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武汉大学学报（工学版） 2022年第10期55卷 1027-1033页

作者：刘元德安旭文黄天翔甘肃省张掖公路事业发展中心甘肃张掖734000 武汉大学土木建筑工程学院湖北武汉430072 湖北省交通投资集团有限公司湖北武汉430050

根据道路等级、气候条件和路面混凝土的功能要求,以道路废弃混凝土为再生集料,设计了粗粒式密级配AC-25C型、中粒式密级配AC-16C型和玛蹄脂SMA-20型沥青混凝土,以再生集料取代率和沥青用量为试验变化参数,制作了标准的马歇尔试件,分别... 详细信息

根据道路等级、气候条件和路面混凝土的功能要求,以道路废弃混凝土为再生集料,设计了粗粒式密级配AC-25C型、中粒式密级配AC-16C型和玛蹄脂SMA-20型沥青混凝土,以再生集料取代率和沥青用量为试验变化参数,制作了标准的马歇尔试件,分别对再生集料沥青混凝土的密度、稳定度、流值进行了试验研究。结果表明:按建议级配配置的再生集料沥青混凝土,可根据需要用于高速公路、一级公路和其他等级的公路路面。研究成果不仅可为废弃混凝土的再生利用提供试验依据和技术支持,还可为同类工程提供参考。

关键词：废弃混凝土再生集料试验研究沥青混凝土

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基于FPGA的MobileNetV1目标检测加速器设计

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现代电子技术 2025年第1期48卷 151-156页

作者：严飞郑绪文孟川李楚刘银萍南京信息工程大学自动化学院江苏南京210044 江苏省大气环境与装备技术协同创新中心江苏南京210044 南京信息工程大学应急管理学院江苏南京210044

卷积神经网络是目标检测中的常用算法,但由于卷积神经网络参数量和计算量巨大导致检测速度慢、功耗高,且难以部署到硬件平台,故文中提出一种采用CPU与FPGA融合结构实现MobileNetV1目标检测加速的应用方法。首先,通过设置宽度超参数和分... 详细信息

卷积神经网络是目标检测中的常用算法,但由于卷积神经网络参数量和计算量巨大导致检测速度慢、功耗高,且难以部署到硬件平台,故文中提出一种采用CPU与FPGA融合结构实现MobileNetV1目标检测加速的应用方法。首先,通过设置宽度超参数和分辨率超参数以及网络参数定点化来减少网络模型的参数量和计算量;其次,对卷积层和批量归一化层进行融合,减少网络复杂性,提升网络计算速度;然后,设计一种八通道核间并行卷积计算引擎,每个通道利用行缓存乘法和加法树结构实现卷积运算;最后,利用FPGA并行计算和流水线结构,通过对此八通道卷积计算引擎合理的复用完成三种不同类型的卷积计算,减少硬件资源使用量、降低功耗。实验结果表明,该设计可以对MobileNetV1目标检测进行硬件加速,帧率可达56.7 f/s,功耗仅为0.603 W。

关键词：卷积神经网络目标检测 FPGA MobileNetV1 并行计算硬件加速

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Fibrin gel-assisted stone extraction in retrograde intrarenal surgery

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BJU INTERNATIONAL 2022年第2期129卷 170-173页

作者： Yu, Yue Xi, Haibo Chen, Yujun Li, xuwen liu, Wei Hu, Jieping Deng, Jun liu, Xiaoqiang Lin, Longhui Li, Chen Wang, Mengzhen Fu, Bin Wang, Gongxian Kuang, Renrui Zhou, Xiaochen Nanchang Univ Affiliated Hosp 1 Dept Urol Nanchang Jiangxi Peoples R China

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Impact of gender and age on 6-Minute Walking Test performance of patients with coronary heart disease compared to healthy elders 43

Impact of gender and age on 6-Minute Walking Test performanc...

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43rd Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (IEEE EMBC)

作者： liu, Lin Ma, Mei Yang, xuwen Yang, Yifan Huang, Xiayu Meng, Lin Ming, Dong Tianjin Univ Acad Med Engn & Translat Med Tianjin 300072 Peoples R China Tianjin Univ Chest Hosp Tianjin 300072 Peoples R China Tianjin Univ Int Engn Inst Tianjin 300072 Peoples R China

ISBN: (纸本)9781728111797

The performance of 6-minute walking test (6MWT) of patients with coronary heart disease (CHD) was significantly related to patients' cardiopulmonary functions. The 6MWT may provide prognostic information for patients. However, the impact of gender and age on the 6MWT performance and related cardiopulmonary parameters of patients with CHD compared to the healthy group has not be fully investigated and discussed. In this study, a total of 118 subjects, including 70 CHD patients and 48 healthy elders, were enrolled. The subjects performed the 6MWT while fourteen cardiopulmonary parameters were measured during the task and the walking distance was recorded at the end. Factors of gender, age, and disease on the 6MWT performance were analyzed using multivariate analysis of variance and the parameters between the patients and healthy people in age- and gender-specific subgroups were compared by Pearson's correlation coefficient. Results showed that age (60-65 and >= 65 years) and gender significantly influenced the 6MWT performance of subjects. Featured parameters were observed in older subgroups (>= 65 years) between the patients and healthy people while patients aged 60-65 had similar 6MWT performance with the healthy control group. It would be potential to distinguish patients with CHD from healthy elders based on the 6MWT where factors of age and gender should be considered.

关键词： 6-minute walking test walking distance coronary heart disease cardiopulmonary function

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Cation defect engineering in LaCoO3 perovskite as the "Two birds one stone" strategy to enhanced Fenton-like reaction: Regulating Co spin state and optimizing electron transfer ability

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SEPARATION AND PURIFICATION TECHNOLOGY 2024年 337卷

作者： Fang, Zhimo Feng, xuwen Zhou, Zhou Zeng, Zepeng Xia, Yuangu Li, Jihong liu, Ji Hu, Bin Li, Kai Lu, Qiang North China Elect Power Univ Natl Engn Res Ctr New Energy Power Generat Beijing 102206 Peoples R China

The reactive oxygen species (ROS) triggered by peroxymonosulfate (PMS), primarily composed of radicals and nonradicals, can deeply and selectively remove pollutants in complex wastewater. However, the low efficiency of electron transfer and insufficient surface catalytic sites remain the main obstacles to the development of efficient and selective PMS activators. Herein, we constructed ABO(3) perovskite catalysts (LaCoO3) with adjustable La vacancies (V-La) densities through urea introduction. Experiment, characterization, and theoretical calculation jointly revealed that VLa could not only induce electron delocalization in Co site to enhance the Co 3d - O 2p covalency for accelerating ROS (sulfate radicals (SO4 center dot-), singlet oxygen (O-1(2)), and high valent cobalt (Co(IV) = O)) generation, but also trigger the transition of spin-polarization configuration to form Co3+ (t(2g)(5)e(g)(1)) with the intermediate spin state as new active sites for surface-bound PMS* complexes production. The nonradical-dominated and radical-assisted system containing multi-site achieved efficient PMS utilization (95.6 %), excellent decontamination activity (0.753 min(-1)), good mineralization ability (82.7 %), satisfactory acid-base resistance (working pH range 3-11), and environmental robustness for actual water treatment. This study reveals the role of cation vacancy engineering in achieving "Two birds one stone" for PMS activation at the atomic level, which will guide the rational design of Fenton-like catalysts.

关键词： Peroxymonosulfate La vacancies Spin state Delocalization Radicals and nonradicals

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Identification of the Metabolites in Rat Urine after Oral Administration and Elucidation of the Metabolic Process of Naozhenning Granule Using LC-MS

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JOURNAL OF CHROMATOGRAPHIC SCIENCE 2020年第9期58卷 804-813页

作者： Li, Rongrong liu, Yanzhi liu, Haixia Wei, Chunhong Wang, Jiang Qin, Xuemei Wang, xuwen Li, Zhenyu Shanxi Univ Modern Res Ctr Tradit Chinese Med Taiyuan 030006 Peoples R China Shanxi Zhendong Ante Biol Pharmaceut Co Ltd Jinzhong 030600 Peoples R China

Naozhenning (NZN) granule, a Chinese herbal formula, is widely used to treat craniocerebral trauma and promote functional recovery. In our previous study, the chemical components, as well as the serum metabolites in the male Sprague-Dawley rats of the NZN granule after oral administration were characterized. In this study, the urine metabolites in the male Sprague-Dawley rats were further investigated by ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-Orbitrap high-resolution accurate mass spectrometry. In order to identify the urine metabolites comprehensively, three sample preparation methods were used, including solid-phase extraction, protein precipitation method and solvent partition. Based on the accurate molecular weight and the fragmentation information from the MS spectra, a total of 76 urine metabolites were identified, which including 17 prototypes and 59 metabolites. The results showed that the detected urine metabolites were different for the different pretreatment methods, as some metabolites could only be detected in the particular pretreatment method. In addition, the metabolic processes of the components from NZN granule to the serum and urine were also elucidated and discussed. The results will provide useful information for further studying the relationship between the chemical components and pharmacological activity of NZN granule.

关键词： Metabolites

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Correction of Read Biases Induced by Complex Reference Genome Regions for Improving Copy Number Variation Detection Using a Gaussian Mixture Model

Correction of Read Biases Induced by Complex Reference Genom...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： xuwen Wang Zhili Chang Shenjie Wang Ruoyu liu Yuqian liu Xiaoyan Zhu Yang Shao Xin Lai Shuanying Yang Jiayin Wang Department of Respiratory Medicine The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China School of Computer Science and Technology Xi'an Jiaotong University Xi'an China Shaanxi Engineering Research Center of Medical and Health Big Data Xi'an Jiaotong University Xi'an China Nanjing Geneseeq Technology INC.

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

Copy number variations are crucial in cancer research, but their detection through next-generation sequencing is often hindered by read biases, particularly in complex genomic regions. Existing bias-correction methods address common issues like GC content but often fail in regions with repetitive sequences or segmental duplications, leading to false-positive CNVs. We propose refMask, a hybrid Gaussian model-based method that dynamically identifies low-confidence regions in the reference genome, correcting read biases and improving CNV detection accuracy. By integrating features from hg38 and T2T genomes, refMask tailors a custom blacklist for each sequencing sample, enhancing the reliability of CNV detection across diverse conditions. Our method provides a more accurate and flexible solution compared to current fixed blacklists, offering improved performance in challenging genomic regions.

关键词： Sequential analysis Accuracy Genomics Feature extraction Blocklists Reliability Bioinformatics Next generation networking Gaussian mixture model Cancer

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Establishment of a personalized fetal growth curve model

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S311-S317页

作者： Bao, Xinyu Wang, Yan Zhang, Song Yang, Lin liu, Guoli Yang, Yimin Li, xuwen Hao, Dongmei Chen, Aiqing liu, Xiaohong Shao, Jing Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Fetal weight is one of the important indicators for judging whether fetal growth and development are normal. Fetal weight exceeding the normal range may lead to poor delivery outcomes. OBJECTIVE: We aimed to establish a personalized fetal growth curve in order to effectively monitor fetal growth during pregnancy. Fetal weight can be monitored while fetal growth and development are assessed. METHODS: This study retrospectively analyzed the birth weight and ultrasound database of 3,093 newborns delivered at normal term. The personalized fetal growth curve model was generated based on the birth weight formula established by Gardosi combined with the proportional weight equation. RESULTS: (1) The average birth weight of the single fetus at normal term was 3,457g. (2) According to the regression results of the proportion of fetal weight in full-term pregnancy and gestational week, the proportional weight equation is Weight% = 500.9 + 51.60GA + 1.727GA(2) 0.01718GA(3) (GA is gestational week), R-2 is 98%, P < 0.001. CONCLUSIONS: In this study, the normal birth weight of newborns and normal range of fetal weight can be estimated by using the personalized fetal growth curve model.

关键词： Fetal weight fetal growth curve birth weight proportional weight equation normal range

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The Pararectus approach in acetabular fractures treatment: functional and radiologcial results

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BMC MUSCULOSKELETAL DISORDERS 2022年第1期23卷 370-370页

作者： liu, Guoming Chen, Jinli Liang, Chengzhi Zhang, Chengdong Li, xuwen Hu, Yanling Qingdao Univ Dept Orthoped Affiliated Hosp Qingdao 266003 Shandong Peoples R China

Background The surgical treatment of complex acetabular fractures is one of the most challenging procedures for orthopedic surgeons. The Pararectus approach, as a reasonable alternative to the existing surgical procedures, was performed for the treatment of acetabular fractures involving the anterior column. This study aimed to evaluate outcome using the Pararectus approach for acetabular fractures involving anterior columns. Methods Thirty-seven with displaced acetabular fractures involving anterior columns were treated between July 2016 and October 2019 using the Pararectus approach. The functional outcomes (using the Merle d Aubigne and Postel scoring system, WOMAC and modified Harris scoring), the quality of surgical reduction (using the Matta criteria), and postoperative complications were assessed during approximately 26 months follow-up period. Results Thirty-seven patients (mean age 53 years, range: 30-71;28 male) underwent surgery. Mean intraoperative blood loss was 840 ml (rang: 400-2000 ml) and mean operating time was 210 min (rang: 140-500 min). The modified Merle d Aubigne score was excellent and good in 27 cases (73%), fair in 6 cases (16%), and poor in 3 cases (11%). The mean score was 88.5 (range:77-96) for the modified Harris Hip scores, and 22 (range:7-35) for the WOMAC scores after operation. Postoperative functional outcomes were significantly improved compared with preoperative outcomes (P < 0.0001). The quality of reduction was anatomical in 21 cases (57%), satisfactory in 9 cases (24%), and unsatisfactory in 7 cases (19%). At follow-up, four patients developed a DVT, and heterotopic bone formation was observed in one patient. The hip osteoarthritis was not observed. Conclusion The Pararectus approach achieved good functional outcomes and anatomical reduction in the treatment of acetabular fractures involving anterior column with minimal access morbidity.

关键词： Acetabular fracture Pararectus approach Surgical exposure Outcome Radiological results

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Induction ofγ-aminobutyric acid plays a positive role to Arabidopsis resistance against Pseudomonas syringae^°°

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Journal of Integrative Plant Biology 2020年第11期62卷 1797-1812页

作者： Xiangxiong Deng xuwen Xu Yu liu Yan Zhang liuyi Yang Shuqun Zhang Juan Xu State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Division of Biochemistry University of MissouriColumbiaMissouri 65211USA

Gamma-aminobutyric acid(GABA)is an important metabolite which functions in plant growth,development,and stress ***,its role in plant defense and how it is regulated are largely ***,we report a detailed analysis of GABA induction during the resistance response to Pseudomonas syringae in Arabidopsis *** searching for the mechanism underlying the pathogen-responsive mitogenactivated protein kinase(MPK)3/MPK6 signaling cascade in plant immunity,we found that activation of MPK3/MPK6 greatly induced GABA biosynthesis,which is dependent on the glutamate decarboxylase genes GAD1 and *** with Pseudomonas syringae pv tomato DC3000(Pst)and Pst-avrRpt2 expressing the civrRpt2 effector gene induced GACH and GAD4 gene expression and increased the levels of *** evidence revealed that GAD1,GAD2,and GAD4 play important roles in bothGABA biosynthesis and plant resistance in response to Pst-avrRpt2 *** gad1/2/4 triple and gad1/2/4/5 quad-ruple mutants,in which the GABA levels were extremelylow,were more susceptible to both Pst and *** loss of MPK3/MPK6,or their upstream MKK4/MKK5,or their downstream substrate WRKY33 sup-pressed the induction of GAD1 and GAD4 expression afterPst-avrRpt2 *** findings shed light on both theregulation and role of GABA in the plant immunity to abacterial pathogen.

关键词： resistance Arabidopsis immunity

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