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Advances in Multimodal Imaging Techniques for Evaluating and Predicting the Efficacy of Immunotherapy for NSCLC

Cancer Management and Research 2025年 17卷 1073-1086页

作者： Jingyi liu Mei Xie Jing Shen Jie Yao xuwen Lin Xinyu Bao Xin Zhang Yiran Liang Yun Yang Gege Jiang Ximeng Diao Wenya Han Hai Du Xinying Xue Jianlin Wu Department of Radiology Affiliated Zhongshan Hospital of Dalian University Dalian 116001 People’s Republic of China Department of Respiratory and Critical Care Emergency and Critical Care Medical Center Beijing Shijitan Hospital Capital Medical University Beijing 100038 People’s Republic of China Department of Respiratory and Critical Care Affiliated Hospital of Shandong Second Medical University Weifang People’s Republic of China Department of Respiratory and Critical Care Medicine Taihe Hospital Hubei University of Medicine Shiyan 442000 People’s Republic of China Ordos Central Hospital Ordos City 017000 People’s Republic of China Department of Respiratory and Critical Care Xuanwu Hospital Capital Medical University Beijing 100038 People’s Republic of China

Immunotherapy has emerged as a transformative treatment for non-small cell lung cancer (NSCLC), yet its clinical benefits remain variable among patients. Early and accurate evaluation of treatment response is critical to guide therapeutic adjustments and improve outcomes. This review synthesizes recent advancements in multimodal imaging techniques—computed tomography (CT), positron emission tomography (PET)/CT, magnetic resonance imaging (MRI), and radiomics—for evaluating and predicting immunotherapy efficacy in NSCLC. We analyze the strengths and limitations of conventional morphological criteria (eg, RECIST, iRECIST) and highlight emerging quantitative biomarkers, including CT texture analysis, metabolic parameters (MTV, TLG), and diffusion-weighted MRI metrics. Notably, radiomics demonstrates promise in decoding tumor heterogeneity, PD-L1 expression, and immune microenvironment features, while immuno-PET probes targeting immune checkpoints offer novel insights into immune activity in vivo. Challenges such as pseudo-progression, nodal immune flare, and discrepancies between imaging responses and pathological responses are critically discussed. By integrating morphological, metabolic, and microenvironmental data, multimodal imaging enhances precision in patient stratification and therapeutic monitoring. Future research should prioritize multicenter, AI-driven radiomics validation and targeted tracer development to optimize NSCLC immunotherapy management. This review provides clinicians and researchers with new directions for utilizing multimodal imaging techniques in developing personalized treatment strategies.

关键词： non-small cell lung cancer immunotherapy efficacy prediction CT PET MRI

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基于轻量级神经网络MobileNetV3-large的黄茶闷黄程度判别

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湖南农业大学学报（自然科学版） 2024年第1期50卷 91-99页

作者：葛炳钢张旭雯刘岁杨亚周铁军傅冬和茶学教育部重点实验室湖南长沙410128 国家植物功能成分利用工程技术研究中心湖南长沙410128 植物功能成分利用省部(教育部)共建协同创新中心湖南长沙410128 湖南农业大学信息与智能科学技术学院湖南长沙410128

以碧香早品种为材料,通过相机采集不同闷黄时长下的闷黄叶图像共675张,建立了3种闷黄程度的黄茶样本数据集,采用位置变换、随机亮度、增加对比度、添加噪声、随机缩放操作对闷黄叶图像集进行数据增强,运用迁移学习方法,在ImageNet数据... 详细信息

以碧香早品种为材料,通过相机采集不同闷黄时长下的闷黄叶图像共675张,建立了3种闷黄程度的黄茶样本数据集,采用位置变换、随机亮度、增加对比度、添加噪声、随机缩放操作对闷黄叶图像集进行数据增强,运用迁移学习方法,在ImageNet数据集取得MobileNetV3-Large的预训练模型,对迁移网络的所有权重信息进行训练,最终建立了针对黄茶闷黄程度的轻量级卷积神经网络MobileNetV3-Large识别模型,并利用Grad-CAM热力图可视化和置信分数监控黄茶品质的变化。结果表明:经训练后的MobileNetV3-Large模型测试的识别准确率达到98.51%,精确率为99.10%,召回率为98.93%,加权分数为98.20%;MobileNetV3-Large模型的识别准确率高于传统机器学习模型SVM、XGBoost和KNN;通过Grad-CAM热力图可视化显示,MobileNetV3-Large模型在不同的识别场景下能够准确定位并提取闷黄叶特征,准确地识别闷黄程度。可见,MobileNetV3-Large模型有较好的泛化性,可以快速、无损地识别黄茶的闷黄程度。

关键词：黄茶闷黄程度识别卷积神经网络迁移学习

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尕斯E_3~1油藏高温高矿化度调剖剂的研制与性能评价

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石油与天然气化工 2018年第4期47卷 68-72页

作者：王健余恒薛强何涛徐鹏刘旭文西南石油大学油气藏地质及开发工程国家重点实验室

尕斯库勒E_3~1油藏高温高矿化度、油藏非均质性强、剩余油分散、在注水开发过程中水窜严重,导致水驱波及效率较低。对该类油藏,常规化学调剖堵水剂容易产生破胶、降解等现象,难以发挥明显作用。通过实验研制出在平均油藏温度为126℃,平... 详细信息

尕斯库勒E_3~1油藏高温高矿化度、油藏非均质性强、剩余油分散、在注水开发过程中水窜严重,导致水驱波及效率较低。对该类油藏,常规化学调剖堵水剂容易产生破胶、降解等现象,难以发挥明显作用。通过实验研制出在平均油藏温度为126℃,平均地层水矿化度为16.5×10~4 mg/L地层中调剖剂体系的优化配方:粗品魔芋粉(质量浓度5.0g/L)+悬浮剂(质量浓度700~1 000mg/L)+交联剂(体积分数1.0%~1.2%)+除氧剂(质量浓度100~200mg/L)。实验结果表明,该调剖剂在高温(126℃)、高盐(矿化度为16.5×10~4 mg/L)条件下老化30天后,堵剂体系微量脱水,无破胶现象,具有良好的耐温耐盐性能。

关键词：高温高矿化度油藏魔芋胶调剖剂配方性能评价

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耐事故核燃料UN抗氧化机制与性能增强的研究进展

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工程科学学报 2025年第4期47卷 682-696页

作者：张钰赵旭文张玉娟杨宇吕文婷刘晓光褚明福杨振亮许靖堃葛昌纯北京科技大学材料科学与工程学院北京100083 北京应用物理与计算数学研究所北京100088 中国工程物理研究院材料研究所绵阳621900

氮化铀具有高铀密度、高热导率和高熔点等优点,被认为是最有潜力的耐事故核燃料之一.尽管氮化铀在核能安全等方面展现出极高的应用价值,但高温抗氧化性能和腐蚀性能不佳是其作为候选耐事故核燃料亟需解决的问题.针对氮化铀基核燃料在堆... 详细信息

氮化铀具有高铀密度、高热导率和高熔点等优点,被认为是最有潜力的耐事故核燃料之一.尽管氮化铀在核能安全等方面展现出极高的应用价值,但高温抗氧化性能和腐蚀性能不佳是其作为候选耐事故核燃料亟需解决的问题.针对氮化铀基核燃料在堆内服役条件下的低抗氧化性能,本文总结了氮化铀在空气中的氧化反应过程和提升氮化铀核燃料抗氧化性能的方法,具体包括采用高耐腐蚀陶瓷烧结形成保护屏障、添加合适的金属元素合金化、表面涂层技术等方法.重点讨论了氮化铀与各种陶瓷抗氧化相包括二氧化铀,二硅化三铀和其他陶瓷抗氧化相烧结形成复合燃料的抗氧化性能.其中,氮化铀-二氧化铀型复合燃料相比于氮化铀在高温和高压蒸汽环境下具有更高的氧化起始温度,显示出较高的抗氧化性能.因此重点探索了氮化铀-二氧化铀型复合燃料成分和微观结构对抗氧化性能影响的微观机制以及改进措施.三氮化二铀相的生成在提高氮化铀-二氧化铀抗氧化性能方面起到关键作用,但其高温稳定性仍存在争议.另外,本文还归纳了当前氮化铀基新型燃料在抗氧化性能提升研究方面亟需解决的科学问题.

关键词：耐事故燃料氮化铀抗氧化性能二氧化铀三氮化二铀

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Impact analysis of different axis layouts of detached breakwater on flow and sediment transport

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ARABIAN JOURNAL OF GEOSCIENCES 2021年第8期14卷 705-705页

作者： Yu, Haitao Luo, Feng Li, Ruijie liu, Yanran Fang, xuwen Li, Yuting Hohai Univ Minist Educ Key Lab Coastal Disaster & Def Nanjing 210098 Peoples R China Hohai Univ Coll Harbour Coastal & Offshore Engn Nanjing 210098 Peoples R China Hohai Univ Coll Oceanog Nanjing 210098 Peoples R China Nanjing Environm Monitoring Ctr Nanjing 210098 Peoples R China Xiamen Univ Marine Monitoring & Informat Serv Ctr Xiamen 361005 Peoples R China Nanjing Normal Univ Key Lab Virtual Geog Environm Nanjing 210023 Peoples R China

An incorporation and application of a two-dimensional, unstructured grid hydrodynamic model with a suspended sediment transport module is presented in the study. The model has a satisfactory verification with available measured data. After the verification, the variation of tidal current field and the seabed evolution are simulated. Based on the simulation results, the paper compares and analyzes the effects of different axis layouts of detached breakwater on flow field and seabed evolution. The results show that after the construction of the breakwater, the flow velocity of the both sides of the breakwater decreases, the flow velocity of the east entrance increases, and the erosion and siltation of sediment are consistent with the change of the flow field. In addition, the smaller the angle between the breakwater axis and the depth contour is, the smaller the impact on the change of the tidal current field and sediment erosion and siltation is.

关键词： Detached breakwater Axis layout Flow and sediment transport Hydrodynamic model

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Computational Experiments Meet Large Language Model Based Agents: A Survey and Perspective

arXiv

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arXiv 2024年

作者： Ma, Qun Xue, Xiao Zhou, Deyu Yu, Xiangning liu, Donghua Zhang, xuwen Zhao, Zihan Shen, Yifan Ji, Peilin Li, Juanjuan Wang, Gang Ma, Wanpeng College of Intelligence and Computing Tianjin University Tianjin China School of Computer Software College of Intelligence and Computing Tianjin University Tianjin China School of Software Shandong University Jinan China Wuhan University Wuhan China College of Computer and Information Hohai University China Beijing Institute of Technology Beijing China University of Texas at San Antonio. United States Army Aviation Research Institute United States

Computational experiments have emerged as a valuable method for studying complex systems, involving the algorithmization of counterfactuals. However, accurately representing real social systems in Agent-based Modeling (ABM) is challenging due to the diverse and intricate characteristics of humans, including bounded rationality and heterogeneity. To address this limitation, the integration of Large Language Models (LLMs) has been proposed, enabling agents to possess anthropomorphic abilities such as complex reasoning and autonomous learning. These agents, known as LLM-based Agent, offer the potential to enhance the anthropomorphism lacking in ABM. Nonetheless, the absence of explicit explainability in LLMs significantly hinders their application in the social sciences. Conversely, computational experiments excel in providing causal analysis of individual behaviors and complex phenomena. Thus, combining computational experiments with LLM-based Agent holds substantial research potential. This paper aims to present a comprehensive exploration of this fusion. Primarily, it outlines the historical development of agent structures and their evolution into artificial societies, emphasizing their importance in computational experiments. Then it elucidates the advantages that computational experiments and LLM-based Agents offer each other, considering the perspectives of LLM-based Agent for computational experiments and vice versa. Finally, this paper addresses the challenges and future trends in this research domain, offering guidance for subsequent related studies. Copyright © 2024, The Authors. All rights reserved.

关键词： Autonomous agents

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Probabilistic chip-collecting games with modulo winning conditions

arXiv

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arXiv 2022年

作者： Harrington, Joshua Hua, xuwen liu, Xufei Nash, Alex Rios, Rodrigo Wong, Tony W.H. Department of Mathematics Cedar Crest College Department of Mathematics Pomona College Department of Industrial Engineering Georgia Institute of Technology Department of Mathematics Dickinson College Department of Mathematics Florida Atlantic University United States Department of Mathematics Kutztown University of Pennsylvania United States

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中国-东盟信息港南宁核心基地高质量发展路径研究

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东南亚纵横 2023年第4期 80-89页

作者：林智荣刘曙华黄旭文广西社会科学院院刊编辑部广西社会科学院越南研究所

“数字丝绸之路”注重营造一个更加开放、和平、安全和创新的网络空间,在政治维度重塑全球数字治理价值共识,在经济维度构筑全球数字经济发展新模式,在安全维度提出全球跨境数据流动规制新路径,已经成为“一带一路”倡议的重要组成部分... 详细信息

“数字丝绸之路”注重营造一个更加开放、和平、安全和创新的网络空间,在政治维度重塑全球数字治理价值共识,在经济维度构筑全球数字经济发展新模式,在安全维度提出全球跨境数据流动规制新路径,已经成为“一带一路”倡议的重要组成部分。广西明确建设面向东盟的“数字丝绸之路”,并将中国—东盟信息港作为主要支撑平台。中国-东盟信息港南宁核心基地是南宁建设面向东盟的“数字丝绸之路”的核心载体,其成为“数字丝绸之路”建设的地方实践。基于以上背景和目标,文章分析了中国-东盟信息港南宁核心基地的建设成效、现存问题、发展机遇和面临挑战,并从基础设施、信息共享、技术合作、经贸服务、人文交流五大平台的角度,提出高质量推进中国-东盟信息港南宁核心基地的具体路径及对策措施,以期为深化中国—东盟数字领域合作提供助力。

关键词：信息港中国-东盟数字丝绸之路南宁核心基地数字经济合作

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1,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells

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INNATE IMMUNITY 2017年第7期23卷 584-591页

作者： Zhang, Dong Li, Miaomiao Dong, Yang Zhang, Xinhui liu, Xingyun Chen, Zhangming Zhu, Yongji Wang, Huiming liu, xuwen Zhu, Jialiang Shen, Yujun Korner, Heinrich Ying, Songcheng Fang, Shengyun Shen, Yuxian Anhui Med Univ Sch Basic Med Sci Dept Immunol Hefei 230032 Anhui Peoples R China Anhui Med Univ Biopharmaceut Res Inst Hefei 230032 Anhui Peoples R China Menzies Inst Med Res Tasmania Hobart Tas Australia Anhui Med Univ Sch Pharm Hefei Anhui Peoples R China

Vitamin D supplementation is regarded as a novel approach to treat Alzheimer's disease, but the underlying mechanism remains elusive. The cytokine IL-34 provides strong neuroprotective and survival signals in brain injury and neurodegeneration and could be an immunological mediator for the vitamin D-induced protection. The aim of this study was to investigate whether human IL-34 is up-regulated in neuronal cells by the hormonally active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D-3]. We found that IL-34 was detectable in a variety of cell lines and its expression was strongly induced in SH-SY5Y neural cells in a dose- and time-dependent manner by 1,25(OH)(2)D-3 through the vitamin D receptor (VDR). Furthermore, we identified the core promoter of IL-34 gene and a VDR binding site (CGCCCT) that was required for 1,25(OH)(2)D-3-induced IL-34 expression. These findings suggest that the induction of IL-34 expression by 1,25(OH)(2)D-3 may constitute a mechanism that explains the protective function of vitamin D in Alzheimer's disease.

关键词： 1 25-Dihydroxyvitamin D3 Alzheimer disease expression IL-34 neuronal cell

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Tertiary lymphoid structures as potential biomarkers for cancer prediction and prognosis

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INTERNATIONAL IMMUNOPHARMACOLOGY 2024年 140卷 112790页

作者： Zhang, Xin Yao, Jie Xie, Mei Liang, Yiran Lin, xuwen Song, Jialin Bao, Xinyu Ma, Xidong Wang, Yuanyong Zhang, Yinguang liu, Yiming Han, Wenya Pan, Lei Xue, Xinying Shandong Second Med Univ Sch Clin Med Weifang 261000 Shandong Peoples R China Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing 100038 Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Resp & Crit Care Beijing 100835 Peoples R China Air Force Mil Med Univ Tangdu Hosp Dept Thorac Surg Xian 710038 Shanxi Peoples R China Capital Med Univ Beijing Tiantan Hosp Dept Thorac Surg Beijing 100070 Peoples R China Hubei Univ Med Taihe Hosp Dept Resp & Crit Care Med Shiyan 442000 Peoples R China

Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates formed in non-lymphoid tissues, including cancers, and are loci for the generation of in situ anti-tumor immune responses, which play a crucial role in cancer control. The state of TLS presence in cancer and its composition can significantly impact the treatment response and prognosis of patients. TLSs have the potential to serve as predictive and prognostic biomarkers for cancer. However, the mechanisms underlying TLS formation in cancer and how the essential components of TLSs affect cancer are not fully understood. In this review, we summarized TLS formation in cancer, the value of the TLS in different states of existence, and its key constituents for cancer prediction and prognosis. Finally, we discussed the impact of cancer treatment on TLSs.

关键词： Tertiary lymphoid structure Cancer Prediction Prognosis Biomarker

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