检索结果-内蒙古大学图书馆

Latex microspheres lateral flow immunoassay with smartphone-based device for rapid detection of Cryptococcus

TALANTA 2025年 284卷 127254页

作者： Zang, Xuelei Zhou, Yangyu Li, Shuming Shi, Gang Deng, Hengyu Zang, Xuefeng Cao, Jingrong Yang, Ruonan lin, xuwen Deng, Hui Huang, Yemei Yang, Chen Wu, Ningxin Song, Chao Wu, Lidong Xue, Xinying Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing 100038 Peoples R China Shandong Second Med Univ Weifang 261053 Peoples R China Datang Telecom Convergence Commun Technol Co Ltd Beijing 100094 Peoples R China Chinese Acad Fishery Sci Beijing 100141 Peoples R China Capital Med Univ Xuanwu Hosp Dept Clin Lab Beijing 100053 Peoples R China Nanjing Normal Univ Sch Food Sci & Pharmaceut Engn Nanjing 210023 Peoples R China Chinese Peoples Liberat Army Gen Hosp Med Lab Ctr Med Ctr 1 Beijing 1000853 Peoples R China 971 Hosp Chinese Peoples Liberat Army Navy Dept Cadres Qingdao 266000 Peoples R China Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Wuxi 214081 Peoples R China

Cryptococcus is a pathogenic fungus that poses a threat to human health. Conventional detection methods have limited the rapid and accurate qualitative and quantitative analysis of Cryptococcus, affecting early diagnosis and treatment. In this study, we developed a Point-of-Care Testing (POCT) platform that integrates lateral flow immunoassay (LFIA) with smartphones, enabling both rapid qualitative and quantitative detection of Cryptococcus. The LFIA strip utilizes latex microspheres (LMs) as labeling probes, achieving a detection limit of 3000 CFU/mL and presenting higher sensitivity than the Colloidal Gold Nanoparticles Lateral Flow Immunoassay (AuNPs-LFIA) strip, and approximately eight times that of the AuNPs-LFIA strip. Additionally, it exhibiting no cross-reactivity with over 24 common pathogens and validated in clinical samples. For quantitative analysis, artificial intelligence algorithms were employed to convert smartphone-captured images into grayscale values. Eleven feature values were utilized as a dataset for machine learning to construct a linear regression model, with Mean Squared Error (MSE) and R2 reaching 0.45 and 0.91, respectively. Moreover, the recovery rates in the serum samples ranged from 90.0 % to 108 %, indicating a good practicability. This research presents a rapid diagnostic technology for Cryptococcus and lays the theoretical and technical groundwork for detecting other pathogens.

关键词： Gold nanoparticles

来源：评论

学校读者我要写书评

暂无评论

Single Charged Top-Pion Production at the Next Generation e^＋e^- Colliders

引用

Communications in Theoretical Physics 2005年第1期43卷 133-138页

作者： WANGXue-Lei DUlin-lin xuwen-Na CollegeofPhysicsandInformationEngineering HenanNormalUniversityXinxiang453002China

The single charged top-pion production processes e~+ e~- → tbΠ_t~- and e~+e~- → W~+Π_t~- are studied in the framework of top-color-assisted technicolor (TC2) model. Ourstudies show that the cross section σ(e~+ e~- → tbΠ_t~-) Teaches the level of tens of fb andσ(e~+ e~- → W~+Π_t~-) reaches the level of a few fb. With the yearly integrated luminosity of ￡～ 500 fb~(-1) expected at the planned colliders, one could collect thousands of charged top-pion ofevents via the process e~+ e~- → tbΠ_t~- and hundreds of events via the process e~+ e~- →W~+Π_t~-. The flavor changing decay mode Π_t~- → bc is the best channel to detect chargedtop-pion due to the clean SM background. With a large number of events and the clean background, thecharged top-pion should be observable at the planned colliders. Therefore, our studies in thispaper can help us to search for charged top-pion, and furthermore, to test the TC2 model.

关键词： top-pion top-color-asisted technicolor model linear colliders

来源：评论

学校读者我要写书评

暂无评论

Cardiovascular toxicity in antitumor therapy: biological and therapeutic insights

引用

TRENDS IN CANCER 2024年第10期10卷 920-934页

作者： lin, xuwen Ma, Xidong Zhao, Sheng Yao, Jie Han, Leng Jing, Ying Xue, Xinying Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Fuwai Hosp Natl Ctr Cardiovasc Dis State Key Lab Cardiovasc DisDept Cardiol Beijing Peoples R China Shandong Second Med Univ Dept Resp & Crit Care Weifang Peoples R China Indiana Univ Brown Ctr Immunotherapy Sch Med Indianapolis IN 46202 USA Indiana Univ Sch Med Dept Biostat & Hlth Data Sci Indianapolis IN 46202 USA Fudan Univ Greater Bay Area Inst Precis Med Guangzhou Ctr Intelligent Med Res Sch Life Sci Guangzhou Peoples R China

The evolution of antitumor therapies has significantly improved cancer prognosis but has concurrently resulted in cardiovascular toxicities. Understanding the biological mechanisms behind these toxicities is crucial for effective management. Immunotherapy-related cardiovascular toxicities are primarily mediated by immune cells and secreted cytokines. Chemotherapy may cause cardiovascular damage through autophagy disruption and mitochondrial dysfunction. Targeted therapies can induce toxicity through endothelin-1 (ET-1) production and cardiac signaling disruption. Radiotherapy may lead to cardiomyopathy and myocardial fibrosis by affecting endothelial cells, triggering inflammatory responses and accelerating atherosclerosis. This review provides insights into these mechanisms and strategies, aiming to enhance the clinical prevention and treatment of cardiovascular toxicities.

关键词： cardiovascular toxicities immunotherapy chemotherapy radiotherapy targeted therapy biological mechanisms

来源：评论

学校读者我要写书评

暂无评论

Arbidol/IFN-a2b therapy for patients with corona virus disease 2019: a retrospective multicenter cohort study

引用

MICROBES AND INFECTION 2020年第4-5期22卷 200-205页

作者： Xu, Ping Huang, Jianping Fan, Zhao Huang, Wendi Qi, Minghua lin, xuwen Song, Weidong Yi, Li Peking Univ Shenzhen Hosp Dept Resp & Crit Care Med Shenzhen 518036 Guangdong Peoples R China Hubei Jianli People Hosp Dept Infect Dis Jingzhou 433300 Hubei Peoples R China Peking Univ Dept Emergency Shenzhen Hosp Shenzhen Guangdong Peoples R China Peking Univ Dept Neurol Shenzhen Hosp 1120 Lianhua Rd Futian Area Shenzhen 518036 Guangdong Peoples R China

The spread of COVID-19 is accelerating. At present, there is no specific antiviral drugs for COVID-19 outbreak. This is a multicenter retrospective cohort study of patients with laboratory-confirmed COVID-19 infection pneumonia from 3 hospitals in Hubei and Guangdong province, 141 adults (aged ≥18 years) without ventilation were included. Combined group patients were given Arbidol and IFN-α2b, monotherapy group patients inhaled IFN-α2b for 10-14 days. Of 141 COVID-19 patients, baseline clinical and laboratory characteristics were similar between combined group and monotherapy group, that 30% of the patients leucocytes counts were below the normal range and 36.4% of the patients experienced lymphocytopenia. The duration of viral RNA of respiratory tract in the monotherapy group was not longer than that in the combined therapy group. There was no significant differences between two groups. The absorption of pneumonia in the combined group was faster than that in the monotherapy group. We inferred that Arbidol/IFN - 2 b therapy can be used as an effective method to improve the COVID-19 pneumonia of mild patients, although it helpless with accelerating the virus clearance. These results should be verified in a larger prospective randomized environment.

关键词： COVID-19 2019-nCoV Pneumonia Arbidol IFN-α2b Treatment RNA

来源：评论

学校读者我要写书评

暂无评论

Optimization of car-sharing scheduling based on genetic combined with simulated annealing strategy 3

Optimization of car-sharing scheduling based on genetic comb...

引用

3rd International Academic Exchange Conference on Science and Technology Innovation, IAECST 2021

作者： Zhou, Chao Guo, Danyang Li, Jiaqi Rong, Aiqiong Liang, Sihua lin, xuwen Guangzhou City University of Technology College of Mechanical Engineering Guang Zhou510800 China

ISBN: (纸本)9781665402675

This paper conducts scientific research on the joint scheduling of vehicles and personnel based on the distribution of car-sharing use[1], so as to propose an optimal control scheduling scheme that improves car utilization while making customers more satisfied and maximizing corporate profits. To begin with, we used the partitioning method to pre-processing the shared vehicle location data set, and use Excel software to disassemble the coordinate information. We need to divide the data according to the parking points, count the data according to different parking points, make descriptive statistics on the total number of parked vehicles at the parking points, and then analyze the use distribution of car-sharing[2]. Additionally, a joint car-sharing scheduling optimization model is built and the model is improved, which is then transformed into a two-layer mTSP model[3]. The upper model is an mTSP model with uncertain number of vehicles with time windows, while the lower model is an mTSP model with uncertain number of persons with time windows. At the same time, the genetic algorithm is used to solve the model, and after the operation of selection, cross over and variation combined with the simulated annealing strategy[4] to achieve better optimization results and construct the most beneficial scheduling solution for the enterprise. © 2021 IEEE.

关键词： Genetic algorithms

来源：评论

学校读者我要写书评

暂无评论

Threshold Huffman-Based Covert Timing Channel Detection

引用

International Journal of Network Security 2025年第1期27卷 61-71页

作者： lin, Yuwei Chen, Yonghong Zhuang, Xiaolong Huang, xuwen School of Computer Science and Technology Huaqiao University Fujian Xiamen361000 China Xiamen Key Laboratory of Data Security and Blockchain Technology Huaqiao University Fujian Xiamen361000 China

Network covert timing channels in computer networks evade effective detection by traditional security mechanisms such as firewalls, posing a significant threat to network security. However, most existing methods struggle to detect such channels when the window size is small. Additionally, the emergence of the new ϵ-κlibur channel has resulted in a decline in performance for detection methods such as GAS, SnapCatch, and DNN when detecting this particular channel. In this paper, we investigate a Huffman tree-based approach for detecting anomalous nodes in traffic and achieving the classification of channels through the design of weight intervals. Our method achieves an average detection rate of over 95% for each channel. Additionally, compared to GAS, SnapCatch, and DNN, our method improves the detection rates for the ϵ-κlibur channel by 11.75%, 8.46%, and 4.81%, respectively. The experimental results demonstrate that our proposed approach successfully detects ϵ-κlibur and achieves detection in a small window. © (2025), (Femto Technique Co., Ltd.). All rights reserved.

关键词： Computer system firewalls

来源：评论

学校读者我要写书评

暂无评论

Semi-interpenetrating network membranes based on poly(phenylene oxide) and poly(acrylonitrile-vinylimidazole) for high-temperature proton exchange membrane fuel cell applications

引用

INTERNATIONAL JOURNAL OF HYDROGEN ENERGY 2025年 116卷 1-7页

作者： Han, Yuyang Xu, Fei Huang, Kai Li, Yanting Yang, Qinwu Bao, xuwen lin, Bencai Changzhou Univ Jiangsu Collaborat Innovat Ctr Photovolat Sci & En Sch Mat Sci & Engn Changzhou 213164 Jiangsu Peoples R China

In this study, a series of semi-interpenetrating network (semi-IPN) structure proton exchange membranes (PEMs) based on linear polyolefins and cross-linked poly(phenylene oxide) (cPPO) was fabricated for fuel cell applications. The newly synthesized membranes exhibit better flexibility and higher chemical and thermal stability than cPPO membrane owing to a semi-IPN structure. After treatment with Fenton's reagent at 80 degrees C for 240 h, all the synthesized semi-IPN membranes (cPPO-[AN-VBIm]x) show a remaining mass of >90%, indicating good oxidation stability. The proton conductivity and fuel cell performance of cPPO-[AN-VBIm](50) membranes (91 mS cm(-1) at 160 degrees C and 514 mW cm(-2) at 140 degrees C, respectively) are better than those of cPPO membranes (51 mS cm(-1) and 87 mW cm(-2), respectively under the same conditions). This study contributes significantly toward membrane research, reporting a facile and efficient method for fabricating high-performance phosphoric acid-doped membranes for high-temperature fuel cell applications that could guide future studies on efficient and practicable high-temperature PEMs.

关键词： Poly(phenylene oxide) Semi-interpenetrating network Proton exchange membrane Fuel cells Proton conductivity Phosphoric acid-doped membranes

来源：评论

学校读者我要写书评

暂无评论

Tertiary Lymphoid Structure in Tumor Microenvironment and Immunotherapy of Lung Cancer

引用

ARCHIVOS DE BRONCONEUMOLOGIA 2024年 60卷 S77-S85页

作者： Xie, Mei lin, xuwen Bao, Xinyu Liang, Yiran Deng, Hui Song, Jialin Ma, Xidong Zhang, Xin Yao, Jie Pan, Lei Xue, Xinying Capital Med Univ Beijing Shijitan Hosp Dept Resp & Crit Care Emergency & Crit Care Med Ctr Beijing 100038 Peoples R China Shandong Second Med Univ Sch Clin Med Dept Resp & Crit Care Weifang Shandong Peoples R China

Immune checkpoint inhibitors have opened an era of lung cancer therapy. However, a notable disparity exists in the efficacy of immunotherapy among individual patients. The tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregation that appears under pathological conditions and is the primary site of action for anti-tumor immunity. It is commonly reported that the presence of TLS within the tumor microenvironment (TME) relates to a favorable clinical prognosis and an excellent response to immunotherapy in lung cancer patients. A thorough understanding of TLS and its dynamic changes in TME has become an attractive focus for optimizing immunotherapy strategies for lung cancer. In this review, we comprehensively generalize the composition, formation, mechanism, detection methods of TLS, and summarize the role of TLS in lung cancer immunotherapy. Finally, induction of TLS is also discussed, which may provide more effective therapeutic strategies for lung cancer therapy. (c) 2024 The Authors. Published by Elsevier Espana, S.L.U. on behalf of SEPAR.

关键词： Tertiary lymphoid structures Lung cancer Immunotherapy Prognosis

来源：评论

学校读者我要写书评

暂无评论

CUSHIONING MEMBER FOR FURNITURE SLIDING RAIL AND FURNITURE SLIDING RAIL USING SAME

CUSHIONING MEMBER FOR FURNITURE SLIDING RAIL AND FURNITURE S...

引用

作者： lin, xuwen

标准号: WO2018010331(A1)

Provided are a cushioning member for a furniture sliding rail and a furniture sliding rail (100) using the same. The cushioning member comprises a cushioning base (101), a release member (3), a cushioning base sliding block (2), a seat (1), a reset spring (11, 12), a damping cushioning member (13), and a self-locking connection fastener (4). The self-locking connection fastener (4) comprises a first rotary joint means (41) and a lower hook arm (46) which are arranged at the front and back, respectively. A second rotary joint means (24) is disposed at a head end portion of the sliding block (2). A trap (17) is arranged at a tail end portion of the seat (1). When the release member (3) drives the self-locking connection fastener (4) to move backwards, the lower hook arm (46) retreats to a position above the trap (17) and rotates downwardly to enter the trap (17), and a first slide-out joint means (45) descends accordingly. The descended first slide-out joint means (45) can avoid a second slide-out joint means (33) that is moving backwards, such that the second slide-out joint means (33) passes over the first slide-out joint means (45) and continues to move backwards, thereby separating the release member (3) from the self-locking connection fastener (4). The invention has the above advantages, and is applicable to a cushioning member for a furniture sliding rail and a furniture sliding rail (100) using the same.

关键词：

来源：评论

学校读者我要写书评

暂无评论

The Role of Glutathione S-Transferase in the Regulation of Plant Growth, and Responses to Environmental Stresses

引用

Phyton-International Journal of Experimental Botany 2025年第3期94卷 583-601页

作者： Chen lin Zidan Zhang Zhao Zhang Yuxiang Long xuwen Shen Jinghao Zhang Youping Wang Key Laboratory of Plant Functional Genomics of the Ministry of Education Yangzhou UniversityYangzhou225009China Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding Yangzhou UniversityYangzhou225009China

Glutathione S-transferases (GSTs) represent a large and diverse enzyme family ubiquitously distributed across the plant kingdom. These proteins catalyze the conjugation of glutathione (GSH) with electrophilic substrates in response to various stress conditions. Beyond their role in stress adaptation, certain GSTs are integral regulators of plant growth and development, contributing to a range of physiological processes. Most GST proteins exhibit dual enzymatic activities, functioning as both transferases and peroxidases, which enables their involvement in diverse cellular processes, including detoxification and stress responses. Recent advancements, particularly in X-ray crystallography, have enabled detailed structural analysis of GST proteins, significantly enhancing our understanding of their biological functions. This review offers a comprehensive overview of the classification and structural characteristics of GSTs in plants. It also highlights recent findings on their roles in plant growth and development, cell signaling, catalytic transport, and stress tolerance. Furthermore, key scientific challenges related to GSTs are discussed, focusing on their potential applications in agriculture. These insights aim to facilitate the screening of functional GST genes and support molecular breeding efforts across diverse crop species.

关键词： Glutathione S-transferase biotic and abiotic stress plant growth and development signal transduction biological functions

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：