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Prediction of hypertensive disorders in pregnancy based on placental growth factor

TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S165-S170页

作者： Xu, Qi Sun, Ge Zhang, Song liu, Guoli Yang, Lin Meng, Yu Chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei liu, Xiaohong Shao, Jing Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: The prediction of hypertensive disorders in pregnancy (HDP) mainly involves various aspects such as maternal characteristics and biomarkers. OBJECTIVE: We aimed to study the effect of the HDP prediction model with or without placental growth factor (PlGF). METHODS: This study used maternal factors and PlGF, and standardized the data uniformly. At 12-20 weeks, the comprehensive comparison of model quality with or without PlGF was conducted by logistic regression. RESULTS: The area under curve and the model accuracy of the model with PlGF were higher than those of the model without PlGF. The accuracy of the model with PlGF was above 90%. CONCLUSIONS: Adding PlGF to the model for predicting HDP improved the accuracy and effectiveness of the model. This study confirmed the predictive performance of PlGF.

关键词： Model accuracy placental growth factor logistic regression

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Intelligent generation method of 3D machining process based on process knowledge

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INTERNATIONAL JOURNAL OF COMPUTER INTEGRATED MANUFACTURING 2020年第1期33卷 38-61页

作者： Jing, xuwen Zhu, Yuping liu, Jinfeng Zhou, Honggen Zhao, Peng liu, Xiaojun Tian, Guizhong Ye, Hua Li, Qun Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Jiangsu Peoples R China Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang Jiangsu Peoples R China Southeast Univ Sch Mech Engn Nanjing Jiangsu Peoples R China Hudong Heavy Machinery Co Ltd Inst Comprehens Technol Shanghai Peoples R China

Intelligent manufacturing has become the trend of global manufacturing industry, and the core of the new industrial revolution and the commanding point of Made in China 2025. Process planning is an important part of intelligent manufacturing. To improve the speed and accuracy of intelligent generation of machining process, a systematic intelligent generation method of machining process based on process knowledge is proposed. Firstly, a method of modelling and management of process knowledge is presented. Secondly, by combining case-based reasoning with rule-based reasoning, accurate process information of machining features is obtained. Then, the skeleton process is formed. Thirdly, through the analysis of the precedence constraints and the processing experience constraints, the precedence relation between machining features is determined. Moreover, the precedence between process operations is formulated by process constraint matrix. Finally, a genetic algorithm (GA) approach is presented to obtain the global optimal process route for the part based on working step with process information. Taking the connecting rod and piston of marine diesel engine and the spindle box shell as the research object, the feasibility of this method is verified.

关键词： Process knowledge skeleton process process constraint matrix genetic algorithm machining process

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Marketization and Energy Poverty: Empirical Evidence from China

SSRN

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SSRN 2022年

作者： Shi, Xinjie Zeng, Pei Qiu, Tongwei Jiang, Qiang Cui, liu Gao, xuwen Peking University China

Along with economic growth, improving the quality of life of its citizens is a focal issue for the Chinese government. Energy poverty—a topic closely related to people’s quality of life—has received global attention. This article focuses on the relationship between marketization and energy poverty, estimating the intrinsic relationship between marketization and energy poverty by constructing panel data using the instrumental variable method. The study reveals a significant upward trend in marketization in China in recent years, with a concomitant decrease in energy poverty. The results confirm that marketization improves the quantity of energy supply and alleviates energy poverty, and that the quality of energy supply is also an effective way for marketization to impact energy poverty. However, this mechanism is mainly reflected in the fact that marketization increases the accumulation of human capital and promotes the use of clean energy, but not in the improvement of energy supply efficiency by marketization. Additionally, marketization-led increase in people’s income alleviates energy poverty. This study adds to the existing literature and provides important policy insights for market-based development and energy poverty reduction. © 2022, The Authors. All rights reserved.

关键词： Economic analysis

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Predicting hypertensive disorders in pregnancy using multiple methods: Models with the placental growth factor parameter

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S427-S432页

作者： Sun, Ge Xu, Qi Zhang, Song Yang, Lin liu, Guoli Meng, Yu Chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei liu, Xiaohong Shao, Jing Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Placental growth factor (PlGF), one of the biomarkers, has a certain predictive effect on hypertensive disorders in pregnancy (HDP). OBJECTIVE: To study the HDP prediction effect of different methods for variable selection and modeling for models containing PlGF. METHODS: For the model containing PlGF, the appropriate range of PlGF parameters needed to be selected. Step-logistic regression and lasso were used to compare the model effect of twice range selection. The PlGF model with good predictive effect and appropriate detecting gestational age was selected for the final prediction. RESULTS: The effect of the model containing PlGF tested at 15-16 weeks was better than the PlGF value without comprehensive screening. The sensitivity of both methods was over 92%. By comprehensive comparison, the final model of lasso method in this study was more effective. CONCLUSIONS: In this study, a variety of methods were used to screen models containing PlGF parameters. According to clinical needs and model effects, the optimal HDP prediction model with PlGF parameters in the second trimester of 15-26 weeks of pregnancy was finally selected.

关键词： Placental growth factor model parameters variable selection

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零件加工隐性工艺知识获取方法研究

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图学学报 2024年第2期45卷 399-408页

作者：张一鸣刘金锋陈亚杰瞿鹏飞景旭文刘晓军江苏科技大学机械工程学院江苏镇江212028 上海船舶设备研究所上海200030 东南大学机械工程学院江苏南京211100

随着制造业数字化工艺的深入应用,如何高效利用积累的工艺知识,已成为提升工艺设计效率与质量的关键,然而隐性工艺知识却存在难以获取、描述与转化的技术瓶颈,严重阻碍智能化工艺设计模式推广。为此,提出了一种复杂零件加工的隐性工艺... 详细信息

随着制造业数字化工艺的深入应用,如何高效利用积累的工艺知识,已成为提升工艺设计效率与质量的关键,然而隐性工艺知识却存在难以获取、描述与转化的技术瓶颈,严重阻碍智能化工艺设计模式推广。为此,提出了一种复杂零件加工的隐性工艺知识获取方法。首先,利用等宽法对结构化工艺数据进行离散化处理,构建基于文本挖掘的隐性工艺知识获取流程,并通过产生式规则对隐性工艺知识表达;然后,基于案例推理和规则推理融合的知识推理方法,并采用最近邻算法实现隐性工艺知识的识别;最后,以船用柴油机缸盖类复杂加工零件为验证对象,对加工隐性工艺知识获取方法进行了有效验证。

关键词：隐性知识产生式规则文本挖掘案例推理规则推理最近邻算法

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A novel calcium phosphate-based nanocomposite for the augmentation of cement-injectable cannulated pedicle screws fixation: A cadaver and biomechanical study

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JOURNAL OF ORTHOPAEDIC TRANSLATION 2020年 20卷 56-66页

作者： Sun, Haolin liu, Chun Li, xuwen liu, Huiling Zhang, Weiguang Yang, Huilin Li, Chunde Yang, Lei Peking Univ Dept Orthoped Hosp 1 8 Xishiku St Beijing 100034 Peoples R China Soochow Univ Inst Orthoped Dept Orthoped Suzhou Peoples R China Peking Univ Sch Basic Med Sci Dept Human Anat 38 Xueyuan Rd Beijing 100191 Peoples R China Hebei Univ Technol Ctr Hlth Sci & Engn Sch Mat Sci & Engn Tianjin Key Lab Mat Laminating Fabricat & Interfa Tianjin Peoples R China

Background/objective: Both polymethylmethacrylate (PMMA) and traditional calcium phosphate-based cements have some deficiencies as augmentation materials for pedicle screw fixation. Here, a novel calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was developed based on previous study, and the handling properties, biomechanical performance, and biodegradation behaviour of CPN were evaluated and compared with clinical PMMA by means of a cadaver study and animal tests. Methods: Bone mineral density of the lumbar vertebrae was tested. Pedicle screws were placed into the lumbar vertebrae under the guidance of three dimensionally printed templates;each of which was designed based on computed tomography (CT) reconstruction of each vertebrae and augmented with either PMMA or CPN. X-ray and CT scan were used to evaluate the accuracy of screw placement and dispersion as well as interdigitation of bone cement. The axial pull-out strength and maximum torque were tested using a mechanical testing machine. Degradation behaviour of CPN was evaluated by in vitro immersion tests for 8 weeks and in vivo rabbit femur defect model for up to 6 months, respectively. Results: Standard mechanical tests revealed that PMMA was much stronger than CPN after setting (compressive strength 95 vs. 49 MPa, respectively, p < 0.001). Results of the projection area and volume distribution of cement along the distal end of the screws revealed that CPN exhibited unique dispersing and interdigitation abilities compared with PMMA. Specifically, CPN dispersed uniformly and symmetrically along the screw, while PMMA was limited to the proximal part of the screw. Axial pull-out test results showed that the axial pull-out strengths of CPN- and PMMA-augmented pedicle screws were similar (1199 +/- 225 N vs 1337 +/- 483 N, respectively) and not significantly different (p = 0.47), although CPN was an intrinsically weaker material than PMMA. Similarly, CPN showed average torq

关键词： Calcium phosphate-based cement Injectable Osteoporosis Pedicle screw PMMA

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Gestational diabetes mellitus prediction model: A risk factors analysis of pregnant women with gestational diabetes mellitus but have normal oral glucose tolerance test results in the second trimester of pregnancy

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S57-S63页

作者： Lu, Jiayu Zhang, Song Jiang, Hongqing Yang, Lin Hao, Dongmei Yang, Yimin Li, xuwen Chen, Aiqing Shao, Jing liu, Xiaohong Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing 100124 Peoples R China Haidian Maternal & Children Hlth Hosp Beijing 100080 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Oral glucose tolerance test (OGTT) is a standard for the diagnosis of gestational diabetes mellitus (GDM). However, clinically, some cases with normal results were diagnosed as GDM in the third trimester. OBJECTIVE: To establish a risk model based on energy metabolism, epidemiology, and biochemistry that could predict the GDM pregnant women with normal OGTT results in the second trimester. METHODS: Qualitative and quantitative data were analyzed to find out the risk factors, and the binary logistic backward LR regression was used to establish the prediction model of each factor and comprehensive factor, respectively. RESULTS: The risk factors including the rest energy expenditure per kilogram of body weight, oxygen consumption per kilogram of body weight, if more than the weight gain criteria of the Institute of Medicine, the increase of body mass index between the second trimester and pre-pregnancy, and fasting blood glucose. By comparison, the comprehensive model had the best prediction performance, indicating that 85% of high-risk individuals were correctly classified. CONCLUSION: Energy metabolism, epidemiology, and biochemistry had better recognition ability for the GDM pregnant women with normal OGTT results in the second trimester. The addition of metabolic factors in the second trimester also improved the overall prediction performance.

关键词： Prediction model gestational diabetes mellitus rest energy metabolism

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Transcytosis Mediated Deep Tumor Penetration for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer

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ADVANCED FUNCTIONAL MATERIALS 2023年第28期33卷

作者： Chen, Hongyi Song, Haolin Luo, Yifan Li, Chufeng Wang, Yu liu, Jie Luo, Feifei Fan, Hongrui Li, xuwen Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryState Key Lab Med Neur Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fudan Univ Huashan Hosp Dept Digest Dis Shanghai 200040 Peoples R China

The hyperproliferative tumor stroma of pancreatic ductal adenocarcinoma (PDAC) severely limits drug permeation and constructs an immunosuppressive microenvironment, causing resistance to chemotherapy and immunotherapy. Traditional nanomedicine mainly focuses on manipulating nanoparticles' particle size or electrical characteristics to penetrate deep PDAC through the paracellular pathway, but the transcellular pathway is often ignored. Therefore, a versatile drug-polymer conjugate PODEA-Gem-HMI is prepared and assembled into nanoparticles for the codelivery of chemotherapy drug gemcitabine and focal adhesion kinase (FAK) inhibitor defactinib. While sensing the mild acidity in the tumor microenvironment, the nanoparticle will disintegrate and release defactinib to modulate the tumor stroma. The PODEA block of the conjugate can bind with cell membranes reversibly and trigger adsorption-mediated transcytosis (AMT) for promoted tumor penetration and cellular uptake. The internalized conjugates will release gemcitabine responding to the overexpressed glutathione (GSH) for enhanced chemotherapy, and PHMI can condensate the STING monomers for prolonged spontaneous immune stimulation.

关键词： sting activation stroma modulation transcytosis tumor penetration

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Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models

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SAUDI JOURNAL OF BIOLOGICAL SCIENCES 2020年第9期27卷 2485-2490页

作者： Qin, Zhenlong Wang, Lei Li, Guoyan Qian, xuwen Zhang, Jie Guo, Ying liu, Guokai Beijing Univ Chinese Med Affiliated Hosp 3 Dept Anesthesiol Beijing 100029 Peoples R China Beijing Univ Chinese Med Dongzhimen Hosp Dept Anesthesiol 5 Haiyuncang Hutong Beijing 100700 Peoples R China

Objective: To investigate the analgesic effect of amitriptyline on neuropathic pain model rats, diabetic neuropathic pain model rats and fibromyalgia model rats. Methods: The healthy male Sprague wrote - Dawley (SD) rats were taken as the research object, and they were randomly divided into model group (group A), beside the sciatic nerve and injection of 5 mm amitriptyline group (group B), beside the sciatic nerve and injection of 10 mm amitriptyline group (group C), beside the sciatic nerve and injection of 15 mm amitriptyline group (group D), intraperitoneal injection of amitriptyline group (group E). Pain induced by selective injury of sciatic nerve branches in rats, pain induced by chronic compression of sciatic nerve, diabetic neuropathic pain and fibromyalgia were conducted to determine the pain threshold of mechanical stimulation in rats after drug administration. Results: The pain threshold of mechanical stimulation in the local amitriptyline group (group B, C, D) was significantly higher than that in the group A and group E at each time point after drug treatment, and the pain threshold of mechanical stimulation gradually increased with the increase of concentration. There was no statistically significant difference in mechanical stimulation pain threshold between group A and group E at each time point after drug treatment. Conclusion: Para-sciatic injection of amitriptyline at different concentrations has analgesic effects on neuropathic pain, diabetic neuropathic pain and fibromyalgia in rat models, and amitriptyline directly ACTS on the local sciatic nerve. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

关键词： Tricyclic antidepressants Rat model Neuropathic pain Diabetic neuropathic pain Fibromyalgia

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Mid-Miocene (17-11 Ma) Fast Exhumation in the Upper Jinsha River and its Implication for Regional Faulting in Southeast Tibet

SSRN

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SSRN 2023年

作者： Shen, xuwen liu-Zeng, Jing Shen, Xiaoming Ge, Yukui Zeng, Xianyang Wang, Zijun Xing, Yukun Wang, Heng School of Earth System Science Tianjin University Tianjin300072 China National Institute of Natural Hazards Ministry of Emergency Management of China Beijing100085 China State Key Laboratory of Earthquake Dynamics Institute of Geology China Earthquake Administration Beijing100029 China School of Geography Earth and Atmospheric Sciences University of Melbourne VIC3010 Australia

The rugged southeast (SE) Tibet hosts a network of evolving faults, many of which are poorly understood due to a lack of sedimentary records and poor accessibility. The Jinsha River fault zone (JRFZ) is vaguely considered as a major fault bounding the Chuan-Dian Block in the northwest, yet little is known about its tectonic evolution history, which hinders our clear understanding of the tectonic deformation pattern, process and geomorphic response of SE Tibet. Here, we collected 10 samples from the hanging wall of the Xiongsong reverse fault, one strand of the JRFZ, near Markam area and on the trunk of the upper Jinsha River, to reveal its exhumation and kinematic history through low-temperature thermochronology. The ZHe ages (~17-13 Ma) of the samples from the hanging wall are much younger than the published ones in the footwall, but the AFT (~11-9 Ma) and AHe ages (~14-6 Ma) are only slightly younger than those in the footwall. The QTQt and 3-D thermo-kinematic Pecube modeling suggest consistently that the Xiongsong fault experienced strong activity during the mid-Miocene (~17-11 Ma) and then weakened. Post-11 Ma decreases in exhumation here on the trunk of the Jinsha river, if interpreted as river incision, is opposite to previously inferred river response to late Miocene surface uplift driven by the lower crust flow, implying the importance of local faulting in regional exhumation and perhaps the development of the Jinsha River. The late Miocene transition of faulting activity is found on other major faults in SE Tibet as well. We infer that the near synchronized change in regional fault activity may be caused by the clockwise rotation of the Chuan-Dian block, while its being extruded southeastward from the pushing front of the Indian collision. © 2023, The Authors. All rights reserved.

关键词： Rivers

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