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利用构造地貌方法限定走滑断裂第四纪滑动速率的不确定性及意义:以海原断裂带为例

地球科学 2024年第2期49卷 759-780页

作者：王子君姚文倩刘静邵延秀王文鑫沈续文高云鹏徐晶天津大学地球系统科学学院表层地球系统科学研究院天津300072 中国地震局地质研究所地震动力学国家重点实验室北京100029 中国地震局第二监测中心陕西西安710054

断层滑动速率是理解复杂断层系统应变分配与评估地震危险性的重要参数,在多种研究方法中,利用构造地貌学方法限定走滑断裂的第四纪滑动速率较为普遍.在青藏高原活动断裂体系中,海原断裂带承载了部分印度-欧亚板块碰撞产生的应变,其滑动... 详细信息

断层滑动速率是理解复杂断层系统应变分配与评估地震危险性的重要参数,在多种研究方法中,利用构造地貌学方法限定走滑断裂的第四纪滑动速率较为普遍.在青藏高原活动断裂体系中,海原断裂带承载了部分印度-欧亚板块碰撞产生的应变,其滑动速率的精细厘定也是高原构造变形动力学分析的重要参数.过去三十年间前人采用构造地貌学方法对其进行了大量的滑动速率研究,结果位于2.3~16 mm/a之间,不同研究间相差较大,因此引发了众多争议与困惑.在对已有研究进行详细评述的基础上,指出前人研究结果不确定性的重要原因是上级阶地与下级阶地重建模型的选择.结果认为,基于两种位移累积起始时间定义的模型得到的往往是滑动速率的上限或下限,不能简单地将其等同于滑动速率真实值.当缺乏观测数据可以辅助判别两种模型的可靠程度时,应基于上、下级阶地废弃年龄同时对滑动速率进行限定,这是对滑动速率计算过程中客观存在的不确定性的尊重和认可.海原断裂带滑动速率的评估将为后续基于青藏高原内部诸多活动断裂进行两种端元变形模型合理性的分析工作提供重要的方法借鉴.

关键词：滑动速率海原断裂带构造地貌学河流阶地陡坎上、下限评估

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Research progress, problems and prospects of mine water treatment technology and resource utilization in China

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CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY 2020年第4期50卷 331-383页

作者： Zhang, Siyu Wang, Hao He, xuwen Guo, Shaoqing Xia, Yu Zhou, Yuexi liu, Kai Yang, Shipeng China Univ Min & Technol Sch Chem & Environm Engn Beijing 100083 Peoples R China Chinese Res Inst Environm Sci Res Ctr Water Pollut Control Technol Beijing Peoples R China Chinese Acad Sci Res Ctr Ecoenvironm Sci Beijing Peoples R China Tsinghua Univ Sch Environm Beijing Peoples R China

The National Development and Reform Commission and the Energy Bureau jointly issued the 'Plant Water Utilization Development Plan' on January 29, 2013, which requires that China should gradually establish a more complete legal system, macro management and technical support system for mine water in 2015. But so far, due to the influence of geological conditions and other factors, the impurity composition and content of mine water is very different. Based on the comprehensive summary of the theory, method, application technology, practical engineering and processing technology of mine water disaster and its reutilization in China. This article systematically analyzed the latest research progress and achievements, which include basic theory, hydrogeology (supplement) exploration, advanced detection and monitoring as well as early warning. These can further promote application of current technology, develop new technology and methods, point out the challenges and the existing problems of the mine water field, the gaps with requirements of fast, intensive, and large-scale development of the coal industry in China. Finally, the development trends, future important scientific innovation and key technology were discussed. The prospects of the industry and technology were also forecast.

关键词： Mine water resource utilization treatment technology

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Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2024年第Part2期257卷 128623页

作者： Wang, Ruyu Chen, xuwen Li, Hongtao Chen, Xixiang Sun, Donghui Yu, Danmei Lu, Jiani Xie, Yuanyuan Zhang, Qian Xu, Jianrong Zhang, Weidong Chen, Hongzhuan liu, Shunying Chen, Lili Shanghai Univ Tradit Chinese Med Inst Interdisciplinary Integrat Med Res Shanghai Frontiers Sci Ctr TCM Chem Biol Shanghai Peoples R China East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Sch Chem & Mol Engn Shanghai 200062 Peoples R China Shanghai Univ Tradit Chinese Med Acad Integrat Med 1200 Cailun Rd Shanghai 201203 Peoples R China Fudan Univ Sch Pharm Dept Med Chem Shanghai 201203 Peoples R China Shanghai Univ Tradit Chinese Med Shanghai Inst Infect Dis & Biosafety Inst Interdisciplinary Integrat Med Res Shanghai 201203 Peoples R China Shanghai Univ Tradit Chinese Med Inst Interdisciplinary Integrat Med Res Shanghai 201203 Peoples R China

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to human. Since there are still no effective treatment options against the new emerging variants of SARS-CoV-2, it is necessary to devote a continuous endeavor for more targeted drugs and the preparation for the next pandemic. Salvia miltiorrhiza and its active ingredients possess wide antiviral ac-tivities, including against SARS-CoV-2. Danshensu, as one of the most important active ingredients in Salvia miltiorrhiza, has been reported to inhibit the entry of SARS-CoV-2 into ACE2 (angiotensin-converting enzyme 2)-overexpressed HEK-293T cells and Vero-E6 cells. However, there is a paucity of information regarding its detailed target and mechanism against SARS-CoV-2. Here, we present Danshensu as a covalent inhibitor of 3-chymotrypsin-like protease (3CLpro) against SARS-CoV-2 by the time-dependent inhibition assay (TDI) and mass spectrometry analysis. Further molecular docking, site-directed mutagenesis, circular dichroism (CD) and fluorescence spectra revealed that Danshensu covalently binds to C145 of SARS-CoV-2 3CLpro, meanwhile forming the hydrogen bonds with S144, H163 and E166 in the S1 site. Structure-based optimization of Danshensu led to the discovery of the promising compounds with good inhibitory activity and microsomal stability in vitro. Due to Danshensu inhibiting lung inflammation in the mouse model, we found that Danshensu derivatives also showed better anti-inflammatory activity than Danshensu in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Thus, our study provides not only the clue of the efficacy of Salvia miltiorrhiza against SARS-CoV-2, but also a detailed mechanistic insight into the covalent mode of action of Danshensu for design of co-valent inhibitors against SARS-CoV-2 3CLpro, highlighting its potential as a bifunctional molecule with antivirus and anti-inflammation.

关键词： Danshensu SARS-CoV-23CLpro Covalent inhibitor Anti-inflammation Bifunctional molecule

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基于多尺度卷积编码器的说话人验证网络

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计算机科学 2024年第S01期51卷 75-80页

作者：刘小湖陈德富李俊周旭文胡姗周浩浙江工业大学信息工程学院杭州310023 浙江讯飞智能科技有限公司杭州310000

说话人验证是一种有效的生物身份验证方法,说话人嵌入特征的质量在很大程度上影响着说话人验证系统的性能。最近,Transformer模型在自动语音识别领域展现出了巨大的潜力,但由于Transformer中传统的自注意力机制对局部特征的提取能力较弱... 详细信息

说话人验证是一种有效的生物身份验证方法,说话人嵌入特征的质量在很大程度上影响着说话人验证系统的性能。最近,Transformer模型在自动语音识别领域展现出了巨大的潜力,但由于Transformer中传统的自注意力机制对局部特征的提取能力较弱,难以提取有效的说话人嵌入特征,因此Transformer模型在说话人验证领域的性能难以超越以往的基于卷积网络的模型。为了提高Transformer对局部特征的提取能力,文中提出了一种新的自注意力机制用于Transformer编码器,称为多尺度卷积自注意力编码器(Multi-scale Convolutional Self-Attention Encoder,MCAE)。利用不同尺度的卷积操作来提取多时间尺度信息,并通过融合时域和频域的特征,使模型获得更丰富的局部特征表示,这样的编码器设计对于说话人验证是更有效的。通过实验表明,在3个公开的测试集上,所提方法的综合性能表现更佳。与传统的Transformer编码器相比,MCAE也是更轻量级的,这更有利于模型的应用部署。

关键词：说话人验证说话人嵌入自注意力机制 Transformer编码器多尺度卷积

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“双减”政策背景下学校体育“家校社”协同育人的问题检视与实践超越

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体育科技文献通报 2023年第2期31卷 157-159,163页

作者：李旭雯刘辉陈凯长沙市雅礼实验中学湖南长沙410000

“双减”政策颁布的目的旨在从根本上释放学生学习压力,并将学校体育“家校社”协同育人发展推至新阶段。如何最大化发挥家庭体育、学校体育、社会体育的各自特色,实现1+1+1>3的育人效果,亟需深思。本文运用文献综述法、逻辑分析法... 详细信息

“双减”政策颁布的目的旨在从根本上释放学生学习压力,并将学校体育“家校社”协同育人发展推至新阶段。如何最大化发挥家庭体育、学校体育、社会体育的各自特色,实现1+1+1>3的育人效果,亟需深思。本文运用文献综述法、逻辑分析法等研究方法,探析“双减”政策背景下学校体育“家校社”协同育人实践问题,提出相应改进策略建议。研究认为,问题检视:“家校社”体育认知程度浅显;“家校社”体育资源供给乏力;“家校社”合作机制条件欠缺。建议:觉醒认知意识,更新学校体育“家校社”三方教育观念;凝聚体质合力,整合学校体育“家校社”三方优势资源;融合信息技术,塑造学校体育“家校社”三方交流平台。

关键词： “双减”政策家校社协同育人学校体育

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FETAL TYPE CLASSIFICATION BASED ON FETAL ELECTROCARDIOGRAPH IN NON-STRESS TESTS

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JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 2021年第9期21卷 2140052-2140052页

作者： liu, Jianli Yang, Yimin Zhang, Song Li, xuwen Yang, Lin Hao, Dongmei Beijing Univ Technol Fac Environm & Life Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100024 Peoples R China

Electronic fetal heart rate (FHR) monitoring is a technical means to evaluate the state of the fetus in the uterus by monitoring FHR. The main purpose is to detect intrauterine hypoxia and take corresponding medical measures timely. Because the fetus sleeps quietly for up to 1 hour sometimes, ultrasound Doppler is not easy to continuously detect for a long time. The electronic fetal monitor obtains the fetal heart rate, which not only improves the accuracy and comfort, but also the convenient implementation of long-term monitoring. It is beneficial to reduce perinatal fetal morbidity and mortality. This study used maternal-fetal Holter monitor which is based on the technology of fetal electrocardiograph (FECG) to collect the FHR, and then design algorithm to extract the baseline FHR, acceleration, variation, sleep-wake cycle and nonlinear parameters. There were significant differences in the 22 parameters between the normal and the suspicious group. Using the 22 characteristic parameters, the support vector machine was used to classify the normal and the suspected group of fetuses. 80% of the data was used to train a classification model. The remaining 20% of the data was used as a test set and its accuracy reached 93.75%.

关键词： Fetal Holter monitor fetal heart rate support vector machine

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Adhesive Coacervates Driven by Hydrogen-Bonding Interaction

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SMALL 2020年第43期16卷 2004132-2004132页

作者： Peng, Qiongyao Chen, Jingsi Zeng, Zicheng Wang, Tao Xiang, Li Peng, xuwen liu, Jifang Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 510700 Guangdong Peoples R China

Coacervation plays a critical role in numerous biological activities such as constructing biological tissues and achieving robust wet adhesion of marine sessile organisms, which conventionally occurs when oppositely charged polyelectrolytes are mixed in aqueous solutions driven by electrostatic attraction. Here, a novel type of adhesive coacervate is reported, driven by hydrogen-bonding interactions, readily formed by mixing silicotungstic acid and nonionic polyethylene glycol in water, providing a new approach for developing coacervates from nonionic systems. The as-prepared coacervate is easily paintable underwater, show strong wet adhesion to diverse substrates, and has been successfully applied as a hemostatic agent to treat organ injuries without displaying hemolytic activity, while with inherent antimicrobial properties thus avoiding inflammations and infections due to microorganism accumulation. This work demonstrates that coacervation can occur in salt-free environments via non-electrostatic interactions, providing a new platform for engineering multifunctional coacervate materials as tissue glues, wound dressings and membrane-free cell systems.

关键词： adhesive coacervates antimicrobial properties coacervation hydrogen bonding wet adhesion

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医疗美容纠纷司法鉴定若干问题的研究

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中国卫生法制 2023年第4期31卷 26-30,39页

作者：宋健文刘斌周旭文广东司法警官职业学院广州510520 广东正理法医临床司法鉴定所广东揭阳市522000

当前医疗美容行业蓬勃发展,但由于相关法律法规不完善等问题,医疗美容纠纷频发。医疗美容造成损害后果而引发纠纷可以提起医疗损害责任纠纷诉讼。医疗损害鉴定意见作为科学证据,为医疗美容纠纷解决提供技术支持。然而,目前医疗损害鉴定... 详细信息

当前医疗美容行业蓬勃发展,但由于相关法律法规不完善等问题,医疗美容纠纷频发。医疗美容造成损害后果而引发纠纷可以提起医疗损害责任纠纷诉讼。医疗损害鉴定意见作为科学证据,为医疗美容纠纷解决提供技术支持。然而,目前医疗损害鉴定尚未建立系统的理论体系,也缺乏规范的鉴定程序,作为新兴行业的医疗美容,相关研究几乎空白。根据医疗美容的特点,结合相关案例及文献,围绕鉴定制度与管理、技术鉴定中常见的几个问题进行探讨,以期为鉴定实践提供参考。

关键词：医疗美容医疗损害鉴定医疗纠纷诊疗义务同行评议

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Impermeability Performance and Corrosion Resistance Mechanism of Basalt Fiber Recycled Concrete Under the Coastal Tidal Environment

SSRN

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SSRN 2023年

作者： Yang, Wenrui Huang, Yuewen Tang, Zhiyi Xiong, Xiaolong Li, Chengwei Zhong, xuwen liu, Liai Zhou, Hai Zhang, Xun School of Civil and Architectural Engineering East China University of Technology Nanchang330012 China

The development of the modernization process has resulted in the consumption of natural resources and the accumulation of construction waste, and the environmental bearing capacity faces severe challenges to a certain extent. The recovery and reuse of concrete is one of the effective ways to alleviate the environmental load. However, pouring concrete with recycled aggregate inevitably reduces the strength of the building. More seriously, the coastal tidal environment can have a coupled effect of salt erosion and dry-wet cycles on concrete components, thereby shortening the service life of concrete. The incorporation of fibers can improve the performance of the Recycled Aggregate Concrete (RAC) under special conditions. This article analyzes the changes in the performance of concrete specimens under different Basalt Fiber (BF) volume ratios (0%, 0.5%, 1.0%, and 1.5%) and composite salt simulated accelerated erosion cycles (0 d, 30 d, 60, and 90 d). The comparison results of RAC in apparent corrosion morphology, internal microstructure, and impermeability test show that BF can inhibit the expansion of microcracks and micropores in the test block and improve the overall compactness of the internal structure of RAC. When the fiber content of BF is 1.0%, the toughening effect of concrete is optimal, and impermeability and corrosion resistance of RAC are also significantly improved. Furthermore, the corrosion damage mechanism of Basalt Fiber Recycled Aggregate Concrete (BFRAC) under the combined effects of composite salts and dry-wet cycles was comprehensively summarized and substantiated through chemical reaction principles. The paper proposed a salt solution erosion model of BFRAC, which elucidates the mechanism of fiber crack resistance and explains the accelerated corrosion mechanism of salt solution from the perspective of "ion crack channels." The proposed model provides theoretical support for the salt erosion damage of fiber-reinforced concrete. © 2023, The Author

关键词： Erosion

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Observation of Dirac nodal line states in topological semimetal candidate PrSbTe

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Physical Review B 2024年第4期109卷 045113-045113页

作者： Dengpeng Yuan Dajian Huang Xin Ma Xu Chen Huifen Ren Yun Zhang Wei Feng Xiegang Zhu Bo Wang xuwen He Jian Wu Shiyong Tan Qunqing Hao Qiang Zhang Yi liu Qin liu Zhengtai liu Chao Cao Qiuyun Chen Xinchun Lai Science and Technology on Surface Physics and Chemistry Laboratory Mianyang 621907 China Center for Correlated Matter and School of Physics Zhejiang University Hangzhou 310058 China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201210 China

The interplay among topology, crystal symmetry, magnetic order, and strong electron correlation can give rise to a plethora of exotic physical phenomena. The ZrSiS family is known as typical topological Dirac semimetals, among them LnSbTe (Ln denotes lanthanide) compounds exhibit intriguing characteristics due to the presence of Ln 4f electrons, resulting in quantum states and unique properties. In this paper, the topological electronic structure of PrSbTe is systematically studied by angle-resolved photoemission spectroscopy (ARPES), combined with magnetic, specific heat measurements, and band structure calculations. The detailed three-dimensional electronic structure of PrSbTe has been obtained, and a diamond-shaped Fermi surface and multiple Dirac nodal lines have been observed, which are in remarkable agreement with theoretical calculations. Moreover, the 4f electrons in PrSbTe are rather localized, which can be revealed by on-resonant ARPES data and further confirmed by the rather small Sommerfeld coefficient of γ=2.6231mJ/molK2. Our results provide more detailed information about the LnSbTe family, which gives a deeper understanding of the interaction between Ln 4f electrons and the topological states.

关键词： Electronic structure Fermi surface Topological materials Dirac semimetal Node-line semimetals Angle-resolved photoemission spectroscopy Magnetic techniques Specific heat measurements

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