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Research Square 2021年

作者： liu, Jinfeng Dong, Jianwei Jing, xuwen Cao, Xuwu Du, Chenxiao Li, Lei School of Mechanical Engineering Jiangsu University of Science and Technology Zhenjiang212100 China

In the process design and reuse of marine component products, there are a lot of heterogeneous models, causing the problem that the process knowledge and process design experience contained in them are difficult to express and reuse. Therefore, a process knowledge representation model for ship heterogeneous model is proposed in this paper. Firstly, the multi-element process knowledge graph is constructed, and the heterogeneous ship model is described in a unified way. Then, the multi-strategy ontology mapping method is applied, and the semantic expression between the process knowledge graph and the entity model is realized. Finally, by obtaining implicit semantics based on case-based reasoning and checking the similarity of the matching results, the case knowledge reuse is achieved, to achieve rapid design of the process. This method provides reliable technical support for the design of ship component assembly and welding process, greatly shortens the design cycle, and improves the working efficiency. In addition, a case study of the test model is carried out to verify the feasibility and efficiency of the proposed method. © 2021, CC BY.

关键词： Case based reasoning

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Room temperature ferromagnetism in D-D neutron irradiated rutile TiO2 single crystals

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RSC ADVANCES 2020年第32期10卷 18687-18693页

作者： liu, Huan Li, Gongping Dejun, E. Xu, Nannan Lin, Qiaolu Gao, Xudong Lan, Changlin Chen, Jingsheng Wang, Canglong Zhan, xuwen Zhang, Kai Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Gansu Peoples R China Chinese Acad Sci Inst Modern Phys Lanzhou 730000 Gansu Peoples R China Natl Univ Singapore Dept Mat Sci & Engn Singapore 117608 Singapore China Inst Atom Energy Beijing 102413 Peoples R China

Room temperature ferromagnetism (RTFM) was observed in unirradiated rutile TiO2 single crystals prepared by the floating zone method due to oxygen vacancy (V-O) defects. D-D neutrons mainly collide elastically with TiO2, producing V-O, titanium vacancies (V-Ti) and other point defects;the density and kind of defect is related to the neutron irradiation fluence. D-D neutron irradiation is used to regulate the concentration and type of defect, avoiding impurity elements. As the irradiation fluence increases, the saturation magnetization (M-s) first increases, then decreases and then increases. To verify the origin of RTFM, the CASTEP module was used to calculate the magnetic and structural properties of point defects in TiO2. V-O induces a 2.39 mu(B) magnetic moment, Ti3+ and F+ induce 1.28 mu(B) and 1.70 mu(B) magnetic moments, respectively, while V-Ti induces a magnetic moment of similar to 4 mu(B). Combining experimental and theoretical results, increases in V-O concentration lead to M-s increases;more V-O combine with electrons to form F+, inducing a smaller magnetic moment. V-O and V-Ti play a key role and M-s changes accordingly with larger fluence. V-O, F+ and V-Ti are the most likely origins of RTFM.

关键词： Magnetic moments

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股骨颈动力交叉钉系统与空心螺钉固定治疗65~75岁年龄段患者股骨颈骨折的效果比较

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中华创伤骨科杂志 2024年第3期26卷 228-233页

作者：张成栋王开李绪文王天瑞刘国明杜现法叶发刚扈延龄青岛大学附属医院创伤外科青岛266000

目的比较股骨颈动力交叉钉系统(FNS)与空心螺钉(CCS)固定治疗65~75岁年龄段患者股骨颈骨折的临床效果。方法回顾性分析2015年1月至2022年9月期间青岛大学附属医院创伤外科收治的39例65~75岁年龄段股骨颈骨折患者资料。按内固定方式不同... 详细信息

目的比较股骨颈动力交叉钉系统(FNS)与空心螺钉(CCS)固定治疗65~75岁年龄段患者股骨颈骨折的临床效果。方法回顾性分析2015年1月至2022年9月期间青岛大学附属医院创伤外科收治的39例65~75岁年龄段股骨颈骨折患者资料。按内固定方式不同分为两组:FNS组18例,男8例,女10例;年龄(71.1±2.8)岁;采用FNS固定治疗。CCS组21例,男7例,女14例;年龄(70.1±2.9)岁;采用CCS固定治疗。比较两组患者的术中透视次数、手术时间、术中出血量、住院费用、骨折愈合时间、内固定失败情况,以及术后1年髋关节Harris评分、颈干角变化、股骨颈短缩程度。结果两组患者术前一般资料及随访时间比较差异均无统计学意义(P>0.05),具有可比性。FNS组患者的术中透视次数[(15.1±2.3)次]显著少于CCS组患者[(19.5±3.5)次]、手术时间[(49.2±5.2) min]显著短于CCS组患者[(62.4±11.2)min],术中出血量[(74.2±15.6) mL]、住院费用[(39 928.7±1 438.3)元]显著多于CCS组患者[(53.1±17.3)mL、(23 527.9±2 126.3)元],差异均有统计学意义(P<0.05)。而两组患者的骨折愈合时间比较差异无统计学意义(P>0.05)。FNS组患者术后1年颈干角减小角度(2.65°±1.66°)、股骨颈短缩程度[(3.9±1.3)mm]均显著小于CCS组患者[4.18°±2.13°、(6.3±2.5)mm],髋关节Harris评分[(82.2±7.2)分]显著高于CCS组患者[(76.4±5.9)分],差异均有统计学意义(P<0.05)。FNS组和CCS组分别有1、4例患者发生内固定失败,差异无统计学意义(P>0.05)。结论与CCS比较,FNS固定治疗65~75岁年龄段患者股骨颈骨折的疗效更好,但也要考虑内固定失败的发生风险。

关键词：股骨颈骨折骨折固定术,内骨钉股骨颈动力交叉钉系统老年人

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Considerations in testing treatment effects on transient event driven health status changes measured by patient reported outcomes

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STATISTICS IN MEDICINE 2019年第29期38卷 5497-5511页

作者： liu, Jingyuan Legg, Jason C. Mo, May Zhang, xuwen Xiamen Univ Sch Econ Wang Yanan Inst Studies Econ Dept StatMOE Key Lab Econometr 422 Siming South Rd Xiamen 361005 Fujian Peoples R China Xiamen Univ Fujian Key Lab Stat Sci 422 Siming South Rd Xiamen 361005 Fujian Peoples R China Amgen Inc Global Biostat Sci Newbury Pk CA USA

Many treatments and drugs are intended to reduce the occurrence of negative events of interest, control the severity of the events, accelerate recovery from the events, or a combination of these effects. While assessing the clinical effect is typically the primary objective of a trial, testing the treatment effect on the health status of patients based on patient reported outcome (PRO) can be a useful component in determining the value of a treatment. Analysis of PROs in this setting, however, face the following challenges: the PRO value immediately after the event occurrence is often not captured, and the effect of the event on health status measured by the PRO is transient as subjects recover over time. Therefore, traditional statistical methods used to assess treatment effects suffer from low power for PROs. In this manuscript, we apply a kernel smoothing technique to estimate before- and after-event PRO values. We also propose new test outcomes based on observed and estimated PRO values and evaluate tests that focus on the tail distributions. We demonstrate that the tail distribution tests using the new outcomes can achieve high power under certain conditions.

关键词： maximum sequential difference modified area under curve patient reported outcome tail distribution test

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Phenotypic plasticity and genetic variation of cotton yield and its related traits under water-limited conditions

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The Crop Journal 2020年第6期8卷 966-976页

作者： Baoqi Li Qin Tian xuwen Wang Bei Han Li liu Xianhui Kong Aijun Si Juan Wang Zhongxu Lin Xianlong Zhang Yu Yu Xiyan Yang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina Cotton Institute Xinjiang Academy of Agriculture and Reclamation ScienceShihezi 832000XinjiangChina

Global warming is limiting availability of water resources in arid and semi-arid regions,and so understanding water use efficiency(WUE)is increasingly important for agricultural production in those *** China is the largest cotton producing area,the problem of balancing WUE and efficient cotton production is a major *** this study,we used a natural population of 517 Upland cotton accessions to conduct a water-controlled trial in south and north of Xinjiang over two years.A total of 18 traits including agronomic traits,fiber yield indices and fiber quality indices,were investigated for broad-sense heritability and coefficient of *** water limitation was found to promote the establishment of favorable agronomic traits in cotton,associated with an increased cotton yield of 8.46%in Xinjiang,at the expense of a certain degree of fiber quality,such as decreased fiber length and an over-higher micronaire *** detected 33 QTL related to response to water limitation using a drought resistance coefficient(DRC),and 6 QTL were found using a comprehensive indicator of CIDT(comprehensive index of drought tolerance)at the genetic level by integrating resequencing *** novel QTL-hotspots including six differentially expressed genes(DEGs)were further identified related to the drought response of *** findings not only suggested a new approach to irrigation of cotton fields in Xinjiang,but also provided abundant genetic evidence for genetic breeders to study drought improvement of crops.

关键词： Upland cotton Water-limited conditions Fiber yield Fiber quality QTL hotspot

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Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis

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ACS APPLIED MATERIALS & INTERFACES 2020年第52期12卷 57757-57767页

作者： Guo, Qin Chen, Qinjun Zhang, Yujie Zhou, Wenxi Li, xuwen Li, Chao Zhang, Yiwen Chen, Hongyi liu, Peixin Chu, Yongchao Sun, Tao Jiang, Chen Fudan Univ State Key Lab Med Neurobiol Key Lab Smart Drug Delivery Minist Educ Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China

As a rapid proliferating tissue, tumor cells have to optimize nutrient utilization to withstand harsh conditions. Several approaches have been explored to inhibit the growth and metastasis of tumor by disrupting the reprogrammed tumor metabolism. However, nutrient limitations within solid tumors may induce the metabolic flexibility of malignant cells to sustain growth and survival using one nutrient to fill metabolite pools normally supplied by the other. To overcome this predicament, a promising click-nucleic-acid-containing platform for codelivery of rapamycin, anti-PFKFB4 siRNA, and targeting ligand aptamer AS1411 was applied. PFKFB4 could act as a promising target for tumor therapy for being a molecular fulcrum that could couple glycolysis to autophagy by promoting aggressive metastatic tumors. The downregulation of PFKFB4 can help inhibit the SRC3/Akt/mTOR pathway, leading autophagy to the direction of promoting apoptosis of tumor cells, which is induced by the collapse of tumor cellular homeostasis, while low dosages of rapamycin could decrease surgery-induced immune dysfunction. Enhanced tumor autophagy, favorable in vivo antitumor efficacy, and effective systematic immune activation are observed after treatment, suggesting that autophagy and glycolysis can serve as an integrated target for tumor treatment.

关键词： tumor metabolism codelivery click nucleic acid immune activation tumor therapy

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T1ρ和T2 mapping成像观察青少年尺桡骨远端骺板

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中国医学影像技术 2022年第5期38卷 739-742页

作者：张慈慈梁治平刘琼冯友珍钟敏之曾旭文暨南大学附属广州红十字会医院放射科广东广州510220 暨南大学附属第一医院影像中心广东广州510632

目的以T1ρ和T2 mapping成像观察青少年尺、桡骨远端骺板表现,分析其可行性。方法前瞻性纳入20名健康青少年志愿者,采集双侧腕关节T1ρ和T2 mapping,观察尺、桡骨远端骺板形态,测量尺骨远端骺板内、外侧区和桡骨远端骺板内侧区、中间区... 详细信息

目的以T1ρ和T2 mapping成像观察青少年尺、桡骨远端骺板表现,分析其可行性。方法前瞻性纳入20名健康青少年志愿者,采集双侧腕关节T1ρ和T2 mapping,观察尺、桡骨远端骺板形态,测量尺骨远端骺板内、外侧区和桡骨远端骺板内侧区、中间区及外侧区T1ρ和T2值;比较不同侧别、性别间尺、桡骨远端骺板总体及不同区域的T1ρ和T2值差异,分析尺、桡骨和远端骺板T1ρ及T2值与年龄的相关性。结果尺、桡骨远端骺板于T1ρ和T2 mapping原始图中均呈板状高信号。不同侧别、性别之间,尺、桡骨远端骺板总体及不同区域T1ρ和T2值差异均无统计学意义(P均>0.05)。桡骨远端骺板T1ρ值与年龄呈正相关(r=0.596,P=0.006),其余参数均与年龄无明显相关性(P均>0.05)。结论T1ρ及T2 mapping成像可直观显示青少年尺、桡骨远端骺板形态,定量观察骺板生化改变,可行性好。

关键词：尺骨桡骨生长板磁共振成像 T1ρ T2 mapping 前瞻性研究

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Identification of genetic loci associated with rough dwarf disease resistance in maize by integrating GWAS and linkage mapping

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PLANT SCIENCE 2022年 315卷 111100-111100页

作者： Zhao, Meiai liu, Shuangshuang Pei, Yuhe Jiang, xuwen Jaqueth, Jennifer S. Li, Bailin Han, Jing Jeffers, Daniel Wang, Jiabo Song, Xiyun Qingdao Agr Univ Coll Life Sci Key Lab Plant Biotechnol Univ Shandong Prov Qingdao 266109 Peoples R China Qingdao Agr Univ Coll Agron Key Lab Qingdao Major Crop Germplasm Resource Inn Qingdao 266109 Peoples R China Corteva Agrisci 7300 NW 62nd Ave Johnston IA 50131 USA Shandong Denghai Pioneer Jinan 254000 Shandong Peoples R China Yunnan Acad Agr Sci Yunnan Off Kunming 650205 Yunnan Peoples R China Southwest Minzu Univ Minist Educ Key Lab Qinghai Tibetan Plateau Anim Genet Resour Chengdu 160041 Sichuan Peoples R China

Maize rough dwarf disease (MRDD) is a viral disease that causes substantial yield loss, especially in China's summer planted maize area. Discovery of resistance genes would help in developing high-yielding resistant maize hybrids. Genome-wide association studies (GWASs) have advanced quickly and are now a powerful tool for dissecting complex genetic architectures. In this study, the disease severity index (DSI) of 292 maize inbred lines and an F6 linkage population were investigated across multiple environments for two years. Using the genotypes obtained from the Maize SNP 50K chip, a GWAS was performed with four analytical models. The results showed that 22 SNPs distributed on chromosomes 1, 3, 4, 6, 7 and 8 were significantly associated with resistance to MRDD (P<0.0001). The SNPs on chromosomes 3, 6 and 8 were consistent with the quantitative trait locus (QTL) regions from linkage mapping in an RIL population. Candidate genes identified by GWAS included an LRR receptor-like serine/threonine-protein kinase (GRMZM2G141288), and a DRE-binding protein (GRMZM2G006745). In addition, we performed an allele variation analysis of the SNP loci selected by GWAS and linkage mapping and found that the main alleles of the two SNP loci PZE_101170408 and PZE_106082685 on chromosome 1 differed in terms of disease-resistant materials and disease-susceptible materials. The identified SNPs and genes provide useful information for MRDD-related gene cloning and insights on the underlying disease resistance mechanisms, and they can be used in marker-assisted breeding to develop MRDD-resistant maize.

关键词： Maize MRDD GWAS Linkage mapping Candidate genes

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Comparison and development of a metagenomic next-generation sequencing protocol for combined detection of DNA and RNA pathogens in cerebrospinal fluid

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BMC INFECTIOUS DISEASES 2022年第1期22卷 326-326页

作者： Jiang, Hanfang Xing, Zhihao liu, Xiaorong Chai, Qiang Xin, Zefeng Zhu, Chunqing Lin, Ruihong Deng, xuwen Cui, Dong Gao, HongDan Ma, Dongli Shenzhen Childrens Hosp Inst Pediat Clin Lab Shenzhen Guangdong Peoples R China Shenzhen Childrens Hosp Inst Pediat Shenzhen Guangdong Peoples R China Bengbu Med Coll Med Technol Bengbu Anhui Peoples R China

Background: The purpose of this study was to evaluate different pretreatment, extraction, amplification, and library generation methods for metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) and to develop an efficient procedure for the simultaneous detection of DNA and RNA pathogens. Methods: We generated thirteen mock CSF samples with four representative pathogens of encephalitis. Each sample was subjected to ten different methods by varying sample pretreatment/nucleic acid extraction (microbial DNA, total DNA, total NA, total RNA, Whole Transcriptome Amplification (WTA)) and library generation (Illumina or NEB). Negative extraction controls (NECs) were used for each method variation. Results: We found that the quality of mNGS sequencing reads was higher from the NEB kit for library generation. Microbial DNA and total RNA increased microbial deposition by depleting the host DNA. Methods total NA and total RNA can detect gram-positive, gram-negative, RNA and DNA pathogens. We applied mNGS, including total NA and NEB library generation, to CSF samples from five patients diagnosed with infectious encephalitis and correctly determined all pathogens identified in clinical etiological tests. Conclusions: Our findings suggested that total nucleic acid extraction combined with NEB library generation is the most effective mNGS procedure in CSF pathogen detection. The optimization of positive criteria and databases can improve the specificity and sensitivity of mNGS diagnosis.

关键词： Encephalitis Next-generation sequencing Metagenomic diagnosis

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夹脊温针与中药熏蒸结合西医常规疗法治疗腰椎间盘突出急性炎症期的临床研究

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国际中医中药杂志 2023年第9期45卷 1095-1099页

作者：袁绪文董海彦吴月刘一畅亳州市中医院针灸科亳州236800

目的评价夹脊温针与中药熏蒸结合西医常规疗法对腰椎间盘突出症(LDH)急性炎症期患者的临床疗效。方法随机对照试验研究。选取2019年12月-2021年12月本院140例LDH急性炎症期患者作为观察对象,采用随机数字表法将患者分为2组,每组70例。... 详细信息

目的评价夹脊温针与中药熏蒸结合西医常规疗法对腰椎间盘突出症(LDH)急性炎症期患者的临床疗效。方法随机对照试验研究。选取2019年12月-2021年12月本院140例LDH急性炎症期患者作为观察对象,采用随机数字表法将患者分为2组,每组70例。对照组给予西医常规疗法治疗,观察组在对照组基础上联合夹脊温针与中药熏蒸治疗。2组均连续治疗1个月。分别于治疗前后进行中医证候评分,采用VAS量表评估腰椎疼痛程度,日本骨科协会评估治疗(JOA评分)评估腰椎功能障碍程度,采用ELISA法检测血清CRP、IL-6、TNF-α水平,评价临床疗效。结果观察组总有效率为95.71%(67/70)、对照组为82.86%(58/70),2组比较差异有统计学意义(χ^(2)=6.05,P=0.014)。观察组治疗后中医证候积分[(4.45±1.09)分比(10.67±2.82)分,t=16.85]、VAS评分[(1.54±0.43)分比(3.28±1.04)分,t=12.94]低于对照组(P<0.01),JOA评分中主观感觉[(7.54±2.87)分比(6.24±1.76)分,t=5.72]、体征[(6.76±2.00)分比(4.34±1.67)分,t=7.77]、日常活动受限[(9.56±3.27)分比(7.89±2.97)分,t=3.16]、膀胱功能[(2.88±0.84)分比(2.63±0.64)分,t=2.89]评分及总分[(25.04±7.44)分比(20.35±6.87)分,t=4.63]高于对照组(P<0.01)。观察组治疗后血清IL-6[(18.12±4.23)μg/L比(26.46±4.58)μg/L,t=11.19]、CRP[(18.87±6.07)mg/L比(25.89±5.72)mg/L,t=7.04]、TNF-α[(24.42±5.37)ng/L比(29.45±5.44)ng/L,t=5.51]水平低于对照组(P<0.01)。结论夹脊温针与中药熏蒸结合西医常规疗法可有效缓解LDH急性炎症期患者的腰部疼痛感,降低炎症因子水平,提高临床疗效。

关键词：椎间盘移位腰椎针刺疗法温针疗法熏洗疗法

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