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2017 6th International Conference on Advanced Materials and Computer Science(ICAMCS 2017)

作者： Qiang Wu liang Xu xuwen Li College of Information and Communication Engineering Faculty of Information TechnologyBeijing University of Technology College of Life Science and Bioengineering Beijing University of Technology

As a common high-speed interface,PCIe interface is very extensive in the field of data *** a development framework of Microsoft,WDF（Windows Driver Foundation）driver model can reduce the difficulty of the *** on the PCIe high-speed image acquisition card which is developed by ourselves,this paper designed a stable and reliable WDF driver for the high data transmission rate in the image acquisition process,and used the memory allocation method in WDF to share buffer with the *** order to enhance the speed of the image acquisition,this paper designed a ring buffer mechanism to ensure the continuity and stability in the image acquisition and transmission process.

关键词： Windows Driver PCIe Bus WDF Model DMA Transmission Ring Buffer

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椎体骨质疏松性骨折MRI研究进展

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中国介入影像与治疗学 2018年第2期15卷 119-122页

作者：郭威曾旭文梁治平熊玉超彭丽君暨南大学第一临床医学院广东广州510220 广州市红十字会医院暨南大学医学院附属广州红十字会医院放射科广东广州510220

椎体骨质疏松性骨折(OCVF)的发病率逐年上升。MRI可无创观察OCVF的类型、病理分期及严重程度等,且无辐射。近年来,MRI已成为评价OCVF的重要手段,可为临床选择治疗方案提供影像学依据。本文对OCVF的MRI研究进展进行综述。

关键词：磁共振成像脊柱骨折骨质疏松

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丁苯酞对缺血性脑卒中的保护机制及治疗研究进展

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医学综述 2018年第19期24卷 3841-3846页

作者：侯园园梁志刚孙旭文烟台毓璜顶医院神经内科山东烟台264000

缺血性脑卒中是中国乃至全世界较常见的高病死率及致残率疾病之一。丁苯酞作为中国自主研发的新药,临床在缺血性脑卒中患者中个体化应用。除有线粒体保护作用外,其还有抑制细胞氧化应激、改善脑血管侧支循环和微循环、保护血脑屏障等一... 详细信息

缺血性脑卒中是中国乃至全世界较常见的高病死率及致残率疾病之一。丁苯酞作为中国自主研发的新药,临床在缺血性脑卒中患者中个体化应用。除有线粒体保护作用外,其还有抑制细胞氧化应激、改善脑血管侧支循环和微循环、保护血脑屏障等一系列作用。丁苯酞通过多项机制保护缺血性脑卒中患者的神经功能,改善患者的生活能力及认知功能,明显改善患者短期预后。未来,需设计更多严谨的前瞻性临床试验进一步验证丁苯酞的临床有效性,为缺血性脑卒中急性期治疗提供新方法。

关键词：缺血性脑卒中丁苯酞神经保护侧支循环

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褐藻多糖硫酸酯对MPP^+损伤的MN9D细胞氧化应激及凋亡的保护作用

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中国医药导报 2019年第7期16卷 20-24页

作者：梁志刚孙旭文刘竹丽杨绍婉罗鼎真青岛大学附属烟台毓璜顶医院神经内科山东烟台264000 山东省立医院老年病科山东济南250021

目的探讨褐藻多糖硫酸酯(FUC)对帕金森病(PD)细胞模型的保护作用及机制。方法采用100μmol/L MPP+损伤的MN9D细胞制作PD模型,用MTS检测FUC预处理后PD细胞模型的细胞存活率。荧光检测法测定细胞内活性氧(ROS),荧光素酶法检测细胞内Caspas... 详细信息

目的探讨褐藻多糖硫酸酯(FUC)对帕金森病(PD)细胞模型的保护作用及机制。方法采用100μmol/L MPP+损伤的MN9D细胞制作PD模型,用MTS检测FUC预处理后PD细胞模型的细胞存活率。荧光检测法测定细胞内活性氧(ROS),荧光素酶法检测细胞内Caspase-3的活性变化,Western blot检测凋亡相关蛋白Bax及Bcl-2的变化。结果 FUC 100μmol/L作用24 h明显增加了MPP+损伤的MN9D细胞存活率,差异有高度统计学意义(P<0.01);FUC预保护明显降低了MPP+损伤3 h的MN9D细胞内ROS活性及6 h时Caspase-3的表达,差异有高度统计学意义(P<0.01);FUC、司来吉兰预保护后MN9D细胞凋亡相关蛋白Bax表达明显下降,而Bcl-2表达明显增加,差异有高度统计学意义(P<0.01)。结论褐藻多糖硫酸酯可能通过抗氧化、降低Caspase-3表达、抑制细胞凋亡来保护PD细胞模型。

关键词：褐藻多糖硫酸酯帕金森病 MN9D细胞氧化应激细胞凋亡

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胃蛋白酶片质量分析及探索性研究

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中国药品标准 2019年第6期20卷 510-514页

作者：焦旭雯梁蔚阳蒋玉辉穆矛薛巧如陈宇堃广东省药品检验所国家药品监督管理局血液制品重点实验室

目的:评价国内不同企业生产的胃蛋白酶片的质量,并从溶出曲线、纯度、比活力等方面进行探索性研究,为企业提高产品质量提供改进方法。方法:采用4种溶出介质考察各企业产品的溶出行为;采用HPLC法,以1.7 mol·L^-1硫酸铵磷酸盐缓冲液(... 详细信息

目的:评价国内不同企业生产的胃蛋白酶片的质量,并从溶出曲线、纯度、比活力等方面进行探索性研究,为企业提高产品质量提供改进方法。方法:采用4种溶出介质考察各企业产品的溶出行为;采用HPLC法,以1.7 mol·L^-1硫酸铵磷酸盐缓冲液(pH 7.0)为流动相,梯度洗脱的方法测定胃蛋白酶片的纯度,并与SDS-PAGE蛋白电泳进行比对;采用蛋白质测定法与效价测定法对比活力进行研究。结果:(1)53批样品中,溶出度最大值为112%,最小值为28%;(2)HPLC结果与SDS-PAGE电泳结果显示胃蛋白酶为多组分物质;(3)原料比活力为12.2~13.2 U·mg-1蛋白,片剂比活力为8.0~15.3 U·mg-1蛋白。结论:胃蛋白酶片现行质量标准安全性和有效性指标控制不足,建议企业加强药品生产全过程风险管理,降低产品批次间的差异,进一步提高制剂工艺的稳定性。本文为全面评价胃蛋白酶片的质量和完善其质量标准提供借鉴和参考。

关键词：胃蛋白酶片国家评价性抽验质量研究与分析溶出度纯度

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中国南海天然气水合物第二次试采主要进展

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中国地质 2020年第3期47卷 557-568页

作者：叶建良秦绪文谢文卫卢海龙马宝金邱海峻梁金强陆敬安匡增桂陆程梁前勇魏士鹏于彦江刘春生李彬申凯翔史浩贤卢秋平李晶寇贝贝宋刚李博张贺恩陆红锋马超董一飞边航中国地质调查局北京100037 中国地质调查局广州海洋地质调查局广东广州510075 中国地质调查局勘探技术研究所河北廊坊065000 北京大学北京100871 中国石油集团海洋工程有限公司北京100102 中国地质调查局油气调查中心北京100083 南方海洋科学与工程广东省实验室(广州) 广东广州510000

泥质粉砂型天然气水合物被认为是储量最大开采难度亦最大的水合物储层,2017年南海天然气水合物试采,初步验证了此类水合物储层具备可开采性。在总结前次试采认识的基础上,对试采矿体进行优选、精细评价、数值与试验模拟和陆地试验,中国... 详细信息

泥质粉砂型天然气水合物被认为是储量最大开采难度亦最大的水合物储层,2017年南海天然气水合物试采,初步验证了此类水合物储层具备可开采性。在总结前次试采认识的基础上,对试采矿体进行优选、精细评价、数值与试验模拟和陆地试验,中国地质调查局于2019年10月-2020年4月在南海水深1225 m神狐海域进行了第二次天然气水合物试采。本次试采攻克了钻井井口稳定性、水平井定向钻进、储层增产改造与防砂、精准降压等一系列深水浅软地层水平井技术难题,实现连续产气30 d,总产气量86.14×104m3,日均产气2.87×104m3,是首次试采日产气量的5.57倍,大大提高了日产气量和产气总量。试采监测结果表明,整个试采过程海底、海水及大气甲烷含量无异常。本次成功试采进一步表明,泥质粉砂储层天然气水合物具备可安全高效开采的可行性。

关键词：南海天然气水合物第二次试采水平井储层改造环境影响油气资源工程神狐海域南海

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Onboard Interference Prediction for the Cognitive Medium Access in the LEO Satellite Uplink Transmission

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INTERNATIONAL JOURNAL OF DISTRIBUTED SENSOR NETWORKS 2014年第unknown期000卷 1-1页

作者： Xie, Zhuochen Liu, Huijie liang, xuwen Chinese Acad Sci Shanghai Inst Microsyst & Informat Technol Key Lab Microsatellites Shanghai 200050 Peoples R China

Cognitive radio (CR) is an efficient way to increase spectrum efficiency for the small low earth orbit (LEO) satellite communication system. Due to the implementation difficulties, we focus on the CR in the uplink transmission. In CR, the cognitive medium access (CMA) is designed to enable the coexistence with the interferences from other systems. However, the CMA schemes designed for the terrestrial system cannot deal well with the global history of interferences in our system. Here, we design the memorized centroid bucket (MCB) scheme that can efficiently utilize the global history of interferences onboard without storing the complete interference samples. With MCB, we can achieve the effective long-term interference prediction to meet the special requirements of the LEO satellite. The key component in MCB is the matching algorithm that can help retrieve the useful historical information. In this paper, we propose three different matching algorithms and the corresponding MCB schemes. The schemes are also compared with the widely used Markovian method and the pair counting-based method. Among all the schemes, the Bayesian scheme MCB-FSNMI-Bayes is the best. The conclusion is validated experimentally with the real data that were collected by an LEO satellite.

关键词： COGNITIVE radio (Wireless communication systems) COMPUTERS -- Access control LOW earth orbit satellites DATA transmission systems COMPUTER algorithms

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Metabolomics analysis of Danggui Sini decoction on treatment of collagen-induced arthritis in

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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2017年 1061卷 282-291页

作者： Cheng, Bang Zheng, Hua Wu, Fang Wu, Jinxia Liu, xuwen Tang, Chaoling Lu, Shiyin Chen, Zhaoni Song, Fangming Ruan, Junxiang Zhang, Hongye Song, Hui Liu, Wei Guo, Hongwei liang, Yonghong Su, Zhiheng Guangxi Med Univ Pharmaceut Coll Nanning 530021 Peoples R China Guangxi Med Univ Inst Life Sci Nanning 530021 Peoples R China Shenyang Pharmaceut Univ Dept Clin Pharm Shenyang 110016 Peoples R China

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation leading to bone and cartilage damage and even disability. However, the pathogenesis of RA is multi-factorial and to a large degree, remains unknown. Danggui Sini decoction (DSD), a traditional Chinese medicine (TCM) formula, has been widely used as a remedy for rheumatoid arthritis (RA) in recent years. In our study, H-1-nuclear magnetic resonance (H-1 NMR) based metabolomics analysis of 7 potential biomarkers, including taurine (1), urea (2), betaine (3), pyruvate (4), hippurate (5), succinate (6) and acetone (7) was performed to investigate the progression of RA and assess the efficacy of DSD in collagen-induced arthritis (CIA) rats. According to pathway analysis using identified metabolites and correlation construction, taurine and hypotaurine metabolism, gut microbiota metabolism, pyruvate metabolism, glycolysis/gluconeogenesis, the citrate cycle (TCA cycle) and lipid metabolism were recognized as being the most influenced metabolic pathways associated with RA. As a result, deviations of metabolites 1, 3, 4, 5, 6 and 7 in CIA rats were improved by DSD, which suggested that DSD mediated the abnormal metabolic pathways synergistically. In summary, the efficacy and its underlying therapeutic mechanisms of DSD on RA were systematically investigated and expect to provide a new insight in relevant studies of other TCM formulas.

关键词： Metabolomics H-1 NMR Rheumatoid arthritis Collagen-induced arthritis TCM

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A method to estimate the effects of the antenna jitters of an agile SAR satellite on the appearance of the images

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Journal of Computational Information Systems 2014年第10期10卷 4319-4329页

作者： Pang, Yan Huang, Mo Zhang, Rui liang, xuwen Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Shanghai Engineering Center for Microsatellites Shanghai 201203 China Institute of Electronics Chinese Academy of Sciences Beijing 100190 China

Efficient synthetic aperture radar (SAR) processing algorithms are unable to compensate envelope errors caused by the instability of the antennas;because the traditional motion compensations (MoCo) of SAR processing performs only phase corrections. During the motion compensation, the antenna direction is assumed stable, resulting in azimuth envelop errors which impact the resolution and the geometric fidelity of the processed SAR images. This paper proposes a Fourier transform-and Taylor series-based methodology capable of precisely estimating the effects of the pointing jitter on the appearance of the radar image. In addition to the overall system design of the agile SAR satellites, the theoretic research of the motion compensation can also benefit from this approach, especially for the a high-resolution SAR system with a narrow beam placed on an unstable platform. Data from a simulated X-band SAR system with pointing jitters are used to demonstrate the estimation performance of the proposed approach. 1553-9105/Copyright © 2014 Binary Information Press.

关键词： Synthetic aperture radar

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A new loop delay estimation algorithm for digital predistortion

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Journal of Computational Information Systems 2014年第6期10卷 2543-2553页

作者： Hu, Zexin Liu, Huijie liang, xuwen Zhang, Wuxiong Shanghai Institute of Microsystem and Information Technology Chinese Academy of Science Shanghai 200050 China Shanghai Engineering Center for Microsatellites Shanghai 201203 China

In this paper, we present a new loop delay estimation algorithm to accurately calculate the loop delay in the digital predistortion system (DPD), the performance of which can be significantly degraded by loop delay mismatch between input and output signals of power amplifier (PA). The algorithm, which is based on carrier phase detection (phase detection-delay estimation, PD-DE), is able to simultaneously provide integer and fractional sampling interval (SI) delays by calculating the real-time carrier phase difference between transmitter and receiver. The simulation based on Matlab and experimental results on FPGA/DSP hardware platform show better performances than conventional loop delay estimation algorithms in terms of convergence speed and computational complexities. Copyright © 2014 Binary Information Press.

关键词： Power amplifiers

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