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NOD2-mediated HDAC6/NF-κb signalling pathway regulates ferroptosis induced by extracellular histone H3 in acute liver failure

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2022年第21期26卷 5528-5538页

作者： Chen, Qian Zhang, Qingqi cao, Pan Shi, Chunxia Zhang, Luyi Wang, luwen Gong, Zuojiong Wuhan Univ Dept Infect Dis Renmin Hosp Wuhan 430060 Peoples R China

Acute liver failure (ALF) is life-threatening and often associated with high mortality rates. The aim of the present study was to investigate whether extracellular histone H3 could induce ferroptosis in hepatic macrophages in ALF and explore its potential mechanism. RAW264.7 macrophages and C57BL/6 mice were used in this study. LPS, D-galactosamine (D-Gal), histone H3, histone H3 antibody, NOD2 agonist Muramyl Dipeptide (MDP) and HDAC6-siRNA were administered in this study. The key molecules of ferroptosis, NOD2, HDAC6 and the NF-kappa b pathway, were detected. In vitro, histone H3 was released into the extracellular environment from cell nucleus after LPS exposure. In addition, histone H3 could induce ferroptosis in RAW264.7 macrophages with increased level of Fe2+ and ROS and decreased levels of GPX4 and GSH. MDP further aggravated ferroptosis in RAW264.7 macrophages stimulated by histone H3, which was accompanied by elevated NOD2, HDAC6, p-P65 and I kappa B alpha. HDAC6-siRNA ameliorated ferroptosis in RAW264.7 macrophages induced by histone H3, which was accompanied by decreased levels of HDAC6, p-P65 and IKI3tx. However, HDAC6-siRNA did not alter NOD2 levels in RAW264.7 macrophages administered histone H3. In vivo, the levels of NOD2, HDAC6 the NF-kappa b pathway and ferroptosis were increased in ALF mice, which were downregulated by histone H3 antibody and upregulated by histone H3. Extracellular histone H3 could induce ferroptosis in hepatic macrophages in ALF by regulating theNOD2-mediated HDAC6/NF-kappa b signalling pathway.

关键词： ALF HDAC6 histone H3 NF-kappa b NOD2

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MAID: Model Attribution via Inverse Diffusion

MAID: Model Attribution via Inverse Diffusion

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2025 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2025

作者： Zhu, Luyu Ye, Kai Yao, Jiayu Li, Chenxi Zhao, luwen cao, Yuxin Wang, Derui Hao, Jie Beijing University of Posts and Telecommunications China The University of Hong Kong Hong Kong National University of Singapore Singapore CSIRO's Data61 Australia

ISBN: (纸本)9798350368741

The surge in AI-generated images, blending authentic and synthetic content, raises security concerns and complicates model attribution, especially with limited transparency. Existing methods either struggle to attribute across multiple frameworks or rely on additional conditions, such as textual descriptions and white-box access to the source model, limiting their practicality and effectiveness in real-world scenarios. To address this gap, we introduce Model Attribution via Inverse Diffusion (MAID), the first framework-agnostic and self-sufficient approach that leverages the source model features extracted by diffusion models, which also works for images generated from GANs. By employing the inverse diffusion process, we are able to utilize pre-trained Diffusion Models as Denoising Autoencoders, mapping images into a latent space and extracting the Diffusion Model Activations (DMA). This mapping effectively captures the unique characteristics of images originating from different source models, including authentic images, which showcase distinct latent Gaussian signatures. Experimental results show that, even in data-asymmetric unfair comparisons, the attribution classifier trained with our proposed DMA achieves approximately 15% and 3% higher ACC compared to SOTA methods on the DiffusionForensics and Artifact datasets, respectively. The code is available at https://***/Zhu-Luyu/MAID. © 2025 IEEE.

关键词： Deepfake Diffusion Model Model Attribution

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Form-stable phase-change materials supported by 1-octadecylamine-modified montmorillonite for latent heat storage

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INTERNATIONAL JOURNAL OF ENERGY RESEARCH 2021年第6期45卷 8871-8881页

作者： Fan, Dongli Meng, Yuan Shen, Danni cao, Yufeng Chen, Kangli Qian, luwen Liu, Jie Zhao, Qin Nantong Univ Sch Chem & Chem Engn Nantong Peoples R China

Form-stable phase-change materials (FSPCMs) are of great significance for relieving the contradiction of energy supply and demand. Unfortunately, the practical application of FSPCMs is severely compromised by their intrinsic drawbacks including lower latent heat storage (LHS) capacities, inferior interfacial compatibility, and cycling durability. Herein, we have provided a group of novel FSPCMs with higher LHS capacities, using paraffin as the LHS materials, which tightly intertwines with the 1-octadecylamine-modified montmorillonite (C18-MMT) under the capillary action as well as induced dipole force due to its n-alkyl chains compatibility. The obtained composite FSPCMs not only exhibit high melting enthalpies (137.56 J/g) but also demonstrate enhanced shape stability and thermal stability. In addition, the composites also render an impressive long-term thermal cycling capability and structure stability even after 100 thermal cycling durability tests, which are believed to have great potential for application in the thermal management of green energy-saving buildings.

关键词： 1-octadecylamine-modified montmorillonite form-stable phase-change materials high latent heat storage capacity paraffin

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Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1αpathways

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第1期24卷 50-63页

作者： Qiong ZHAO luwen ZHANG Qiufen HE Hui CHANG Zhiqiang WANG Hongcui cao Ying ZHOU Ruolang PAN Ye CHEN Department of Genetics and Department of Genetic and Metabolic DiseaseThe Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders Institute of GeneticsZhejiang UniversityHangzhou 310058China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Xiangshan Hospital of TCM Medical and Health Group Ningbo 315700China Zhejiang Provincial Key Laboratory of Cell-Based Drug and Applied Technology Development Hangzhou 311121China

Accumulating evidence has confirmed the links between transfer RNA(tRNA)modifications and tumor *** present study is the first to explore the role of tRNA methyltransferase 5(TRMT5),which catalyzes the m1G37 modification of mitochondrial tRNAs in hepatocellular carcinoma(HCC)***,based on bioinformatics and clinical analyses,we identified that TRMT5 expression was upregulated in HCC,which correlated with poor *** TRMT5 attenuated HCC proliferation and metastasis both in vivo and in vitro,which may be partially explained by declined extracellular acidification rate(ECAR)and oxygen consumption rate(OCR).Mechanistically,we discovered that knockdown of TRMT5 inactivated the hypoxia-inducible factor-1(HIF-1)signaling pathway by preventing HIF-1αstability through the enhancement of cellular oxygen ***,our data indicated that inhibition of TRMT5 sensitized HCC to doxorubicin by adjusting HIF-1α.In conclusion,our study revealed that targeting TRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy ***,TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy.

关键词： Transfer RNA(tRNA) tRNA methyltransferase 5(TRMT5) Hepatocellular carcinoma(HCC) Hypoxia-inducible factor-1α(HIF-1α)

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Boundary-aware registration network for 4D-CT lung image with sliding motion

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BIOMEDICAL SIGNAL PROCESSING AND CONTROL 2023年第PartC期86卷

作者： Duan, luwen cao, Yuzhu Wang, Ziyu Liu, Desen Fu, Tianxiao Yuan, Gang Zheng, Jian Univ Sci & Technol China Sch Biomed Engn Suzhou Div Life Sci & Med Hefei 230026 Peoples R China Chinese Acad Sci Suzhou Inst Biomed Engn & Technol Med Imaging Dept Suzhou 215163 Peoples R China Jinan Guoke Med Technol Dev Co Ltd Jinan 250101 Peoples R China Shanghai Jiao Tong Univ Suzhou Kowloon Hosp Sch Med Dept Thorac Surg Suzhou 215028 Peoples R China Soochow Univ Affiliated Hosp 1 Dept Radiat Oncol Suzhou 215006 Peoples R China

Background and Objective: Fast and accurate registration of 4D-CT lung images is significant for respiratory motion modeling and radiotherapy planning. However, since the complex respiratory motion involves sliding motion at lung boundary, the traditional registration methods and regularization terms perform poorly in recovering both sliding and smooth deformation in 4D-CT lung image ***: In order to overcome these limitations of the traditional registration methods and regularization terms, we propose a boundary-aware registration model with a spatially adaptive regularization term. We incorporate a lung segmentation network into the registration model. With the lung boundary-aware information from the segmentation network, we construct a spatially adaptive regularization term, which integrates the smooth regularization and the non-smooth regularization, to accommodate both smooth and sliding ***: We evaluate the proposed registration model on clinical 4D-CT data and the public DIR-Lab dataset. Our model provides a minimum Target Registration Error (1.59 & PLUSMN;0.57 mm) of landmarks compared with the other lung registration methods. The ablation studies show that the proposed spatially adaptive regularization term provides superior performance in HD (13.75 & PLUSMN;3.36 mm) and MHD (1.63 & PLUSMN;0.32 mm) to the smooth regularization term and non-smooth regularization ***: The proposed boundary-aware registration model enables adaptive regularization term, which can flexibly regulate both the sliding motion at the lung boundary and the smooth motion inside the lung simultaneously. Therefore, our model can perform fast and accurate registration for 4D-CT lung images with sliding motion, which is beneficial to respiratory motion modeling and lung cancer radiotherapy.

关键词： 4D-CT lung image Registration network Segmentation network Sliding motion Regularization term

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Research on Reactive Power Compensation Technology in Distribution Grid 29

Research on Reactive Power Compensation Technology in Distri...

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第29届中国控制与决策会议

作者： Youjie Ma luwen cao Xuesong Zhou Zhiqiang Gao Key Research Laboratory for Control Theory & Applications in Complicated Systems Tianjin University of Technology

ISBN: (纸本)9781509046584

The researches of reactive power compensation in distribution network mainly consist of two aspects:the research of reactive power compensation optimization theory and the research of reactive power compensation *** to certain configuration principle and optimization principle,the mode and capacity of reactive power compensation can be optimized,which can effectively reduce the system loss and improve the power quality of distribution *** present,reactive power compensation devices include shunt capacitor,static var compensator and static synchronous compensator(D-STATCOM).We could choose the appropriate reactive power compensation device to compensate the distribution network in the view of practice and *** article would introduce some aspects of reactive power compensation breifly,including several studies on compensation mode selection and capacity *** addition,we would also introduce the working principle and the reactive current detection technology of D-STATCOM which is the most advanced reactive power compensation device.

关键词： Reactive Power Compensation Distribution Grid D-STATCOM Reactive Current Detection

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Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2022年 594卷 1-7页

作者： Shi, Chunxia Pei, Maohua Wang, Yao Chen, Qian cao, Pan Zhang, Luyi Guo, Jin Deng, Wei Wang, luwen Li, Xun Gong, Zuojiong Wuhan Univ Dept Infect Dis Renmin Hosp Wuhan 430060 Peoples R China

Evidence shows that trimethylamine (TMA)/trimethylamine-N-oxide (TMAO) is closely related to nonalcoholic fatty liver disease (NAFLD). The conversion of TMA to TMAO is mainly catalyzed by flavincontaining monooxygenases 3 (FMO3) and FMO1. In this study, we explored the role of TMA in the process of NAFLD. The human NAFLD liver puncture data set GSE89632 and rat TMAO gene chip GSE135856 was downloaded for gene differential expression analysis. Besides, oleic acid (OA) combined with palmitate were used to establish high-fat cell model. TMA, TMAO and FMO1-siRNA were used to stimulate L02 cells. Contents of free fatty acid (FFA), triglyceride (TG), TMAO, FMO1 and unfolded protein response (UPR) related proteins GRP78, XBP1, Derlin-1 were detected. Our results showed that FMO1 and PEG10 were important in the progression of NAFLD. Immunohistochemistry showed that FMO1 in NAFLD liver was increased. In addition, the contents of FFA, TG, FMO1 expression, and TMAO were significantly increased after OA thorn palmitate and TMA stimulation. However, after silencing FMO1 with siRNA, the expressions of these molecules were decreased. Besides, the protein levels of GRP78, XBP1, Derlin-1 were increased after TMAO treatment (all P < 0.05). In Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. When FMO1 is silenced, the effects of high fat and TMA on TMAO are blocked. And the role of TMAO in NAFLD may be through the activation of UPR. (c) 2022 Elsevier Inc. All rights reserved.

关键词： NAFLD TMA TMAO FMOs UPR

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HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2021年第15期25卷 7218-7228页

作者： Chen, Qian Wang, Yao Jiao, Fangzhou cao, Pan Shi, Chunxia Pei, Maohua Wang, luwen Gong, Zuojiong Wuhan Univ Renmin Hosp Dept Infect Dis Wuhan Peoples R China

Acute liver failure (ALF) is a rare and critical medical condition. This study was designed to investigate the protective effects and underlying mechanism of ACY1215 in ALF mice. Our findings suggested that ACY1215 treatment ameliorates the pathological hepatic damage of ALF and decreases the serum levels of ALT and AST. Furthermore, ACY1215 pretreatment increased the level of ATM, gamma-H2AX, Chk2, p53, p21, F-actin and vinculin in ALF. Moreover, ACY1215 inhibited the level of NLRP3, ASC, caspase-1, IL-1 beta and IL-18 in ALF. The ATM inhibitor KU55933 could decrease the level of ATM, gamma-H2AX, Chk2, p53, p21, F-actin and vinculin in ALF with ACY1215 pretreatment. The F-actin inhibitor cytochalasin B decreased the level of F-actin and vinculin in ALF with ACY1215 pretreatment. However, cytochalasin B had no effect on protein levels of ATM, Chk2, p53 and p21 in ALF with ACY1215 pretreatment. Cytochalasin B could dramatically increase the level of NLRP3, ASC, caspase-1, IL-1 beta and IL-18 in ALF with ACY1215 pretreatment. These results indicated that ACY1215 exhibited hepatoprotective properties, which was associated with the inhibition of NLRP3 inflammasome, and this effect of ACY1215 was connected with upregulation of the ATM/F-actin mediated signalling pathways.

关键词： acute liver failure ACY1215 ATM F-actin NLRP3

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Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD⁺ salvage metabolic pathway

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GUT PATHOGENS 2022年第1期14卷 29-29页

作者： cao, Pan Chen, Qian Shi, Chunxia Wang, luwen Gong, Zuojiong Wuhan Univ Dept Infect Dis Renmin Hosp 238 Jie Fang Rd Wuhan 430060 Peoples R China

Background Acute liver failure (ALF) patients are often accompanied by severe energy metabolism abnormalities and intestinal microecological imbalance. The intestinal mucosal barrier is severely damaged. Intestinal endotoxin can induce intestinal endotoxemia through the "Gut-Liver axis". More and more evidence shows that members of the gut microbiota, especially Fusobacterium nucleatum (F. nucleatum), are related to inflammatory bowel disease, but whether F. nucleatum is involved in the development of ALF and whether it affects the liver energy metabolism is unclear. Methods This study first detected the abundance of F. nucleatum and its effect on ALF disease, and explored whether F. nucleatum aggravated liver inflammation in vitro and in vivo. Results Our data showed that liver tissues of ALF patients contained different abundances of F. nucleatum, which were related to the degree of liver inflammation. In addition, we found that F. nucleatum infection affected the energy metabolism of the liver during the development of ALF, inhibited the synthesis pathway of nicotinamide adenine dinucleotide (NAD(+))'s salvage metabolism, and promoted inflammatory damage in the liver. In terms of mechanism, F. nucleatum inhibited NAD(+) and the NAD(+)-dependent SIRT1/AMPK signaling pathway, and promoted liver damage of ALF. Conclusions Fusobacterium nucleatum coordinates a molecular network including NAD(+) and SIRT1 to control the progress of ALF. Detection and targeting of F. nucleatum and its related pathways may provide valuable insights for the treatment of ALF.

关键词： Acute liver failure Energy metabolism Gut-liver axis Fusobacterium nucleatum Inflammation

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MAID: Model Attribution via Inverse Diffusion

MAID: Model Attribution via Inverse Diffusion

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： Luyu Zhu Kai Ye Jiayu Yao Chenxi Li luwen Zhao Yuxin cao Derui Wang Jie Hao Beijing University of Posts and Telecommunications China The University of Hong Kong Hong Kong SAR National University of Singapore Singapore CSIRO’s Data61 Australia

ISBN: (数字)9798350368741

ISBN: (纸本)9798350368758

关键词： Limiting Noise reduction Autoencoders Diffusion processes Feature extraction Diffusion models Security Surges Speech processing Glass box

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