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SSRN 2020年

作者： Yao, Cong Zhan, Ping Han, Xiuguo Tao, Qianyuan Luo, xuwen Li, Feilong Wang, Fuqiang Gu, Zhiping Xu, Huaen Xu, Qiang Yu, Xiaolong Zhang, Bin Dai, Min Nie, Tao liu, Xuqiang Department of Orthopedics The First Affiliated Hospital of Nanchang University Artificial Joints Engineering and Technology Research Center of Jiangxi Province Jiangxi Nanchang China Department of Orthopaedics Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine 1665 Kongjiang Road Shanghai China

Post-operative infections in orthopaedic implants are severe complications that require urgent solutions. Owing to the presence of implants and the formation of bacterial biofilms, the efficacy of antibiotics is limited. Furthermore, osteoclasts can become extremely active, accompanied by bone loss in the infected microenvironment. Therefore, implants often need to be removed. To improve the concentrations of antibiotics in bony tissues and enhance their effectiveness in preventing bacterial biofilm formation, the infection rate must be controlled to preserve the implants. Enoxacin exerts combined antibacterial and osteoclast inhibitory effects. It also plays a role in limiting infections and preventing bone loss. Aspartic acid octapeptide (ASP8) can also recognize and combine with hydroxyapatite crystals in bones and can be targeted to increase antibiotic concentrations in bones. Our previous research showed that preparing mesoporous nanomaterials resulted in optimal drug loading, releasing, and bone-targeting properties. Based on earlier research, a new bone-targeted antibiotic release system was developed. Enoxacin and ASP8 were loaded on mesoporous silica nanoparticles (MSNs) to increase antibiotic concentrations, prevent bacterial biofilm formation, inhibit aberrant osteoclast activities, and reduce bone loss. Enoxacin-loaded MSNs (Gen@MSN-D) were assessed using a variety of experimental methods, including rat models. We studied the in vitro antibacterial properties of the new drug delivery system. We found that these materials had antibacterial properties in vivo, inhibitory effects on osteoclasts, and can be used to prevent and treat post-implantation infections and bone loss. Therefore, we believe these materials will provide a new method for preventing and treating post-operative, orthopaedic implant-associated infections. © 2020, The Authors. All rights reserved.

关键词： Antibiotics

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银川市社区老年人医养结合服务需求及影响因素研究

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中外女性健康研究 2020年第4期 7-8+17页

作者：仇艳敏刘国莲何旭文牛萌刘赟赟郑连花宁夏医科大学护理学院

目的:了解银川市社区老年人医养结合服务需求及影响因素,为银川市更好地开展医养结合服务提供一定的参考依据。方法:采用便利抽样法,于2019年1至2019年3月选择银川市3个社区卫生站120例符合纳入排除标准的社区老年人为研究对象,采用《... 详细信息

目的:了解银川市社区老年人医养结合服务需求及影响因素,为银川市更好地开展医养结合服务提供一定的参考依据。方法:采用便利抽样法,于2019年1至2019年3月选择银川市3个社区卫生站120例符合纳入排除标准的社区老年人为研究对象,采用《社区老年人医养结合服务需求调查问卷》进行问卷调查。结果:社区老年人医养结合服务需求率为92.7%。多元线性回归结果显示影响社区老年人医养结合服务需求的因素包括婚姻状态、居住状况、家庭月收入、患慢性病情况、半年就诊次数和医养结合知晓度等。结论:银川市社区老年人医养结合需求较高,其中社会福利类需求最高。建议社区卫生机构以社区老年人医养结合服务需求为导向,更好地开展社区老年人医养结合工作。

关键词：社区老年人医养结合影响因素

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Damage imaging in composite plate by using double-turn coil omnidirectional shear-horizontal wave magnetostrictive patch transducer array

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ADVANCED COMPOSITE MATERIALS 2017年第Sup1期26卷 67-78页

作者： liu, Zenghua Zhong, xuwen Xie, Muwen liu, Xiucheng He, Cunfu Wu, Bin Beijing Univ Technol Coll Mech Engn & Appl Elect Technol Beijing 100124 Peoples R China

A double-turn coil omnidirectional shear-horizontal wave magnetostrictive patch transducer (DC-OSH-MPT) array for imaging detection in composite plates is presented. DC-OSH-MPT parameters are optimized in order to make the transducer more suitable for imaging detection. Besides, the characteristic of the lowest shear-horizontal mode (SH0), which can be generated and received in all directions by DC-OSH-MPT bonded on composite plate, is beneficial for imaging. Due to anisotropic property of composite plates, the group velocity of SH0 mode in different azimuthal directions was experimentally measured in damage imaging. The location of simulated damage, which was a bonded circular cylinder, was estimated by DC-OSH-MPT array and ellipse imaging algorithm. The imaging results have demonstrated that DC-OSH-MPT can be considered as a spatially distributed array suitable for imaging detection in composite plates.

关键词： composite plate omnidirectional shear-horizontal wave ellipse imaging magnetostrictive patch transducer array

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运用多层螺旋CT探讨第一对角支斑块形成的危险因素

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中华介入放射学电子杂志 2021年第2期9卷 200-203页

作者：陈松谭文斌张慈慈段丽霞熊玉超刘雅慧曾旭文暨南大学附属广州红十字会医院放射科广东广州510220 仁伯爵综合医院影像科澳门999078

目的运用多层螺旋CT探讨第一对角支开口处斑块形成的危险因素。方法收集我院2017年5月至2020年5月同时行冠状动脉CT血管造影(CCTA)和冠状动脉造影的冠心病患者共94例,48例第一对角支开口处有斑块为观察组,46例第一对角支开口处无斑块为... 详细信息

目的运用多层螺旋CT探讨第一对角支开口处斑块形成的危险因素。方法收集我院2017年5月至2020年5月同时行冠状动脉CT血管造影(CCTA)和冠状动脉造影的冠心病患者共94例,48例第一对角支开口处有斑块为观察组,46例第一对角支开口处无斑块为对照组。分析两组的血压、前降支狭窄程度和血流速度、前降支与第一对角支夹角的差异,并分析上述因素对第一对角支斑块形成的影响。结果两组间的血压、前降支狭窄程度和血流速度、前降支与第一对角支夹角的差异具有统计学意义(P<0.05),前降支狭窄程度和血压是第一对角支开口处形成斑块的危险因素,其OR值分别为1.030、1.128。结论血压及前降支的狭窄程度是第一对角支斑块形成的危险因素,且随着血压的增高,前降支狭窄程度的增大,第一对角支开口处斑块的发生率增加。

关键词：多层螺旋CT 冠心病对角支斑块

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基于CDIO理念的社区护理学课程形成性评价方案的构建与实践

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卫生职业教育 2020年第7期38卷 23-25页

作者：刘国莲宁艳花何旭文牛萌刘赟赟郑连花仇艳敏宁夏医科大学护理学院宁夏银川750004

目的基于CDIO理念探讨形成性评价方案在社区护理学教学中的应用效果。方法选择宁夏医科大学2016级94名护理本科生为研究对象,其中1班为实验组,2班为对照组。实验组采用基于CDIO理念的形成性评价方案,对照组采用传统教学方法。课程结束后... 详细信息

目的基于CDIO理念探讨形成性评价方案在社区护理学教学中的应用效果。方法选择宁夏医科大学2016级94名护理本科生为研究对象,其中1班为实验组,2班为对照组。实验组采用基于CDIO理念的形成性评价方案,对照组采用传统教学方法。课程结束后,采用自行设计的调查问卷对护生学习积极主动性、课程满意度及自主学习能力等进行分析。结果实验组自主学习能力、学习积极主动性、课程满意度均优于对照组。结论基于CDIO理念的社区护理学形成性评价方案突出护生主体地位,有助于提高护生学习积极性、自主学习能力及课程满意度。

关键词： CDIO理念形成性评价社区护理学

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琼脂糖凝胶电泳法测定人血白蛋白及人免疫球蛋白类制品的纯度

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中国药品标准 2020年第2期21卷 159-166页

作者：穆矛刘冰滢陈宇堃焦旭雯梁蔚阳广东省药品检验所广州510663

目的:建立琼脂糖凝胶电泳法测定人血白蛋白及人免疫球蛋白类制品的纯度。方法:采用Helena公司的SPIFE Touch型自动电泳仪及配套的试剂盒,对琼脂糖凝胶电泳法的方法学进行验证。以供试品浓度5%,对33批人血白蛋白样品以及16批人免疫球蛋... 详细信息

目的:建立琼脂糖凝胶电泳法测定人血白蛋白及人免疫球蛋白类制品的纯度。方法:采用Helena公司的SPIFE Touch型自动电泳仪及配套的试剂盒,对琼脂糖凝胶电泳法的方法学进行验证。以供试品浓度5%,对33批人血白蛋白样品以及16批人免疫球蛋白类制品进行纯度测定,并与《中国药典》2015版规定方法(醋酸纤维素薄膜法)的测定结果进行比较。结果:该方法检测正常人血清中白蛋白与免疫球蛋白的RSD分别为1.15%和1.45%,最佳供试品蛋白浓度为5%,仪器通道间差异的RSD小于0.4%,重复性的RSD均小于0.5%。对比两种方法的检测结果,人血白蛋白的两法结果趋势一致且高度相关(Pearson′s r=0.88),但琼脂糖凝胶电泳法比醋酸纤维素薄膜法测定结果低1%~4%;人免疫球蛋白类制品的检测结果两种方法基本一致(Pearson′s r=0.66,两法差值小于1%)。结论:该法经方法学验证,可作为人血白蛋白和人免疫球蛋白类制品的纯度测定替代方法。

关键词：琼脂糖凝胶电泳人血白蛋白人免疫球蛋白纯度

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Factors associated with blooms of cyanobacteria in a large shallow lake, China

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ENVIRONMENTAL SCIENCES EUROPE 2018年第1期30卷 1-15页

作者： Li, Di Wu, Naicheng Tang, Song Su, Guanyong Li, xuwen Zhang, Yong Wang, Guoxiang Zhang, Junyi liu, Hongling Hecker, Markus Giesy, John P. Yu, Hongxia Nanjing Univ Sch Environm State Key Lab Pollut Control & Resource Reuse Nanjing 210046 Jiangsu Peoples R China Jiangsu Environm Monitoring Ctr Nanjing 210036 Jiangsu Peoples R China Univ Kiel Dept Hydrol & Water Resources Management D-24118 Kiel Germany Chinese Ctr Dis Control & Prevent Natl Inst Environm Hlth Beijing 100021 Peoples R China Nanjing Univ Sci & Technol Sch Environm & Biol Engn Jiangsu Key Lab Chem Pollut Control & Resources R Nanjing 210094 Jiangsu Peoples R China Nanjing Normal Univ Sch Environm Nanjing 210023 Jiangsu Peoples R China Wuxi Environm Monitoring Ctr Wuxi 214000 Jiangsu Peoples R China Univ Saskatchewan Toxicol Ctr Saskatoon SK S7N 5B3 Canada Univ Saskatchewan Sch Environm & Sustainabil Saskatoon SK S7N 5C3 Canada Univ Saskatchewan Dept Vet Biomed Sci Saskatoon SK S7N 5B3 Canada Univ Saskatchewan Toxicol Ctr Saskatoon SK S7N 5B3 Canada Michigan State Univ Dept Zool E Lansing MI 48824 USA Michigan State Univ Ctr Integrat Toxicol E Lansing MI 48824 USA Univ Hong Kong Sch Biol Sci Hong Kong Hong Kong Peoples R China

Background: Eutrophication of freshwater systems can result in blooms of phytoplankton, in many cases cyanobacteria. This can lead to shifts in structure and functions of phytoplankton communities adversely affecting the quality of drinking water sources, which in turn impairs public health. Relationships between structures of phytoplankton communities and concentrations of the toxicant, microcystin-leucine-arginine (MC-LR), have not been well examined in large shallow lakes. The present study investigated phytoplankton communities at seven locations from January to December of 2015 in Tai Lake, and relationships between structures and diversities of phytoplankton communities and water quality parameters, including concentrations of MC-LR and metals, were analyzed. Results: A total of 124 taxa of phytoplankton were observed, and the predominant taxa were Microcystis sp. and Dolichospermum flos-aquae of Cyanophyta and Planctonema sp. of Chlorophyta. The greatest diversities of phytoplankton communities, as indicated by species richness, Simpson, Shannon-Wiener, the Berger and Parker, and the Pielou evenness indices, were observed in spring. Furthermore, productivity of phytoplankton was significantly and negatively correlated with diversities. These results demonstrated that Simpson, Shannon-Wiener, the Berger and Parker, and the Pielou evenness indices of phytoplankton communities were significantly related to trophic status and overall primary productivity in Tai Lake. In addition, temperature of surface water, pH, permanganate index, biochemical oxygen demand, total phosphorus, arsenic, total nitrogen/total phosphorous ratio, and MC-LR were the main factors associated with structures of phytoplankton communities in Tai Lake. Conclusion: The present study provided helpful information on phytoplankton community structure and diversity in Tai Lake from January to December of 2015. Our findings demonstrated that Simpson, Shannon-Wiener, the Berger and Parker, and the

关键词： Eutrophication Nutrients Phosphorus Nitrogen Phytoplankton productivity Diversity Microcystin-LR

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A 0.42-mW 1-Mb/s 3-to4-GHz Transceiver in 0.18-μm CMOS With Flexible Efficiency, Bandwidth, and Distance Control for IoT Applications

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IEEE JOURNAL OF SOLID-STATE CIRCUITS 2017年第6期52卷 1479-1494页

作者： liu, Dang Ni, xuwen Zhou, Ranran Rhee, Woogeun Wang, Zhihua Tsinghua Univ Inst Microelect Beijing 100084 Peoples R China

This paper describes a short-range transceiver architecture using frequency-hopped sinusoidal OOK pulses. Since signal bandwidth does not necessarily have to satisfy > 500 MHz requirement like conventional ultra-wideband (UWB) pulses, the proposed transceiver named as a very-wide band (VWB) transceiver offers degrees of freedom to choose an optimum operation duty cycle in terms of energy efficiency, bandwidth efficiency, and communication range, while providing much lower operation duty cycle than that of narrow band OOK transceiver. The VWB transmission significantly relaxes the complexity of transceiver design without requiring advanced CMOS technology. In the transmitter, pulse generation circuit design is simplified with the duty-cycled sinusoidal signal compared to that in the impulse-radio UWB (IR-UWB) transmitter. In the receiver, an asynchronous energy detection topology is proposed to achieve robust energy detection by overcoming the synchronization issue as well as the saturation problem of the integrator circuit. A prototype 3-to-4 GHz VWB transceiver is implemented in 0.18 mu m CMOS. The transceiver achieves the communication distance of > 2 m at 1 Mb/s data rate with the peak-to-peak pulse amplitude of only 300 mV and the duty cycle of 0.6%, consuming 0.42 mW from a 1.8 V supply.

关键词： Bandwidth efficient energy detection energy efficient impulse radio (IR) transceiver ultra-wideband (UWB) wireless

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Charge Transfer Platform and Catalytic Amplification of Phenanthroimidazole Derivative: A New Strategy for DNA Bases Recognition

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ANALYTICAL CHEMISTRY 2019年第18期91卷 11938-11945页

作者： Lu, Nannan liu, He Huang, Rui Gu, Yue Yan, Xiaoyi Zhang, Tinging Xu, Zhiqian Xu, Haixin Xing, Yue Song, Yu Li, xuwen Zhang, Zhiquan Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China

Research about DNA composition has been concentrated on DNA damage in the past few decades. However, it still remains a great challenge to construct a rapid, facile, and accurate approach for simultaneously monitoring four DNA bases, guanine (G), adenine (A), thymine (T), and cytosine (C). Herein, a novel electrochemical sensor based on phenanthroimidazole derivative, 2-(4-bromophenyl)-1-phenyl-1H-phenanthro[9,10-d]-imidazole (PPI), is successfully fabricated by a simple electrochemical method. The bromophenyl group in PI could expand their aromatic plane, induce the pi-conjugated extension, and enhance the charge transfer and pi-pi interaction. The phenyl group at N1 position could regulate the intermolecular interaction, which could promote the possibility of intermolecular connection. The PPI polymer (poly(PPI)) with pi-electron enriched conjugation architecture has been applied in simultaneous determination of G, A, T, and C in neutral solution by square wave voltammetry (SWV) method with well-separated peak potentials at 0.714, 1.004, 1.177, and 1.353 V, respectively. The sensor functionalized with poly(PPI) exhibits wide linear response for G, A, T, and C in the concentration ranges of 3-300, 1-300, 30-800, and 20-750 mu M, respectively. With favorable selectivity, stability, and reproducibility, the sensor is successfully utilized to monitor four DNA bases in real samples, displaying a promising prospect for electrochemical sensing devices.

关键词： Cytosine Genetics Electrodes Oxidation Acid and base chemistry

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面向含有辅助特征的工艺模型创建方法

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计算机集成制造系统 2019年第8期25卷 1956-1964页

作者：刘金锋王鹏军景旭文周宏根田桂中李磊李国超江苏科技大学机械工程学院江苏镇江212003 江苏科技大学江苏省船海机械装备先进制造重点实验室江苏镇江212003

为了创建含有工艺辅助特征的工艺模型以提高工艺规划效率,提出面向含有工艺辅助特征三维工艺模型的快速建模方法。基于工艺辅助特征的具体作用,将其分为辅助加工特征、辅助装夹特征、辅助测量特征和辅助装配特征4类;对各类型辅助特征进... 详细信息

为了创建含有工艺辅助特征的工艺模型以提高工艺规划效率,提出面向含有工艺辅助特征三维工艺模型的快速建模方法。基于工艺辅助特征的具体作用,将其分为辅助加工特征、辅助装夹特征、辅助测量特征和辅助装配特征4类;对各类型辅助特征进行参数化设计,并建立工艺辅助特征库进行管理;基于工艺辅助特征的关联准则和添加方法添加工艺辅助特征,并创建了三维工艺模型。通过NX开发的相应功能模块验证了所提方法的有效性。

关键词：工艺辅助特征特征分类三维工艺模型特征匹配航空制造

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