Objective To study the value of 1.5T MRI in long-term follow-up of rat C6 glioma model and the efficacy of EGFR antisence RNA therapy in *** Forty-three male Wistar rats, weighing 150 to 200 g, were used for this stud...
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Objective To study the value of 1.5T MRI in long-term follow-up of rat C6 glioma model and the efficacy of EGFR antisence RNA therapy in *** Forty-three male Wistar rats, weighing 150 to 200 g, were used for this study. They were divided into four groups: group Ⅰ (7 normal rats); group Ⅱ (16 rats inoculated C6 cells in the right caudate nucleus); group Ⅲ (12 rats with the C6 gliomas treated with EGFR antisence RNA by in site injection); and group Ⅳ (8 rats inoculated C6 cells transfected with EGFR antisence RNA in the right caudate nucleus). Group Ⅰ was examined by plain and enhanced MR scanning. Group Ⅱ-Ⅳ were followed up by plain and enhanced MR scanning and were sacrificed in variable time points for pathological *** Cerebral hemispheres of normal rat were shown clearly on the MR image. The tumor could be seen about 1 week after inoculation. According to the findings on the follow-up MR scan, we could observe growth of the tumor or its regression after treatment. The tumor growth was significantly inhibited in group Ⅲ and group Ⅳ as compared to those in group Ⅱ.Conclusion The growth of the rat C6 glioma model and its change after treatment could be shown clearly in 1.5T MR imaging; EGFR antisence RNA significantly inhibited the growth of glioma in vivo.
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