang, Yu Zhou, Zheng Song, Haolin Su, Boyu Li, Chufeng Li, xuwen Zhang, Tongyu You, Haoyu Wu, Yuxing Tian, Zonghua Zhang, Shilin Guo, Yun Fan, Hongrui Chen, Qinjun Jiang, Chen Sun, Tao Fudan Univ Minhang Hosp Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is the main block for the penetration of chemotherapy. In the tumor microenvironment, a dense matrix composed of fibrin is formed on the exterior, while the interior is featured by high reduction, hypoxia and low pH. How to match the special microenvironment to on-demand drug release is the key to improve chemotherapeutic efficacy. Herein, a microenvironment-responsive micellar system is developed to deepen tumoral penetration. Briefly, the conjugation of a fibrin-targeting peptide to PEG-poly amino acid has been utilized to achieve accumulation of micelles in the tumor stroma. By modification of micelles with hypoxia-reducible nitroimidazole which becomes protonated under acidic conditions, their surface charge is more positive, facilitating deeper penetration into tumors. Paclitaxel was loaded onto the micelles via a disulfide bond to enable glutathione (GSH)-responsive release. Therefore, the immunosuppressive microenvironment is relived through the alleviation of hypoxia and depletion of GSH. Hopefully, this work could establish paradigms by designing sophisticated drug-delivery systems to tactfully employ and retroact the tamed tumoral microenvironment to improve the therapeutic efficacy based on understanding the multiple hallmarks and learning the mutual regulation.

关键词： Pancreatic cancer Penetration Nitroimidazole Tumor hypoxia Gemcitabine

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非线性曲面梁形态优化及恒压支撑装置设计

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机械强度 2024年第1期46卷 161-168页

作者：谢苗张文卓李伟东刘杰邹青海邢旭文辽宁工程技术大学机械工程学院华能煤炭技术研究有限公司庆阳新庄煤业有限公司新庄煤矿

基于超前支护设备顶梁支撑结构研究一种恒压支撑装置的设计方法，恒压支撑装置由正刚度线性弹簧、负刚度非线性平面曲梁及承压气囊组合而成。通过对巷道顶板应力场分析，得到支撑结构的边界条件；利用B样条曲线简述负刚度非线性平面曲... 详细信息

基于超前支护设备顶梁支撑结构研究一种恒压支撑装置的设计方法，恒压支撑装置由正刚度线性弹簧、负刚度非线性平面曲梁及承压气囊组合而成。通过对巷道顶板应力场分析，得到支撑结构的边界条件；利用B样条曲线简述负刚度非线性平面曲梁的特点；基于遗传算法与非线性有限元法对负刚度非线性平面曲梁进行形态优化设计；依据恒压支撑装置的工作原理，对线性螺旋弹簧刚度/强度特性进行分析与设计；对恒压支撑装置的零部组件进行设计，实现支撑装置输出压强大小恒定及自我保护功能。恒压支撑装置设计方法为综掘巷道超前支护研制提供了有力技术支撑。

关键词：恒压支撑装置非线性平面曲梁形态优化

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Prediction of hypertensive disorders in pregnancy based on placental growth factor

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S165-S170页

作者： Xu, Qi Sun, Ge Zhang, Song liu, Guoli Yang, Lin Meng, Yu Chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei liu, Xiaohong Shao, Jing Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: The prediction of hypertensive disorders in pregnancy (HDP) mainly involves various aspects such as maternal characteristics and biomarkers. OBJECTIVE: We aimed to study the effect of the HDP prediction model with or without placental growth factor (PlGF). METHODS: This study used maternal factors and PlGF, and standardized the data uniformly. At 12-20 weeks, the comprehensive comparison of model quality with or without PlGF was conducted by logistic regression. RESULTS: The area under curve and the model accuracy of the model with PlGF were higher than those of the model without PlGF. The accuracy of the model with PlGF was above 90%. CONCLUSIONS: Adding PlGF to the model for predicting HDP improved the accuracy and effectiveness of the model. This study confirmed the predictive performance of PlGF.

关键词： Model accuracy placental growth factor logistic regression

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Intelligent generation method of 3D machining process based on process knowledge

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INTERNATIONAL JOURNAL OF COMPUTER INTEGRATED MANUFACTURING 2020年第1期33卷 38-61页

作者： Jing, xuwen Zhu, Yuping liu, Jinfeng Zhou, Honggen Zhao, Peng liu, Xiaojun Tian, Guizhong Ye, Hua Li, Qun Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Jiangsu Peoples R China Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang Jiangsu Peoples R China Southeast Univ Sch Mech Engn Nanjing Jiangsu Peoples R China Hudong Heavy Machinery Co Ltd Inst Comprehens Technol Shanghai Peoples R China

Intelligent manufacturing has become the trend of global manufacturing industry, and the core of the new industrial revolution and the commanding point of Made in China 2025. Process planning is an important part of intelligent manufacturing. To improve the speed and accuracy of intelligent generation of machining process, a systematic intelligent generation method of machining process based on process knowledge is proposed. Firstly, a method of modelling and management of process knowledge is presented. Secondly, by combining case-based reasoning with rule-based reasoning, accurate process information of machining features is obtained. Then, the skeleton process is formed. Thirdly, through the analysis of the precedence constraints and the processing experience constraints, the precedence relation between machining features is determined. Moreover, the precedence between process operations is formulated by process constraint matrix. Finally, a genetic algorithm (GA) approach is presented to obtain the global optimal process route for the part based on working step with process information. Taking the connecting rod and piston of marine diesel engine and the spindle box shell as the research object, the feasibility of this method is verified.

关键词： Process knowledge skeleton process process constraint matrix genetic algorithm machining process

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Marketization and Energy Poverty: Empirical Evidence from China

SSRN

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SSRN 2022年

作者： Shi, Xinjie Zeng, Pei Qiu, Tongwei Jiang, Qiang Cui, liu Gao, xuwen Peking University China

Along with economic growth, improving the quality of life of its citizens is a focal issue for the Chinese government. Energy poverty—a topic closely related to people’s quality of life—has received global attention. This article focuses on the relationship between marketization and energy poverty, estimating the intrinsic relationship between marketization and energy poverty by constructing panel data using the instrumental variable method. The study reveals a significant upward trend in marketization in China in recent years, with a concomitant decrease in energy poverty. The results confirm that marketization improves the quantity of energy supply and alleviates energy poverty, and that the quality of energy supply is also an effective way for marketization to impact energy poverty. However, this mechanism is mainly reflected in the fact that marketization increases the accumulation of human capital and promotes the use of clean energy, but not in the improvement of energy supply efficiency by marketization. Additionally, marketization-led increase in people’s income alleviates energy poverty. This study adds to the existing literature and provides important policy insights for market-based development and energy poverty reduction. © 2022, The Authors. All rights reserved.

关键词： Economic analysis

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