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Nanodiamond embedded ta-C composite film by pulsed filtered vacuum arc deposition from a single target

APPLIED PHYSICS LETTERS 2016年第20期109卷 201905-201905页

作者： Iyer, Ajai Etula, Jarkko Ge, Yanling liu, xuwen Koskinen, Jari Aalto Univ Sch Chem Technol Dept Mat Sci & Engn POB 16200 Espoo 00076 Finland

Detonation Nanodiamonds (DNDs) are known to have sp(3) core, sp(2) shell, small size (few nm) and are gaining importance as multi-functional nanoparticles. Diverse methods have been used to form composites, containing detonation nanodiamonds (DNDs) embedded in conductive and dielectric matrices for various applications. Here we show a method, wherein DND-ta-C composite film, consisting of DNDs embedded in ta-C matrix have been co-deposited from the same cathode by pulsed filtered cathodic vacuum arc method. Transmission Electron Microscope analysis of these films revel the presence of DNDs embedded in the matrix of amorphous carbon. Raman spectroscopy indicates that the presence of DNDs does not adversely affect the sp(3) content of DND-ta-C composite film compared to ta-C film of same thickness. Nanoindentation and nanowear tests indicate that DND-ta-C composite films possess improved mechanical properties in comparison to ta-C films of similar thickness. Published by AIP Publishing.

关键词： NANODIAMONDS ANTHOLOGY films VACUUM arcs NANOPARTICLES DIELECTRICS

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Exchange bias effect in epitaxial La0.35Sr0.65MnO3/La0.7Sr0.3MnO3 bilayers: Impact of antiferromagnet growth conditions

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VACUUM 2020年 175卷 109280-109280页

作者： Zhao, xuwen Wong, Hon Fai liu, Yu Kuai Ng, Sheung Mei Cheng, Wang Fai Mak, Chee Leung Leung, Chi Wah Hong Kong Polytech Univ Dept Appl Phys Hung Hom Hong Kong Peoples R China

Antiferromagnets have shown great potential for replacing ferromagnets in spintronics applications in recent years. In this work, antiferromagnetic La0.35Sr0.65MnO3 (AFM-LSMO) thin films were grown on ultrathin ferromagnetic La0.7Sr0.3MnO3 (FM-LSMO) layer over a wide temperature range. The different AFM-LSMO growth temperatures introduced variation of strain states in the AFM-LSMO layer, changing the AFM-LSMO magnetic properties. Considering the thermally activated switching model of antiferromagnetic grains, the behaviour of AFM-LSMO growth temperature-dependent exchange bias effect are explained. This work demonstrates the modulation of exchange bias effect through the control of AFM-LSMO growth conditions, suggesting possibility to control and probe oxide antiferromagnets via exchange bias coupling.

关键词： Pulsed laser deposition Perovskite oxide thin films Exchange bias effect

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Rapid masculinization and effects on the liver of female western mosquitofish (Gambusia affinis) by norethindrone

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CHEMOSPHERE 2019年 216卷 94-102页

作者： Hou, Liping Chen, Shangduo Chen, Hongxing Ying, Guangguo Chen, Diyun liu, Juan Liang, Ye Wu, Rongrong Fang, xuwen Zhang, Cuiping Xie, Lingtian Guangzhou Univ Sch Life Sci Guangzhou 510655 Guangdong Peoples R China South China Normal Univ Environm Res Inst MOE Key Lab Theoret Chem Environm Guangzhou 510006 Guangdong Peoples R China Guangzhou Univ Sch Environm Sci & Engn Guangdong Prov Key Lab Radionuclides Pollut Contr Guangzhou 510006 Guangdong Peoples R China Guangzhou Univ Minist Educ Inst Environm Res Greater Bay Innovat Ctr Guangzhou 510006 Guangdong Peoples R China Guangzhou Univ Minist Educ Key Lab Waters Safety & Protect Pearl River Delta Guangzhou 510006 Guangdong Peoples R China

Natural and synthetic progestins in receiving streams can disrupt the normal endocrine systems of fish. Norethindrone (NET) is a widely used synthetic progestin that often appears in wastewater effluents. For this research, adult female western mosquitofish (Gambusia affinis) were exposed to NET at three concentrations. The effects of NET on the following biological factors were evaluated: the histology of the ovaries and livers, the anal fin morphology, and transcription of genes related to steroidogenesis signaling pathways in the livers. After 42 d exposure to NET at 33.0 ng L-1 and 347.5 ng L-1, rapid masculinization, an increase in the number of atretic and postovulatory follicles in the ovary, enhanced vascularization, degenerated hepatocytes and irregular nuclei in the livers were observed. Exposure to NET did not affect the expression of the androgenic and estrogenic receptor genes and Cyp19a except for a significant up-regulation of Er alpha. However, the expression of Vtg A, Vtg B, and Vtg C were markedly inhibited in the females exposed to three concentrations of NET. Compared to the control female, exposure to NET at 33.0 ng L-1 and 347.5 ng L-1 caused a 4.4- and 5.8-fold increase in the expression of Hsd17 beta 3 in the livers, respectively. The results demonstrate that NET can cause rapid masculinization of female G. affinis, hepatopathological alterations and inhibited expressions of Vtg A, Vtg B, and Vtg C. The results imply that G. affinis populations might be threatened in NET-contaminated environment. (C) 2018 Elsevier Ltd. All rights reserved.

关键词： Norethindrone Gambusia affinis Masculinization Progestins Endocrine disrupting chemicals

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Biomimetic Dendrimer-Peptide Conjugates for Early Multi-Target Therapy of Alzheimer's Disease by Inflammatory Microenvironment Modulation

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ADVANCED MATERIALS 2021年第26期33卷 2100746-2100746页

作者： liu, Peixin Zhang, Tongyu Chen, Qinjun Li, Chao Chu, Yongchao Guo, Qin Zhang, Yiwen Zhou, Wenxi Chen, Hongyi Zhou, Zheng Wang, Yu Zhao, Zhenhao Luo, Yifan Li, xuwen Song, Haolin Su, Boyu Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Key Lab Smart Drug Delivery Minist Educ State Key Lab Med Neurobiol Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Dept Pharmaceut Sch Pharm Shanghai 201203 Peoples R China

Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on beta-amyloid (A beta) targeting. However, such therapeutic strategies have limited clinical outcomes due to the chronic and irreversible impairment of the nervous system in the late stage of AD. Recently, inflammatory responses, manifested in oxidative stress and glial cell activation, have been reported as hallmarks in the early stages of AD. Based on the crosstalk between inflammatory response and brain cells, a reactive oxygen species (ROS)-responsive dendrimer-peptide conjugate (APBP) is devised to target the AD microenvironment and inhibit inflammatory responses at an early stage. With the modification of the targeting peptide, this nanoconjugate can efficiently deliver peptides to the infected regions and restore the antioxidant ability of neurons by activating the nuclear factor (erythroid-derived 2)-like 2 signaling pathway. Moreover, this multi-target strategy exhibits a synergistic function of ROS scavenging, promoting A beta phagocytosis, and normalizing the glial cell phenotype. As a result, the nanoconjugate can reduce ROS level, decrease A beta burden, alleviate glial cell activation, and eventually enhance cognitive functions in APPswe/PSEN1dE9 model mice. These results indicate that APBP can be a promising candidate for the multi-target treatment of AD.

关键词： Alzheimer&apos s disease antioxidant ability glial cell activation inflammatory responses multi‐ target treatments synergistic function

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Anti-allergic Effects of Ginsenosides Extracted by High Temperature and High Pressure Method

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Chemical Research in Chinese Universities 2018年第3期34卷 382-388页

作者： liu Ying LI xuwen ZHANG Hanqi WU Qian SHI Xiaolei JIN Yongri College of Chemistry Jilin University Changchun 130021 P. R. China College of Food Science and Engineering Jilin University Changchun 130062 P. R. China

Ginseng（Panax ginseng C. A. Mey.） is a traditional medicinal herb in Asia. Studies have shown that ginsenosides significantly affect immnnoregulation and rare ginsenosides have anti-allergic effects. In this research, a high temperature and high pressure method was utilized to increase the contents of rare ginsenosides in the ginseng extract（GE）. The anti-allergic effects of this extract were investigated in vivo. Water was used as the extraction solvent in extracting the rare ginsenosides via the high temperature and high pressure method. Extraction time and temperature were investigated in order to increase the contents of rare ginsenosides. Rare ginsenosides were qualitatively analyzed by HPLC-ESI-MS and quantitatively analyzed by HPLC-UV. Anti-allergic effects of the extracts were assessed using the ovalbumin（OVA）-induced allergic asthma model in vivo. An extraction temperature of 145 ℃ and extraction time of 2.0 h were chosen as the optimal conditions. Compared with traditional method, the contents of total rare ginsenosides extracted were considerably higher using the new method, that is, 14.74 times that extracted by the traditional method. In our in vivo experiments, treatment with high concentration GE may have anti-allergic erects in decreasing the total amount of IgE in serum and IL-4 in bronchoalveolar lavage fluid（BALF）, aud in improving the ratio of CD4^＋ to CD8^＋ T cells. The high temperature and high pressure method was an effective method to obtain GE containing more rare ginsenosides, which maybe become anti-allergic agents.

关键词： Food allergy High temperature and high pressure method Ovalbumin Rare ginsenoside

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Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade

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ISCIENCE 2020年第9期23卷 101446页

作者： Qiu, Yan Yang, Yuanyuan Wei, Yuda liu, Xiaojian Feng, Zhuanghui Zeng, xuwen Chen, Yanhao liu, Yan Zhao, Yongxu Chen, Lanlan Luo, Lijun Ding, Qiurong Univ Chinese Acad Sci Chinese Acad Sci Shanghai Inst Nutr & Hlth Shanghai Inst Biol SciCAS Key Lab Nutr Metab & F Shanghai 200031 Peoples R China Tongji Univ Affiliated Stomatol Hosp 399 Yanchang Rd Shanghai 200072 Peoples R China Chinese Acad Sci Inst Stem Cell & Regenerat Beijing 100101 Peoples R China

Identification of safe and effective compounds to increase or activate UCP1 expression in brown or white adipocytes remains a potent therapeutic strategy to combat obesity. Here we reported that, glyburide, one of the FDA-approved drugs currently used to treat type 2 diabetes, can significantly enhance UCP1 expression in both brown and white adipocytes. Glyburide-fed mice exhibited a clear resistance to high-fat diet-induced obesity, reduced blood triglyceride level, and increased UCP1 expression in brown adipose tissue. Moreover, in situ injection of glyburide to inguinal white adipose tissue remarkably enhanced UCP1 expression and increased thermogenesis. Further mechanistic studies indicated that the glyburide effect in UCP1 expression in adipocyteswas KATP channel independent but may involve the regulation of the Ca2+-Calcineurin-NFAT signal pathway. Overall, our findings revealed the significant effects of glyburide in regulating UCP1 expression and thermogenesis in adipocytes, which can be potentially repurposed to treat obesity.

关键词： Human Metabolism Molecular Biology

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An Algorithm for the Noninvasive and Personalized Measurement of Microvascular Blood Viscosity Using Physiological Parameters

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BIOMED RESEARCH INTERNATIONAL 2020年第0期2020卷 000-000页

作者： Sun, Ge Yang, Lin Wang, Weiwei Zhang, Song Luo, Zhichang Wu, Guanghui liu, Xiaohong Hao, Dongmei Yang, Yimin Li, xuwen Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Chinese Acad Med Sci Fuwai Hosp Beijing 100037 Peoples R China Capital Med Univ Beijing Inst Heart Lung & Blood Vessel Dis Beijing Anzhen Hosp Beijing 100029 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

Blood viscosity is one of the important parameters to characterize hemorheological properties of the human body. Its real-time and dynamic measurement has important physiological significance for studying the development and prevention of chronic diseases. This study researched noninvasive and personalized measurement of microvascular blood viscosity. In the microcirculation capillary network blood flow model, combined with pulse wave parameters, multiple regression analysis was used to fit the simulated radius of personalized physiological blood vessels to calculate the microvascular blood viscosity. The fitted value related to the simulated radius of the physiological blood vessel had a high correlation with the corresponding theoretically derived value (correlation coefficient: 0.904,P <= 0.001). The calculated value of the microvascular blood viscosity had a certain correlation with the clinical whole blood viscosity at a low shear rate (correlation coefficient: 0.443,P<0.05). This algorithm could provide effective means for noninvasive and long-term individual monitoring and family health care.

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早熟棉花新品种金垦1161的选育及栽培技术

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种子 2020年第1期39卷 140-141页

作者：王旭文余渝孔宪辉刘丽王娟新疆农垦科学院棉花研究所/农业部西北内陆区棉花生物学与遗传育种重点实验室

金垦1161是新疆农垦科学院棉花研究所以ZJ 6为母本,X 4为父本,通过杂交系谱法选育而成的早熟棉花新品种。2015—2016年进入新疆棉花品种区域试验,皮棉平均产量2098.5 kg·hm^-2,比对照新陆早36号增产20.2%。2017年参加新疆棉花品种... 详细信息

金垦1161是新疆农垦科学院棉花研究所以ZJ 6为母本,X 4为父本,通过杂交系谱法选育而成的早熟棉花新品种。2015—2016年进入新疆棉花品种区域试验,皮棉平均产量2098.5 kg·hm^-2,比对照新陆早36号增产20.2%。2017年参加新疆棉花品种生产试验,皮棉平均产量1980.0 kg·hm^-2,为对照新陆早61号的99.7%。金垦1161高抗枯萎病,耐黄萎病,2018年通过新疆维吾尔自治区农作物品种审定委员会审定,适宜在新疆北疆早熟棉区种植。

关键词：棉花金垦1161 选育栽培技术

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TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells

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NATURE COMMUNICATIONS 2019年第1期10卷 1-17页

作者： Chen, Jiajing Wang, Zikang Guo, Xudong Li, Fudong Wei, Qingtao Chen, xuwen Gong, Deshun Xu, Yanxin Chen, Wen liu, Yongrui Kang, Jiuhong Shi, Yunyu Univ Sci & Technol China Hefei Natl Lab Phys Sci Microscale Hefei 230026 Anhui Peoples R China Univ Sci & Technol China Sch Life Sci Hefei 230026 Anhui Peoples R China Tongji Univ Shanghai Matern & Infant Hosp 1Clin & Translat R Shanghai Key Lab Signaling & Dis ResInst Adv Stu Collaborat Innovat Ctr Brain SciSch Life Sci & T Shanghai 200092 Peoples R China Tsinghua Univ Beijing Adv Innovat Ctr Struct Biol Tsinghua Peking Joint Ctr Life Sci Sch Life Sci Beijing 100084 Peoples R China

Recognition of specific chromatin modifications by distinct structural domains within "reader" proteins plays a critical role in the maintenance of genomic stability. However, the specific mechanisms involved in this process remain unclear. Here we report that the PHD-Bromo tandem domain of tripartite motif-containing 66 (TRIM66) recognizes the unmodified H3R2-H3K4 and acetylated H3K56. The aberrant deletion of Trim66 results in severe DNA damage and genomic instability in embryonic stem cells (ESCs). Moreover, we find that the recognition of histone modification by TRIM66 is critical for DNA damage repair (DDR) in ESCs. TRIM66 recruits Sirt6 to deacetylate H3K56ac, negatively regulating the level of H3K56ac and facilitating the initiation of DDR. Importantly, Trim66-deficient blastocysts also exhibit higher levels of H3K56ac and DNA damage. Collectively, the present findings indicate the vital role of TRIM66 in DDR in ESCs, establishing the relationship between histone readers and maintenance of genomic stability.

关键词： DNA damage and repair Embryonic stem cells Structural biology

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Influence of cutting and clamping forces on machining distortion of diesel engine connecting rod

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INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY 2018年第1-4期99卷 897-910页

作者： Zhou, Honggen Wang, Chuhui Jing, xuwen Tian, Guizhong Li, Guochao liu, Shan Sun, Zhengkun Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Peoples R China Jiangsu Univ Sci & Technol Jiangsu Prov Key Lab Adv Mfg Marine Mech Equipmen Zhenjiang Peoples R China

As an important transmission component of diesel engines, the connecting rod has to meet a very high processing accuracy. However, as an elongated part, the connecting rod has a weak rigidity, and the unevenness of the cutting force and the clamping force during the machining processes will lead to the deformation of the connecting rod. In previous researches, cutting and clamping are always studied separately, and their interactions are neglected. In this paper, the finite element simulation method is used to analyze the deformation of the connecting rod. Based on the Deform-3D software, the article builds a connecting rod milling finite element simulation model and predicts the residual stress of the connecting rod milling simulation and the formation of milling chips. The residual stress of the simulation is compared with the residual stress of the experimental measurement and the simulation chip is compared with the actual chip to verify the accuracy of the simulation model, which provides a theoretical basis for the model construction of the next simulation study. Based on the Deform-3D software, simulation studies the influence of different milling parameters on the deformation of the connecting rods. And optimize the link milling process parameters. Based on ANSYS software, the effect of superposition of cutting force and clamping force on machining deformation of the connecting rod was simulated and analyzed. The resultant milling force should not be greater than 734N. This method makes up for the defects that cutting and clamping are studied separately and their interactions are neglected.

关键词： Connecting rod Machining deformation Finite element simulation Simulation model

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