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Predicting hypertensive disorders in pregnancy using multiple methods: Models with the placental growth factor parameter

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S427-S432页

作者： Sun, Ge Xu, Qi Zhang, Song Yang, Lin liu, Guoli Meng, Yu Chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei liu, Xiaohong Shao, Jing Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Placental growth factor (PlGF), one of the biomarkers, has a certain predictive effect on hypertensive disorders in pregnancy (HDP). OBJECTIVE: To study the HDP prediction effect of different methods for variable selection and modeling for models containing PlGF. METHODS: For the model containing PlGF, the appropriate range of PlGF parameters needed to be selected. Step-logistic regression and lasso were used to compare the model effect of twice range selection. The PlGF model with good predictive effect and appropriate detecting gestational age was selected for the final prediction. RESULTS: The effect of the model containing PlGF tested at 15-16 weeks was better than the PlGF value without comprehensive screening. The sensitivity of both methods was over 92%. By comprehensive comparison, the final model of lasso method in this study was more effective. CONCLUSIONS: In this study, a variety of methods were used to screen models containing PlGF parameters. According to clinical needs and model effects, the optimal HDP prediction model with PlGF parameters in the second trimester of 15-26 weeks of pregnancy was finally selected.

关键词： Placental growth factor model parameters variable selection

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零件加工隐性工艺知识获取方法研究

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图学学报 2024年第2期45卷 399-408页

作者：张一鸣刘金锋陈亚杰瞿鹏飞景旭文刘晓军江苏科技大学机械工程学院江苏镇江212028 上海船舶设备研究所上海200030 东南大学机械工程学院江苏南京211100

随着制造业数字化工艺的深入应用,如何高效利用积累的工艺知识,已成为提升工艺设计效率与质量的关键,然而隐性工艺知识却存在难以获取、描述与转化的技术瓶颈,严重阻碍智能化工艺设计模式推广。为此,提出了一种复杂零件加工的隐性工艺... 详细信息

随着制造业数字化工艺的深入应用,如何高效利用积累的工艺知识,已成为提升工艺设计效率与质量的关键,然而隐性工艺知识却存在难以获取、描述与转化的技术瓶颈,严重阻碍智能化工艺设计模式推广。为此,提出了一种复杂零件加工的隐性工艺知识获取方法。首先,利用等宽法对结构化工艺数据进行离散化处理,构建基于文本挖掘的隐性工艺知识获取流程,并通过产生式规则对隐性工艺知识表达;然后,基于案例推理和规则推理融合的知识推理方法,并采用最近邻算法实现隐性工艺知识的识别;最后,以船用柴油机缸盖类复杂加工零件为验证对象,对加工隐性工艺知识获取方法进行了有效验证。

关键词：隐性知识产生式规则文本挖掘案例推理规则推理最近邻算法

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A novel calcium phosphate-based nanocomposite for the augmentation of cement-injectable cannulated pedicle screws fixation: A cadaver and biomechanical study

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JOURNAL OF ORTHOPAEDIC TRANSLATION 2020年 20卷 56-66页

作者： Sun, Haolin liu, Chun Li, xuwen liu, Huiling Zhang, Weiguang Yang, Huilin Li, Chunde Yang, Lei Peking Univ Dept Orthoped Hosp 1 8 Xishiku St Beijing 100034 Peoples R China Soochow Univ Inst Orthoped Dept Orthoped Suzhou Peoples R China Peking Univ Sch Basic Med Sci Dept Human Anat 38 Xueyuan Rd Beijing 100191 Peoples R China Hebei Univ Technol Ctr Hlth Sci & Engn Sch Mat Sci & Engn Tianjin Key Lab Mat Laminating Fabricat & Interfa Tianjin Peoples R China

Background/objective: Both polymethylmethacrylate (PMMA) and traditional calcium phosphate-based cements have some deficiencies as augmentation materials for pedicle screw fixation. Here, a novel calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was developed based on previous study, and the handling properties, biomechanical performance, and biodegradation behaviour of CPN were evaluated and compared with clinical PMMA by means of a cadaver study and animal tests. Methods: Bone mineral density of the lumbar vertebrae was tested. Pedicle screws were placed into the lumbar vertebrae under the guidance of three dimensionally printed templates;each of which was designed based on computed tomography (CT) reconstruction of each vertebrae and augmented with either PMMA or CPN. X-ray and CT scan were used to evaluate the accuracy of screw placement and dispersion as well as interdigitation of bone cement. The axial pull-out strength and maximum torque were tested using a mechanical testing machine. Degradation behaviour of CPN was evaluated by in vitro immersion tests for 8 weeks and in vivo rabbit femur defect model for up to 6 months, respectively. Results: Standard mechanical tests revealed that PMMA was much stronger than CPN after setting (compressive strength 95 vs. 49 MPa, respectively, p < 0.001). Results of the projection area and volume distribution of cement along the distal end of the screws revealed that CPN exhibited unique dispersing and interdigitation abilities compared with PMMA. Specifically, CPN dispersed uniformly and symmetrically along the screw, while PMMA was limited to the proximal part of the screw. Axial pull-out test results showed that the axial pull-out strengths of CPN- and PMMA-augmented pedicle screws were similar (1199 +/- 225 N vs 1337 +/- 483 N, respectively) and not significantly different (p = 0.47), although CPN was an intrinsically weaker material than PMMA. Similarly, CPN showed average torq

关键词： Calcium phosphate-based cement Injectable Osteoporosis Pedicle screw PMMA

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Gestational diabetes mellitus prediction model: A risk factors analysis of pregnant women with gestational diabetes mellitus but have normal oral glucose tolerance test results in the second trimester of pregnancy

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S57-S63页

作者： Lu, Jiayu Zhang, Song Jiang, Hongqing Yang, Lin Hao, Dongmei Yang, Yimin Li, xuwen Chen, Aiqing Shao, Jing liu, Xiaohong Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing 100124 Peoples R China Haidian Maternal & Children Hlth Hosp Beijing 100080 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Oral glucose tolerance test (OGTT) is a standard for the diagnosis of gestational diabetes mellitus (GDM). However, clinically, some cases with normal results were diagnosed as GDM in the third trimester. OBJECTIVE: To establish a risk model based on energy metabolism, epidemiology, and biochemistry that could predict the GDM pregnant women with normal OGTT results in the second trimester. METHODS: Qualitative and quantitative data were analyzed to find out the risk factors, and the binary logistic backward LR regression was used to establish the prediction model of each factor and comprehensive factor, respectively. RESULTS: The risk factors including the rest energy expenditure per kilogram of body weight, oxygen consumption per kilogram of body weight, if more than the weight gain criteria of the Institute of Medicine, the increase of body mass index between the second trimester and pre-pregnancy, and fasting blood glucose. By comparison, the comprehensive model had the best prediction performance, indicating that 85% of high-risk individuals were correctly classified. CONCLUSION: Energy metabolism, epidemiology, and biochemistry had better recognition ability for the GDM pregnant women with normal OGTT results in the second trimester. The addition of metabolic factors in the second trimester also improved the overall prediction performance.

关键词： Prediction model gestational diabetes mellitus rest energy metabolism

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Transcytosis Mediated Deep Tumor Penetration for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer

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ADVANCED FUNCTIONAL MATERIALS 2023年第28期33卷

作者： Chen, Hongyi Song, Haolin Luo, Yifan Li, Chufeng Wang, Yu liu, Jie Luo, Feifei Fan, Hongrui Li, xuwen Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryState Key Lab Med Neur Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fudan Univ Huashan Hosp Dept Digest Dis Shanghai 200040 Peoples R China

The hyperproliferative tumor stroma of pancreatic ductal adenocarcinoma (PDAC) severely limits drug permeation and constructs an immunosuppressive microenvironment, causing resistance to chemotherapy and immunotherapy. Traditional nanomedicine mainly focuses on manipulating nanoparticles' particle size or electrical characteristics to penetrate deep PDAC through the paracellular pathway, but the transcellular pathway is often ignored. Therefore, a versatile drug-polymer conjugate PODEA-Gem-HMI is prepared and assembled into nanoparticles for the codelivery of chemotherapy drug gemcitabine and focal adhesion kinase (FAK) inhibitor defactinib. While sensing the mild acidity in the tumor microenvironment, the nanoparticle will disintegrate and release defactinib to modulate the tumor stroma. The PODEA block of the conjugate can bind with cell membranes reversibly and trigger adsorption-mediated transcytosis (AMT) for promoted tumor penetration and cellular uptake. The internalized conjugates will release gemcitabine responding to the overexpressed glutathione (GSH) for enhanced chemotherapy, and PHMI can condensate the STING monomers for prolonged spontaneous immune stimulation.

关键词： sting activation stroma modulation transcytosis tumor penetration

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Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models

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SAUDI JOURNAL OF BIOLOGICAL SCIENCES 2020年第9期27卷 2485-2490页

作者： Qin, Zhenlong Wang, Lei Li, Guoyan Qian, xuwen Zhang, Jie Guo, Ying liu, Guokai Beijing Univ Chinese Med Affiliated Hosp 3 Dept Anesthesiol Beijing 100029 Peoples R China Beijing Univ Chinese Med Dongzhimen Hosp Dept Anesthesiol 5 Haiyuncang Hutong Beijing 100700 Peoples R China

Objective: To investigate the analgesic effect of amitriptyline on neuropathic pain model rats, diabetic neuropathic pain model rats and fibromyalgia model rats. Methods: The healthy male Sprague wrote - Dawley (SD) rats were taken as the research object, and they were randomly divided into model group (group A), beside the sciatic nerve and injection of 5 mm amitriptyline group (group B), beside the sciatic nerve and injection of 10 mm amitriptyline group (group C), beside the sciatic nerve and injection of 15 mm amitriptyline group (group D), intraperitoneal injection of amitriptyline group (group E). Pain induced by selective injury of sciatic nerve branches in rats, pain induced by chronic compression of sciatic nerve, diabetic neuropathic pain and fibromyalgia were conducted to determine the pain threshold of mechanical stimulation in rats after drug administration. Results: The pain threshold of mechanical stimulation in the local amitriptyline group (group B, C, D) was significantly higher than that in the group A and group E at each time point after drug treatment, and the pain threshold of mechanical stimulation gradually increased with the increase of concentration. There was no statistically significant difference in mechanical stimulation pain threshold between group A and group E at each time point after drug treatment. Conclusion: Para-sciatic injection of amitriptyline at different concentrations has analgesic effects on neuropathic pain, diabetic neuropathic pain and fibromyalgia in rat models, and amitriptyline directly ACTS on the local sciatic nerve. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

关键词： Tricyclic antidepressants Rat model Neuropathic pain Diabetic neuropathic pain Fibromyalgia

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Mid-Miocene (17-11 Ma) Fast Exhumation in the Upper Jinsha River and its Implication for Regional Faulting in Southeast Tibet

SSRN

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SSRN 2023年

作者： Shen, xuwen liu-Zeng, Jing Shen, Xiaoming Ge, Yukui Zeng, Xianyang Wang, Zijun Xing, Yukun Wang, Heng School of Earth System Science Tianjin University Tianjin300072 China National Institute of Natural Hazards Ministry of Emergency Management of China Beijing100085 China State Key Laboratory of Earthquake Dynamics Institute of Geology China Earthquake Administration Beijing100029 China School of Geography Earth and Atmospheric Sciences University of Melbourne VIC3010 Australia

The rugged southeast (SE) Tibet hosts a network of evolving faults, many of which are poorly understood due to a lack of sedimentary records and poor accessibility. The Jinsha River fault zone (JRFZ) is vaguely considered as a major fault bounding the Chuan-Dian Block in the northwest, yet little is known about its tectonic evolution history, which hinders our clear understanding of the tectonic deformation pattern, process and geomorphic response of SE Tibet. Here, we collected 10 samples from the hanging wall of the Xiongsong reverse fault, one strand of the JRFZ, near Markam area and on the trunk of the upper Jinsha River, to reveal its exhumation and kinematic history through low-temperature thermochronology. The ZHe ages (~17-13 Ma) of the samples from the hanging wall are much younger than the published ones in the footwall, but the AFT (~11-9 Ma) and AHe ages (~14-6 Ma) are only slightly younger than those in the footwall. The QTQt and 3-D thermo-kinematic Pecube modeling suggest consistently that the Xiongsong fault experienced strong activity during the mid-Miocene (~17-11 Ma) and then weakened. Post-11 Ma decreases in exhumation here on the trunk of the Jinsha river, if interpreted as river incision, is opposite to previously inferred river response to late Miocene surface uplift driven by the lower crust flow, implying the importance of local faulting in regional exhumation and perhaps the development of the Jinsha River. The late Miocene transition of faulting activity is found on other major faults in SE Tibet as well. We infer that the near synchronized change in regional fault activity may be caused by the clockwise rotation of the Chuan-Dian block, while its being extruded southeastward from the pushing front of the Indian collision. © 2023, The Authors. All rights reserved.

关键词： Rivers

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A Lossless Compression Algorithm Based on Differential and Canonical Huffman Encoding for Spaceborne Magnetic Data 20

A Lossless Compression Algorithm Based on Differential and C...

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2nd International Conference on Image, Video and Signal Processing, IVSP 2020

作者： Li, Li liu, Huijie Zhu, Ye Liang, xuwen liu, Lei Innovation Academy for Microsatellites of CAS Shanghai China

ISBN: (纸本)9781450376952

Lossless compression for spaceborne magnetic data is significant, especially for small, low-cost satellites or deep space exploration spacecrafts. However, most of existing lossless compression algorithms are difficult to adapt to the embedded platform or the existing embedded algorithms have low compression ratio. In light of this, taking full advantage of the characteristics that the spaceborne magnetic data change slowly in a short time, a lossless compression algorithm based on differential encoding and canonical Huffman encoding is proposed. The original magnetic values are replaced with differential values with variable byte length to shorter the length of raw data. Canonical Huffman encoding can be performed twice after differential operation to further improve the compression ratio if the memory is sufficient. Experiments are carried out on spaceborne magnetic data of a satellite on an onboard computer. This algorithm can get compression ratio of 1.76 and 1.83 with canonical Huffman encoding disabled and enabled respectively, and the results demonstrate the superiority of the proposed algorithm in comparison with embedded LZW algorithms. © 2020 ACM.

关键词： Signal encoding

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仿刺参中两种新海参烷型皂苷

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高等学校化学学报 2023年第4期44卷 27-34页

作者：孙志恒刘桂英王冰姿陈义夫冯月竹金永日李绪文吉林大学化学学院长春130012 辽宁省海洋水产科学研究院大连116023

从仿刺参(Apostichopus japonicus Selenka)乙醇提取物中分离得到2个新的海参烷型皂苷类化合物,通过波谱数据分析并结合理化性质鉴定其分别为3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃喹诺糖]-4-O-[... 详细信息

从仿刺参(Apostichopus japonicus Selenka)乙醇提取物中分离得到2个新的海参烷型皂苷类化合物,通过波谱数据分析并结合理化性质鉴定其分别为3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃喹诺糖]-4-O-[β-D-吡喃葡萄糖]-β-D-吡喃木糖}-海参烷-7(8),25(26)-二烯-16-酮(化合物1,命名为Holotoxin E1)和3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃葡萄糖]-4-O-[β-D-吡喃葡萄糖-(1→3)-β-D-吡喃葡萄糖]-β-D-吡喃木糖}-海参烷-7(8),25(26)-二烯-16-酮(化合物2,命名为Holotoxin E2).采用CCK-8法考察了包含上述2个新成分在内的共6个海参烷型皂苷对乳腺癌MDA-MB-231细胞和肝癌HepG2细胞的细胞毒活性.结果表明,除Holotoxin E2外,其余5种化合物对MDA-MB-231(IC50=2.386~4.686μmol/L)和HepG2(IC50=5.909~18.860μmol/L)均具有较好的抑制作用.

关键词：仿刺参海参烷型皂苷分离结构鉴定细胞毒活性

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Metabolomics coupled with SystemsDock reveal the protective effect and the potential active components of Naozhenning granule against traumatic brain injury

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JOURNAL OF ETHNOPHARMACOLOGY 2020年 246卷 112247-000页

作者： Cao, Jianhua Duan, Yahui liu, Yanzhi liu, Haixia Wei, Chunhong Wang, Jiang Qin, Xuemei Wang, xuwen Li, Zhenyu Shanxi Univ Modern Res Ctr Tradit Chinese Med Taiyuan 030006 Shanxi Peoples R China Shanxi Univ Coll Chem & Chem Engn Taiyuan 030006 Shanxi Peoples R China Shanxi Zhendong Ante Biol Pharmaceut Co Ltd Jinzhong 030600 Peoples R China

Ethnopharmacological relevance: Naozhenning granule (NZN), a widely traditional Chinese medicine (TCM) prescription with a long history of clinical, which is mainly used in the treatment of concussion, cerebral post-traumatic syndrome, consists of Di Huang (Radix of Rehmannia glutinosa (Gaertn.) DC.), Dang Gui (Radix of Angelica sinensis (Olio.) Diels), Chen Pi (Pericarpium of Citrus reticulata Blanco), Dan shen (Radix of Salvia Miltiorrhiza Bunge.), Di Long (Pheretima aspergillum (E. Perrier)), Mu Dan Pi (Cortex of Paeonia suffruticosa Andrews), Suan Zao Ren (Semen of Ziziphus jujuba Mill.), Chuan Xiong (Rhizoma of Ligusticum striatum DC.), Zhu Ru (Phyllostachys nigra (Lodd. Ex Lindl.) Munro), Bai Zi Ren (Semen of Platycladus orientalis (L.) Franco) and Fu Ling (sclerotium of Poria cocos (Schw.)Wolf). Aim of the study: This study aimed to unravel the mechanism and material basis of NZN against traumatic brain injury. Materials and methods: In this study, a H-1 nuclear magnetic resonance (NMR) based metabolomic approach combined with systemsDock was employed to study the protective effect of NZN against traumatic brain injury using a cerebral concussion rat model. The morris water maze test and biochemical indexes were used to evaluate the efficacy of NZN. Results: The results of morris water maze test suggested NZN can improve the spatial learning and memory of model rats, and the superoxide dismutas (SOD) and malonyldialdehyde (MDA) level indicated that the effect of NZN was related with the regulation of oxidative stress. Multivariate analysis revealed that the effect of NZN was related with regulation of 18 brain metabolites, and the corresponding metabolic pathways were further revealed by MetPA analysis. 13 serum absorbed components were found to hit the targets both related with the metabolic regulation and cerebral trauma through systemsDock-aided molecular docking experiments, and these compounds might be served as the active compounds in NZN against cerebr

关键词： Naozhenning granule Cerebral concussion Metabolomics Molecular docking

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