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Platelet microparticles-derived miR-25-3p promotes the hepatocyte proliferation and cell autophagy via reducing B-cell translocation gene 2

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JOURNAL OF CELLULAR BIOCHEMISTRY 2020年第12期121卷 4959-4973页

作者： Xu, Yuyuan Li, Wenfei liang, Guangyu Peng, Jie Xu, xuwen Southern Med Univ Nanfang Hosp Dept Infect Dis 1838 North Guangzhou Ave Guangzhou 510515 Guandong Peoples R China

Platelets are critical regulators of liver regeneration, but the mechanisms are still not fully understood. Platelets have been shown to contain a wide variety of microRNAs (miRNAs) and play an important role in many diseases. However, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate the hepatocyte proliferation is not very clear. In this study, we have successfully isolated and identified PMPs. We also found that PMPs, which could be well integrated into the HHL-5 cells, could upregulate the level of miR-25-3p in HHL-5 cells. Meanwhile, we found that PMPs-derived miR-25-3p promoted HHL-5 cells proliferation by accelerating cells into the S phase, and enhanced the autophagy by increasing the LC3II expression and reducing the P62 expression. Then, we proved that the miR-25-3p could target the B-cell translocation gene 2 (BTG2) and downregulate the expression levels of the BTG2 gene in HHL-5 cells. In addition, the overexpression of BTG2 significantly inhibited the proliferation and autophagy abilities of HHL-5 cells, while cotransfected miR-25-3p mimics or PMPs could partially rescue HHL-5 cells proliferation and autophagy. Furthermore, we proved that PMPs accelerated hepatocyte proliferation by regulating autophagy pathways. Therefore, PMPs-derived miR-25-3p promoted HHL-5 cell proliferation and autophagy by targeting BTG2, which may be a new therapeutic method for liver regeneration.

关键词： autophagy B-cell translocation gene 2 liver regeneration miR-25-3p platelet microparticles proliferation

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"Twisted" small molecule donors with enhanced intermolecular interactions in the condensed phase towards efficient and thick-film all-small-molecule organic solar cells

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JOURNAL OF MATERIALS CHEMISTRY A 2023年第26期11卷 13984-13993页

作者： Cheng, Xiafei liang, Ziqi liang, Shifeng Zhang, xuwen Xu, Jie Xu, Yan Ni, Wang Li, Miaomiao Geng, Yanhou Tianjin Univ Sch Mat Sci & Engn Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Tianjin Inst Power Sources Sci & Technol Power Sources Lab Tianjin 300384 Peoples R China Sinopec Beijing Res Inst Chem Ind Co Ltd Beijing 100013 Peoples R China Joint Sch Natl Univ Singapore & Tianjin Univ Int Campus Tianjin Univ Fuzhou 350207 Peoples R China

How to achieve high crystallinity and suitable phase scale simultaneously from the perspective of molecular engineering remains a long-standing challenge for all-small-molecule organic solar cells (ASM-OSCs). Herein, two small molecule donors, named DRTT-2Se (with two alkylselenophenyl chains) and DRTT-6Se (with six alkylselenophenyl chains), were designed and synthesized by introducing "twisted" backbones and building units with strong intermolecular interactions. The "twisted" skeletons of the molecules can suppress the molecular crystallization and avoid excessive aggregation during the film forming process, while the strong intermolecular interactions of the building units can encourage the formation of ordered molecular packing and nanoscale phase separation via post-treatments. Owing to the enhanced intermolecular interactions induced by alkylselenophenyl side chains, DRTT-2Se and DRTT-6Se with a "twisted" structure displayed more ordered pi-pi packing, and retained the similar nanoscale microstructures in the blend films in comparison to the "twisted" molecule with alkylthiophenyl side chains (DRTT-T), yielding improved hole transport and reduced charge recombination in OSCs. In addition, the alkylselenophenyl substituted molecules showed higher HOMO energy levels, which caused the larger HOMO offset to drive exciton dissociation, but did not increase the energy loss. As a result, the ASM-OSCs based on the selenophene-containing donors exhibited higher FF and J(sc), and similar V-oc, yielding superior PCEs (14.79% and 15.03%) compared to the DRTT-T based device (13.37%). More importantly, the appropriate film morphology made the device efficiency of DRTT-2Se and DRTT-6Se less sensitive to the thickness of active layers. This study provides some implications in designing small molecule donors with suitable crystallization behavior towards high-performance ASM-OSCs.

关键词： Molecules

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JOINTS RELATION INFERENCE NETWORK FOR SKELETON-BASED ACTION RECOGNITION 26

JOINTS RELATION INFERENCE NETWORK FOR SKELETON-BASED ACTION ...

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26th IEEE International Conference on Image Processing (ICIP)

作者： Ye, Fanfan Tang, Huiming Wang, xuwen liang, Xiao Zhejiang Univ Coll Informat Sci & Elect Engn Hangzhou Peoples R China

ISBN: (纸本)9781538662496

Recently, the graph convolutional networks based methods have achieved remarkable performance in skeleton-based action recognition. However, current methods do not make full use of the topology of the skeleton graph, because they set and fixed the relation of skeleton joints or adjacency matrix for all input samples manually. In order to solve the problem, we design an end-to-end architecture consisting of joints relation inference network (JRIN) and skeleton graph convolutional network (SGCN). JRIN can aggregate spatial-temporal feature of every two joints globally, then infer the optimal relation between every two joints automatically. These relations of joints is quantified as the optimal adjacency matrices. Then SGCN will take the optimal matrices to do the final action recognition. During training, special initialization and alternate training strategies are proposed to optimize the model. Our method achieves very competitive performance on widely used NTU-RGB+D and Kinetics datasets.

关键词： Action Recognition Relation Inference Graph Convolutional Network Skeleton

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Stable self-crosslinking phase change composites with vertically aligned boron nitride for high thermal conductivity thermal interface materials

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CERAMICS INTERNATIONAL 2024年第11期50卷 19829-19837页

作者： Liu, Chunlei Duan, Xiaoyuan Zhang, Wei Huo, Qianqiang Sui, xuwen Liu, Yaqing liang, Chaobo North Univ China Coll Mat Sci & Engn Key Lab Funct Nanocomposites Shanxi Prov Taiyuan 030051 Peoples R China Northwestern Polytech Univ Sch Chem & Chem Engn Shaanxi Key Lab Macromol Sci & Technol Xian 710072 Peoples R China

Thermal interface materials (TIMs) must have a high through-plane thermal conductivity in order to efficiently transfer the heat generated by electronic components to heat sinks. Nevertheless, the achievement of high through-plane thermal conductivity is still a great challenge due to the inadequate thermal conductivity network as well as the lack of thermal response from the polymer matrix. Herein, we have developed a solid-solid phase change polymer matrix achieved through self-crosslinking polyethylene glycol (SCPEG). Subsequently, highperformance TIMs based on the SCPEG matrix and vertically aligned boron nitride (BN) nanosheets are obtained by bidirectional freezing, hot pressing, and longitudinal slicing. The prepared BN/SCPEG composites (BN content of 80 vol%) with a vertically oriented network achieved a through-plane thermal conductivity of 23.03 W m-1 K-1. More importantly, the vertically aligned BN nanosheets improve the thermal conductivity of composites, while the SCPEG matrix can reduce the hardness of composites by absorbing the heat, thus decreasing the contact thermal resistance.

关键词： Thermal interface materials Solid-solid phase change polymer matrix Self-crosslinking polyethylene glycol Vertically aligned boron nitride nanosheets

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Efficient Production of Melanin by Aureobasidium Melanogenum Using a Simplified Medium and pH-Controlled Fermentation Strategy with the Cell Morphology Analysis

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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2024年第2期196卷 1122-1141页

作者： Zhou, Ran Ma, Lan Qin, xuwen Zhu, Hui Chen, Guiguang liang, Zhiqun Zeng, Wei Guilin Med Univ Key Lab Biochem & Mol Biol Educ Dept Guangxi Zhuang Autonomous Reg 1 Zhiyuan Rd Guilin 541199 Guangxi Peoples R China Guilin Med Univ Sch Intelligent Med & Biotechnol 1 Zhiyuan Rd Guilin 541199 Guangxi Peoples R China Guangxi Univ Coll Life Sci & Technol Guangxi Microorganism & Enzyme Res Ctr Engn Techno State Key Lab Conservat & Utilizat Subtrop Agrobio 100 Daxue Rd Nanning 530004 Guangxi Peoples R China

Natural melanin is a biopolymer with wide application prospects in medicine, food, cosmetics, environmental protection, agriculture, and so on. Microbial fermentation is an important and effective way to produce melanin. In this study, Aureobasidium melanogenum, known as black yeast with cellular pleomorphism, was used for the production of melanin. Based on the characteristic of A. melanogenum secreting melanin under oligotrophic stress, a simple medium containing only glucose, MgSO4 center dot 7H(2)O, and KCl was constructed for the production of melanin. The melanin titer of 6.64 +/- 0.22 g/L was obtained after 20 days of fermentation without pH control. The cell morphological changes of A. melanogenum during the production of melanin were recorded, and the results showed that chlamydospore might be the most favorable cell morphology for melanin synthesis. Then, different fermentation strategies with cell morphology analysis were developed to further improve the production of melanin in a 5-L fermenter. Results showed that the maximum titer of melanin reached 18.50 g/L by using the fermentation strategy integrating pH control, ammonium salt addition, and H2O2 stimulation, which increased by 178.6% than that of the strategy without pH control. Furthermore, the melanin obtained from the fermentation broth was characterized as eumelanin containing an indole structure. This study provided a potentially feasible fermentation strategy for the industrial production of melanin.

关键词： Melanin Aureobasidium melanogenum Simplified medium pH-controlled strategy Cell morphology Characterization

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Influence of temperature and humidity coupling on rutting deformation of asphalt pavement

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SCIENCE AND ENGINEERING OF COMPOSITE MATERIALS 2023年第1期30卷

作者： Zhang, Kai Wang, Shiyu Yang, Wenrui Zhong, xuwen liang, Sheng Tang, Zhiyi Quan, Weijie East China Univ Technol Sch Civil & Architectural Engn Nanchang Peoples R China Jiangxi Transportat Inst Co LTD Jiangxi Rd Mat & Struct Engn Technol Res Ctr Nanchang Peoples R China Wuhan Univ Technol Sch Transportat & Logist Engn Wuhan Peoples R China

In this article, ABAQUS finite-element software is used to establish an asphalt pavement structure model under high-temperature environment in summer. The changes in the temperature field and moisture concentration field of asphalt pavement are studied under the condition of 1-day continuous temperature change. The creep model is used to analyse the influence of ambient temperature and humidity on the rutting deformation of asphalt pavement. The results show that the maximum temperature of asphalt pavement can reach 60 degrees C in the high-temperature environment in summer. The temperature accumulation effect causes the temperature of the middle and lower layers to increase by approximately 10 degrees C, which easily induces rutting. Ambient humidity has a great influence on the change in moisture concentration in the upper layer. Considering the influence of ambient humidity in the high-temperature environment, the rut depth increases by 67%.

关键词： temperature field moisture concentration field rutting deformation

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Memristive Artificial Synapses for Neuromorphic Computing

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Nano-Micro Letters 2021年第5期13卷 218-245页

作者： Wen Huang xuwen Xia Chen Zhu Parker Steichen Weidong Quan Weiwei Mao Jianping Yang liang Chu Xing’ao Li New Energy Technology Engineering Laboratory of Jiangsu Province and School of Science Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advanced MaterialsSchool of Materials Science and EngineeringNanjing University of Posts and Telecommunications(NUPT)9 Wenyuan RoadNanjing 210023People’s Republic of China College of Electronic and Optical Engineering and College of Microelectronics Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China Department of Materials Science and Engineering University of WashingtonSeattleWA 98195‑2120USA

Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann *** computing is realized based on memristive hardware neural networks in which synaptic devices that mimic biological synapses of the brain are the primary *** synaptic functions with these devices is critical in neuromorphic *** the last decade,electrical and optical signals have been incorporated into the synaptic devices and promoted the simulation of various synaptic *** this review,these devices are discussed by categorizing them into electrically stimulated,optically stimulated,and photoelectric synergetic synaptic devices based on stimulation of electrical and optical *** working mechanisms of the devices are analyzed in *** is followed by a discussion of the progress in mimicking synaptic *** addition,existing application scenarios of various synaptic devices are ***,the performances and future development of the synaptic devices that could be significant for building efficient neuromorphic systems are prospected.

关键词： Synaptic devices Neuromorphic computing Electrical pulses Optical pulses Photoelectric synergetic effects

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TMEM35B as a novel biomarker for diagnosing gliomas

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BIOMARKERS IN MEDICINE 2024年第24期18卷 1103-1111页

作者： liang, Gongbo Lai, xuwen Yan, Guangning He, Wenyuan Su, Longjun Luo, Jinxia Wang, Zhuocai Gen Hosp Southern Theater Command Dept Pathol 111 LiuHua Rd Guangzhou 510010 Peoples R China

AimsThere is little information about transmembrane protein 35B (TMEM35B) expression in glioma, and its functions in glioma remains no *** & MethodsImmunohistochemistry was used to measure TMEM35B expression levels and CCK8 and Transwell assays were analyzed the proliferative and migratory and ***35B protein was significantly higher in gliomas and correlated with a higher tumor TNM stages. Receiver operating characteristic curve analysis revealed that TMEM35B had high diagnostic value in distinguishing among glioma, normal tissues, tumor stages III+IV, and I+II. Additionally, TMEM35B knockdown inhibited the proliferative, migratory, and invasive capacities of glioma ***35B expression is upregulated in gliomas, and its knockdown hinders tumor progression, highlighting the protein as a potential biomarker for glioma diagnosis.

关键词： Glioma TMEM35B proliferation metastasis biomarker

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Direct Arylation Polycondensation of β-Fluorinated Bithiophenes to Polythiophenes: Effect of Side Chains in C-Br Monomers

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MACROMOLECULES 2022年第18期55卷 8095-8105页

作者： Zhang, xuwen Shi, Yibo Dang, Yanfeng liang, Ziqi Wang, Zhongli Deng, Yunfeng Han, Yang Hu, Wenping Geng, Yanhou Tianjin Univ Sch Mat Sci & Engn Tianjin 300072 Peoples R China Tianjin Univ Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Collaborat Innovat Ctr Chem Sci & Engn Tianjin Sch Mat Sci & Engn Tianjin 300072 Peoples R China Tianjin Univ Dept Chem Tianjin 300072 Peoples R China Collaborat Innovat Ctr Chem Sci & Engn Tianjin Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Tianjin Univ Natl Univ Singapore Joint Sch Int Campus Fuzhou 350207 Peoples R China Tianjin Univ Int Campus Fuzhou 350207 Peoples R China

Six polythiophenes (PThs) were synthesized via direct arylation polycondensation (DArP) with beta-fluorinated bithiophenes, that is, 4,4' -difluoro-2,2'-bithiophene (2FBT) and 3,3',4,4'-tetrafluoro-2,2'-bithiophene (4FBT), as the C-H monomers and 5,5'-dibromo-2,2'-bithiophenes DCBT-2Br, DABT-2Br, and DTBT-2Br that carry alkoxycarbonyl, alkyl, and alkylthienyl side chains at 4,4'-positions, respectively, as the C-Br monomers. Both 2FBT and 4FBT are highly reactive for DArP, and high molecular weight PThs with unobservable chain defects were successfully synthesized from 2FBT/DCBT-2Br, 2FBT/DABT-2Br, 2FBT/DTBT-2Br, and 4FBT/DTBT-2Br. However, the DArP of 4FBT with DCBT-2Br and DABT-2Br produced PThs containing C-H/C-H homo-coupling defects along with relatively lower molecular weights. Detailed theoretical analysis suggests that the occurrence of C-Br reduction-provoked C-H/C-H homo-coupling for 4FBT/DCBT-2Br and 4FBT/DABT-2Br monomer pairs originated from the poor selectivity between the cis- and trans-forms of transition states in the concerted metalation-deprotonation (CMD) process is responsible for the formation of structural defects and depressed molecular weights. This research reveals that a C-H monomer with high reactivity and selectivity is not sufficient for the synthesis of well-defined conjugated polymers via DArP, and the structure of the C-Br monomer also has a significant impact on the results of DArP via influencing the catalytic cycles.

关键词： Defects Monomers Polymerization Polymers Selectivity

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Direct Arylation Polycondensation toward Water/Alcohol-Soluble Conjugated Polymers: Influence of Side Chain Functional Groups

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ACS MACRO LETTERS 2021年第4期10卷 419-425页

作者： Zhao, Bowen liang, Ziqi Zhang, Ying Sui, Ying Shi, Yibo Zhang, xuwen Li, Miaomiao Deng, Yunfeng Geng, Yanhou Tianjin Univ Sch Mat Sci & Engn Tianjin 300072 Peoples R China Tianjin Univ Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Tianjin Univ Joint Sch Natl Univ Singapore & Tianjin Univ Int Campus Fuzhou 350207 Peoples R China

Direct arylation of 2,7-dibromofluorene with n-octyl, 6-diethoxylphosphorylhexyl, 6-(N,N-diethylamino)hexyl or 6-bromohexyl side chains and 1,2,4,5-tetrafluorobenzene (TFB) were conducted to investigate the effect of side chain functional groups on the coupling, and the resulting TFB-substituted fluorene derivatives were used as C-H monomers for the synthesis of water/alcohol soluble conjugated polymers (WSCPs) by direct arylation polycondensation (DArP). The direct arylation and DArP of the monomers carrying phosphonate and amino groups went on smoothly in typical DArP conditions, that is, Pd(OAc)(2)/(PBu2Me)-Bu-t-HBF4/base/DMAc and Pd-2(dba)(3)center dot CHCl3/P(o-MeOPh)(3)/pivalic acid/base/THF, and high molecular weight polymers with these groups were successfully synthesized. However, for fluorenemonomers with bromohexyl side chains, the target products could not be obtained from the above conditions but could be prepared in the absence of carboxylic acid additives in low polar solvents. With the above DArP-made polymers as cathode interfacial layers, high performance organic solar cells (OSCs) were successfully fabricated.

关键词： Monomers Organic reactions Organophosphorus compounds Condensation Polymers

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