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GluR1 Phosphorylation and Persistent Expression of Levodopa-induced Motor Response Alterations in the Hemi-Parkinsonian Rat

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NEUROCHEMICAL RESEARCH 2011年第6期36卷 1135-1144页

作者： Ba, Maowen Kong, Min Yu, Guoping Sun, xuwen liu, Zhuli Wang, Xiaotong Qingdao Med Univ Yuhuangding Hosp Dept Neurol Yantai 264000 Shandong Peoples R China Yantaishan Hosp Dept Neurol Yantai 264000 Shandong Peoples R China

The phosphorylation of glutamate receptor 1 (GluR1) has been increasingly implicated in the formation and maintenance of plastic responses. To investigate molecular mechanisms that underlie the persisting alterations in motor response occurring with levodopa treatment of parkinsonian patients, we evaluated the time course of these changes in relation to the phosphorylation of GluR1 in 6-hydroxydopamine (6-OHDA) lesioned animals. Three weeks of twice-daily levodopa administration to rats shortened the duration of the rotational responses and increased the peak turning responses, which lasted at least 7 days after withdrawal of chronic levodopa treatment. The shortened response duration and increased peak turning, resembling human wearing-off fluctuations and dyskinesia, were associated with a marked increase in Ser-845 phosphorylated GluR1 (pGluR1S845) immunoreactivity in lesioned striatum in response to levodopa treatment. The time course of changes in GluR1 phosphorylation correlated with the time course of changes in motor behavior after withdrawal of chronic levodopa therapy. Our immunostaining data showed that these changes were confined to parvalbumin-positive neurons where GluR1 are exclusively expressed. Both the altered motor response and the degree of pGluR1S845 were attenuated by the intrastriatal administration of protein kinase A (PKA) inhibitor Rp-cAMPS or GluR1 antisense oligonucleotides. The results suggest that Ser-845 GluR1 phosphorylation within parvalbumin-positive neurons contributes to the persistence of the motor response alterations produced by chronic intermittent dopaminergic stimulation.

关键词： GluR1 Phosphorylation Protein kinase A Motor response alterations Parkinson's disease

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Matrix solid phase dispersion extraction of ginsenosides in the leaves of Panax ginseng CM Mey

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FOOD CHEMISTRY 2011年第3期129卷 1253-1257页

作者： Shi, Xiaolei Jin, Yongri liu, Jingbo Zhou, Hongyu Wei, Wei Zhang, Hanqi Li, xuwen Jilin Univ Coll Chem Changchun 130012 Peoples R China Jilin Univ Coll Quartermaster Technol Changchun 130012 Peoples R China

The matrix solid phase dispersion (MSPD) was applied to the extraction of eight kinds of ginsenosides from the leaves of Panax ginseng C.M. Mey. The experimental conditions were examined and optimised. The extracts were analysed by high performance liquid chromatography (HPLC). When the diatomaceous earth was used as dispersant and 75% methanol was used as elution solvent, the highest extraction yields of the eight kinds of ginsenosides were obtained. For comparison, the reflux extraction was applied. The extraction yields obtained by the proposed method were comparable with those obtained by the reflux extraction. The proposed method is convenient, time-saving, and organic solvent minimising. (C) 2011 Published by Elsevier Ltd.

关键词： MSPD Extraction Leaves of Panax ginseng SEM

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Structural changes in pyramidal cell dendrites and synapses in the unaffected side of the sensorimotor cortex following transcranial magnetic stimulation and rehabilitation training in a rat model of focal cerebral infarct

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Neural Regeneration Research 2011年第9期6卷 676-680页

作者： Chuanyu liu Surong Zhou xuwen Sun Zhuli liu Hongliang Wu Yuanwu Mei Department of Neurology the Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College Yantai 264000 Shandong Province China Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

Very little is known about the effects of transcranial magnetic stimulation and rehabilitation training on pyramidal cell dendrites and synapses of the contralateral, unaffected sensorimotor cortex in a rat model of focal cerebral infarct. The present study was designed to explore the mechanisms underlying improved motor function via transcranial magnetic stimulation and rehabilitation training following cerebral infarction. Results showed that rehabilitation training or transcranial magnetic stimulation alone reduced neurological impairment in rats following cerebral infarction, as well as significantly increased synaptic curvatures and post-synaptic density in the non-injured cerebral hemisphere sensorimotor cortex and narrowed the synapse cleft width. In addition, the percentage of perforated synapses increased. The combination of transcranial magnetic stimulation and rehabilitation resulted in significantly increased total dendritic length, dendritic branching points, and dendritic density in layer V pyramidal cells of the non-injured cerebral hemisphere motor cortex. These results demonstrated that transcranial magnetic stimulation and rehabilitation training altered structural parameters of pyramidal cell dendrites and synapses in the non-injured cerebral hemisphere sensorimotor cortex, thereby improving the ability to compensate for neurological functions in rats following cerebral infarction.

关键词： cerebral infarction transcranial magnetic stimulation rehabilitation training sensorimotor cortex pyramidal cell dendrites synapse neural regeneration

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RETRACTED ARTICLE: AAdvanced treatment of coking wastewater in relation to COD using three-dimensional electrodes

RETRACTED ARTICLE: AAdvanced treatment of coking wastewater ...

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作者： He, xuwen Gong, Jingwen liu, Liyuan Wang, Hao Zhang, Gong Qin, Qiang School of Chemical and Environmental Engineering China University of Mining and Technology Beijing 100083 China

ISBN: (纸本)9781424450893

Saturated coke as filler materials, experiment on the advanced treatment of coking wastewater by three-dimensional fixed bed electrode reactor was carried out. It was indicated that coke powder can be used as catalytic electrode, an optimized conditions for electrolysis time 60min, current density 8A, particle size 10-20mesh number, dosing quantity 400ml, plate spacing 1cm,COD removal efficiency was up to 70%. Analyzing the code that was used before and after experiments by SEM, we find that coke was appropriate as filled electrode as its compact structure, high crystallinity and proper porosity. The degradation mechanism of COD in the experiment was also carried out and obeyed the first order dynamics. © 2011 IEEE.

关键词： Wastewater treatment

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On the Best Condition of Electrolysis Coking Wastewater by Orthogonal Method

On the Best Condition of Electrolysis Coking Wastewater by O...

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International Conference on Advances in Computer Science, Environment, Ecoinformatics, and Education

作者： He, xuwen Xin, Lu Zhang, Chunhui Lin, Hui liu, Liyuan Zhang, Jingjing He, Xiong China Univ Min & Technol Sch Chem & Environm Engn Beijing 100083 Peoples R China

ISBN: (纸本)9783642233234

Coking wastewater was advanced treated by electrolytic experiment. Through the orthogonal method, we found out the optimum experimental condition as current density 20 mA/cm2, electrode plate span 1cm, electrolytic time 60 min, PH 7 and electrical conductivity 8000 mu s/cm. The removal rates of COD, NH3-N and phenol were 58.62%, 89.9% and 96.8% respectively and the corresponding concentrations were 97.78mg/L, 14.3mg/L and 0.43mg/L respectively, which can meet first discharge standard of GB 13456-1992.

关键词： The orthogonal method electrolysis coking wastewater advanced treatment

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Study on corrosion electrochemical behavior of several different coating systems by EIS

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PROGRESS IN ORGANIC COATINGS 2009年第4期64卷 497-503页

作者： liu, xuwen Xiong, Jinping Lv, Yongwu Zuo, Yu Beijing Inst Chem Technol Sch Mat Sci & Engn Beijing 100029 Peoples R China

Corrosion electrochemical behavior of chlorinated rubber top coating (single-layer), inorganic zinc-rich primer/chlorinated rubber top coating (double-layers) and inorganic zinc-rich primer/epoxy middle paste/chlorinated rubber top coating (tri-layers) in 3.5 wt% NaCl solution was studied by electrochemical impedance spectroscopy (EIS). A series of impedance spectra of the three coating systems during immersion were measured: and their protective properties were compared according to the spectra. The experimental results showed that, the protective properties of the double-layers coating system were even worse than that of the single-layer coating system;and the tri-layers coating system had the best protective properties in the three coating systems;epoxy middle paste had played a very important role for protective properties of the composite coating system. (C) 2008 Published by Elsevier B.V.

关键词： Coatings EIS immersion

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Research on nitrogen removal of secondary effluent of wastewater treatment plant in horizontal subsurface-flow constructed wetlands

Research on nitrogen removal of secondary effluent of wastew...

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2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011

作者： He, xuwen Chai, Zhen Wang, Hao He, Xiong liu, Liyuan Jia, Jianli Wang, Jianbing School of Chemical and Environmental Engineering China University of Mining and Technology Beijing Beijing China

ISBN: (纸本)9781424491711

By investigating the nitrogen concentrations in effluents of the horizontal subsurface-flow constructed wetlands under the conditions of different kinds of substrates, residence time and heights, as well as the nitrogen concentrations changes along the flow in the wetlands, the nitrogen removal routes in the wetlands were analyzed. The results demonstrated that the wetland system with zeolites demonstrated greater efficiency in the removal of nitrogen. There was a higher nitrogen removal rates at the bottom of the wetland system owing to an aerobic-anoxic environment. In that a more efficient reoxygenation was attained at the front of the system, it achieved a higher nitrogen removal rates. © 2011 IEEE.

关键词： Nitrogen removal

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RETRACTED ARTICLE: Electrochemical treatment of contaminants in coking

RETRACTED ARTICLE: Electrochemical treatment of contaminants...

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作者： He, xuwen liu, Liyuan Wang, Hao Gong, Jingwen Qin, Qiang Wang, Jianbing Zhang, Chunhui School of Chemical and Environmental Engineering China University of Mining and Technology Beijing 100083 China

ISBN: (纸本)9781424450893

The electrochemical oxidation of contaminants in coking wastewater using Ti/RuO2-IrO2electrodes was studied. The effects of interelectrode distance, current density and chloride concentration on contamination degradation efficiency were also investigated. The results show that the Ti/RuO2-IrO2electrodes in electrolysis could effectively decompose ammonium and COD. At interelectrode distance of 0.5cm and current density of 12.0 mA/cm2, the degradation efficiency of NH3-N and COD were 25.3% and 45.5% in 50 minutes, respectively. At the chloride concentration of 6g/L, the degradation efficiency of NH3-N and COD were 66.1% and 63.5% in 50 minutes, respectively. © 2011 IEEE.

关键词： Electrochemical electrodes

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RETRACTED ARTICLE: Adsorption characteristics of different constructed wetland substrates

RETRACTED ARTICLE: Adsorption characteristics of different c...

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作者： He, xuwen Chai, Zhen Wang, Hao Lin, Hui Zhang, Yue liu, Liyuan Jia, Jianli Wang, Jianbing School of Chemical and Environmental Engineering China University of Mining and Technology Beijing China

ISBN: (纸本)9781424450893

Substrate as an important component of constructed wetlands, played an important role in the purification of nitrogen and phosphorous. The nitrogen and phosphorus adsorption properties of four substrates, including gravel, clinoptilolite, limestoneand and lytag, were studied through the basic experiments. The results revealed that the nitrogen and phosphorus adsorption rates of clinoptilolite were the highest among the four substrates. The adsorption performances of the four substrates were all greatly affected by pH. The phosphorus Adsorption capacity of clinoptilolite and limestone increased as pH rose, and the opposite is true for lytag and gravel; neutral and acidic conditions were conducive to clinoptilolite absorption of ammonia nitrogen, while for the other three substrates, the ammonia nitrogen Adsorption capacity increased with the rise of pH, and the surface characteristics of the substrates were analyzed by scanning electron microscopy. © 2011 IEEE.

关键词： Gas adsorption

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“现实的个人”及其全面发展

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山东师范大学学报（人文社会科学版） 2011年第2期56卷 114-117页

作者：陈旭雯刘星昊衢州学院社会科学教研部浙江衢州324000 西北工业大学人文经法学院陕西西安710072

马克思主义的创始人"从现实的、有生命的个人本身出发",把自己的学说归结为"关于现实的人及其历史发展的科学",揭示了人的自由本质。"现实的个人"是历史的主体,扮演了"剧中人物和剧作者"的双... 详细信息

马克思主义的创始人"从现实的、有生命的个人本身出发",把自己的学说归结为"关于现实的人及其历史发展的科学",揭示了人的自由本质。"现实的个人"是历史的主体,扮演了"剧中人物和剧作者"的双重角色。人类历史的发展过程是现实的人的自我发展和解放的过程;现实的个人的自由个性和全面发展体现了历史的进步和社会的发展。

关键词： “现实的个人” 哲学意蕴全面发展

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